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Eiichi Sakurai et al.
Biological trace element research, 142(3), 713-722 (2010-08-20)
The aim of this study was to examine enhancing effect of L: -histidine into cultured rat lung microvascular endothelial cells (LMECs), which constitute the gas-blood barrier. Uptake of L: -histidine into LMECs markedly increased with the addition of ZnSO(4) (0.1 mmol/L)
Wenping Luo et al.
American journal of translational research, 12(10), 6665-6681 (2020-11-17)
L-type amino acid transporter 1 (LAT1) is a neutral amino acid transporter expressed in trophoblast giant cells onembryonic day 8 in mice. LAT1 is responsible for metabolism in blastocysts and cancer cells. Despite research concerning the aberrant high expression and
Luca Sebastianelli et al.
Experimental neurology, 212(1), 230-233 (2008-05-27)
It is not yet clear how L-dopa, that is the most effective drug for the treatment of Parkinson's disease, enters into the dopaminergic neurons to be transformed into dopamine. It is suggested that L-dopa is mainly transported into cells by
Hisao Imai et al.
Anticancer research, 30(12), 4819-4828 (2010-12-29)
L-type amino acid transporter 1 (LAT1) is highly expressed in various human neoplasms. Antitumor activity of inhibiting LAT1 was analyzed in non-small cell lung cancer (NSCLC). Expression of LAT1 mRNA in 54 lung cancer cell lines was examined by RT-PCR.
Isabel Göhring et al.
The Journal of endocrinology, 212(3), 239-242 (2012-01-11)
In this issue of Journal of Endocrinology, Dr Han and colleagues report a protective effect of the glutamate dehydrogenase activator 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) under diabetes-like conditions that impair β-cell function in both a pancreatic β-cell line and db/db mice. Based
Chem. Abstr., 117, 64436p-64436p (1992)
Jean-Claude Henquin et al.
Diabetes, obesity & metabolism, 19(8), 1061-1070 (2017-01-25)
To understand better the control of insulin secretion by human β cells and to identify similarities to and differences from rodent models. Dynamic insulin secretion was measured in perifused human islets treated with pharmacological agents of known modes of action.
Ryan K Alexander et al.
eLife, 9 (2020-05-13)
Metabolic pathways and inflammatory processes are under circadian regulation. Rhythmic immune cell recruitment is known to impact infection outcomes, but whether the circadian clock modulates immunometabolism remains unclear. We find that the molecular clock Bmal1 is induced by inflammatory stimulants
Magdalena Czeredys et al.
Biochemical and biophysical research communications, 376(2), 267-270 (2008-09-06)
Brain capillary endothelial cells control the uptake and efflux from the brain of many hydrophilic compounds due to highly specialized transporters often localized in a polarized way. Localization of Na(+)- and Cl(-)-dependent amino acid and carnitine transporter B(0,+) (ATB(0,+)) was
No-Seung Park et al.
Anticancer research, 28(5A), 2649-2655 (2008-11-28)
The amino acid transport system L is a major nutrient transport system that is responsible for transport of neutral amino acids, including several essential amino acids. The current study attempted to investigate the expression and functional characterization of amino acid
B Brawek et al.
Naunyn-Schmiedeberg's archives of pharmacology, 379(4), 361-369 (2008-11-13)
One site of action of the anticonvulsant, analgesic, and anxiolytic drugs gabapentin and pregabalin is the alpha(2)delta-subunit of voltage-sensitive Ca(2+) channels (VSCC). We therefore analyzed the effects of gabapentin and pregabalin on K(+)-evoked release of (3)H-gamma-aminobutyric acid (GABA) and (3)H-glutamate
Piman Pocasap et al.
International journal of molecular sciences, 21(6) (2020-04-05)
l-type amino acid transporter 1 (LAT1) is an amino acid transporter that is overexpressed in several types of cancer and, thus, it can be a potential target for chemotherapy. The objectives of this study were to (a) synthesize LAT1-targeted chlorambucil
Yu Takahashi et al.
Pharmaceutical research, 35(12), 246-246 (2018-10-31)
The anti-epileptic drug pregabalin crosses the blood-brain barrier (BBB) in spite of its low lipophilicity. This study was performed to determine whether L-type amino acid transporters (LAT1/SLC7A5 and LAT2/SLC7A8) contribute to the uptake of pregabalin. Pregabalin uptake by LATs-transfected HEK293
Qian Wang et al.
International journal of cancer, 135(5), 1060-1071 (2014-02-18)
Amino acids, especially leucine and glutamine, are important for tumor cell growth, survival and metabolism. A range of different transporters deliver each specific amino acid into cells, some of which are increased in cancer. These amino acids consequently activate the
M M Sánchez del Pino et al.
The Journal of biological chemistry, 267(36), 25951-25957 (1992-12-25)
Endothelial cell membranes, the site of the blood-brain barrier, were obtained from the capillaries of cow brain. The luminal and abluminal membranes were separated by centrifugation on a discontinuous Ficoll gradient. Electron microscopy revealed that the membrane preparations consisted almost
Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods
Singh N, et al.
International Journal of Molecular Sciences, 20(1), 27-27 (2019)
Satoru Takeuchi et al.
Amino acids, 43(2), 717-724 (2011-10-20)
Glioma is the most common type of brain tumor, and has the worst prognosis in human malignancy. Experimental evidence suggests that the use of high concentrations of various amino acids may perturb neoplastic cell growth. Thus, the aim of this
Andrew J M Howden et al.
Nature immunology, 20(11), 1542-1554 (2019-10-09)
Quantitative mass spectrometry reveals how CD4+ and CD8+ T cells restructure proteomes in response to antigen and mammalian target of rapamycin complex 1 (mTORC1). Analysis of copy numbers per cell of >9,000 proteins provides new understanding of T cell phenotypes
Kohichi Yamauchi et al.
Cancer letters, 276(1), 95-101 (2008-12-09)
LAT1, a subunit of heterodimeric system L transporter responsible for transporting neutral amino acids into cells, has been investigated in several cancers because of its onco-fetal nature. Based on the studies of its functional inhibition, LAT1 has been proposed to
Shinya Fukumoto et al.
Biochemical and biophysical research communications, 439(1), 103-108 (2013-08-21)
L-type amino acid transporter 1 (LAT1), an isoform of amino acid transport system L, transports branched or aromatic amino acids essential for fundamental cellular activities such as cellular growth, proliferation and maintenance. This amino acid transporter recently has received attention
Shadi Baniasadi et al.
Archives of pharmacal research, 30(4), 444-452 (2007-05-11)
Inhibition of LAT1 (L-type amino acid transporter 1) activity in tumor cells could be effective in the inhibition of tumor cell growth by depriving tumor cells of essential amino acids. Because of the high level of expression of LAT1 in
Mossaad Abdel-Ghany et al.
Life sciences, 87(23-26), 667-671 (2010-10-05)
To determine whether protein acylation plays a role in the effects of glucose on the insulin secreting β-cell. The measurement of (3)H-palmitate incorporation into protein in the INS 832/13 cell that has a robust and well-characterized biphasic insulin secretory response
Lili Quan et al.
Journal of experimental & clinical cancer research : CR, 39(1), 266-266 (2020-12-02)
Tumor angiogenesis is regarded as a rational anti-cancer target. The efficacy and indications of anti-angiogenic therapies in clinical practice, however, are relatively limited. Therefore, there still exists a demand for revealing the distinct characteristics of tumor endothelium that is crucial
L E Kerper et al.
The American journal of physiology, 262(5 Pt 2), R761-R765 (1992-05-01)
The mechanism by which methylmercury (MeHg) crosses the blood-brain barrier was examined in the rat. Previous studies demonstrated that intravenous injection of L-cysteine with MeHg accelerates MeHg uptake into brain. Since the complex of MeHg with L-cysteine is structurally similar
Eiichi Sakurai et al.
American journal of physiology. Lung cellular and molecular physiology, 282(6), L1192-L1197 (2002-05-11)
The transport characteristics of L- and D-histidine through the blood-lung barrier were studied in cultured rat lung microvascular endothelial cells (LMECs). L-Histidine uptake was a saturable process. The addition of metabolic inhibitors [2,4-dinitrophenol (DNP) and rotenone] reduced the uptake rate
Jian Chen et al.
Analytical biochemistry, 486, 81-85 (2015-07-08)
Large neutral amino acid transporter 1 (LAT1) transports neutral amino acids with aromatic or branched side chains as well as their derivatives or prodrugs. Because the transporter is highly expressed at the blood-brain barrier and in some tumor cells, it
Gavin C Preston et al.
The EMBO journal, 34(15), 2008-2024 (2015-07-03)
Myc controls the metabolic reprogramming that supports effector T cell differentiation. The expression of Myc is regulated by the T cell antigen receptor (TCR) and pro-inflammatory cytokines such as interleukin-2 (IL-2). We now show that the TCR is a digital
Sheng Li et al.
American journal of physiology. Cell physiology, 292(4), C1263-C1271 (2006-11-10)
System L amino acid transporters have been shown to be responsible for cellular uptake of S-nitroso-L-cysteine (l-CSNO). In this study, we examined the characteristics of L-CSNO uptake in Xenopus laevis oocytes expressing system L transporters and found that uptake increased
Michelle van Geldermalsen et al.
BMC cancer, 18(1), 689-689 (2018-06-27)
Cancer cells require increased levels of nutrients such as amino acids to sustain their rapid growth. In particular, leucine and glutamine have been shown to be important for growth and proliferation of some breast cancers, and therefore targeting the primary
G C Gazzola et al.
The Journal of biological chemistry, 255(3), 929-936 (1980-02-10)
The transport of neutral amino acids and their interactions for uptake have been studied in skin-derived-diploid human fibroblasts cultured at confluency. Properly timed preincubations in a medium defined in composition and requirements have been adopted to control size of internal
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