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Xuanyue Li et al.
Biofabrication, 11(1), 014101-014101 (2018-10-05)
Current methods to treat large soft-tissue defects mainly rely on autologous transfer of adipocutaneous flaps, a method that is often limited by donor site availability. Engineered vascularized adipose tissues can potentially be a viable and readily accessible substitute to autologous
Thomas D Madsen et al.
Nature communications, 11(1), 4033-4033 (2020-08-21)
Peptide hormones and neuropeptides encompass a large class of bioactive peptides that regulate physiological processes like anxiety, blood glucose, appetite, inflammation and blood pressure. Here, we execute a focused discovery strategy to provide an extensive map of O-glycans on peptide
Jennifer Martinez et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9281-9289 (2014-07-11)
Neurons in the CNS do not regenerate following injury; regeneration is blocked by inhibitory proteins in myelin, such as myelin-associated glycoprotein (MAG). Elevating neuronal levels of the second messenger cAMP overcomes this blocked axonal outgrowth. One way to elevate cAMP
Harriët Schellekens et al.
ACS chemical neuroscience, 6(7), 1186-1197 (2015-03-03)
Understanding the intricate pathways that modulate appetite and subsequent food intake is of particular importance considering the rise in the incidence of obesity across the globe. The serotonergic system, specifically the 5-HT2C receptor, has been shown to be of critical
Randi Mosenden et al.
Cellular signalling, 23(6), 1009-1016 (2010-12-07)
The canonical second messenger cAMP is well established as a potent negative regulator of T cell immune function. Through protein kinase A (PKA) it regulates T cell function at the level of transcription factors, members of the mitogen-activated protein kinase
Yue Liu et al.
Journal of molecular cell biology, 12(7), 515-529 (2020-01-05)
After leaving the testis, mammalian sperm undergo a sequential maturation process in the epididymis followed by capacitation during their movement through the female reproductive tract. These phenotypic changes are associated with modification of protein phosphorylation and membrane remodeling, which is
Frédéric Labéguère et al.
Journal of medicinal chemistry, 63(22), 13526-13545 (2020-09-10)
GPR84 is a medium chain free fatty acid-binding G-protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist of GPR84 (PBI-4050) that displays relatively low potency and selectivity, a clear need exists for an improved modulator. Structural
Nicholas A Kalogriopoulos et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(46), 28763-28774 (2020-11-04)
The molecular mechanisms by which receptor tyrosine kinases (RTKs) and heterotrimeric G proteins, two major signaling hubs in eukaryotes, independently relay signals across the plasma membrane have been extensively characterized. How these hubs cross-talk has been a long-standing question, but
Celina Göttel et al.
International journal of molecular sciences, 21(18) (2020-09-25)
Phosphodiesterases (PDEs) are essential enzymes for the regulation of pathways mediated by cyclic adenosine monophosphate (cAMP). Secondary plant compounds like anthocyanins (ACs) can inhibit PDE activity and, consequently, may be beneficial for lipid metabolism. This study investigated 18 AC-rich juice
Anat Ben-Shlomo et al.
The Journal of clinical investigation, 130(11), 5738-5755 (2020-07-17)
Drivers of sporadic benign pituitary adenoma growth are largely unknown. Whole-exome sequencing of 159 prospectively resected pituitary adenomas showed that somatic copy number alteration (SCNA) rather than mutation is a hallmark of hormone-secreting adenomas and that SCNAs correlate with adenoma
Yufen Zhao et al.
Reproduction (Cambridge, England), 160(6), 853-862 (2020-10-29)
Although urokinase-type plasminogen activator (PLAU) and urokinase-type plasminogen activator receptor (PLAUR) have been reported to play key roles in ovarian function, their precise contribution to mammalian follicular development remains unclear. In this study, we first observed that PLAU and PLAUR
Xuehong Liu et al.
Prostaglandins & other lipid mediators, 132, 31-40 (2016-09-22)
Epoxyeicosatrienoic acids (EETs) are potent vasodilators that play important roles in cardiovascular physiology and disease, yet the molecular mechanisms underlying the biological actions of EETs are not fully understood. Multiple lines of evidence suggest that the actions of EETs are
Tomomi Ohmura et al.
Molecular biology of the cell, 28(12), 1622-1635 (2017-04-22)
The role of prostaglandin A2 (PGA2) in modulation of vascular endothelial function is unknown. We investigated effects of PGA2 on pulmonary endothelial cell (EC) permeability and inflammatory activation and identified a receptor mediating these effects. PGA2 enhanced the EC barrier
Ludivine Drougat et al.
Genetics in medicine : official journal of the American College of Medical Genetics, 23(1), 174-182 (2020-09-09)
Protein kinase A (PKA) subunit defects (in PRKAR1A and PRKACA) are known to contribute to adrenal tumor pathogenesis. We studied the PRKAR1B gene for any genetic changes in bilateral adrenocortical hyperplasia (BAH) and cortisol-producing adrenal adenomas (CPA). Exome sequencing and
Mohsen Mirdamadi et al.
Life sciences, 263, 118584-118584 (2020-10-16)
The non-genomic (prompt) actions of sex steroids on pregnant uterine contractility are not fully explored yet, the aim of our study was to clarify such effects of 17-β estradiol (E2), progesterone (P4) and testosterone (T) on late (22-day) pregnant uterine
Yoshio Muguruma et al.
Biomedical chromatography : BMC, 34(2), e4722-e4722 (2019-10-28)
The metabolome presence of nucleobases, nucleosides, nucleotides and related phosphorylated metabolites has been examined for Alzheimer's disease (AD). Although reversed-phase liquid chromatography tandem mass spectrometry (LC-MS/MS) has been used for the determination of these analytes, they were limited in chromatographic
Nicolas Aznar et al.
eLife, 4, e07091-e07091 (2015-07-01)
Wnt signaling is essential for tissue homeostasis and its dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), which belong to the G-protein coupled receptor superfamily. However, the mechanisms of G protein activation in Wnt signaling remain
Gillian P Johnson et al.
Bone, 145, 115846-115846 (2021-01-16)
The benefits of physical loading to skeletal mass are well known. The primary cilium has emerged as an important organelle in bone mechanobiology/mechanotransduction, particularly in mesenchymal stem/stromal cells, yet the molecular mechanisms of cilium mechanotransduction are poorly understood. In this
Paul Smolen et al.
Journal of computational neuroscience, 49(1), 37-56 (2020-11-12)
Genetic disorders such as Rubinstein-Taybi syndrome (RTS) and Coffin-Lowry syndrome (CLS) cause lifelong cognitive disability, including deficits in learning and memory. Can pharmacological therapies be suggested that improve learning and memory in these disorders? To address this question, we simulated
Giovanni Tangherlini et al.
ChemMedChem, 15(19), 1834-1853 (2021-01-16)
κ-Opioid receptors (KORs) play a predominant role in pain alleviation, itching skin diseases, depression and neurodegenerative disorders such as multiple sclerosis. Therefore, imaging of KOR by a fluorinated PET tracer was envisaged. Two strategies were followed to introduce a F
Eyal Ozeri et al.
Cellular immunology, 361, 104281-104281 (2021-01-17)
Dendritic cells (DCs) mature upon an inflammatory trigger. However, an inflammatory trigger can lead to a semi-mature phenotype, allowing DCs to evoke tolerance and expedite the resolution of inflammation. This duality likely involves context-dependent modulation of inflammatory signaling. Human α1-antitrypsin
Tayloria N G Adams et al.
Biosensors & bioelectronics, 152, 111982-111982 (2020-02-15)
Human neural stem and progenitor cells (hNSPCs) have therapeutic potential to treat neural diseases and injuries since they provide neuroprotection and differentiate into astrocytes, neurons, and oligodendrocytes. However, cultures of hNSPCs are heterogeneous, containing cells linked to distinct differentiated cell
Junhui Sun et al.
Journal of the American Heart Association, 8(24), e013465-e013465 (2019-12-11)
Background Heart failure is one of the leading causes of death in Western countries, and there is a need for new therapeutic approaches. Relaxin-2 is a peptide hormone that mediates pleiotropic cardiovascular effects, including antifibrotic, angiogenic, vasodilatory, antiapoptotic, and anti-inflammatory
Jinbo Cheng et al.
Autophagy, 16(12), 2193-2205 (2020-02-01)
Microglial activation-induced neuroinflammation is closely associated with the development of Parkinson disease (PD). Macroautophagy/autophagy regulates many biological processes, but the role of autophagy in microglial activation during PD development remains largely unclear. In this study, we showed that deletion of
Romain Duroux et al.
Molecules (Basel, Switzerland), 25(20) (2020-10-22)
Olfactory receptors (ORs) are expressed and active in various human tissues, including the skin. Although the sense of smell plays an important physiological role in the regulation of mood and stress, a link between olfactive compounds, ORs, and skin stress
Christian Twittenhoff et al.
PLoS pathogens, 16(1), e1008184-e1008184 (2020-01-18)
Frequent transitions of bacterial pathogens between their warm-blooded host and external reservoirs are accompanied by abrupt temperature shifts. A temperature of 37°C serves as reliable signal for ingestion by a mammalian host, which induces a major reprogramming of bacterial gene
Francis B Arnaldo et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(6), R634-R642 (2014-08-01)
Dopamine-mediated regulation of Na(+)-K(+)-ATPase activity in the posterior gills of some crustaceans has been reported to be involved in osmoregulation. The dopamine receptors of invertebrates are classified into three groups based on their structure and pharmacology: D1- and D2-like receptors
Minna Wu et al.
Digestion, 101(6), 692-705 (2019-08-28)
Fructus has motivation effect on gastrointestinal tract. Hesperidin is extracts of Fructus, and we attempted to prove its effects on improving the gastrointestinal transmission function and determine the possible mechanisms by a loperamide-induced slow transit constipation (STC) model. Constipation phenotypes
SoRa Kim et al.
Biomolecules & therapeutics, 22(5), 400-405 (2014-11-22)
G-protein coupled receptor 119 (GPR119) has emerged as a novel target for the treatment of type 2 diabetes mellitus. GPR119 is involved in glucose-stimulated insulin secretion (GSIS) from the pancreatic β-cells and intestinal cells. In this study, we identified a
Spencer R Andrei et al.
Channels (Austin, Tex.), 11(6), 587-603 (2017-08-10)
Transient receptor potential channels of the ankyrin subtype-1 (TRPA1) are non-selective cation channels that show high permeability to calcium. Previous studies from our laboratory have demonstrated that TRPA1 ion channels are expressed in adult mouse ventricular cardiomyocytes (CMs) and are
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