CN
Search Within
A5060
应用筛选条件
关键词:'A5060'
显示 1-30 共 582 条结果 关于 "A5060" 范围 论文
Betty Jurek et al.
Annals of neurology, 86(5), 656-670 (2019-07-22)
Maternal autoantibodies are a risk factor for impaired brain development in offspring. Antibodies (ABs) against the NR1 (GluN1) subunit of the N-methyl-d-aspartate receptor (NMDAR) are among the most frequently diagnosed anti-neuronal surface ABs, yet little is known about effects on
Emiliano Fratini et al.
International journal of oncology, 55(5), 1149-1156 (2019-09-24)
Neuroblastoma (NB) is a heterogeneous extra‑cranial childhood type of cancer, responsible for approximately 15% of all paediatric cancer‑related deaths. Although several critical genetic aberrations have been related to NB, only a few established molecular markers have been associated with prognosis [V‑myc
Harina Vin et al.
eLife, 2, e00969-e00969 (2013-11-07)
Vemurafenib and dabrafenib selectively inhibit the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) kinase, resulting in high response rates and increased survival in melanoma. Approximately 22% of individuals treated with vemurafenib develop cutaneous squamous cell carcinoma (cSCC) during therapy.
Sanjeev Sharma et al.
Cell reports, 27(7), 1979-1990 (2019-05-16)
Phosphatidylinositol 3,4,5-trisphosphate (PIP3) generation at the plasma membrane is a key event during activation of receptor tyrosine kinases such as the insulin receptor required for normal growth and metabolism. We report that in Drosophila, phosphatidylinositol 5 phosphate 4-kinase (PIP4K) is
Oliver H Krämer et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22(5), 1369-1379 (2007-12-13)
The chromosomal translocation products AML1-ETO and PML-RARalpha contribute to the pathogenesis of leukemias. Here, we demonstrate that both AML1-ETO and PML-RARalpha are degraded by the ubiquitin-proteasome system and that their turnover critically depends on the E2-conjugase UbcH8 and the E3-ligase
Lack of Clinical Relevance of ANA and ASMA Positivity in Patients with Liver Transplantation without a History of Autoimmune Diseases.
Pellegrini L, et al.
BioMed Research International, 2017 (2017)
Nguyen Huu Tu et al.
Cancers, 13(18) (2021-09-29)
Oral squamous cell carcinoma (SCC) pain is more prevalent and severe than pain generated by any other form of cancer. We previously showed that protease-activated receptor-2 (PAR2) contributes to oral SCC pain. Cathepsin S is a lysosomal cysteine protease released
Karen K L Chan et al.
Cancer cell international, 18, 65-65 (2018-05-11)
Ovarian cancer is the most lethal gynaecological malignancy. Chemotherapy is the main stay of treatment for metastatic disease, with modest response rates but significant side effects. Therefore, there is a need for alternative therapies that can control the disease while
Oscar G W Wong et al.
The American journal of pathology, 188(10), 2307-2317 (2018-07-23)
The placentas of Down syndrome (DS) pregnancies exhibit morphologic and functional abnormalities. Although the increase in dosage of certain genes on chromosome 21 has been associated with the DS phenotype, the effects on placenta have seldom been studied. Herein, we
Hongyun Li et al.
Neurobiology of aging, 36(5), 1820-1833 (2015-03-19)
Apolipoprotein D (apoD) is expressed in the brain and levels are increased in affected brain regions in Alzheimer's disease (AD). The role that apoD may play in regulating AD pathology has not been addressed. Here, we crossed both apoD-null mice
Abdalla D Mohamed et al.
Scientific reports, 8(1), 15674-15674 (2018-10-26)
Persistent hyperactivity of the Hippo effector YAP in activated satellite cells is sufficient to cause embryonal rhabdomyosarcoma (ERMS) in mice. In humans, YAP is abundant and nuclear in the majority of ERMS cases, and high YAP expression is associated with
Viral G Jain et al.
Journal of immunology (Baltimore, Md. : 1950), 204(10), 2651-2660 (2020-04-03)
Preterm birth (PTB) is a major cause of neonatal mortality and morbidity, often triggered by chorioamnionitis or intrauterine inflammation (IUI) with or without infection. Recently, there has been a strong association of IL-1 with PTB. We hypothesized that IL-1R-associated kinase
Oliver H Krämer et al.
The EMBO journal, 22(13), 3411-3420 (2003-07-04)
Histone-modifying enzymes play essential roles in physiological and aberrant gene regulation. Since histone deacetylases (HDACs) are promising targets of cancer therapy, it is important to understand the mechanisms of HDAC regulation. Selective modulators of HDAC isoenzymes could serve as efficient
Cytoskeletal regulation of platelet formation: Coordination of F-actin and microtubules.
Poulter N S and Thomas S G
The International Journal of Biochemistry & Cell Biology, 66, 69-74 (2015)
Eva-Maria Hock et al.
Cell reports, 24(4), 987-1000 (2018-07-26)
The primarily nuclear RNA-binding protein FUS (fused in sarcoma) forms pathological cytoplasmic inclusions in a subset of early-onset amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients. In response to cellular stress, FUS is recruited to cytoplasmic stress granules, which
Rakesh Kumar Sharma et al.
Cell death discovery, 9(1), 203-203 (2023-06-30)
Cancer cells often hijack metabolic pathways to obtain the energy required to sustain their proliferation. Understanding the molecular mechanisms underlying cancer cell metabolism is key to fine-tune the metabolic preference of specific tumors, and potentially offer new therapeutic strategies. Here
Lorenz Thurner et al.
Nature communications, 11(1), 2465-2465 (2020-05-20)
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma of B-cell origin with frequent expression of functional B-cell receptors (BCRs). Here we report that expression cloning followed by antigen screening identifies DNA-directed RNA polymerase beta' (RpoC) from Moraxella catarrhalis as
Simon Gemble et al.
Nature, 604(7904), 146-151 (2022-04-01)
Diploid and stable karyotypes are associated with health and fitness in animals. By contrast, whole-genome duplications-doublings of the entire complement of chromosomes-are linked to genetic instability and frequently found in human cancers1-3. It has been established that whole-genome duplications fuel
Lucia Knopfová et al.
Molecular cancer, 11, 15-15 (2012-03-24)
The c-Myb transcription factor is essential for the maintenance of stem-progenitor cells in bone marrow, colon epithelia, and neurogenic niches. c-Myb malfunction contributes to several types of malignancies including breast cancer. However, the function of c-Myb in the metastatic spread
Productive HIV-1 infection of tissue macrophages by fusion with infected CD4+ T cells.
Mascarau, et al.
The Journal of cell biology, 222 (2023)
Ting-Ting Du et al.
Aging, 12(7), 6324-6339 (2020-04-09)
Deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) is effective in treating temporal lobe epilepsy (TLE) and protects hippocampal neurons. Autophagy plays an essential role in epileptogenesis; however, the underlying effect of autophagy on ANT-DBS-mediated neuroprotection remains
Maria Grazia Volpe et al.
Foods (Basel, Switzerland), 8(4) (2019-04-04)
In this study different methods were used to evaluate the effectiveness of a carrageenan coating and carrageenan coating incorporating lemon essential oil (ELO) in preserving the physicochemical and olfactory characteristics of trout fillets stored at 4 °C up to 12
Han-Xiang Deng et al.
Communications biology, 4(1), 396-396 (2021-03-27)
CRISPR/Cas9-mediated genome editing provides potential for therapeutic development. Efficacy and long-term safety represent major concerns that remain to be adequately addressed in preclinical studies. Here we show that CRISPR/Cas9-mediated genome editing in two distinct SOD1-amyotrophic lateral sclerosis (ALS) transgenic mouse
Arnold Markovics et al.
The Journal of investigative dermatology, 140(10), 1909-1918 (2020-03-07)
We have shown previously that endocannabinoids promote sebaceous lipogenesis, and sebocytes are involved in the metabolism of the endocannabinoid-like substance oleoylethanolamide (OEA). OEA is an endogenous activator of GPR119, a recently deorphanized receptor, which currently is being investigated as a
Asma Omezzine et al.
Biology of reproduction, 69(3), 752-760 (2003-05-02)
Although the apoptotic cell death process in the prostate is known to be under the control of androgens, the key components targeted by the hormones remain to be investigated. In the present study, we report that the expression and the
Yuji Kajiwara et al.
Acta neuropathologica communications, 6(1), 144-144 (2018-12-24)
GJA1 (connexin43) has been predicted as the top key driver of an astrocyte enriched subnetwork associated with Alzheimer's disease (AD). In this study, we comprehensively examined GJA1 expression across 29 transcriptomic and proteomic datasets from post-mortem AD and normal control
Block or degrade? Balancing on- and off-target effects of antisense strategies against transcripts with expanded triplet repeats in DM1.
El Boujnouni, et al.
Molecular Therapy. Nucleic Acids, 32, 622-636 (2023)
Asuka Iwanaga et al.
Transgenic research, 17(6), 1045-1058 (2008-06-25)
The specific and efficient activation of mitogen-activated protein kinase (MAPK) signaling modules is mediated, at least in part, by scaffold proteins. c-Jun NH(2)-terminal kinase (JNK)-associated leucine zipper protein (JLP) was identified as a scaffold protein for JNK and p38 MAPK
Guillaume Vial et al.
Physiological reports, 4(3) (2016-02-06)
The aim of this study was to characterize the early alterations of the liver mitochondrial function in ZDF (fa/fa) rats that develop diabetes compared to that of their lean counterparts ZDF (fa/+). Liver mitochondrial function was examined in 11- and
Chikako Nakajima et al.
The Journal of biological chemistry, 288(30), 21909-21923 (2013-06-14)
The lipoprotein receptor LRP1 is essential in neurons of the central nervous system, as was revealed by the analysis of conditional Lrp1-deficient mouse models. The molecular basis of its neuronal functions, however, is still incompletely understood. Here we show by
1/20