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Nemailla Bonturi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 919-920, 67-74 (2013-02-16)
The number of studies on gene therapy using plasmid vectors (pDNA) has increased in recent years. As a result, the demand for preparations of pDNA in compliance with recommendations of regulatory agencies (EMEA, FDA) has also increased. Plasmid DNA is
Taavi K Neklesa et al.
PLoS genetics, 5(6), e1000515-e1000515 (2009-06-13)
TORC1 is a central regulator of cell growth in response to amino acid availability, yet little is known about how it is regulated. Here, we performed a reverse genetic screen in yeast for genes necessary to inactivate TORC1. The screen
Joseph O Rich et al.
Bioresource technology, 196, 347-354 (2015-08-11)
Bacterial contaminants can inhibit ethanol production in biofuel fermentations, and even result in stuck fermentations. Contaminants may persist in production facilities by forming recalcitrant biofilms. A two-year longitudinal study was conducted of bacterial contaminants from a Midwestern dry grind corn
Shabir Ahmad Lone et al.
BMC complementary medicine and therapies, 20(1), 131-131 (2020-05-01)
The global prevalence of fungal diseases is increasing rapidly, which affects more than a billion people every year with significant mortality rate. On the other hand, the development of new drugs to treat these fungal infections is slow, while the
A Sousa et al.
Journal of chromatography. A, 1355, 125-133 (2014-06-21)
Preparation of high quantities of supercoiled plasmid DNA of pharmaceutical grade purity is a research area where intensive investigation is being performed. From this standpoint, several downstream methods have been proposed, among them the monolithic chromatographic strategies owing to excellent
Ponnian Stanely Mainzen Prince et al.
Chemico-biological interactions, 232, 68-76 (2015-03-22)
The present study aims to evaluate the preventive effects of vanillic acid on altered ion pumps, ions and Fas-receptor and caspase mediated apoptosis-signaling pathway and cardiomyocyte death in isoproterenol induced myocardial infarcted rats. Male albino Wistar rats were pretreated with
Syed Irfan Raza et al.
Annals of human genetics, 79(2), 92-98 (2014-12-23)
Ectodermal dysplasias (EDs) belong to a group of genetic diseases which result from alterations in ectoderm-derived appendages including hair, nail, teeth and sweat glands. Ectodermal dysplasia syndactyly syndrome (EDSS1) is one of the rare forms of ED caused by mutations
Diana A Alvarez Arias et al.
Cancer immunology research, 2(3), 207-216 (2014-04-30)
Tumor growth is associated with the inhibition of host antitumor immune responses that can impose serious obstacles to cancer immunotherapy. To define the potential contribution of Qa-1-restricted CD8 regulatory T cells (Treg) to the development of tumor immunity, we studied
S Realdon et al.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 28(4), 394-403 (2014-04-09)
Human epidermal growth factor receptor 2 (HER2) is involved in the malignant progression of several human cancers, including esophageal adenocarcinoma (EAC). The purpose of this study was to evaluate HER2 overexpression and to explore the feasibility of confocal laser endomicroscopy
Arnd Petersen et al.
The Journal of allergy and clinical immunology, 136(5), 1295-1301 (2015-06-04)
Peanut is one of the most hazardous sources of food allergens. Unknown allergens are still hidden in the complex lipophilic matrix. These allergens need to be discovered to allow estimation of the allergenic risk for patients with peanut allergy and
Cho-Hao Lin et al.
Vascular pharmacology, 63(2), 88-96 (2014-12-04)
A feature of vascular smooth muscle cells is their unique ability to exist in multiple phenotypes permitting a broad range of functions that include contraction, proliferation, or synthesis and secretion of extracellular matrix. Although it is known that these phenotypes
Sabina Tabaczar et al.
Pharmacological reports : PR, 67(3), 527-534 (2015-05-03)
Considering the role of oxidative stress in carcinogenesis, we investigated the effect of synthetic antioxidant Pirolin (3-carbamoyl-2,2,5,5-tetramethylpyrroline-1-oxyl) on breast cancer progression. Since the anticancer drugs may cause cardiotoxicity due to oxidative stress in the heart muscle, we also evaluated Pirolin
Chen Li et al.
Chemical communications (Cambridge, England), 49(11), 1100-1102 (2013-01-04)
The morphological evolution of PANI helixes was achieved without the use of chiral dopants, but by a facile process through the generation of onion-like multi-lamellar vesicles used as a novel soft-template and a liquid crystal acting as a promoter for
Xuye Lang et al.
Biotechnology and bioengineering, 117(7), 1970-1978 (2020-04-03)
Kinetic enhancement of organophosphate hydrolysis is a long-standing challenge in catalysis. For prophylactic treatment against organophosphate exposure, enzymatic hydrolysis needs to occur at high rates in the presence of low substrate concentrations and enzymatic activity should persist over days and
Philipp A Jaeger et al.
Applied and environmental microbiology, 81(16), 5639-5649 (2015-06-14)
Agar, a seaweed extract, has been the standard support matrix for microbial experiments for over a century. Recent developments in high-throughput genetic screens have created a need to reevaluate the suitability of agar for use as colony support, as modern
Michael Tscherner et al.
PLoS pathogens, 11(10), e1005218-e1005218 (2015-10-17)
Human fungal pathogens like Candida albicans respond to host immune surveillance by rapidly adapting their transcriptional programs. Chromatin assembly factors are involved in the regulation of stress genes by modulating the histone density at these loci. Here, we report a
W F Tonnis et al.
Molecular pharmaceutics, 12(3), 684-694 (2015-01-13)
Protein-based biopharmaceuticals are generally produced as aqueous solutions and stored refrigerated to obtain sufficient shelf life. Alternatively, proteins may be freeze-dried in the presence of sugars to allow storage stability at ambient conditions for prolonged periods. However, to act as
Daniel Weindl et al.
Journal of chromatography. A, 1389, 112-119 (2015-03-10)
Robust quantification of analytes is a prerequisite for meaningful metabolomics experiments. In non-targeted metabolomics it is still hard to compare measurements across multiple batches or instruments. For targeted analyses isotope dilution mass spectrometry is used to provide a robust normalization
Ravi Chand Bollineni et al.
The Analyst, 140(24), 8109-8117 (2015-11-07)
Depletion of highly abundant proteins is an approved step in blood plasma analysis by mass spectrometry (MS). In this study, we explored a precipitation and differential protein solubility approach as a fractionation strategy for abundant protein removal from plasma. Total
Jeong Yeon Kang et al.
Pharmaceutical research, 32(3), 852-862 (2014-08-28)
Cardiotoxicity associated with the use of doxorubicin (DOX), and other chemotherapeutics, limits their clinical potential. This study determined the pharmacokinetics and antitumor and cardioprotective activity of free and liposome encapsulated phenyl-2-aminoethyl-selenide (PAESe). The pharmacokinetics of free PAESe and PAESe encapsulated
Rattaya Amornpisutt et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(7), 4973-4978 (2015-02-06)
Cholangiocarcinoma (CCA) is a malignancy of the bile duct epithelium which is caused by liver fluke infection. The clinical symptoms of CCA were revealed as the disease progresses to advanced stage. Thus, specific diagnostic biomarkers are important for this fatal
Mariana Eksteen et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5751-5760 (2015-05-15)
Human platelet Ag (HPA)-1a, located on integrin β3, is the main target for alloantibodies responsible for fetal and neonatal alloimmune thrombocytopenia (FNAIT) in the white population. There are ongoing efforts to develop an Ab prophylaxis and therapy to prevent or
Hongxia Jiang et al.
World journal of microbiology & biotechnology, 31(10), 1605-1618 (2015-08-13)
The establishment of safe and effective methods for controlling fungal disease is an urgent issue in agriculture and forestry. Microbiological control of plant disease is expected to achieve better results than use of chemically derived fungicides. This study aimed to
Xiangyao Liu et al.
Carbohydrate polymers, 92(1), 659-661 (2012-12-12)
Cellulose fibers were engineered by in situ oxidative polymerization of aniline using ammonium persulfate as oxidant/initiator. The polyaniline/cellulose fiber composite was used for the treatment of Cr(VI)-contaminated water, and its effect was evaluated. Under the conditions studied, the composite exhibited
Sung-Gil Hong et al.
Environmental science & technology, 49(7), 4466-4472 (2015-03-31)
We developed a process for one-pot CO2 conversion and utilization based on simple conversion of CO2 to bicarbonate at ambient temperature with no energy input, by using the cross-linking-based composites of carboxylated polyaniline nanofibers (cPANFs) and carbonic anhydrase. Carbonic anhydrase
Chunyan Yang et al.
Protein science : a publication of the Protein Society, 22(3), 314-326 (2013-01-03)
The hepatitis E virus (HEV) capsid protein has been demonstrated to be able to assemble into particles in vitro. However, this process and the mechanism of protein-protein interactions during particle assembly remain unclear. In this study, we investigated the assembly
S Patil et al.
Animal reproduction science, 214, 106304-106304 (2020-02-24)
The study aim was to determine how to minimize effects of buffalo semen dilution by evaluating the use of egg yolk (EY), low-density lipoprotein (LDL), and OptiXcell (OC) extenders. Ejaculates (n = 18 from six bulls) were divided into three
James F Hunter et al.
Environmental science & technology, 48(17), 10227-10234 (2014-08-06)
A large number of organic species emitted into the atmosphere contain cycloalkyl groups. While cyclic species are believed to be important secondary organic aerosol (SOA) precursors, the specific role of cyclic moieties (particularly for species with multiple or fused rings)
Christina Michailidi et al.
Cancer prevention research (Philadelphia, Pa.), 8(3), 208-221 (2015-01-15)
Exposure to toxicants leads to cumulative molecular changes that overtime increase a subject's risk of developing urothelial carcinoma. To assess the impact of arsenic exposure at a time progressive manner, we developed and characterized a cell culture model and tested
Hengwen Yang et al.
Nature communications, 6, 5717-5717 (2015-01-08)
The conserved phosphatidylserine receptor (PSR) was first identified as a receptor for phosphatidylserine, an 'eat-me' signal exposed by apoptotic cells. However, several studies suggest that PSR may also act as an arginine demethylase, a lysyl hydroxylase, or an RNA-binding protein
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