CN
Search Within
AB1504
应用筛选条件
关键词:'AB1504'
显示 1-30 共 295 条结果 关于 "AB1504" 范围 论文
Isabella Farhy-Tselnicker et al.
Neuron, 96(2), 428-445 (2017-10-13)
The generation of precise synaptic connections between developing neurons is critical to the formation of functional neural circuits. Astrocyte-secreted glypican 4 induces formation of active excitatory synapses by recruiting AMPA glutamate receptors to the postsynaptic cell surface. We now identify
Aline Brechet et al.
Nature communications, 8, 15910-15910 (2017-07-05)
AMPA-type glutamate receptors (AMPARs), key elements in excitatory neurotransmission in the brain, are macromolecular complexes whose properties and cellular functions are determined by the co-assembled constituents of their proteome. Here we identify AMPAR complexes that transiently form in the endoplasmic
B S Reive et al.
Chronic stress (Thousand Oaks, Calif.), 7, 24705470231164920-24705470231164920 (2023-03-28)
Reelin, an extracellular matrix protein with putative antidepressant-like properties, becomes dysregulated by chronic stress. Improvement in cognitive dysfunction and depression-like behavior induced by chronic stress has been reported with both intrahippocampal and intravenous Reelin treatment but the mechanisms responsible are
Leonardo Santana Novaes et al.
Translational psychiatry, 11(1), 18-18 (2021-01-09)
The persistence of anxiety and the deficit of fear memory extinction are both phenomena related to the symptoms of a trauma-related disorder, such as post-traumatic stress disorder (PTSD). Recently we have shown that single acute restraint stress (2 h) in rats
Effects of acute cocaine or dopamine receptor agonists on AMPA receptor distribution in the rat nucleus accumbens.
Ferrario, CR; Li, X; Wolf, ME
Synapse null
Attila D Kovács et al.
Neuroscience letters, 607, 29-34 (2015-09-17)
Mutations in the CLN3 gene cause a fatal neurodegenerative disorder, juvenile CLN3 disease. Exploring the cause of the motor coordination deficit in the Cln3(-/-) mouse model of the disease we have previously found that attenuation of AMPA receptor activity in
Suleman Hussain et al.
PloS one, 10(10), e0140868-e0140868 (2015-10-22)
Vertebrate organisms adapt to a continuously changing environment by regulating the strength of synaptic connections between brain cells. Excitatory synapses are believed to increase their strength by vesicular insertion of transmitter glutamate receptors into the postsynaptic plasma membrane. These vesicles
George Chenaux et al.
eNeuro, 3(5) (2016-11-02)
Modification of the strength of excitatory synaptic connections is a fundamental mechanism by which neural circuits are refined during development and learning. Synapse Differentiation Induced Gene 1 (SynDIG1) has been shown to play a key role in regulating synaptic strength
Katherine E Horn et al.
Cell reports, 3(1), 173-185 (2013-01-08)
The transmembrane protein deleted in colorectal cancer (DCC) and its ligand, netrin-1, regulate synaptogenesis during development, but their function in the mature central nervous system is unknown. Given that DCC promotes cell-cell adhesion, is expressed by neurons, and activates proteins
Clarissa A Pisanò et al.
British journal of pharmacology (2021-11-13)
Regulator of G-protein signalling 4 (RGS4) is a signal transduction protein that accelerates intrinsic GTPase activity of Gαi/o and Gαq subunits, suppressing GPCR signalling. Here, we investigate whether RGS4 modulates nociceptin/orphanin FQ (N/OFQ) opioid (NOP) receptor signalling and if this
NMDAR-dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity.
Dipen Rajgor et al.
The EMBO journal, 37(11) (2018-05-02)
MicroRNAs (miRNAs) repress translation of target mRNAs by associating with Argonaute (Ago) proteins to form the RNA-induced silencing complex (RISC), underpinning a powerful mechanism for fine-tuning protein expression. Specific miRNAs are required for NMDA receptor (NMDAR)-dependent synaptic plasticity by modulating
Sudarat Nimitvilai et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(13), 3646-3660 (2017-03-09)
Cognitive impairments, uncontrolled drinking, and neuropathological cortical changes characterize alcohol use disorder. Dysfunction of the orbitofrontal cortex (OFC), a critical cortical subregion that controls learning, decision-making, and prediction of reward outcomes, contributes to executive cognitive function deficits in alcoholic individuals.
Jonathan E Draffin et al.
The EMBO journal, 40(2), e105513-e105513 (2020-11-17)
Glycogen synthase kinase-3 (GSK3) is an important signalling protein in the brain and modulates different forms of synaptic plasticity. Neuronal functions of GSK3 are typically attributed to one of its two isoforms, GSK3β, simply because of its prevalent expression in
Natural reward experience alters AMPA and NMDA receptor distribution and function in the nucleus accumbens.
Pitchers, KK; Schmid, S; Di Sebastiano, AR; Wang, X; Laviolette, SR; Lehman, MN; Coolen, LM
Testing null
M A Hutchison et al.
Molecular psychiatry, 23(5), 1213-1225 (2017-02-15)
Midbrain dopamine neurons are crucial for many behavioral and cognitive functions. As the major excitatory input, glutamatergic afferents are important for control of the activity and plasticity of dopamine neurons. However, the role of glutamatergic input as a whole onto
Rozzy Finn et al.
Neurochemistry international, 58(6), 648-655 (2011-02-15)
The juvenile onset form of neuronal ceroid lipofuscinoses (JNCL) is a recessively inherited lysosomal storage disorder characterized by progressive neurodegeneration. JNCL results from mutations in the CLN3 gene that encodes a lysosomal membrane protein with unknown function. Utilizing a Cln3-knock-out
Joana Fernandes et al.
PloS one, 9(6), e99958-e99958 (2014-06-25)
Transient global cerebral ischemia induces profound changes in the transcriptome of brain cells, which is partially associated with the induction or repression of genes that influence the ischemic response. However, the mechanisms responsible for the selective vulnerability of hippocampal neurons
Margaret H Hastings et al.
Behavioural brain research, 386, 112596-112596 (2020-03-21)
Cocaine-cue extinction training combined with brief interventions of environmental enrichment (EE) was shown previously to facilitate extinction and attenuate reacquisition of cocaine self-administration in rats. It is unknown whether or not the usefulness of this approach would be undermined if
Ning Li et al.
Neural regeneration research, 14(6), 1037-1045 (2019-02-15)
Mounting evidence suggests that synaptic plasticity provides the cellular biological basis of learning and memory, and plasticity deficits play a key role in dementia caused by Alzheimer's disease. However, the mechanisms by which synaptic dysfunction contributes to the pathogenesis of
Yi-Chuan Chen et al.
Nature neuroscience, 19(11), 1513-1522 (2016-10-28)
Cortico-basal ganglia circuits are critical for speech and language and are implicated in autism spectrum disorder, in which language function can be severely affected. We demonstrate that in the mouse striatum, the gene Foxp2 negatively interacts with the synapse suppressor
Caitlin E Burgdorf et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(49), 11894-11911 (2017-11-02)
Exposure to cocaine-associated contextual cues contributes significantly to relapse. Extinction of these contextual associations, which involves a new form of learning, reduces cocaine-seeking behavior; however, the molecular mechanisms underlying this process remain largely unknown. We report that extinction, but not
Quan Gan et al.
The Journal of biological chemistry, 291(12), 6595-6606 (2016-02-04)
AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the central nervous system. Functional AMPARs are tetrameric complexes with a highly modular structure, consisting of four evolutionarily distinct structural domains: an amino-terminal domain (ATD), a ligand-binding domain (LBD), a channel-forming transmembrane
Jan Giesen et al.
The European journal of neuroscience, 55(1), 18-31 (2021-12-14)
In the central nervous system, the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signalling cascade has an established role in fine-tuning of synaptic transmission. In the present study, we asked which isoform of NO-sensitive guanylyl cyclase, NO-GC1 or NO-GC2, is responsible
Emiliano M Rial Verde et al.
Neuron, 52(3), 461-474 (2006-11-08)
Arc/Arg3.1 is an immediate-early gene whose expression levels are increased by strong synaptic activation, including synapse-strengthening activity patterns. Arc/Arg3.1 mRNA is transported to activated dendritic regions, conferring the distribution of Arc/Arg3.1 protein both temporal correlation with the inducing stimulus and
Jiandong Sun et al.
The EMBO journal, 41(5), e108119-e108119 (2022-02-01)
Lysosomes function not only as degradatory compartments but also as dynamic intracellular calcium ion stores. The transient receptor potential mucolipin 1 (TRPML1) channel mediates lysosomal Ca2+ release, thereby participating in multiple cellular functions. The pentameric Ragulator complex, which plays a
Zehra Minbay et al.
Bosnian journal of basic medical sciences, 17(1), 29-37 (2016-12-28)
In this study, we aimed to determine the presence as well as the diverse distribution of N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptor subunits in the rat red nucleus. Using adult Sprague-Dawley rats as the experimental animals, immunohistochemistry was performed on
Hong Jiang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(34), 7278-7299 (2021-07-18)
Comorbid anxiety and depressive symptoms in chronic pain are a common health problem, but the underlying mechanisms remain unclear. Previously, we have demonstrated that sensitization of the CeA neurons via decreased GABAergic inhibition contributes to anxiety-like behaviors in neuropathic pain
Joy Y Sebe et al.
Journal of neurophysiology, 109(2), 429-436 (2012-10-27)
LIS1 gene mutations lead to a rare neurological disorder, classical lissencephaly, characterized by brain malformations, mental retardation, seizures, and premature death. Mice heterozygous for Lis1 (Lis1(+/-)) exhibit cortical malformations, defects in neuronal migration, increased glutamate-mediated synaptic transmission, and spontaneous electrographic
Jung Min Song et al.
Experimental neurology, 252, 105-113 (2013-12-10)
We recently reported that the tetra(ethylene glycol) derivative of benzothiazole aniline, BTA-EG4, acts as an amyloid-binding small molecule that promotes dendritic spine density and cognitive function in wild-type mice. This raised the possibility that BTA-EG4 may benefit the functional decline
Jochen Schwenk et al.
Neuron, 84(1), 41-54 (2014-09-23)
Native AMPA receptors (AMPARs) in the mammalian brain are macromolecular complexes whose functional characteristics vary across the different brain regions and change during postnatal development or in response to neuronal activity. The structural and functional properties of the AMPARs are
1/10