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关键词:'AB1558'
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Ren-Hong Du et al.
Journal of neuroinflammation, 15(1), 258-258 (2018-09-12)
α-Synuclein (α-Syn)-induced neuroinflammation plays a crucial role in the pathogenesis of Parkinson's disease (PD). Dopamine D2 receptor (Drd2) has been regarded as a potential anti-inflammatory target in the therapy of neurodegenerative diseases. However, the effect of astrocytic Drd2 in α-Syn-induced
Jickssa M Gemechu et al.
Scientific reports, 8(1), 1517-1517 (2018-01-26)
Mutations in parkin gene (Park2) are linked to early-onset autosomal recessive Parkinson's disease (PD) and young-onset sporadic PD. Park2 knockout (PKO) rodents; however, do not display neurodegeneration of the nigrostriatal pathway, suggesting age-dependent compensatory changes. Our goal was to examine
Kelly A Zalocusky et al.
Nature, 531(7596), 642-646 (2016-03-24)
A marked bias towards risk aversion has been observed in nearly every species tested. A minority of individuals, however, instead seem to prefer risk (repeatedly choosing uncertain large rewards over certain but smaller rewards), and even risk-averse individuals sometimes opt
Alexandre Morin et al.
Frontiers in behavioral neuroscience, 15, 770374-770374 (2022-01-22)
Global cerebral ischemia (GCI) in rats has been shown to promote exploration of anxiogenic zones of the Elevated-Plus Maze (EPM) and Open Field Test (OFT). This study investigated changes in impulsive choice and/or defensive responses as possible contributors of heightened
Andrea L Johnstone et al.
Molecular and cellular neurosciences, 50(2), 125-135 (2012-05-09)
Injury to the central nervous system (CNS) can result in lifelong loss of function due in part to the regenerative failure of CNS neurons. Inhibitory proteins derived from myelin and the astroglial scar are major barriers for the successful regeneration
Cell-type specific increases in female hamster nucleus accumbens spine density following female sexual experience.
Staffend, NA; Hedges, VL; Chemel, BR; Watts, VJ; Meisel, RL
Brain Structure &Amp; Function null
Hui Leng et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 31(9), e13655-e13655 (2019-06-07)
Oxytocin (OT) plays an important role in regulating gastric function. How OT regulates stress-induced gastric ulcers is not understood. We investigated OT's protective role in stress-induced gastric ulcers, with a focus on OT's interaction with the ventral tegmental area (VTA)
K E Borgmann-Winter et al.
Neuroscience, 158(2), 642-653 (2008-11-11)
The olfactory epithelium constitutes the sole source of regenerating neural cells that can be obtained from a living human. As such, primary cultures derived from human olfactory epithelial biopsies can be utilized to study neurobiological characteristics of individuals under different
Ning Yin et al.
Neuroscience bulletin, 36(3), 230-242 (2019-10-14)
Ganglion cells (RGCs) are the sole output neurons of the retinal circuity. Here, we investigated whether and how dopamine D2 receptors modulate the excitability of dissociated rat RGCs. Application of the selective D2 receptor agonist quinpirole inhibited outward K+ currents
Valentyna Dubovyk et al.
Hippocampus, 28(2), 136-150 (2017-11-25)
The dorsoventral axis of the hippocampus exhibits functional differentiations with regard to (spatial Vs emotional) learning and information retention (rapid encoding Vs long-term storage), as well as its sensitivity to neuromodulation and information received from extrahippocampal structures. The mechanisms that
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