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Paweł Błażej et al.
PloS one, 10(6), e0130411-e0130411 (2015-06-30)
Most mutations are deleterious and require energetically costly repairs. Therefore, it seems that any minimization of mutation rate is beneficial. On the other hand, mutations generate genetic diversity indispensable for evolution and adaptation of organisms to changing environmental conditions. Thus
Toshinori Suzuki et al.
Chemical & pharmaceutical bulletin, 63(2), 126-129 (2015-03-10)
When a solution of 5-aminolevulinic acid (ALA) was incubated with acetaldehyde at neutral pH, a product was generated. This product was identified as 3-ethylpyrazine-2,5-dipropanoic acid (ETPY). ETPY was stable at neutral pH. It has been reported that ALA dimerizes at
M Lanza et al.
Journal of animal science, 93(6), 3179-3188 (2015-06-27)
In the present study, we have hypothesized that replacing barley with high proportions of dried citrus pulp in a concentrate-based diet for lambs could increase the intake of unsaturated fatty acids and could reduce the rate of the ruminal biohydrogenation
Pratheeba Palasuberniam et al.
Scientific reports, 5, 13298-13298 (2015-08-19)
Photosensitizer protoporphyrin IX (PpIX) fluorescence, intracellular localization and cell response to photodynamic therapy (PDT) were analyzed in MCF10A normal breast epithelial cells and a panel of human breast cancer cells including estrogen receptor (ER) positive, human epidermal growth factor receptor
Shannon M Gallagher-Colombo et al.
Photochemistry and photobiology, 91(5), 1210-1218 (2015-06-04)
Photodynamic therapy (PDT) can treat superficial, early-stage disease with minimal damage to underlying tissues and without cumulative dose-limiting toxicity. Treatment efficacy is affected by disease physiologic properties, but these properties are not routinely measured. We assessed diffuse reflectance spectroscopy (DRS)
Chi Zhang et al.
The Laryngoscope, 128(9), E323-E331 (2018-04-19)
Photodynamic therapy (PDT) is a promising treatment modality for laryngeal dysplasia, early-stage carcinoma, and papilloma, and was reported to have the ability to preserve laryngeal function and voice quality without clinical fibrotic response. We aimed to investigate the mechanism behind
Michael Jermyn et al.
Biomedical optics express, 6(12), 5063-5074 (2015-12-30)
In glioma surgery, Protoporphyrin IX (PpIX) fluorescence may identify residual tumor that could be resected while minimizing damage to normal brain. We demonstrate that improved sensitivity for wide-field spectroscopic fluorescence imaging is achieved with minimal disruption to the neurosurgical workflow
Xinwei Yang et al.
Journal of ethnopharmacology, 174, 1-10 (2015-08-10)
Tang Luo Ning recipe (TLN), a traditional Chinese herbal medicine based on Huangqi Guizhi Wuwu decoction, has been used clinically to treat diabetic peripheral neuropathy in China. However, the effect of TLN on diabetic peripheral neuropathy is unclear. The objective
Katrin Agnes Salva et al.
Photochemistry and photobiology, 91(6), 1444-1451 (2015-08-26)
Conventional photodynamic therapy with aminolevulinate (ALA-PDT) selectively induces apoptosis in diseased cells and is highly effective for treating actinic keratoses. However, similar results are achieved only in a subset of patients with cutaneous T-cell lymphoma (CTCL). Our previous work shows
Annet Westers-Attema et al.
Dermatology (Basel, Switzerland), 230(1), 55-61 (2014-11-18)
In Bowen's disease (BD) there is no consensus on optimal treatment. Photodynamic therapy (PDT) is an effective non-invasive treatment modality for BD with excellent cosmetic results. This retrospective study examines whether clinical and histological features of BD impact PDT response.
Yinhua Dong et al.
International journal of endocrinology, 2015, 903186-903186 (2015-08-22)
Alpha-lipoic acid (ALA) has various pharmacological effects such as antioxidative, anti-inflammatory, and antiapoptotic properties. In the present study, administration of ALA (40 mg/kg, i.p.) for 3 days resulted in a significant decrease in neuronal deficit score and infarct volume and a
Pablo A Valdés et al.
Journal of neurosurgery, 123(3), 771-780 (2015-07-04)
Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide surgery, it has enabled improved resection leading to increased progression-free survival. Despite the benefits of complete
K E Wood et al.
Prostaglandins, leukotrienes, and essential fatty acids, 95, 47-55 (2015-02-18)
This paper presents a systematic review of human studies investigating the effect of altering dietary omega-3 polyunsaturated fatty acid (n-3 PUFA) alpha-linolenic acid (ALA) and omega-6 polyunsaturated fatty acid (n-6 PUFA) linoleic acid (LA) intakes on n-3 long-chain polyunsaturated fatty
Julia E Martin et al.
PLoS genetics, 11(3), e1004977-e1004977 (2015-03-17)
Escherichia coli does not routinely import manganese, but it will do so when iron is unavailable, so that manganese can substitute for iron as an enzyme cofactor. When intracellular manganese levels are low, the cell induces the MntH manganese importer
Caren Nádia Soares de Sousa et al.
Psychiatry research, 230(2), 211-219 (2015-09-10)
Brain derived neurotrophic factor (BDNF) is linked to the pathophysiology of depression. We hypothesized that BDNF is one of the neurobiological pathways related to the augmentation effect of alpha-lipoic acid (ALA) when associated with antidepressants. Female mice were administered vehicle
Zhimin Yang et al.
PloS one, 9(12), e116283-e116283 (2015-01-01)
The objectives of this study were to determine whether foliar application of a chlorophyll precursor, 5-aminolevulinic acid (ALA), could mitigate salinity stress damages in perennial grass species by regulating photosynthetic activities, ion content, antioxidant metabolism, or metabolite accumulation. A salinity-sensitive
Alaa El-Din E El-Sisi et al.
Toxicology and industrial health, 31(2), 97-107 (2013-01-10)
Ifosfamide (IFO) is a highly effective chemotherapeutic agent for treating a variety of pediatric solid tumors. However, its use is limited due to its serious side effect on kidneys. The side-chain oxidation of IFO in renal tubular cells produces a
Jairo E Mateus et al.
Biomedica : revista del Instituto Nacional de Salud, 34(4), 589-597 (2014-12-17)
Photodynamic therapy (PDT) using 5-aminolevulinic acid-induced protoporphyrin IX (ALA-PpIX) constitutes an interesting alternative for cutaneous leishmaniasis treatment. To evaluate the production of PpIXbased on the administration of ALA and MAL and the effect of ALA-PDTat cellular level on non-infected and
Zheng Hu et al.
Journal of dermatological science, 79(2), 155-162 (2015-05-20)
Malignant melanoma is a very refractory skin tumor due to its high metastasis, poor prognosis, and insensitivity to chemotherapy. Sonodynamic therapy has recently evolved as a potential method to treat cancers. In this study, 5-aminolevulinic acid-mediated sonodynamic therapy (ALA-SDT) was
Lalith Kumar Venkareddy et al.
Neurotoxicology, 48, 142-151 (2015-04-08)
Understanding the interaction between dietary protein deficits and neurotoxicants such as lead (Pb) is critical since oxidative stress is a common denominator under such conditions. The Drosophila system is an extensively used model to investigate the interaction between nutrients and
Kelly L Scholes et al.
Clinical laboratory, 61(7), 785-791 (2015-08-25)
Rapid test strips for ethylenediaminetetraacetic acid (EDTA) can be used to verify correct specimen types for clinical assays which require, or cannot be performed on, plasma collection tubes containing EDTA anticoagulant. As the test strip reaction chemistry is based on
Lei Hu et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 35(3), 323-328 (2015-08-05)
To investigate the role of adenosine tri-phosphate (ATP) purinergic signaling in mast cells (MCs) modulated by heat to further understand the molecular mechanisms of moxibustion. Skin temperatures induced by monkshood cake moxibustion were evaluated by measuring the Neiguan acupoint (PC
Marcella Nebbioso et al.
Oxidative medicine and cellular longevity, 2015, 978654-978654 (2015-11-20)
The objective is to assess the modulation of retinal and optic nerve degenerative events induced by the combination of α-lipoic acid (ALA) and superoxide dismutase (SOD) in an animal model of ageing. For this study, 24 male Wistar-Harlan strain rats
Mary M Cranmer-Byng et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 40(2), 142-154 (2015-02-03)
Long-chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (20:5n-3, EPA) and docosahexaenoic acid (22:6n-3, DHA), have known anti-inflammatory effects, including the modulation of adipose tissue-derived inflammatory mediators (i.e., adipokines) implicated in obesity-related pathologies, such as insulin resistance. Less is known
Andrea Willey et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 41(11), 1290-1295 (2015-10-08)
The efficacy of photodynamic therapy (PDT) using topical 5-aminolevulinic acid (ALA) for the treatment of actinic keratosis (AK) is lower on the distal extremities compared with head and neck areas. A recent pilot study demonstrated increased efficacy of ALA PDT
Josep Marcos et al.
Journal of mass spectrometry : JMS, 50(7), 929-937 (2015-09-10)
We document the presence of a previously unknown species in the urine of patients with acute intermittent porphyria (AIP). The compound was fully characterised by liquid chromatography tandem mass spectrometry. Interpretation of both full spectrum acquisition and product ion spectra
B Ferolla da Camara Boueri et al.
Journal of developmental origins of health and disease, 6(6), 553-557 (2015-10-27)
The aim of this study was analyzed if the flour or flaxseed oil treatment contributes to body composition in male rats subjected to early weaning. Pups were weaned for separation from mother at 14 (early weaning, EW) and 21 days
Firas Şueki et al.
Photodiagnosis and photodynamic therapy, 27, 95-99 (2019-05-18)
Photodynamic Therapy (PDT) is a promising antitumor and anti-bacterial treatment method for its high selectivity, non-invasiveness, and minimal side effects. However, cellular mechanisms may lead to PDT resistance and thus effect efficacy. The aim of this study is to test
Saira Tasmin et al.
Environmental research, 136, 318-323 (2014-12-03)
Lead has long been recognized as a harmful environmental pollutant. People in developing countries like Bangladesh still have a higher risk of lead exposure. Previous research has suggested that the delta-aminolevulinic acid dehydratase (ALAD) genotype can modify lead toxicity and
Ran-Ran Zhao et al.
Neuroscience letters, 587, 113-119 (2014-12-24)
Brain oxidative stress due to chronic cerebral hypoperfusion was considered to be the major risk factor in the pathogenesis of vascular dementia. In this study, we investigated the protective efficacy of alpha-lipoic acid, an antioxidant, against vascular dementia in rats
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