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Zhiyuan Tang et al.
EBioMedicine, 53, 102696-102696 (2020-03-07)
Tumor cells display metabolic changes that correlate with malignancy, including an elevated hydrolysis of monoacylglycerol (MAG) in various cancer types. However, evidence is absent for the relationship between MAG lipolysis and NSCLC. MAG hydrolase activity assay, migration, invasion, proliferation, lipids
Fernanda Crunfli et al.
Neurotoxicity research, 35(3), 516-529 (2019-01-05)
The cannabinoid system has the ability to modulate cellular and molecular mechanisms, including excitotoxicity, oxidative stress, apoptosis, and inflammation, acting as a neuroprotective agent, by its relationship with signaling pathways associated to the control of cell proliferation, differentiation, and survival.
R Abalo et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(12), 1721-1735 (2015-09-22)
Cannabinoids have been traditionally used for the treatment of gastrointestinal (GI) symptoms, but the associated central effects, through cannabinoid-1 receptors (CB1R), constitute an important drawback. Our aims were to characterize the effects of the recently developed highly potent long-acting megagonist
Cristina da Costa Oliveira et al.
Toxicology and applied pharmacology, 369, 30-38 (2019-02-15)
Despite all the development of modern medicine, around 100 compounds derived from natural products were undergoing clinical trials only at the end of 2013. Among these natural substances in clinical trials, we found the resveratrol (RES), a pharmacological multi-target drug.
Hao Xu et al.
Nature communications, 9(1), 4118-4118 (2018-10-10)
Dopamine modulates striatal synaptic plasticity, a key substrate for action selection and procedural learning. Thus, characterizing the repertoire of activity-dependent plasticity in striatum and its dependence on dopamine is of crucial importance. We recently unraveled a striatal spike-timing-dependent long-term potentiation
Ali Mohammad Pourrahimi et al.
Neuropeptides, 73, 25-33 (2018-12-28)
Different types of trigeminal pains are frequently associated with psychophysiological concerns. Orexin-A and orexin 1 receptor (OX1R) are involved in modulation of both trigeminal pain and anxiety responses. Ventrolateral periaqueductal gray matter (vlPAG), a controlling site for nociception and emotion
Jia Huo et al.
The Journal of thoracic and cardiovascular surgery, 157(2), 494-503 (2018-09-10)
The aim of the study was to examine whether the cannabinoid agonist WIN55212-2 could attenuate ischemic spinal cord injury (SCI) in rats through inhibition of GAPDH/Siah1 signaling. Male Sprague-Dawley rats were distributed randomly into 5 groups: (1) sham group that
Farinaz Nasirinezhad et al.
Neuropharmacology, 95, 100-109 (2014-12-09)
Distal sensory neuropathies are a hallmark of HIV infections and can result in persistent and disabling pain despite advances in antiretroviral therapies. HIV-sensory neuropathic (HIV-SN) pain may be amenable to cannabinoid treatment, but currently available agonist treatments are limited by
Bruna Cuccurazzu et al.
The international journal of neuropsychopharmacology, 21(11), 1014-1024 (2018-07-10)
In rodent models, chronic exposure to cannabis' psychoactive ingredient, Δ9-tetrahydrocannabinol, during adolescence leads to abnormal behavior in adulthood. In female rats, this maladaptive behavior is characterized by endophenotypes for depressive-like and psychotic-like disorders as well as cognitive deficits. We recently
Flavia S R Lopes et al.
International journal of molecular sciences, 23(19) (2022-10-15)
Pain is a worldwide public health problem and its treatment is still a challenge since clinically available drugs do not completely reverse chronic painful states or induce undesirable effects. Crotalphine is a 14 amino acids synthetic peptide that induces a
Ewa Galaj et al.
Neuropharmacology, 167, 107740-107740 (2019-08-23)
Cocaine abuse continues to be a serious health problem worldwide. Despite intense research there is currently no FDA-approved medication to treat cocaine use disorder. The recent search has been focused on agents targeting primarily the dopamine system, while limited success
Hamidreza Komaki et al.
Brain research bulletin, 131, 168-175 (2017-04-27)
Long-term potentiation (LTP) of synaptic responses is a widely researched model of synaptic plasticity that occurs during learning and memory. The cannabinoid system is an endogenous system that modulate this kind of synaptic plasticity. In addition, voltage dependent calcium channels
Lauren M Hablitz et al.
eNeuro, 7(1) (2020-01-23)
Circadian rhythms are 24-h cycles in physiology regulated by the suprachiasmatic nucleus (SCN) in the brain, where daily cues act on SCN neurons to alter clock timing. Cannabinoid signaling modulates SCN neuronal activity, although the mechanism remains unclear. We propose
Shiho Ito et al.
Psychopharmacology, 236(7), 2235-2242 (2019-03-15)
N-[[1-(5-fluoropentyl)-1H-indazol-3-yl]carbonyl]-L-valine methyl ester (5F-AMB) is a synthetic cannabinoid that has been distributed recently. Although inhalation of 5F-AMB produces adverse effects, such as impaired memory and disturbed consciousness, in humans, the psychopharmacological effects of 5F-AMB in rodents have not been investigated.
Michelle Corkrum et al.
Neuron, 105(6), 1036-1047 (2020-01-20)
Dopamine is involved in physiological processes like learning and memory, motor control and reward, and pathological conditions such as Parkinson's disease and addiction. In contrast to the extensive studies on neurons, astrocyte involvement in dopaminergic signaling remains largely unknown. Using
Josef Večeřa et al.
Journal of cellular physiology, 233(1), 530-548 (2017-03-17)
Although histone acetylation is one of the most widely studied epigenetic modifications, there is still a lack of information regarding how the acetylome is regulated during brain development and pathophysiological processes. We demonstrate that the embryonic brain (E15) is characterized
Mohammad-Hossein Esmaeili et al.
Behavioural pharmacology, 28(1), 83-89 (2016-12-03)
Orexin plays an important role in pain modulation. Orexin-1 and orexin-2 receptors (Ox1r and Ox2r) are found at high density in the ventrolateral periaqueductal gray matter (vlPAG). Our previous study showed that chemical stimulation of the lateral hypothalamus with carbachol
Bin-Xiao Su et al.
Brain research, 1671, 85-92 (2017-07-19)
The essential role of GAPDH/Siah1 signaling pathway in the pathogenesis of various injurious conditions such as traumatic spinal cord injury (SCI) has been gradually recognized. However, the drugs targeting this signaling pathway are still lacking. The endocannabinoid system, including its
Guoxiang Fang et al.
Neurochemical research, 43(9), 1756-1765 (2018-07-11)
Depression is a common mental disorder in adolescents, with a prevalence rate of 5.6%. Current anti-depressive options for adolescents are limited: psychological intervention and conventional antidepressants have low efficacy, a delayed onset of action and increased possibility of suicidal risk.
Maria Morena et al.
British journal of pharmacology, 178(4), 983-996 (2020-12-15)
Women are twice as likely as men to develop post-traumatic stress disorder (PTSD) making the search for biological mechanisms underlying these gender disparities especially crucial. One of the hallmark symptoms of PTSD is an alteration in the ability to extinguish
Yihui Cui et al.
Frontiers in cellular neuroscience, 12, 182-182 (2018-07-22)
Synaptic efficacy changes, long-term potentiation (LTP) and depression (LTD), underlie various forms of learning and memory. Synaptic plasticity is generally assessed under prolonged activation, whereas learning can emerge from few or even a single trial. Here, we investigated the existence
Jian Xu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(50), 16762-16773 (2014-12-17)
Metaplasticity regulates the threshold for modification of synaptic strength and is an important regulator of learning rules; however, it is not known whether these cellular mechanisms for homeostatic regulation of synapses contribute to particular forms of learning. Conditional ablation of
Marjolein Soethoudt et al.
Nature communications, 8, 13958-13958 (2017-01-04)
The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties
Toshiyuki Kimura et al.
Forensic toxicology, 37(1), 207-214 (2019-01-15)
∆9-Tetrahydrocannabinol (∆9-THC) and cannabidiol (CBD), major psychoactive constituents of marijuana, induce potentiation of pentobarbital-induced sleep in mice. We have elucidated the mechanism of enhancement of the anesthetic effect of pentobarbital by cannabinoids. We carried out pharmacological experiment and cannabinoid1 (CB1)
Manoela V Fogaça et al.
Neuropharmacology, 135, 22-33 (2018-03-07)
Repeated injections of cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, attenuate the anxiogenic effects induced by Chronic Unpredictable Stress (CUS). The specific mechanisms remain to be fully understood but seem to involve adult hippocampal neurogenesis
L S Sampaio et al.
British journal of pharmacology, 172(19), 4615-4625 (2014-12-30)
The function of the endocannabinoid system (ECS) in renal tissue is not completely understood. Kidney function is closely related to ion reabsorption in the proximal tubule, the nephron segment responsible for the re-absorption of 70-80% of the filtrate. We studied
Roberto Colangeli et al.
Neurobiology of disease, 125, 135-145 (2019-02-05)
Endocannabinoids (eCBs) and serotonin (5-HT) play a neuromodulatory role in the central nervous system. Both eCBs and 5-HT regulate neuronal excitability and their pharmacological potentiation has been shown to control seizures in pre-clinical and human studies. Compelling evidence indicates that
Yihui Cui et al.
The Journal of physiology, 593(13), 2833-2849 (2015-04-16)
Although learning can arise from few or even a single trial, synaptic plasticity is commonly assessed under prolonged activation. Here, we explored the existence of rapid responsiveness of synaptic plasticity at corticostriatal synapses in a major synaptic learning rule, spike-timing-dependent
Gilson Goncalves Dos Santos et al.
British journal of pharmacology, 177(20), 4615-4626 (2020-06-21)
While dipyrone is a widely used analgesic, its mechanism of action is not completely understood. Recently, we have reported that the dipyrone metabolite 4-aminoantipyrine (4-AA) reduces PGE2 -induced pain-related behaviour through cannabinoid CB1 receptors. Here, we ascertained, in naive and
Cannabinoid-1 receptors mediate the effects of corticotropin-releasing factor on the reinstatement of cocaine seeking and expression of cocaine-induced behavioural sensitization
Kupferschmidt, D.A., et al.
British Journal of Pharmacology, doi: 10-doi: 10 (2012)
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