A4847

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Induction of canonical Wnt signaling by alsterpaullone is sufficient for oral tissue fate during regeneration and embryogenesis in Nematostella vectensis.

Michael Trevino et al.

Developmental dynamics : an official publication of the American Association of Anatomists, 240(12), 2673-2679 (2011-11-05)

Although regeneration is widespread among metazoa, the molecular mechanisms have been studied in only a handful of taxa. Of these taxa, fewer still are amenable to studies of embryogenesis. Our understanding of the evolution of regeneration, and its relation to

Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania.

Mikhail Kalinichev et al.

The international journal of neuropsychopharmacology, 14(8), 1051-1067 (2011-01-07)

There is a growing body of evidence suggesting that animal models can be developed to probe the specific domains of bipolar disorder (BD) using the endophenotype approach. Here we tested clinically active antimanic drugs to validate amphetamine-induced hyperactivity in Black

Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity.

C Schultz et al.

Journal of medicinal chemistry, 42(15), 2909-2919 (1999-07-30)

The paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. To investigate structure-activity relationships and to develop paullones with antitumor activity, derivatives of the lead structure kenpaullone (9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 4a) were synthesized. Paullones with different substituents in the

Epigenomic landscape of enhancer elements during Hydra head organizer formation.

Puli Chandramouli Reddy et al.

Epigenetics & chromatin, 13(1), 43-43 (2020-10-14)

Axis patterning during development is accompanied by large-scale gene expression changes. These are brought about by changes in the histone modifications leading to dynamic alterations in chromatin architecture. The cis regulatory DNA elements also play an important role towards modulating

Apoptosis induced by SRC-family tyrosine kinase inhibitors in cultured rat cortical cells.

Tsuneo Takadera et al.

Neurotoxicity research, 21(3), 309-316 (2011-10-19)

In the central nervous system, members of the Src family of tyrosine kinases (SFKs) are widely expressed and are abundant in neurons. The purpose of this study is to examine whether glycogen synthase-3 (GSK-3) is involved in SFK inhibitor-induced apoptosis.

Wnt/I?-catenin signaling induces axial elasticity patterns of Hydra extracellular matrix.

Veschgini, et al.

iScience, 26, 106416-106416 (2023)

Evidence of Signaling and Adhesion Roles for β-Catenin in the Sponge Ephydatia muelleri.

Klaske J Schippers et al.

Molecular biology and evolution, 35(6), 1407-1421 (2018-03-10)

β-Catenin acts as a transcriptional coactivator in the Wnt/β-catenin signaling pathway and a cytoplasmic effector in cadherin-based cell adhesion. These functions are ancient within animals, but the earliest steps in β-catenin evolution remain unresolved due to limited data from key

Alsterpaullone, a cyclin-dependent kinase inhibitor, mediated toxicity in HeLa cells through apoptosis-inducing effect

Cui C, et al.

Journal of Analytical Methods in Chemistry, 2013(25) (2013)

Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma

Faria C C, et al.

Testing, 6(25), 21718-21718 (2015)

AZD5438 a GSK-3a/b and CDK inhibitor is antiapoptotic modulates mitochondrial activity and protects human neurons from mitochondrial toxins.

Shi, et al.

Scientific Reports, 13, 8334-8334 (2023)

The genetic program for cartilage development has deep homology within Bilateria

Tarazona OA, et al.

Nature, 533(7601), 86-86 (2016)

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