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Kwang-Soo Baek et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 19(4), 365-372 (2015-07-15)
Aripiprazole (ARI) is a commonly prescribed medication used to treat schizophrenia and bipolar disorder. To date, there have been no studies regarding the molecular pathological and immunotoxicological profiling of aripiprazole. Thus, in the present study, we prepared two different formulas
Rationale and design of RETAIN study: Rosuvastatin Effect on Telomere-telomerase system in Acute coronary syndrome patients undergoing percutaneous coronary Intervention.
Xiao-Dong Zhuang et al.
International journal of cardiology, 184, 388-390 (2015-03-10)
Wei-Chih Sun et al.
PloS one, 10(2), e0116978-e0116978 (2015-02-07)
Screenings for hepatitis B surface antigen (HBsAg) and antiviral prophylaxis are recommended for HBsAg-positive patients before the start of cytotoxic chemotherapy; however, compliance with these recommendations varies among doctors. We investigated the compliance of doctors with these recommendations using a
D Sivaramakrishna et al.
Langmuir : the ACS journal of surfaces and colloids, 31(35), 9546-9556 (2015-08-21)
A homologous series of l-alanine alkyl ester hydrochlorides (AEs) bearing 9-18 C atoms in the alkyl chain have been synthesized and characterized with respect to self-assembly, supramolecular structure, and phase transitions. The CMCs of AEs bearing 11-18 C atoms were
Martin Hund et al.
Hypertension in pregnancy, 34(1), 102-115 (2015-01-30)
To assess how routine clinical use of the Roche fully automated Elecsys® sFlt-1/PlGF test changes decision-making of physicians to hospitalize pregnant women with suspected preeclampsia. The Preeclampsia Open Study (PreOS) study is a multicenter, prospective, open-label, non-interventional study in 150
K Hopes et al.
The Analyst, 140(9), 3028-3038 (2015-03-10)
Experiments into the relationship between diet and health have been an area of high interest for a long time. In this study, we investigate the application of multivariate data analysis to differentiate between rat populations fed on two different diets:
Victoria Catalán et al.
Acta diabetologica, 52(2), 257-266 (2014-08-15)
The ribosomal protein S6 kinase 1 (S6K1) is a component of the insulin signalling pathway that has been proposed as a key molecular factor in insulin resistance development under conditions of nutrient overload. The aim was to evaluate the involvement
Hanliu Wang et al.
Biochemistry, 54(42), 6475-6481 (2015-09-30)
We report the use of hydrogen-deuterium amide exchange coupled to mass spectrometry (HDX-MS) to study the interfaces of and conformational changes accompanying CsgE oligomerization. This protein plays an important role in enteric bacteria biofilm formation. Biofilms provide protection for enteric
Sally Yu Shi et al.
Nature communications, 6, 7415-7415 (2015-06-17)
Reactive oxygen species (ROS) have been linked to a wide variety of pathologies, including obesity and diabetes, but ROS also act as endogenous signalling molecules, regulating numerous biological processes. DJ-1 is one of the most evolutionarily conserved proteins across species
Hiroshi Suemizu et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 20(9), 1127-1137 (2014-05-20)
The pathogenesis of biliary atresia (BA), which leads to end-stage cirrhosis in most patients, has been thought to inflame and obstruct the intrahepatic and extrahepatic bile ducts. BA is not believed to be caused by abnormalities in parenchymal hepatocytes. However
Yongfeng Fan et al.
PloS one, 10(8), e0135306-e0135306 (2015-08-15)
The paralytic disease botulism is caused by botulinum neurotoxins (BoNT), multi-domain proteins containing a zinc endopeptidase that cleaves the cognate SNARE protein, thereby blocking acetylcholine neurotransmitter release. Antitoxins currently used to treat botulism neutralize circulating BoNT but cannot enter, bind
Bente Bull-Hansen et al.
Oncotarget, 6(14), 12436-12451 (2015-05-24)
HER2-targeted therapy has been shown to have limited efficacy in ovarian cancer despite frequent overexpression of this receptor. Photochemical internalization (PCI) is a modality for cytosolic drug delivery, currently undergoing clinical evaluation. In the present project we studied the application
Wei Li et al.
Food & function, 6(5), 1418-1427 (2015-05-01)
Platycodin D (PD) is the main active saponin of Platycodon grandiflorum (PG) and is reported to exhibit multiple biological effects, including anti-tumor, anti-inflammation, and anti-obesity properties. Although recently there have been many research reports on the chemical constituents of the
Hadar Ivanir-Dabora et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(30), 10778-10785 (2015-06-16)
Magic-angle spinning solid-state NMR spectroscopy has been applied to study the dynamics of CBM3b-Cbh9A from Clostridium thermocellum (ctCBM3b), a cellulose binding module protein. This 146-residue protein has a nine-stranded β-sandwich fold, in which 35 % of the residues are in the
Rodrigo Juliano Oliveira et al.
BMC cancer, 15, 561-561 (2015-08-01)
A large number of studies are attempting to identify alternative products from natural sources or synthesized compounds that effectively interact with cancer cells without causing adverse effects on healthy cells. Resorcinolic lipids are a class of bioactive compounds that possess
Bin Shi et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 44(12), 1224-1233 (2013-07-25)
To investigate the effect of different hepatic vascular occlusion maneuvers on the growth of hepatocarcinoma after liver ischemia-reperfusion (I/R) injury. A mice hepatocarcinoma model was established by portal vein injection of H22 hepatoma cells. After 3 days, the mice underwent
David Sharon et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1442-1450 (2014-10-11)
The NOD.c3c4 mouse model develops autoimmune biliary disease characterized by spontaneous granulomatous cholangitis, antimitochondrial antibodies and liver failure. This model for primary biliary cirrhosis (PBC) has evidence of biliary infection with mouse mammary tumour virus (MMTV), suggesting that the virus
Ling Hao et al.
The Analyst, 140(2), 467-475 (2014-11-28)
Tandem mass spectrometry (MS/MS)-based relative quantification by isobaric labeling is a useful technique to compare different metabolic expression levels in biological systems. For the first time, we have labeled primary and secondary amine-containing small molecules using 4-plex isobaric N,N-dimethyl leucine
Zhuo Yu et al.
Gut, 63(11), 1793-1804 (2014-01-21)
Androgen receptor (AR) signalling contributes to male predominance in hepatocellular carcinoma (HCC), which is more pronounced in HBV-endemic areas. Cell cycle-related kinase (CCRK) is essential for AR-induced hepatocarcinogenesis but its molecular function in HBV-associated HCC remains obscure. To determine the
Hidenori Toyoda et al.
Journal of gastroenterology and hepatology, 30(7), 1183-1189 (2015-02-14)
Hepatocellular carcinoma (HCC) can develop in patients with chronic hepatitis C after they have achieved a sustained virologic response (SVR) to antiviral therapy, that is eradication of hepatitis C virus (HCV). Thus, surveillance for HCC remains necessary after SVR. We
D D Simon et al.
Cells, tissues, organs, 200(2), 104-117 (2015-05-01)
Cell-populated collagen gels have provided significant insight into the cellular contractile mechanisms and cell-matrix interactions that are necessary for compacting and remodeling extant matrix. Nevertheless, little research has been devoted towards determining how cells entrench these deformations that contribute to
Shanhu Hu et al.
Molecular cancer therapeutics, 14(11), 2576-2585 (2015-08-26)
Chromosomal instability (CIN) is a hallmark of solid tumor biology and is implicated in carcinogenesis. Preferentially eliminating malignant cells by targeting CIN and aneuploidy is an attractive antineoplastic strategy. We previously reported that CDK2 antagonism causes lung cancer cells to
María José Varela Liste et al.
Molecular pharmacology, 87(6), 936-953 (2015-03-15)
G protein-coupled receptors, including the M3 muscarinic acetylcholine receptor, can form homo-oligomers. However, the basis of these interactions and the overall organizational structure of such oligomers are poorly understood. Combinations of site-directed mutagenesis and homogenous time-resolved fluorescence resonance energy transfer
Winnie Ng et al.
Journal of immunotoxicology, 12(1), 24-32 (2013-12-20)
Primary aromatic amine drugs are structural alerts in drug development because of their association with a high incidence of idiosyncratic drug reactions (IDRs). If biomarkers could be found that predict IDR risk, it would have a major impact on drug
Carola W N Damen et al.
Journal of lipid research, 55(8), 1772-1783 (2014-06-04)
An ultraperformance LC (UPLC) method for the separation of different lipid molecular species and lipid isomers using a stationary phase incorporating charged surface hybrid (CSH) technology is described. The resulting enhanced separation possibilities of the method are demonstrated using standards
Nikhil Baban Ghate et al.
PloS one, 10(5), e0128221-e0128221 (2015-05-27)
Free iron typically leads to the formation of excess free radicals, and additional iron deposition in the liver contributes to the oxidative pathologic processes of liver disease. Many pharmacological properties of the insectivorous plant Drosera burmannii Vahl. have been reported
Piotr Luliński et al.
Journal of chromatography. A, 1420, 16-25 (2015-10-16)
In this paper, the optimized synthesis and detailed characterization of novel imprinted material for selective extraction of 2-aminothiazoline-4-carboxylic acid (ATCA) were described. The prepolymeric system contained 1-allyl-2-thiourea and ethylene glycol dimethacrylate in methanol, tetrahydrofuran and dimethyl sulfoxide porogenic mixture and
A H Amrallah et al.
Talanta, 46(4), 491-500 (2008-10-31)
The overall formation constants of 1:1:1 ternary complexes of Cu(II), Zn(II), Cd(11) with glycine, dl-alanine or dl-leucine as primary ligands and o-hydroxyphenylyazo derivatives of 2-cyanomethyl benzimidazole (ABI) and barbituric acid (ABA) as secondary ligands have been investigated potentiometrically in 40%
Ji-Young Na et al.
Biochemical and biophysical research communications, 460(2), 308-313 (2015-03-19)
It has been shown that phosphatidylcholine (PC) extracted from egg yolk possesses a variety of biological activities, such as anti-inflammatory and anti-oxidant effects, and prevents oxidative stress. The aim of this study was to evaluate the hepatoprotective effects of PC
Chang Sun Sim et al.
Yonsei medical journal, 56(1), 235-243 (2014-12-17)
To determine the impact of noise on heart rate variability (HRV) in men, with a focus on the noise type rather than on noise intensity. Forty college-going male volunteers were enrolled in this study and were randomly divided into four
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