A9628

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Nontargeted identification and predicted toxicity of new byproducts generated from UV treatment of water containing micropollutant 2-mercaptobenzothiazole.

Ping Jiang et al.

Water research, 188, 116542-116542 (2020-11-01)

Comprehensive identification of byproducts including intermediate transformation products (TPs) of micropollutants in source water is challenging and paramount for assessment of drinking water quality and treatment technologies. Here, we have developed a nontargeted analysis strategy coupled with computational toxicity assessment

Oligomeric State and Thermal Stability of Apo- and Holo- Human Ornithine δ-Aminotransferase.

Riccardo Montioli et al.

The protein journal, 36(3), 174-185 (2017-03-28)

Human ornithine δ-aminotransferase (hOAT) (EC 2.6.1.13) is a mitochondrial pyridoxal 5'-phosphate (PLP)-dependent aminotransferase whose deficit is associated with gyrate atrophy, a rare autosomal recessive disorder causing progressive blindness and chorioretinal degeneration. Here, both the apo- and holo-form of recombinant hOAT

Redox-neutral indole annulation cascades.

Michael C Haibach et al.

Journal of the American Chemical Society, 133(7), 2100-2103 (2011-02-02)

Aminobenzaldehydes react with indoles in an unprecedented cascade reaction. This acid-catalyzed redox-neutral annulation proceeds via a condensation/1,5-hydride shift/ring-closure sequence. Polycyclic azepinoindoles and related compounds are obtained in a single step with good to excellent yields.

Zn(OTf)2-catalyzed reactions of ethenetricarboxylates with 2-aminobenzaldehydes leading to tetrahydroquinoline derivatives.

Shoko Yamazaki et al.

The Journal of organic chemistry, 75(4), 1188-1196 (2010-01-30)

Quinolines are an important class of compounds, and the development of new efficient synthetic strategies for the construction of quinolines is of considerable interest. Zinc triflate catalyzed cyclization of ethenetricarboxylate derivatives with 2-aminobenzaldehydes has been examined. The reaction of ethenetricarboxylate

Synthesis, infrared spectra and thermal studies of Zn(II), Cd(II) and Hg(II) complexes with 2-aminobenzaldehyde phenylhydrazone "nitrin" ligand.

Moamen S Refat et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 70(1), 234-242 (2007-09-04)

The, nitrin, 2-aminobenzaldehyde phenylhydrazone (2ABPH) was synthesis by refluxing 2-nitrobenzaldehyde with phenylhydrazine in ethanolic solvent. Three transition metal (II) complexes of 2ABPH have been prepared. Elemental analysis, molar conductivity, IR, UV, 1H NMR, and mass spectra, as well as TG/DTG

Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target.

Sarah C Atkinson et al.

Structure (London, England : 1993), 26(7), 948-959 (2018-05-29)

Protein dynamics manifested through structural flexibility play a central role in the function of biological molecules. Here we explore the substrate-mediated change in protein flexibility of an antibiotic target enzyme, Clostridium botulinum dihydrodipicolinate synthase. We demonstrate that the substrate, pyruvate

Molecular and cellular basis of ornithine δ-aminotransferase deficiency caused by the V332M mutation associated with gyrate atrophy of the choroid and retina.

Riccardo Montioli et al.

Biochimica et biophysica acta. Molecular basis of disease, 1864(11), 3629-3638 (2018-09-27)

Gyrate atrophy (GA) is a rare recessive disorder characterized by progressive blindness, chorioretinal degeneration and systemic hyperornithinemia. GA is caused by point mutations in the gene encoding ornithine δ-aminotransferase (OAT), a tetrameric pyridoxal 5'-phosphate-dependent enzyme catalysing the transamination of l-ornithine

R180T variant of δ-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features.

Riccardo Montioli et al.

The FEBS journal, 286(14), 2787-2798 (2019-04-09)

Among the over 50 gyrate atrophy-causing mutations of ornithine δ-aminotransferase (OAT), the R180T involves an active site residue located at the dimer interface, which in the crystal structure of OAT complexed with 5-fluoromethylornithine engages a salt bridge with the α-carboxylate

Assay of ornithine aminotransferase with ninhydrin.

H R Kim et al.

Analytical biochemistry, 223(2), 205-207 (1994-12-01)

We developed an assay system for ornithine aminotransferase (EC 2.6.1.13) using ninhydrin. Pyrroline 5-carboxylate, a product of enzymatic transamination, reacts with ninhydrin under hot acidic conditions to form a reddish pigment soluble in ethanol. The millimolar extinction coefficient of reaction

One-pot organocatalytic asymmetric synthesis of 3-nitro-1,2-dihydroquinolines by a dual-activation protocol.

Yi-Feng Wang et al.

Chemistry, an Asian journal, 4(12), 1834-1838 (2009-10-16)

Generally, amine-catalyzed enantioselective transformations rely on chiral enamine or unsaturated iminium intermediates. Herein, we report a protocol involving dual activation by an aromatic iminium and hydrogen-bonding. An enantioselective aza-Michael-Henry domino reaction of 2-aminobenzaldehydes with nitroolefins has been developed through this

Chondrogenesis of human bone marrow mesenchymal stromal cells in highly porous alginate-foams supplemented with chondroitin sulfate.

Zhao Huang et al.

Materials science & engineering. C, Materials for biological applications, 50, 160-172 (2015-03-10)

To overcome the limited intrinsic cartilage repair, autologous chondrocyte or bone-marrow-derived mesenchymal stromal cell (BM-MSC) was implanted into cartilage defects. For this purpose suitable biocompatible scaffolds are needed to provide cell retention, chondrogenesis and initial mechanical stability. The present study

Biosynthesis of 2-aminobenzaldehyde in flowers of Robinia pseudoacacia and Philadelphus coronarius.

P Spiteller et al.

Phytochemistry, 57(3), 361-363 (2001-06-08)

Feeding experiments with 13C- and fluorine-labelled precursors were performed to reveal the biosynthesis of 2-aminobenzaldehyde in flowers of Robinia pseudoacacia and Philadelphus coronarius. The results are in agreement with the transformation of anthranilic acid to indole followed by oxidative ring

Functional specialization in proline biosynthesis of melanoma.

Jessica De Ingeniis et al.

PloS one, 7(9), e45190-e45190 (2012-10-02)

Proline metabolism is linked to hyperprolinemia, schizophrenia, cutis laxa, and cancer. In the latter case, tumor cells tend to rely on proline biosynthesis rather than salvage. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C)

Simple, sensitive and specific quantification of diamine oxidase activity in complex matrices using newly discovered fluorophores derived from natural substrates.

Thomas Boehm et al.

Inflammation research : official journal of the European Histamine Research Society ... [et al.], 69(9), 937-950 (2020-06-04)

To measure diamine oxidase (DAO) activity with high sensitivity in complex matrices like plasma or tissue extracts radioactive putrescine or horseradish peroxidase (HRP)/hydrogen peroxide (H2O2) coupling must be used. The use of radioactive material should be avoided and HRP/H2O2 coupling

Synthesis and structure-activity relationships of o-sulfonamido-arylhydrazides as inhibitors of LL-diaminopimelate aminotransferase (LL-DAP-AT).

Chenguang Fan et al.

Organic & biomolecular chemistry, 10(30), 5815-5819 (2012-03-01)

Recently, LL-diaminopimelate aminotransferase (LL-DAP-AT), a pyridoxal-5'-phosphate (PLP)-dependent enzyme, was reported to catalyze a key step in the biosynthesis of L-lysine in plants and Chlamydia. Previous screening of a 29,201-compound library against LL-DAP-AT identified an o-sulfonamidoarylhydrazide as a reversible inhibitor with

The consequences of the isotope effect on proline dehydrogenation rates estimated by the tritium loss method.

G Shearer et al.

Analytical biochemistry, 203(2), 191-200 (1992-06-01)

Loss of tritium from a substrate is often used to estimate the rate of dehydrogenation. However, loss of 3H may be much slower than loss of H because of the tritium isotope effect. In order to assess the impact of

LC-MS and NMR characterization of the purple chromophore formed in the o-aminobenzaldehyde assay of dihydrodipicolinate synthase.

Voula Mitsakos et al.

Bioorganic & medicinal chemistry, 19(4), 1535-1540 (2011-01-27)

The enzyme dihydrodipicolinate synthase (DHDPS) has been widely investigated as a target for new antibiotics. The o-aminobenzaldehyde (o-ABA) assay is routinely used as a highly specific, if qualitative, tool for DHDPS purification, whereby fractions containing active DHDPS appear purple upon

B-ring-aryl substituted luotonin A analogues with a new binding mode to the topoisomerase 1-DNA complex show enhanced cytotoxic activity.

Víctor González-Ruiz et al.

PloS one, 9(5), e95998-e95998 (2014-05-17)

Topoisomerase 1 inhibition is an important strategy in targeted cancer chemotherapy. The drugs currently in use acting on this enzyme belong to the family of the camptothecins, and suffer severe limitations because of their low stability, which is associated with

Synthesis and in vivo evaluation of [11C]MPTQ: a potential PET tracer for alpha2A-adrenergic receptors.

Jaya Prabhakaran et al.

Bioorganic & medicinal chemistry letters, 20(12), 3654-3657 (2010-06-10)

Radiosynthesis and in vivo evaluation of [N-methyl-(11)C] 5-methyl-3-[4-(3-phenylallyl)-piperazin-1-ylmethyl]-3,3a,4,5-tetrahydroisoxazolo[4,3-c]quinoline (1), a potential PET tracer for alpha2-adrenergic receptors is described. Syntheses of nonradioactive standard 1 and corresponding desmethyl precursor 2 were achieved from 2-aminobenzaldehyde in 40% and 65% yields, respectively. Methylation using

Mycobacterium tuberculosis lysine-ɛ-aminotransferase a potential target in dormancy: Benzothiazole based inhibitors.

Rudraraju Srilakshmi Reshma et al.

Bioorganic & medicinal chemistry, 25(10), 2761-2771 (2017-04-09)

MTB lysine-ɛ-aminotransferase (LAT) was found to play a crucial role in persistence and antibiotic tolerance. LAT serves as a potential target in the management of latent tuberculosis. In present work we attempted to derivatize the benzothiazole lead identified through high

Simultaneous purification and site-specific modification of pyrroline-carboxy-lysine proteins.

Hsien-Po Chiu et al.

Chembiochem : a European journal of chemical biology, 13(3), 364-366 (2012-01-10)

Sticky residue: Pyrroline-carboxy-lysine (Pcl) can be readily incorporated into proteins expressed in E. coli and mammalian cells by using the pyrrolysyl tRNA/tRNA synthetase pair. Pcl can be used as a single amino acid purification tag and can be site-specifically modified

Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate.

Chad N Hancock et al.

Amino acids, 48(3), 859-872 (2015-12-15)

Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple stress pathways. Because of the roles of PRODH/POX in signaling, and its shared localization to the mitochondrial inner membrane with the electron transport chain (ETC), we investigated whether there was

Aminoindolines versus quinolines: mechanistic insights into the reaction between 2-aminobenzaldehydes and terminal alkynes in the presence of metals and secondary amines.

Nitin T Patil et al.

The Journal of organic chemistry, 77(14), 6179-6185 (2012-07-12)

DFT computational studies in the cyclization of aminoalkyne (see structure), which is generated in situ by 2-aminobenzaldehydes and terminal alkynes in the presence of metals and secondary amines, has been investigated. The study revealed that the mode of cyclization (exo

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