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显示 1-23 共 23 条结果 关于 "A8577" 范围 论文
Hatice S Kaya-Okur et al.
Nature protocols, 15(10), 3264-3283 (2020-09-12)
We recently introduced Cleavage Under Targets & Tagmentation (CUT&Tag), an epigenomic profiling strategy in which antibodies are bound to chromatin proteins in situ in permeabilized nuclei. These antibodies are then used to tether the cut-and-paste transposase Tn5. Activation of the
Chunxia Li et al.
Glycobiology, 31(8), 931-946 (2021-05-13)
Glycan microarrays have played important roles in detection and specificity assignment of glycan recognition by proteins. However, the size and diversity of glycan libraries in current microarray systems are small compared to estimated glycomes, and these may lead to missed
Wei Xu et al.
Nature protocols, 16(8), 4084-4107 (2021-07-21)
Profiling chromatin accessibility at the single-cell level provides critical information about cell type composition and cell-to-cell variation within a complex tissue. Emerging techniques for the interrogation of chromatin accessibility in individual cells allow investigation of the fundamental mechanisms that lead
Nancy Hachicho et al.
PloS one, 10(8), e0134755-e0134755 (2015-08-21)
Morphology and physiology of fish embryos undergo dramatic changes during their development until the onset of feeding, supplied only by endogenous yolk reserves. For obtaining an insight how these restructuring processes are reflected by body mass related parameters, dry weights
Zutao Yu et al.
Nature biotechnology (2023-01-24)
Characterizing drug-target engagement is essential to understand how small molecules influence cellular functions. Here we present Chem-map for in situ mapping of small molecules that interact with DNA or chromatin-associated proteins, utilizing small-molecule-directed transposase Tn5 tagmentation. We demonstrate Chem-map for
Nerry Tatiana Cecílio et al.
International journal of biological macromolecules, 82, 22-30 (2015-10-04)
Recent advances in glycobiology have revealed the essential role of lectins in deciphering the glycocodes at the cell surface to generate important biological signaling responses. ArtinM, a d-mannose-binding lectin isolated from the seeds of jackfruit (Artocarpus heterophyllus), is composed of
Claus G Madsen et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 92, 1-7 (2015-02-11)
This study describes how protein release from polymer matrices correlate with simple measurements on the intrinsic viscosity of the polymer solutions used for casting the matrices and calculations of the solubility parameters of polymers and solvents used. Matrices of poly(dl-lactide-co-glycolide)
Dandan Luo et al.
Journal of controlled release : official journal of the Controlled Release Society, 220(Pt A), 484-494 (2015-11-19)
Drug bioavailability is a key consideration for drug delivery systems. When loaded with doxorubicin, liposomes containing 5 molar % porphyrin-phospholipid (HPPH liposomes) exhibited in vitro and in vivo serum stability that could be fine-tuned by varying the drug-to-lipid ratio. A
Katharina Schönberger et al.
Cell stem cell, 29(1), 131-148 (2021-10-28)
Hematopoietic stem cells (HSCs) rely on complex regulatory networks to preserve stemness. Due to the scarcity of HSCs, technical challenges have limited our insights into the interplay between metabolites, transcription, and the epigenome. In this study, we generated low-input metabolomics
Alexandra L McCubbrey et al.
Cell reports, 38(2), 110222-110222 (2022-01-13)
Phagocytosis of apoptotic cells, termed efferocytosis, is critical for tissue homeostasis and drives anti-inflammatory programming in engulfing macrophages. Here, we assess metabolites in naive and inflammatory macrophages following engulfment of multiple cellular and non-cellular targets. Efferocytosis leads to increases in
Christopher L Nobles et al.
Journal of microbiological methods, 118, 7-17 (2015-08-09)
Bacterial pathogens acquire host iron to power cellular processes and replication. Heme, an iron-containing cofactor bound to hemoglobin, is scavenged by bacterial proteins to attain iron. Methods to measure intracellular heme are laborious, involve complex chemistry, or require radioactivity. Such
CRISPR/Cas9-Mediated Gene Knockout in Cells and Tissues Using Lentivirus.
Lu, et al.
Current protocols, 3, e772-e772 (2023)
Nikolay N Brandt et al.
Journal of biomedical optics, 20(5), 051015-051015 (2014-12-06)
The analysis of the structure-function relationship is extremely important in the study of proteins. The importance of function-related motions of large parts or subglobules of protein molecules stimulates the spectroscopic study in the low-frequency (terahertz) domain. However, only tentative assignments
L L Ong et al.
SLAS discovery : advancing life sciences R & D, 25(2), 176-185 (2019-11-12)
Protein kinases are intensely studied mediators of cellular signaling. While traditional biochemical screens are capable of identifying compounds that modulate kinase activity, these assays are limited in their capability of predicting compound behavior in a cellular environment. Here, we aim
Oxidative damage of albumin in advanced liver disease
Oettl K, et al.
Biochimica et Biophysica Acta, 1782(7-8), 469-473 (2008)
Diana O Ribeiro et al.
The FEBS journal, 287(13), 2723-2743 (2019-12-04)
Understanding the specific molecular interactions between proteins and β1,3-1,4-mixed-linked d-glucans is fundamental to harvest the full biological and biotechnological potential of these carbohydrates and of proteins that specifically recognize them. The family 11 carbohydrate-binding module from Clostridium thermocellum (CtCBM11) is known
Viviana G Correia et al.
Microbiology spectrum, 9(3), e0182621-e0182621 (2021-11-25)
A multigene polysaccharide utilization locus (PUL) encoding enzymes and surface carbohydrate (glycan)-binding proteins (SGBPs) was recently identified in prominent members of Bacteroidetes in the human gut and characterized in Bacteroides ovatus. This PUL-encoded system specifically targets mixed-linkage β1,3-1,4-glucans, a group
Gayathri Kanika et al.
Journal of biochemical and molecular toxicology, 29(8), 349-359 (2015-03-17)
Several reports indicated that histone deacetylases (HDACs) play a crucial role in inflammation and fibrogenesis. Sodium butyrate (SB) is a short-chain fatty acid having HDAC inhibition potential. The present study aimed to evaluate the protective effect of SB against L-arginine
Edwin A Pena et al.
Environmental toxicology and chemistry, 34(9), 1946-1958 (2015-04-14)
Raw menhaden fish oil was developed for biomonitoring polycyclic aromatic hydrocarbons (PAHs) using fluorescence spectroscopy. Menhaden (Genus Brevoortia) were collected in 2010 and/or 2011 from Delaware Bay, New Jersey, USA; James River, Virginia, USA; Vermillion Bay, Louisiana, USA (VBLA); and
The role of fresh cow's milk in iron deficiency: I. Albumin turnover in infants with iron deficiency anemia
Woodruff C W and Clark J L
American Journal of Diseases of Children, 124(1), 18-23 (1972)
Expression of the GLP-1 receptor in mouse, rat, and human pancreas
Tornehave D, et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 56(9), 841-851 (2008)
Michiko Harao et al.
Cancer immunology research, 5(6), 439-445 (2017-05-06)
Triple-negative breast cancer (TNBC) highly infiltrated with CD8
Shaohe Wang et al.
Cell, 184(14), 3702-3716 (2021-06-17)
Many embryonic organs undergo epithelial morphogenesis to form tree-like hierarchical structures. However, it remains unclear what drives the budding and branching of stratified epithelia, such as in the embryonic salivary gland and pancreas. Here, we performed live-organ imaging of mouse
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