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Matthew P Bostock et al.
Frontiers in cell and developmental biology, 8, 590094-590094 (2020-10-30)
Time-lapse imaging is an essential tool to study dynamic biological processes that cannot be discerned from fixed samples alone. However, imaging cell- and tissue-level processes in intact animals poses numerous challenges if the organism is opaque and/or motile. Explant cultures
Johanna M Kobler et al.
Current biology : CB, 30(23), 4693-4709 (2020-10-03)
In spite of the positive effects of bacteria on health, certain species are harmful, and therefore, animals must weigh nutritional benefits against negative post-ingestion consequences and adapt their behavior accordingly. Here, we use Drosophila to unravel how the immune system
Jing Tang et al.
Experimental and therapeutic medicine, 17(5), 3299-3306 (2019-04-17)
The current study aimed to investigate the inhibitory effect of tanshinone IIA (Tan IIA) on the inflammatory response in patients with rheumatoid arthritis (RA) and explore its mechanism. A total of 50 patients with RA were randomly separated into the
Shakti Ranjan Satapathy et al.
Molecular pharmaceutics, 12(11), 4011-4025 (2015-10-09)
A poly(lactic-co-glycolic acid) (PLGA)-based uniform (50-100 nm) hybrid nanoparticle (QAgNP) with positive zeta potential (0.52 ± 0.09 mV) was prepared by single emulsion solvent evaporation method with bioactive small molecule quinacrine (QC) in organic phase and silver (Ag) in aqueous
Nanoparticles containing allotropes of carbon have genotoxic effects on glioblastoma multiforme cells
Hinzmann M et al.
International journal of nanomedicine, 15, 2409-2417 (2014)
Andrew Miri et al.
Journal of neurophysiology, 105(2), 964-980 (2010-11-19)
The advent of methods for optical imaging of large-scale neural activity at cellular resolution in behaving animals presents the problem of identifying behavior-encoding cells within the resulting image time series. Rapid and precise identification of cells with particular neural encoding
Noviana Wulansari et al.
Science advances, 7(8) (2021-02-19)
Loss-of-function mutations of DNAJC6, encoding HSP40 auxilin, have recently been identified in patients with early-onset Parkinson's disease (PD). To study the roles of DNAJC6 in PD pathogenesis, we used human embryonic stem cells with CRISPR-Cas9-mediated gene editing. Here, we show
Andrew Advani et al.
PloS one, 6(10), e24695-e24695 (2011-10-11)
Rarefaction of the renal microvasculature correlates with declining kidney function. However, current technologies commonly used for its evaluation are limited by their reliance on endothelial cell antigen expression and assessment in two dimensions. We set out to establish a widely
Victor Girard et al.
Scientific reports, 10(1), 20023-20023 (2020-11-20)
Glial cells are early sensors of neuronal injury and can store lipids in lipid droplets under oxidative stress conditions. Here, we investigated the functions of the RNA-binding protein, SPEN/SHARP, in the context of Parkinson's disease (PD). Using a data-mining approach
Jun Siong Low et al.
The Journal of experimental medicine, 217(8) (2020-06-12)
CD8+ tissue-resident memory T cells (TRM cells) are poised at the portals of infection and provide long-term protective immunity. Despite their critical roles, the precise mechanics governing TRM cell reactivation in situ are unknown. Using a TCR-transgenic Nur77-GFP reporter to
Chiara Fucci et al.
Cell reports, 32(12), 108162-108162 (2020-09-24)
FAM46C is a non-canonical poly(A) polymerase uniquely mutated in up to 20% of multiple myeloma (MM) patients, implying a tissue-specific tumor suppressor function. Here, we report that FAM46C selectively stabilizes mRNAs encoding endoplasmic reticulum (ER)-targeted proteins, thereby concertedly enhancing the
John-Poul Ng-Blichfeldt et al.
EBioMedicine, 36, 461-474 (2018-09-22)
Despite compelling data describing pro-regenerative effects of all-trans retinoic acid (ATRA) in pre-clinical models of chronic obstructive pulmonary disease (COPD), clinical trials using retinoids for emphysema patients have failed. Crucial information about the specific role of RA signaling in adult
Peng Peng et al.
The ISME journal, 14(3), 815-827 (2020-01-04)
The genus Desulfoluna comprises two anaerobic sulfate-reducing strains, D. spongiiphila AA1T and D. butyratoxydans MSL71T, of which only the former was shown to perform organohalide respiration (OHR). Here we isolated a third strain, designated D. spongiiphila strain DBB, from marine
Carly J Randall et al.
Scientific reports, 9(1), 14596-14596 (2019-10-12)
Embedding and immobilisation of living cells and microorganisms is used in a variety of research and commercial applications. Here we report the successful extended immobilisation of coral larvae in a low-gelling temperature agarose. Embryos and larvae of five broadcast-spawning Scleractinian
Dong Uk Kim et al.
Oncology letters, 17(3), 3589-3598 (2019-03-15)
Colorectal cancer (CRC) is a complex disease involving numerous genetic abnormalities. One of the major characteristics of CRC is enhanced Wnt signaling caused by loss-of-function mutations in the adenomatous polyposis coli (APC) gene. Previously, it has been demonstrated that the
Ivar Dehnisch Ellström et al.
Journal of neuroscience methods, 311, 259-266 (2018-11-06)
The spinal cord is composed of a large number of cells that interact to allow the organism to function. To perform detail studies of cellular processes involved in spinal cord injury (SCI), one must use repeatable and specific methods to
Justin Rofeh et al.
Soft matter, 16(18), 4484-4493 (2020-04-28)
Recently, droplet interface bilayers (DIBs) have been used to determine bilayer tension and thickness in situ by automated image analysis using a microscope and an applied voltage. In this paper, we demonstrate improvements to these measurements by integrating an inexpensive
Philip D Campbell et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(44), 14717-14732 (2014-10-31)
Mutations in Kinesin proteins (Kifs) are linked to various neurological diseases, but the specific and redundant functions of the vertebrate Kifs are incompletely understood. For example, Kif5A, but not other Kinesin-1 heavy-chain family members, is implicated in Charcot-Marie-Tooth disease (CMT)
M S Petronek et al.
Scientific reports, 11(1), 20817-20817 (2021-10-23)
T2* relaxation is an intrinsic magnetic resonance imaging (MRI) parameter that is sensitive to local magnetic field inhomogeneities created by the deposition of endogenous paramagnetic material (e.g. iron). Recent studies suggest that T2* mapping is sensitive to iron oxidation state.
Franziska E Uhl et al.
The European respiratory journal, 46(4), 1150-1166 (2015-05-02)
Chronic obstructive pulmonary disease (COPD) is characterised by a progressive loss of lung tissue. Inducing repair processes within the adult diseased lung is of major interest and Wnt/β-catenin signalling represents a promising target for lung repair. However, the translation of
T Bakuradze et al.
European journal of nutrition, 54(1), 149-156 (2014-04-18)
Coffee consumption has been reported to decrease oxidative damage in peripheral white blood cells (WBC). However, effects on the level of spontaneous DNA strand breaks, a well established marker of health risk, have not been specifically reported yet. We analyzed
Spencer P Lake et al.
Journal of biomedical materials research. Part A, 99(4), 507-515 (2011-09-14)
The mechanical properties of soft tissues depend on the collagen fiber network and the surrounding non-fibrillar matrix. The mechanical role of non-fibrillar material remains poorly understood. Our recent study (Lake and Barocas, Ann Biomed Eng 2011) introduced collagen-agarose co-gels as
Pol Margalef et al.
Cell, 172(3), 439-453 (2018-01-02)
Telomere maintenance critically depends on the distinct activities of telomerase, which adds telomeric repeats to solve the end replication problem, and RTEL1, which dismantles DNA secondary structures at telomeres to facilitate replisome progression. Here, we establish that reversed replication forks
Kevin Sanchez-Thirion et al.
International journal for parasitology, 49(10), 805-817 (2019-07-28)
Parasitism is an important process in ecosystems, but has been largely neglected in ecosystem research. However, parasites are involved in most trophic links in food webs with, in turn, a major role in community structure and ecosystem processes. Several studies
Ana Sancho et al.
Biofabrication, 6(3), 035017-035017 (2014-07-06)
Collagen gels have been extensively used as three-dimensional (3D) cell culture systems. To enhance their mechanical properties, the manufacture of collagen-based gels with agarose has been proposed. However, little is known about the stability of these gels under cold storage
Yi-Jen Sun et al.
Nature communications, 12(1), 2160-2160 (2021-04-14)
The dynamic assembly of the cell wall is key to the maintenance of cell shape during bacterial growth. Here, we present a method for the analysis of Escherichia coli cell wall growth at high spatial and temporal resolution, which is
Smrita Chaudhury et al.
Development (Cambridge, England), 147(18) (2020-08-26)
The lymphatic vasculature develops primarily from pre-existing veins. A pool of lymphatic endothelial cells (LECs) first sprouts from cardinal veins followed by migration and proliferation to colonise embryonic tissues. Although much is known about the molecular regulation of LEC fate
Carlos Pinzon-Arteaga et al.
Scientific reports, 10(1), 7411-7411 (2020-05-06)
Phenotypic selection during animal domestication has resulted in unwanted incorporation of deleterious mutations. In horses, the autosomal recessive condition known as Glycogen Branching Enzyme Deficiency (GBED) is the result of one of these deleterious mutations (102C > A), in the first exon
Insect-like organization of the stomatopod central complex: functional and phylogenetic implications
Thoen HH, et al.
Frontiers in Behavioral Neuroscience, 11(7), 12-12 (2017)
Anastasiya Trushko et al.
Developmental cell, 54(5), 655-668 (2020-08-18)
Many organs are formed through folding of an epithelium. This change in shape is usually attributed to tissue heterogeneities, for example, local apical contraction. In contrast, compressive stresses have been proposed to fold a homogeneous epithelium by buckling. While buckling
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