A7009

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Glutamatergic Alterations in STZ-Induced Diabetic Rats Are Reversed by Exendin-4.

Caroline Zanotto et al.

Molecular neurobiology, 56(5), 3538-3551 (2018-08-27)

Diabetes mellitus is a metabolic disorder that results in glucotoxicity and the formation of advanced glycated end products (AGEs), which mediate several systemic adverse effects, particularly in the brain tissue. Alterations in glutamatergic neurotransmission and cognitive impairment have been reported

Methylglyoxal and carboxyethyllysine reduce glutamate uptake and S100B secretion in the hippocampus independently of RAGE activation.

Fernanda Hansen et al.

Amino acids, 48(2), 375-385 (2015-09-09)

Diabetes is a metabolic disease characterized by high fasting-glucose levels. Diabetic complications have been associated with hyperglycemia and high levels of reactive compounds, such as methylglyoxal (MG) and advanced glycation endproducts (AGEs) formation derived from glucose. Diabetic patients have a

Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production.

Shuai Wang et al.

mBio, 10(3) (2019-05-30)

Oral infection of C57BL/6J mice with Toxoplasma gondii results in a marked bacterial dysbiosis and the development of severe pathology in the distal small intestine that is dependent on CD4+ T cells and interferon gamma (IFN-γ). This dysbiosis and bacterial

Bivalves are NO different: nitric oxide as negative regulator of metamorphosis in the Pacific oyster, Crassostrea gigas.

Susanne Vogeler et al.

BMC developmental biology, 20(1), 23-23 (2020-11-25)

Nitric oxide (NO) is presumed to be a regulator of metamorphosis in many invertebrate species, and although NO pathways have been comparatively well-investigated in gastropods, annelids and crustaceans, there has been very limited research on the effects of NO on

Adsorption and desorption characteristics of a phenolic compound from Ecklonia cava on macroporous resin.

Jong Jin Park et al.

Food chemistry, 338, 128150-128150 (2020-10-24)

This study aimed to develop efficient adsorption and desorption processes to purify phenolic compounds from Ecklonia cava. We compared the adsorption and desorption properties of five resins. HP2MG showed the highest adsorption and desorption capacities and adsorption rate; hence, it

Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.

Ana C A X De-Oliveira et al.

PloS one, 10(1), e0117842-e0117842 (2015-01-31)

Mouse cytochrome P450 (CYP) 2A5 is induced by inflammatory conditions and infectious diseases that down-regulate the expression and activity of most other CYP isoforms. Enhanced oxidative stress and nuclear factor (erythroid 2-related factor) 2 (Nrf2) transcription factor activation have been

Exogenous nitric oxide enhances the prophylactic effect of aminoguanidine, a preferred iNOS inhibitor, on bleomycin-induced fibrosis in the lung: Implications for the direct roles of the NO molecule in vivo.

Chao Chen et al.

Nitric oxide : biology and chemistry, 70, 31-41 (2017-08-02)

Inducible nitric oxide synthase (iNOS) aggravates and endothelial nitric oxide synthase (eNOS) ameliorates fibrosis in the lung. Our previous study demonstrated that aminoguanidine (AG), a preferred iNOS inhibitor, prevents bleomycin-induced injury and fibrosis in the lung. The diethylenetriamine nitric oxide

Methylglyoxal Scavengers Attenuate Angiogenesis Dysfunction Induced by Methylglyoxal and Oxygen-Glucose Deprivation.

Wei Chen et al.

Oxidative medicine and cellular longevity, 2022, 8854457-8854457 (2022-01-18)

Cerebral endothelial cells play an essential role in brain angiogenesis, and their function has been found to be impaired in diabetes. Methylglyoxal (MG) is a highly reactive dicarbonyl metabolite of glucose formed mainly during glycolysis, and its levels can be

A simple assay for mammalian spermine oxidase: a polyamine catabolic enzyme implicated in drug response and disease.

Andrew C Goodwin et al.

Methods in molecular biology (Clifton, N.J.), 720, 173-181 (2011-02-15)

Spermine oxidase (SMO), the most recently characterized polyamine metabolic enzyme, catalyzes the direct back-conversion of spermine to spermidine in an FAD-dependent reaction that also yields the byproducts hydrogen peroxide (H(2)O(2)) and 3-aminopropanal. These metabolites, particularly H(2)O(2), have been implicated in

Hepatocyte SHP-1 is a Critical Modulator of Inflammation During Endotoxemia.

Anupam Adhikari et al.

Scientific reports, 7(1), 2218-2218 (2017-05-24)

Liver hepatocytes (Hep) are known to be central players during the inflammatory response to systemic infection. Interestingly, the protein tyrosine phosphatases (PTP) SHP-1, has been recognized as a major regulator of inflammation; however their implication in the control of Hep-mediated

Effects of nitric oxide on ovulation and ovarian steroidogenesis and prostaglandin production in the rabbit.

J Yamauchi et al.

Endocrinology, 138(9), 3630-3637 (1997-09-01)

Evidence supports the involvement of nitric oxide (NO) in ovarian physiology. The present study was undertaken to investigate the role of the NO/NO synthase (NOS) systems in ovulation, oocyte maturation, ovarian steroidogenesis, and PG production using in vitro perfused rabbit

Lipopolysaccharide exposure modulates the contractile and migratory phenotypes of vascular smooth muscle cells.

Felipe Bichi Strela et al.

Life sciences, 241, 117098-117098 (2019-12-04)

Sepsis survivors are at higher risk for cardiovascular events. Lipopolysaccharide (LPS) activates Toll-like receptor 4 (TLR4) in sepsis. Activation of TLR4 modulates vascular smooth muscle cells (VSMCs) phenotype and contributes to cardiovascular changes after sepsis. Investigate changes in VSMCs phenotype

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