Konrad Teodor Sawicki et al.
Journal of the American Heart Association, 4(8), e002272-e002272 (2015-08-02)
Heme is an essential iron-containing molecule for cardiovascular physiology, but in excess it may increase oxidative stress. Failing human hearts have increased heme levels, with upregulation of the rate-limiting enzyme in heme synthesis, δ-aminolevulinic acid synthase 2 (ALAS2), which is