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Brian R Holder et al.
Biomedical chromatography : BMC, 29(9), 1375-1379 (2015-02-26)
Acetyl-L-carnitine (ALCAR) is a potential biomarker for the modulation of brain neurotransmitter activity, but is also present in cerebrospinal fluid (CSF). Recent studies have utilized hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) based assays to detect and quantify ALCAR within
Juan J Jiménez et al.
Chemosphere, 191, 903-910 (2017-11-18)
The fate of the pharmaceutical drugs tenoxicam, piroxicam and meloxicam in river water is evaluated here for first time. So, biological, photochemical and thermal degradation assays have been conducted to estimate their degradation rates and know their degradation products. Results
Juan J Jiménez et al.
Journal of environmental sciences (China), 51, 13-20 (2017-01-25)
The pharmaceutical compound indomethacin is not totally removed in wastewater treatment plants, whose effluents flow into aquatic environments; concentrations in the 0.1-100ng/L range are commonly found in surface waters, and its fate is unknown. Here, biological, photochemical and thermal degradation
Stefan Ernst et al.
Science advances, 6(20), eaaz8041-eaaz8041 (2020-05-23)
The causative agent of Legionnaires disease, Legionella pneumophila, translocates the phosphocholine transferase AnkX during infection and thereby posttranslationally modifies the small guanosine triphosphatase (GTPase) Rab1 with a phosphocholine moiety at S76 using cytidine diphosphate (CDP)-choline as a cosubstrate. The molecular
Josephine Jüttner et al.
Nature neuroscience, 22(8), 1345-1356 (2019-07-10)
Targeting genes to specific neuronal or glial cell types is valuable for both understanding and repairing brain circuits. Adeno-associated viruses (AAVs) are frequently used for gene delivery, but targeting expression to specific cell types is an unsolved problem. We created
Role of L-carnitine in female infertility
Agarwal A, et al.
Reproductive Biology and Endocrinology, 16 (2018)
Lais Pancotto et al.
PeerJ, 6, e5309-e5309 (2018-08-08)
Studies have suggested that oxidative stress may contribute to the pathogenesis of mental disorders. In this context, molecules with antioxidant activity may be promising agents in the treatment of these deleterious conditions. Acetyl-L-carnitine (ALC) is a multi-target molecule that modulates
Barbara De Santis et al.
Mycotoxin research, 36(2), 235-241 (2020-01-26)
Ochratoxin A is one of the most diffused mycotoxin present in a large spectrum of food commodities, mainly produced by Aspergillus ochraceus, Aspergillus carbonarius, Aspergillus niger and Penicillium verrucosum. EU has set maximum limits for a number of matrices such
Timothy C Durazzo et al.
Alcoholism, clinical and experimental research, 38(11), 2816-2825 (2014-10-23)
This study compared the rate and extent of recovery on measures of learning and memory, processing speed, and working memory in treatment-seeking alcohol-dependent individuals (ALC) who were never smokers (nvsALC), former smokers (fsALC), and active smokers (asALC) over the first
Deepam Pushpam et al.
Indian pediatrics, 56(5), 381-383 (2019-03-23)
The relation of absolute lymphocyte count (ALC) with minimal residual disease (MRD) in T cell - acute lymphoblastic leukemia (T-ALL) is not known. The objective of the study was to correlate ALC with MRD, steroid-response and complete remission (CR). De-novo
Evagelia C Laiakis et al.
Radiation research, 181(4), 350-361 (2014-03-29)
The emergence of the threat of radiological terrorism and other radiological incidents has led to the need for development of fast, accurate and noninvasive methods for detection of radiation exposure. The purpose of this study was to extend radiation metabolomic
Margaret C Wardle et al.
PloS one, 10(10), e0140501-e0140501 (2015-10-30)
Polydrug use is common, and might occur because certain individuals experience positive effects from several different drugs during early stages of use. This study examined individual differences in subjective responses to single oral doses of d-amphetamine, alcohol, and delta-9-tetrahydrocannabinol (THC)
K S Avetisov et al.
Journal of the mechanical behavior of biomedical materials, 103, 103600-103600 (2020-02-25)
The lens capsule, a thin specialized basement membrane that encloses the crystalline lens, is essential for both the structural and biomechanical integrity of the lens. Knowing the mechanical properties of the lens capsule is important for understanding its physiological functioning
Laura Borea et al.
Environmental science and pollution research international, 24(1), 321-333 (2016-10-09)
Membrane bioreactor (MBR) technology is becoming increasingly popular as wastewater treatment due to the unique advantages it offers. However, membrane fouling is being given a great deal of attention so as to improve the performance of this type of technology.
Filiz Kazak et al.
Neuroscience letters, 658, 32-36 (2017-08-22)
Neuroinflammation is the inflammation of nervous tissue that can lead to neurodegeneration. Brain-derived neurotrophic factor (BDNF) is a neurotrophin which affects growth, function and survival of neurons, enhances the stabilization of synapses, regulates synaptic function and branching of dendrites and
Mara Mandrioli et al.
Molecules (Basel, Switzerland), 24(11) (2019-06-07)
Cannabis has regained much attention as a result of updated legislation authorizing many different uses and can be classified on the basis of the content of tetrahydrocannabinol (THC), a psychotropic substance for which there are legal limitations in many countries.
Min Zhu et al.
Biochemical and biophysical research communications, 492(3), 373-378 (2017-08-30)
Renal cell carcinoma (RCC) is the most aggressive type of genitourinary cancer and highly resistant to current available therapies. In this work, we investigated the effects and mechanism of anti-parasitic agent ivermectin in RCC. We show that ivermectin significantly inhibits
Arif Yurdagul et al.
Cell metabolism, 31(3), 518-533 (2020-02-01)
Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here, we show that the process is optimized by linking the metabolism of engulfed cargo from initial
Ahlam Alhusaini et al.
Journal of biochemical and molecular toxicology, 34(4), e22449-e22449 (2020-01-23)
Propionic acid (PRA) is used as a food preservative. This study was aimed to investigate the neuroprotective effect of acetyl-l-carnitine (ALC) and nano-Coenzyme Q (N-CoQ) on brain intoxication induced by PRA in rats. Rats were divided into five groups: group
Kifayatullah Shah et al.
Drug delivery, 24(1), 1631-1647 (2017-10-25)
The study investigated aerosolization, pulmonary inhalation, intracellular trafficking potential in macrophages and pharmacokinetics profiles of rifampicin-oleic acid first-generation nanoemulsion and its respective chitosan- and chitosan-folate conjugate-decorated second and third-generation nanoemulsions, delivered via nebulization technique. The nanoemulsions were prepared by conjugate
Luis F Porrata et al.
Leukemia & lymphoma, 55(12), 2728-2738 (2014-02-20)
A limitation of the prognostic factor peripheral blood absolute lymphocyte/monocyte ratio (ALC/AMC) at diagnosis in diffuse large B-cell lymphoma (DLBCL) is its inability to sequentially assess the host/tumor microenvironment interaction and clinical outcomes during treatment. Therefore, we studied the ALC/AMC
Xiaowei Zou et al.
Alcoholism, clinical and experimental research, 42(6), 1062-1072 (2018-04-20)
Widespread brain atrophy in alcohol-dependent individuals (ALC) has been consistently documented in pathological and magnetic resonance imaging (MRI) studies. Longitudinal MRI studies have shown that the regional brain volume losses in ALC are partially reversible during abstinence from alcohol. The
Chia-Yun Wu et al.
Leukemia & lymphoma, 56(8), 2357-2364 (2014-12-03)
Reactivation of hepatitis B virus (HBV) following rituximab (R)-containing chemotherapy for lymphoma is a major concern, and risk factors remain to be defined. We enrolled 190 patients diagnosed with diffuse large B-cell lymphoma (DLBCL) and resolved hepatitis B, receiving first-line
Sang-Min Baek et al.
International journal of clinical pharmacology and therapeutics, 53(11), 980-986 (2015-09-24)
Acetyl-L-carnitine (ALC) has demonstrated neuroprotective effects in several experiments and is widely prescribed to reduce cognitive impairment in Alzheimer's disease patients or manage neuropathic symptoms in diabetic patients. This study was designed to assess the pharmacokinetic (PK) bioequivalence between a
Vladana Domazetovic et al.
Antioxidants (Basel, Switzerland), 9(2) (2020-02-07)
Diets rich in fruits and vegetables with many antioxidants can be very important in the prevention and treatment of osteoporosis. Studies show that oxidative stress, often due to lack of antioxidants, is involved in alteration of bone remodeling and reduction
Asmaa A Abd-Elghaffar et al.
Vaccine, 34(6), 798-802 (2016-01-06)
Development of safe and protective vaccines against infectious pathogens remains a challenge. Inactivation of rabies virus is a critical step in the production of vaccines and other research reagents. Beta-propiolactone (βPL); the currently used inactivating agent for rabies virus is
Myla D Goldman et al.
PloS one, 15(2), e0228617-e0228617 (2020-02-12)
Determine if patient-specific factors modulate absolute lymphocyte count (ALC), neutrophil count (ANC), and/or Neutrophile-lymphocyte ratio (NLR) in Dimethyl Fumarate (DMF) treated patients. A retrospective study of patients who initiated DMF between 2013-2018. A multicenter study of two MS clinics: Charlottesville
Tingsheng Yu et al.
Disease models & mechanisms, 9(2), 155-163 (2015-12-26)
Osteoclasts are bone-resorbing cells derived from the monocyte/macrophage lineage. Excess osteoclast activity leads to reduced bone mineral density, a hallmark of diseases such as osteoporosis. Processes that regulate osteoclast activity are therefore targeted in current osteoporosis therapies. To identify and
Manuel Gomez et al.
Journal of burn care & research : official publication of the American Burn Association, 38(1), e311-e317 (2016-07-06)
On July 2012, a rehabilitation hospital merged with a trauma center where the regional burn center is located. That rehabilitation center provides the only burn rehabilitation program in our region. The objective of this study was to determine if earlier
Angela Whittom et al.
Alcoholism, clinical and experimental research, 38(11), 2790-2799 (2014-11-26)
Alcohol-dependent (ALC) subjects exhibit glial and neuronal pathology in the prefrontal cortex (PFC). However, in many patients, neurophysiological disturbances are not associated with catastrophic cell depletion despite prolonged alcohol abuse. It is still unclear how some relevant markers of a
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