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Zhenyao Huang et al.
Nanotoxicology, 13(2), 204-220 (2019-01-22)
Iron oxides nanoparticles (FeOX NPs), including α-Fe2O3, γ-Fe2O3, and Fe3O4, are employed in many technological applications. However, very few studies have investigated the embryonic developmental toxicity of FeOX NPs. In this study, metabolomics analysis were used to uncover the potential
Ruichan Li et al.
Free radical biology & medicine, 135, 116-124 (2019-02-09)
Hydrogen possesses antioxidative effects and cures numerous types of ophthalmopathy, but the mechanism of hydrogen on ROS-induced retinal senescence remains elusive. In this study, retinal morphology revealed that hydrogen reduced the number and size of vitreous black deposits in Bruch's
Brian R Holder et al.
Biomedical chromatography : BMC, 29(9), 1375-1379 (2015-02-26)
Acetyl-L-carnitine (ALCAR) is a potential biomarker for the modulation of brain neurotransmitter activity, but is also present in cerebrospinal fluid (CSF). Recent studies have utilized hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) based assays to detect and quantify ALCAR within
Juan J Jiménez et al.
Chemosphere, 191, 903-910 (2017-11-18)
The fate of the pharmaceutical drugs tenoxicam, piroxicam and meloxicam in river water is evaluated here for first time. So, biological, photochemical and thermal degradation assays have been conducted to estimate their degradation rates and know their degradation products. Results
Susan Burks et al.
Neuroscience letters, 703, 86-95 (2019-03-21)
Parkinson's disease (PD) is a progressive motor disease with clinical features emerging due to degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc), which project to the caudate putamen (CPu) where they release dopamine (DA). The current study
Amanda M Fiorenza et al.
Alcoholism, clinical and experimental research, 42(6), 1051-1061 (2018-03-31)
Conditioned stimuli (CS) that predict reward delivery acquire the ability to induce phasic dopamine release in the nucleus accumbens (NAc). This dopamine release may facilitate conditioned approach behavior, which often manifests as approach to the site of reward delivery (called
Timothy C Durazzo et al.
Alcoholism, clinical and experimental research, 38(11), 2816-2825 (2014-10-23)
This study compared the rate and extent of recovery on measures of learning and memory, processing speed, and working memory in treatment-seeking alcohol-dependent individuals (ALC) who were never smokers (nvsALC), former smokers (fsALC), and active smokers (asALC) over the first
Stefan Ernst et al.
Science advances, 6(20), eaaz8041-eaaz8041 (2020-05-23)
The causative agent of Legionnaires disease, Legionella pneumophila, translocates the phosphocholine transferase AnkX during infection and thereby posttranslationally modifies the small guanosine triphosphatase (GTPase) Rab1 with a phosphocholine moiety at S76 using cytidine diphosphate (CDP)-choline as a cosubstrate. The molecular
Juan J Jiménez et al.
Journal of environmental sciences (China), 51, 13-20 (2017-01-25)
The pharmaceutical compound indomethacin is not totally removed in wastewater treatment plants, whose effluents flow into aquatic environments; concentrations in the 0.1-100ng/L range are commonly found in surface waters, and its fate is unknown. Here, biological, photochemical and thermal degradation
Josephine Jüttner et al.
Nature neuroscience, 22(8), 1345-1356 (2019-07-10)
Targeting genes to specific neuronal or glial cell types is valuable for both understanding and repairing brain circuits. Adeno-associated viruses (AAVs) are frequently used for gene delivery, but targeting expression to specific cell types is an unsolved problem. We created
Barbara De Santis et al.
Mycotoxin research, 36(2), 235-241 (2020-01-26)
Ochratoxin A is one of the most diffused mycotoxin present in a large spectrum of food commodities, mainly produced by Aspergillus ochraceus, Aspergillus carbonarius, Aspergillus niger and Penicillium verrucosum. EU has set maximum limits for a number of matrices such
Lais Pancotto et al.
PeerJ, 6, e5309-e5309 (2018-08-08)
Studies have suggested that oxidative stress may contribute to the pathogenesis of mental disorders. In this context, molecules with antioxidant activity may be promising agents in the treatment of these deleterious conditions. Acetyl-L-carnitine (ALC) is a multi-target molecule that modulates
Role of L-carnitine in female infertility
Agarwal A, et al.
Reproductive Biology and Endocrinology, 16 (2018)
Le Tran Phuc Khoa et al.
Cell stem cell, 27(3), 441-458 (2020-07-02)
Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process
Jill K Hiney et al.
Alcoholism, clinical and experimental research, 42(1), 61-68 (2017-10-27)
Alcohol (ALC) causes suppressed secretion of prepubertal luteinizing hormone-releasing hormone (LHRH). Insulin-like growth factor-1 (IGF-1) and kisspeptin (Kp) are major regulators of LHRH and are critical for puberty. IGF-1 may be an upstream mediator of Kp in the preoptic area
Mahendra Singh et al.
Neurobiology of aging, 67, 108-119 (2018-04-16)
Hearing acuity and sound localization are affected by aging and may contribute to cognitive dementias. Although loss of sensorineural conduction is well documented to occur with age, little is known regarding short-term synaptic plasticity in central auditory nuclei. Age-related changes
Bonnie L Robinson et al.
Journal of applied toxicology : JAT, 37(12), 1438-1447 (2017-06-02)
Cyclosporine A (CsA) is an immunosuppressive drug commonly used in organ transplant patients to prevent allograft rejections. Ketamine is a pediatric anesthetic that noncompetitively inhibits the calcium-permeable N-methyl-d-aspartic acid receptors. Adverse drug-drug interaction effects between ketamine and CsA have been
Iole Venditti et al.
Colloids and surfaces. B, Biointerfaces, 131, 93-101 (2015-05-15)
In this work, a simple and versatile methodology to obtain two different bioconjugated systems has been developed by the immobilization of Candida rugosa lipase (CRL) on hydrophilic gold nanoparticles functionalized with 2-diethylaminoethanethiol hydrochloride (DEA) or with sodium 3-mercapto-1-propanesulfonate (3MPS), namely
Vladana Domazetovic et al.
FEBS open bio, 9(6), 1082-1096 (2019-04-22)
Oxidative stress and abnormal osteocyte apoptosis are often related to dysregulation of bone turnover and chronic bone loss, and so fruit and vegetables with high antioxidant potential may play an important role in the prevention and/or management of osteoporosis. Osteocytes
Yongrui Pi et al.
Bioresource technology, 232, 263-269 (2017-02-27)
Rhodococcus erythropolis M-25, one of the representative biosurfactant producers, performed effectively during the biodegradation of four crude oil. The microbial degradation efficiency is positively relevant to the API of the crude oil. The chemical dispersant Corexit 9500A did not enhance
Bonnie Robinson et al.
Neuroscience letters, 706, 36-42 (2019-05-13)
Ketamine, an anesthetic, is a non-competitive antagonist of the calcium-permeable N-methyl-d-aspartate (NMDA) receptor. High concentrations of ketamine have been implicated in cardiotoxicity and neurotoxicity. Often, these toxicities are thought to be mediated by reactive oxygen species (ROS). However, findings to
Luana Naia et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(10), 2776-2794 (2017-01-27)
Transcriptional deregulation and changes in mitochondrial bioenergetics, including pyruvate dehydrogenase (PDH) dysfunction, have been described in Huntington's disease (HD). We showed previously that the histone deacetylase inhibitors (HDACIs) trichostatin A and sodium butyrate (SB) ameliorate mitochondrial function in cells expressing
Yu Yan et al.
Aging, 11(9), 2699-2723 (2019-05-12)
Senescence is a leading cause of age-related cataract (ARC). The current study indicated that the senescence-associated protein, p53, total laminin (LM), LMα4, and transforming growth factor-beta1 (TGF-β1) in the cataractous anterior lens capsules (ALCs) increase with the grades of ARC.
Min Yu et al.
Biochemical and biophysical research communications, 471(4), 639-645 (2016-02-24)
Targeting mitochondrial biogenesis has become a potential therapeutic strategy in cancer due to their unique metabolic dependencies. In this study, we show that levofloxacin, a FDA-approved antibiotic, is an attractive candidate for breast cancer treatment. This is achieved by the
Luigi Nicassio et al.
Experimental gerontology, 98, 99-109 (2017-08-16)
We previously reported the ability of dietary supplementation with acetyl-l-carnitine (ALCAR) to prevent age-related decreases of mitochondrial biogenesis in skeletal muscle and liver of old rats. Here, we investigate the effects of ALCAR supplementation in cerebral hemispheres and cerebellum of
Kayle S Sawyer et al.
Psychiatry research, 263, 15-25 (2017-03-13)
The brain's reward network has been reported to be smaller in alcoholic men compared to nonalcoholic men, but little is known about the volumes of reward regions in alcoholic women. Morphometric analyses were performed on magnetic resonance brain scans of
Simone Porcelli et al.
Medicine and science in sports and exercise, 47(8), 1643-1651 (2014-11-21)
Dietary nitrate supplementation has been shown to reduce O2 cost of submaximal exercise, improve exercise tolerance, and enhance performance in moderately trained individuals. In contrast, data have been provided that elite athletes do not benefit from nitrate supplementation. The aim
Xiaoshan Z Gordy et al.
Journal of dental education, 83(3), 342-350 (2019-01-30)
The aim of this study was to discover how an active learning classroom (ALC) influenced the teaching and learning of dental radiology with dental hygiene students through a mixed-methods approach. A year-long observation of a dental hygiene professor who was
Shunji Nagai et al.
Transplant international : official journal of the European Society for Organ Transplantation, 28(10), 1195-1204 (2015-06-23)
Absolute lymphocyte count (ALC) has been identified as a prognostic factor in liver transplantation. We hypothesized that a lower ALC may be linked to poor outcomes in isolated intestinal/multivisceral transplantation (IIT/MVT). The aim of this study was to investigate the
Giovanni Pagano et al.
International journal of molecular sciences, 15(11), 20169-20208 (2014-11-08)
An extensive number of pathologies are associated with mitochondrial dysfunction (MDF) and oxidative stress (OS). Thus, mitochondrial cofactors termed "mitochondrial nutrients" (MN), such as α-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and l-carnitine (CARN) (or its derivatives) have been tested in
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