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[Phenazone and its value as an indicator of metabolic efficiency of the liver].
A Wiela et al.
Postepy higieny i medycyny doswiadczalnej, 41(2), 136-151 (1987-03-01)
Mei-Quan Cai et al.
Water research, 47(8), 2830-2842 (2013-03-26)
Chlorine has been documented that it can effectively remove some pharmaceuticals. Recently, new active oxidants chlorine monoxide and molecular chlorine, which exist as free active chlorine in solution, were reported during pharmaceuticals chlorination. In this study, reaction kinetics, active oxidants
Pil H Lee et al.
Bioorganic & medicinal chemistry letters, 20(1), 69-73 (2009-12-08)
A multiple linear regression QSAR model was developed based on a set of 61 compounds with internally consistent permeability data measured across Franz cell. The data was normalized using a mean permeability value of a reference compound, 3-isobutyl-1-methylxanthine (IBMX). The
Hiroki Yokoo et al.
PloS one, 7(12), e51539-e51539 (2012-12-14)
Sepsis is a major clinical challenge and septic encephalopathy is its nasty complication. The pathogenesis and underlying mechanisms of septic encephalopathy are not well understood. This study sought to fully characterize sepsis-associated biochemical and histopathological changes in brains of mice
Giorgio Ottaviani et al.
Journal of medicinal chemistry, 49(13), 3948-3954 (2006-06-23)
This work was devoted to the search for new artificial membranes allowing a rapid evaluation of passive human skin permeation of compounds with a parallel artificial membrane permeability assay (PAMPA). Effective permeability coefficients (Pe) determined for a set of compounds
Chen Wang et al.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, 40(6), 505-511 (2014-01-01)
This study was undertaken to investigate the effect of edaravone inhalation on inflammasome activation in a rat hyperoxia-induced lung injury (HILI) model. Sprague Dawley rats (n = 61) were randomly assigned into three groups: Control group, HILI group and Edaravone
A Guerra et al.
European journal of medicinal chemistry, 45(3), 930-940 (2009-12-22)
A neural model based on a numerical molecular representation using CODES program to predict oral absorption of any structure is described. This model predicts both high and low-absorbed compounds with a global accuracy level of 74%. CODES/ANN methodology shows promising
M A Metwally et al.
European journal of medicinal chemistry, 56, 254-262 (2012-10-02)
Iminopropanehydrazonoyl cyanide 4 was achieved upon reaction of antipyrine diazonium salt 2 with 3-iminobutanenitrile (3) in EtOH/AcONa. 3-Aminopyrazole derivative 5 was obtained upon reaction of 4 with hydrazine hydrate. Diazodization of 5 afforded the diazonium salt 6 which coupled with
Bram Baert et al.
Bioorganic & medicinal chemistry, 15(22), 6943-6955 (2007-09-11)
A set of 116 structurally very diverse compounds, mainly drugs, was characterized by 1630 molecular descriptors. The biological property modelled in this study was the transdermal permeability coefficient logK(p). The main objective was to find a limited set of suitable
Tsutomu Yamashita et al.
Vascular pharmacology, 58(1-2), 134-139 (2012-10-31)
Superoxides impair nitric oxide (NO) bioactivity; however, the dynamics of NO release in the peripheral microcirculation remain unknown. We investigated the effect of a free-radical scavenger (edaravone) on dynamic NO release and the expression of eNOS and iNOS in microvessels.
Zhong-Yan Zhao et al.
CNS neuroscience & therapeutics, 19(3), 163-169 (2012-12-21)
Oxidative stress is frequently implicated in the pathology of neurodegenerative diseases. This study aimed to investigate the effects and their underlying mechanism(s) of edaravone upon hydrogen peroxide (H2O2)-induced oxidative stress and apoptosis in HT22 cells, a murine hippocampal neuronal model.
Alex Avdeef et al.
Journal of medicinal chemistry, 53(9), 3566-3584 (2010-04-09)
The study aimed to predict effective human jejunal permeability (P(eff)) using a biophysical model based on parametrized paracellular, aqueous boundary layer, and transcellular permeabilities, and the villus-fold surface area expansion factor (k(VF)). Published human jejunal data (119 P(eff), 53 compounds)
[Study of the determination of urea and citrulline in protein-containing media. Manual and automatic diacetylmonoxime method].
G Siest et al.
Clinica chimica acta; international journal of clinical chemistry, 20(3), 373-379 (1968-01-01)
Larry J Jolivette et al.
Journal of pharmaceutical sciences, 94(7), 1467-1483 (2005-05-28)
Human pharmacokinetic parameters are often predicted prior to clinical study from in vivo preclinical pharmacokinetic data. Recent data suggest that extrapolation of monkey pharmacokinetic data tends to be the most accurate method for predicting human clearance. In this study, the
Manthena V S Varma et al.
Journal of medicinal chemistry, 52(15), 4844-4852 (2009-05-19)
Kidney plays an important role in the elimination of drugs, especially with low or negligible hepatic clearance. An analysis of the interrelation of physicochemical properties and the human renal clearance for a data set of 391 drugs or compounds tested
Gustav Ahlin et al.
Journal of medicinal chemistry, 51(19), 5932-5942 (2008-09-16)
The liver-specific organic cation transport protein (OCT1; SLC22A1) transports several cationic drugs including the antidiabetic drug metformin and the anticancer agents oxaliplatin and imatinib. In this study, we explored the chemical space of registered oral drugs with the aim of
A Starek et al.
Folia medica Cracoviensia, 31(3), 251-258 (1990-01-01)
Pharmacokinetic studies indicate the diurnal rhythmicity of metabolism of many drugs. Partially it is a result of circadian variations of mixed function oxidase system, which metabolizes some drugs. The aim of the experiment was to evaluate the elimination rate phenacetin
J V St Peter et al.
Clinical pharmacokinetics, 20(1), 50-65 (1991-01-01)
The disposition of phenazone (antipyrine), a low extraction compound with low protein binding, is known to be altered in the presence of various types of hepatic dysfunction. As such, its pharmacokinetics may be useful in the objective characterisation of altered
Jayanta Chatterjee et al.
Journal of medicinal chemistry, 50(24), 5878-5881 (2007-11-02)
An unselective cyclic peptide integrin ligand was sequentially N-methylated by a designed approach, where only the externally oriented (solvent exposed) amide bonds were N-methylated. The N-methylation resulted in tremendous enhancement in selectivity among the different integrin receptor subtypes (alpha5beta1, alphavbeta3
Mei-Quan Cai et al.
Environmental science and pollution research international, 22(3), 1854-1867 (2014-09-10)
A simultaneous determination method of 14 multi-class pharmaceuticals using solid-phase extraction (SPE) followed by high-performance liquid chromatography-tandem mass spectrometer (HPLC-MS/MS) was established to measure the occurrence and distribution of these pharmaceuticals in tap water and a drinking water treatment plant
Dynamic interactions among host factors that influence antipyrine metabolism: implications for the design and interpretation of studies on ethnic pharmacokinetic variations.
E S Vesell
Progress in clinical and biological research, 214, 425-451 (1986-01-01)
Factors influencing antipyrine elimination.
I H Stevenson
British journal of clinical pharmacology, 4(3), 261-265 (1977-06-01)
Lóránd Kiss et al.
Journal of pharmaceutical sciences, 103(10), 3107-3119 (2014-07-22)
Sucrose fatty acid esters are increasingly used as excipients in pharmaceutical products, but few data are available on their toxicity profile, mode of action, and efficacy on intestinal epithelial models. Three water-soluble sucrose esters, palmitate (P-1695), myristate (M-1695), laurate (D-1216)
A Anadón et al.
Toxicology letters, 220(2), 135-142 (2013-05-04)
Cyfluthrin effects on in vivo drug metabolizing enzymes were evaluated using the oxidative substrate antipyrine. Antipyrine pharmacokinetics in plasma and urinary excretion of its major metabolites with and without cyfluthrin oral treatment (20mg/kg/day for 6 days) were investigated in rats.
Makoto Otsuka et al.
Bio-medical materials and engineering, 22(5), 311-319 (2012-10-02)
The purpose of this study was to evaluate drug content of hospital powder preparations using non-destructive, non-contact, short-term measurements with near-infrared spectroscopy (NIR). Antipyrine (0-50%) was mixed with additive powder, and packed with semi-transparent (SP) or transparent (TP) paper to
Measurement of blood flow with freely diffusible indicators as inert gases, antipyrine, labelled water and rubidium.
N A Lassen et al.
Acta endocrinologica. Supplementum, 158, 95-111 (1972-01-01)
A P Viktorov et al.
Farmakologiia i toksikologiia, 53(1), 74-77 (1990-01-01)
The data about the use of "antipyrine test" in clinical practice for studying the drug oxidation peculiarities are presented. The data characterize the main pharmacokinetic properties of antipyrine as a "metabolic marker" for quantitative estimation of the effects of inductors
Guang-Yi Li et al.
Rheumatology (Oxford, England), 52(3), 438-447 (2012-11-23)
To investigate the efficacy of edaravone, a novel free radical scavenger, on preventing steroid-induced osteonecrosis (ON) in a rabbit model. Thirty-six New Zealand white rabbits were divided into control (C; n = 6), steroid-administered (S; n = 15) and edaravone-administered
Yufang Yan et al.
Neuroscience letters, 531(2), 160-165 (2012-11-07)
Oxidative stress has been demonstrated to be involved in the pathogenesis of Alzheimer's disease (AD). Thus, antioxidant therapy may represent a promising avenue for the treatment of AD. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a potent free radical scavenger and has been shown
[The antipyrine test: its 35-year history and prospects].
M Hartleb et al.
Wiadomosci lekarskie (Warsaw, Poland : 1960), 40(21), 1495-1500 (1987-11-01)
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