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B S Margulies et al.
Bone, 79, 121-130 (2015-06-09)
Ewing's sarcoma of bone is a primary childhood malignancy of bone that is treated with X-radiation therapy in combination with surgical excision and chemotherapy. To better study Ewing's sarcoma of bone we developed a novel model of primary Ewing's sarcoma
Joanna Kopecka et al.
Oncotarget, 6(9), 6776-6793 (2015-02-18)
Multidrug resistance (MDR) in cancer cells is a challenging phenomenon often associated with P-glycoprotein (Pgp) surface expression. Finding new ways to bypass Pgp-mediated MDR still remains a daunting challenge towards the successful treatment of malignant neoplasms such as colorectal cancer.We
Esther Roselló-Lletí et al.
PloS one, 9(11), e112971-e112971 (2014-11-15)
Dilated cardiomyopathy (DCM) is a public health problem with no available curative treatment, and mitochondrial dysfunction plays a critical role in its development. The present study is the first to analyze the mitochondrial proteome in cardiac tissue of patients with
Reshu Saxena et al.
PloS one, 10(4), e0122994-e0122994 (2015-04-16)
Nef is an accessory viral protein that promotes HIV-1 replication, facilitating alterations in cellular pathways via multiple protein-protein interactions. The advent of proteomics has expanded the focus on better identification of novel molecular pathways regulating disease progression. In this study
Jye-Lin Hsu et al.
PLoS pathogens, 11(4), e1004811-e1004811 (2015-04-16)
Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I). Here we show that US2 function goes far beyond MHC-I
Catherine Béliveau et al.
Journal of virology, 89(17), 8909-8921 (2015-06-19)
Polydnaviruses form a group of unconventional double-stranded DNA (dsDNA) viruses transmitted by endoparasitic wasps during egg laying into caterpillar hosts, where viral gene expression is essential to immature wasp survival. A copy of the viral genome is present in wasp
Marc Vermulst et al.
Nature communications, 6, 8065-8065 (2015-08-26)
Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells that are genetically engineered to display error-prone transcription. We discover that these cells suffer from
Yuan-Yuan Chen et al.
Scientific reports, 5, 11802-11802 (2015-07-03)
The present study aimed to explore the holistic mechanism for the antihypertrophic effect of a compound in Chinese medicine, QiShenYiQi Pills (QSYQ) and the contributions of its components to the effect in rats with cardiac hypertrophy (CH). After induction of
Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies.
Dario Venetz et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(7), 2000-2005 (2015-02-04)
The ability of antibodies to extravasate out of blood vessels is critical for therapeutic activity, because molecular targets for most diseases are located outside of the endothelial lining. By performing detailed biodistribution studies with a novel IL9-armed cancer-specific antibody, we
Aniuska Becerra-Artiles et al.
PloS one, 10(11), e0142871-e0142871 (2015-11-26)
Most of humanity is chronically infected with human herpesvirus 6 (HHV-6), with viral replication controlled at least in part by a poorly characterized CD4 T cell response. Identification of viral epitopes recognized by CD4 T cells is complicated by the
Raquel O Rocha et al.
Journal of agricultural and food chemistry, 63(22), 5335-5343 (2015-06-03)
Several studies have described the effects of seed exudates against microorganisms, but only few of them have investigated the proteins that have defensive activity particularly against nematode parasites. This study focused on the proteins released in the exudates of soybean
Laxmi N Mishra et al.
Journal of proteomics, 128, 218-230 (2015-08-11)
In mammalian spermiogenesis, haploid round spermatids undergo dramatic biochemical and morphological changes and transform into motile mature spermatozoa. A majority of the histones are replaced by transition proteins during mid-spermiogenesis and later replaced by protamines, which occupy the sperm chromatin.
Liu Chunlei et al.
Pakistan journal of pharmaceutical sciences, 28(4 Suppl), 1449-1456 (2015-10-04)
Total proteins of Changbai Mountain hazelnut were extracted and then enzymolysed in solution. The mixture of peptides was separated on chromatograph and identified by shotgun proteomics approach. The identified proteins were analyzed by bioinformatics, 303 proteins were identified, of which
Troii Hall et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 975, 1-8 (2014-12-03)
During the purification development of a bispecific antibody, cation-exchange chromatography was screened for its ability to separate a prominently expressed (>12%) mis-formed disulfide bond variant, termed MAb-diabody, and aggregate from the product of interest. The influence of pH, product load
Alan M Ezrin et al.
American journal of perinatology, 32(6), 605-614 (2015-04-01)
The purpose of this study was to determine whether the proteomic biosignature of circulating microparticles in maternal serum obtained in the second trimester could identify pregnancies that result in spontaneous preterm birth (SPTB). Microparticles were isolated from blinded biorepository-sourced serum
Yan Xiong et al.
Proteomics, 14(15), 1808-1819 (2014-05-21)
Parkinson's disease (PD) is characterized as a movement disorder due to lesions in the basal ganglia. As the major input region of the basal ganglia, striatum plays a vital role in coordinating movements. It receives afferents from the cerebral cortex
Eija Rintala et al.
BMC genomics, 10, 461-461 (2009-10-07)
The industrially important yeast Saccharomyces cerevisiae is able to grow both in the presence and absence of oxygen. However, the regulation of its metabolism in conditions of intermediate oxygen availability is not well characterised. We assessed the effect of oxygen
Valentina R Minciacchi et al.
Oncotarget, 6(13), 11327-11341 (2015-04-11)
Large oncosomes (LO) are atypically large (1-10 µm diameter) cancer-derived extracellular vesicles (EVs), originating from the shedding of membrane blebs and associated with advanced disease. We report that 25% of the proteins, identified by a quantitative proteomics analysis, are differentially
Ji Hye Lee et al.
Proteomics, 15(15), 2669-2677 (2015-04-18)
The objectives of this study were to analyze fetal programming in rat brain using proteomic analysis and to identify fetal programming-related obesity markers. Sprague-Dawley rats were divided into four feeding groups: (i) the Ad Libitum (AdLib)/AdLib group was given a
H Robert Bergen et al.
Skeletal muscle, 5, 21-21 (2015-07-17)
Myostatin is a protein synthesized and secreted by skeletal muscle that negatively regulates muscle mass. The extent to which circulating myostatin levels change in the context of aging is controversial, largely due to methodological barriers. We developed a specific and
Nordine Helassa et al.
The Biochemical journal, 464(2), 213-220 (2014-09-16)
Both lung disease and elevation of blood glucose are associated with increased glucose concentration (from 0.4 to ~4.0 mM) in the airway surface liquid (ASL). This perturbation of ASL glucose makes the airway more susceptible to infection by respiratory pathogens.
F Esra Demircioglu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(38), 13828-13833 (2014-09-06)
Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) and Sec1/Munc18 (SM) proteins constitute the core of an ancient vesicle fusion machine that diversified into distinct sets that now function in different trafficking steps in eukaryotic cells. Deciphering their precise mode of
Karina Alves Toledo et al.
PloS one, 9(11), e112474-e112474 (2014-11-14)
Dengue virus (DENV) is an enveloped RNA virus that is mosquito-transmitted and can infect a variety of immune and non-immune cells. Response to infection ranges from asymptomatic disease to a severe disorder known as dengue hemorrhagic fever. Despite efforts to
T-Y Kao et al.
Cell death & disease, 6, e1642-e1642 (2015-02-13)
Human Lon protease is a mitochondrial matrix protein with several functions, including protein degradation, mitochondrial DNA (mtDNA) binding, and chaperone activity. Lon is currently emerging as an important regulator of mitochondria-contributed tumorigenesis due to its overexpression in cancer cells. To
Quantitative proteomic profiling reveals differentially regulated proteins in cystic fibrosis cells.
Navin Rauniyar et al.
Journal of proteome research, 13(11), 4668-4675 (2014-05-14)
The most prevalent cause of cystic fibrosis (CF) is the deletion of a phenylalanine residue at position 508 in CFTR (ΔF508-CFTR) protein. The mutated protein fails to fold properly, is retained in the endoplasmic reticulum via the action of molecular
Ningning Sun et al.
International journal of molecular sciences, 16(11), 25982-25998 (2015-11-04)
Avian influenza A viruses are serious veterinary pathogens that normally circulate among avian populations, causing substantial economic impacts. Some strains of avian influenza A viruses, such as H5N1, H9N2, and recently reported H7N9, have been occasionally found to adapt to
Jin-Gyun Lee et al.
PloS one, 10(5), e0126243-e0126243 (2015-05-15)
Though the rhesus monkey is one of the most valuable non-human primate animal models for various human diseases because of its manageable size and genetic and proteomic similarities with humans, proteomic research using rhesus monkeys still remains challenging due to
Suji Han et al.
Cancers, 11(12) (2019-11-28)
Glioblastoma is a highly aggressive and lethal brain tumor, with limited treatment options. Abnormal activation of the neddylation pathway is observed in glioblastoma, and the NEDD8-activating enzyme (NAE) inhibitor, MLN4924, was previously shown to be effective in glioblastoma cell line
Mirko Zaffagnini et al.
Antioxidants & redox signaling, 16(1), 17-32 (2011-06-29)
Cysteines (Cys) made acidic by the protein environment are generally sensitive to pro-oxidant molecules. Glutathionylation is a post-translational modification that can occur by spontaneous reaction of reduced glutathione (GSH) with oxidized Cys as sulfenic acids (-SOH). The reverse reaction (deglutathionylation)
Duangnate Isarangkul et al.
International journal of clinical and experimental medicine, 8(6), 9192-9204 (2015-08-27)
The pathogenesis of congenital hydronephrosis in laboratory animals has been studied for many years, yet little is known about the underlying mechanism of this disease. In this study, we investigated a MS-based comparative proteomics approach to characterize the differently expressed
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