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Autoimmune hepatitis: 50 Years of (slow) progress.
M Eric Gershwin et al.
Hepatology (Baltimore, Md.), 59(3), 754-756 (2014-04-09)
Cristina Gontan et al.
The Journal of cell biology, 185(1), 27-34 (2009-04-08)
SRY and other Sox-type transcription factors are important developmental regulators with various implications in human disease. In this study, we identified Exp4 (exportin 4) as an interaction partner of Sox2 in mouse embryonic stem cells and neural progenitors. We show
Ravisha R Weerasinghe et al.
FEBS letters, 583(15), 2521-2526 (2009-07-15)
Amongst the many stimuli orienting the growth of plant roots, of critical importance are the touch signals generated as roots explore the mechanically complex soil environment. However, the molecular mechanisms behind these sensory events remain poorly defined. We report an
M M Imanguli et al.
Leukemia, 28(10), 2016-2027 (2014-03-01)
Activation and migration of regulatory T cells (Treg) into tissue is critical in control of inflammation, but has not been examined extensively in chronic graft versus host disease (cGVHD). In parallel studies of tissues and blood, we determined that FoxP3(+)
J Vilmart-Seuwen et al.
The Journal of cell biology, 103(4), 1279-1288 (1986-10-01)
We have tried to specify a widespread hypothesis on the requirement of ATP for exocytosis (membrane fusion). With Paramecium tetraurelia cells, synchronously (approximately 1 s) exocytosing trichocysts, ATP pools have been measured in different strains, including wild type cells, "non-discharge"
Jessica Herrath et al.
European journal of immunology, 44(10), 2979-2989 (2014-07-06)
Treg cells are important for the maintenance of self-tolerance and are implicated in autoimmunity. Despite enrichment of Treg cells in joints of rheumatoid arthritis (RA) patients, local inflammation persists. As expression of the ATP-hydrolyzing enzymes CD39 and CD73 and the
Ivan D Mascanfroni et al.
Nature immunology, 14(10), 1054-1063 (2013-09-03)
Dendritic cells (DCs) control the balance between effector T cells and regulatory T cells in vivo. Hence, the study of DCs might identify mechanisms of disease pathogenesis and guide new therapeutic approaches for disorders mediated by the immune system. We
CD39: a new surface marker of mouse regulatory γδ T cells.
Atsushi Otsuka et al.
The Journal of allergy and clinical immunology, 132(6), 1448-1451 (2013-07-23)
CD39 target practice.
Debra K Newman
Blood, 121(16), 3061-3062 (2013-04-20)
Jing Wu et al.
Investigative ophthalmology & visual science, 53(11), 7142-7148 (2012-09-22)
To investigate the mechanisms for endogenous production of extracellular adenosine in trabecular meshwork (TM) cells and evaluate its physiological relevance to the regulation of aqueous humor outflow facility. Extra-cellular levels of adenosine monophosphate (AMP) and adenosine in porcine trabecular meshwork
Heather B Cohen et al.
Blood, 122(11), 1935-1945 (2013-08-03)
Sepsis is a highly fatal disease caused by an initial hyperinflammatory response followed by a state of profound immunosuppression. Although it is well appreciated that the initial production of proinflammatory cytokines by macrophages accompanies the onset of sepsis, it remains
David W Rooklin et al.
Journal of the American Chemical Society, 134(37), 15595-15603 (2012-08-30)
Human soluble calcium-activated nucleotidase 1 (hSCAN-1) represents a new family of apyrase enzymes that catalyze the hydrolysis of nucleotide di- and triphosphates, thereby modulating extracellular purinergic and pyrimidinergic signaling. Among well-characterized phosphoryl transfer enzymes, hSCAN-1 is unique not only in
Austin L Hughes
Gene, 527(1), 123-130 (2013-06-25)
Phylogenetic analyses of three families of arthropod apyrases were used to reconstruct the evolutionary relationships of salivary-expressed apyrases, which have an anti-coagulant function in blood-feeding arthropods. Members of the 5'nucleotidase family were recruited for salivary expression in blood-feeding species at
Matthias Zebisch et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 69(Pt 3), 257-262 (2013-03-23)
Nucleoside triphosphate diphosphohydrolases (NTPDases) are a large class of nucleotidases that hydrolyze the (γ/β)- and (β/α)-anhydride bonds of nucleoside triphosphates and diphosphates, respectively. NTPDases are found throughout the eukaryotic domain. In addition, a very small number of members can be
Marie Octave et al.
International journal of molecular sciences, 22(23) (2021-12-11)
Acetyl-CoA carboxylase (ACC) is the first enzyme regulating de novo lipid synthesis via the carboxylation of acetyl-CoA into malonyl-CoA. The inhibition of its activity decreases lipogenesis and, in parallel, increases the acetyl-CoA content, which serves as a substrate for protein
Mehwish Younas et al.
Journal of immunology (Baltimore, Md. : 1950), 191(6), 3161-3168 (2013-08-24)
The heterogeneity of human regulatory T cells (Tregs) may explain the discrepancies between studies on Tregs in physiology and pathology. Contrasting effects of IL-7 on the expansion and survival of human Tregs were reported. Therefore, we investigated the effects of
Chindu Govindaraj et al.
Clinical immunology (Orlando, Fla.), 149(1), 97-110 (2013-08-21)
Ovarian cancer is a prevalent gynecological malignancy with potent immune-suppression capabilities; regulatory T cells (Tregs) are significant contributors to this immune-suppression. As ovarian cancer patients present with high levels of TNF and Tregs expressing TNFR2 are associated with maximal suppressive
Zenichiro Saze et al.
Blood, 122(1), 9-18 (2013-05-17)
Antibody-independent role of B cells in modulating T-cell responses is incompletely understood. Freshly isolated or cultured B cells isolated from the peripheral blood of 30 normal donors were evaluated for CD39 and CD73 coexpression, the ability to produce adenosine 5'-monophosphate
Naresh Kumar et al.
Neurochemistry international, 61(8), 1276-1279 (2012-10-20)
Our electrophysiological studies have shown that both purinergic and glutamatergic receptors are involved in central sensitization of nociceptive neurons in the medullary dorsal horn (MDH). Here we assessed the effects of intrathecal administration of apyrase (a nucleotide degrading enzyme of
Marco Tozzi et al.
Acta physiologica (Oxford, England), 228(2), e13360-e13360 (2019-08-11)
Extracellular ATP signalling is involved in many physiological and pathophysiological processes in several tissues, including adipose tissue. Adipocytes have crucial functions in lipid and glucose metabolism and they express purinergic receptors. However, the sources of extracellular ATP in adipose tissue
Marco Tozzi et al.
Scientific reports, 8(1), 8926-8926 (2018-06-14)
Extracellular ATP is an important short-range signaling molecule that promotes various physiological responses virtually in all cell types, including pancreatic β-cells. It is well documented that pancreatic β-cells release ATP through exocytosis of insulin granules upon glucose stimulation. We hypothesized
V T Nachmias et al.
FEBS letters, 378(3), 258-262 (1996-01-15)
Capping of the barbed-ends of actin filaments is an important mechanism for control of the cytoskeleton. In platelets, a valuable model system, it has been thought that gelsolin was the major capping protein. We now report that platelets contain approximately
Thomas J Bushart et al.
American journal of botany, 100(1), 161-174 (2012-10-11)
Gravity regulates the magnitude and direction of a trans-cell calcium current in germinating spores of Ceratopteris richardii. Blocking this current with nifedipine blocks the spore's downward polarity alignment, a polarization that is fixed by gravity ∼10 h after light induces
Fátima Husein Abdalla et al.
Molecular and cellular biochemistry, 381(1-2), 1-8 (2013-06-26)
This study investigated the effect of quercetin on nucleoside triphosphate diphosphohydrolase (NTP-Dase), 50-nucleotidase, adenosine deaminase (ADA), and acetylcholinesterase (AChE) activities in synaptosomes from cerebral cortex of adult rats exposed to cadmium (Cd). Rats were exposed to Cd (2.5 mg/Kg) and
François Martin et al.
Trends in molecular medicine, 18(12), 742-749 (2012-10-23)
The immune system has important roles in limiting the spread of cancer and shaping the tumor microenvironment. Although the contributions of T helper 17 (Th17) cells (a subtype of CD4(+) T lymphocytes) to autoimmunity and allergy response are well known
Martina Nowak-Machen et al.
American journal of respiratory cell and molecular biology, 48(5), 601-609 (2013-01-26)
Critically ill patients are routinely exposed to high concentrations of supplemental oxygen for prolonged periods of time, which can be life-saving in the short term, but such exposure also causes severe lung injury and increases mortality. To address this therapeutic
Mark Schmitt et al.
Nature, 612(7939), 347-353 (2022-11-18)
Solid cancers exhibit a dynamic balance between cell death and proliferation ensuring continuous tumour maintenance and growth1,2. Increasing evidence links enhanced cancer cell apoptosis to paracrine activation of cells in the tumour microenvironment initiating tissue repair programs that support tumour
Contribution of CD39 to the immunosuppressive microenvironment of acute myeloid leukaemia at diagnosis.
Nicolas Dulphy et al.
British journal of haematology, 165(5), 722-725 (2014-03-29)
Ya-Dong Gao et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 51(10), 997-1003 (2014-10-02)
Mast cell infiltration into airway smooth muscle (ASM) bundle is an important feature of asthma. Extracellular adenosine triphosphate (eATP) contributes to the initiation of airway inflammation. eATP induces mast cells migration by acting through purinergic receptors. CD39 is an ectonucleotidase
Maogen Chen et al.
Arthritis and rheumatism, 65(5), 1181-1193 (2013-02-13)
Current approaches offer no cures for rheumatoid arthritis (RA). Accumulating evidence has revealed that manipulation of bone marrow-derived mesenchymal stem cells (BM-MSCs) may have the potential to control or even prevent RA, but BM-MSC-based therapy faces many challenges, such as
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