AB5166

应用筛选条件

关键词:'AB5166'

显示 1-15 共 15 条结果关于 "AB5166" 范围论文

D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.

Abraham Kovoor et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(8), 2157-2165 (2005-02-25)

Regulator of G-protein signaling 9-2 (RGS9-2), a member of the RGS family of G GTPase accelerating proteins, is expressed specifically in the striatum, which participates in antipsychotic-induced tardive dyskinesia and in levodopa-induced dyskinesia. We report that RGS9 knock-out mice develop

Novel long-range inhibitory nNOS-expressing hippocampal cells.

Zoé Christenson Wick et al.

eLife, 8 (2019-10-15)

The hippocampus, a brain region that is important for spatial navigation and episodic memory, benefits from a rich diversity of neuronal cell-types. Through the use of an intersectional genetic viral vector approach in mice, we report novel hippocampal neurons which

Muscarinic acetylcholine receptors in macaque V1 are most frequently expressed by parvalbumin-immunoreactive neurons.

Anita A Disney et al.

The Journal of comparative neurology, 507(5), 1748-1762 (2008-02-12)

Acetylcholine (ACh) is believed to underlie mechanisms of arousal and attention in mammals. ACh also has a demonstrated functional effect in visual cortex that is both diverse and profound. We have reported previously that cholinergic modulation in V1 of the

Neuroanatomical basis for cholinergic modulation of locomotor networks by sacral relay neurons with ascending lumbar projections.

Eran Finkel et al.

The Journal of comparative neurology, 522(15), 3437-3455 (2014-04-23)

Synaptic excitation by sacrocaudal afferent (SCA) input of sacral relay neurons projecting rostrally through the ventral white matter funiculi (VF neurons) is a potent activator of the hindlimb central pattern generators (CPGs) in rodent spinal cords lacking descending supraspinal control.

Localization of muscarinic acetylcholine receptor 2 to the intestinal crypt stem cell compartment.

Eleanor D Muise et al.

Data in brief, 10, 482-486 (2017-01-06)

The data presented in this article are related to the research article entitled "Distribution of muscarinic acetylcholine receptor subtypes in the murine small intestine" (E.D. Muise, N. Gandotra, J.J. Tackett, M.C. Bamdad, R.A. Cowles, 2016) [1]. We recently demonstrated that

Cholinergic microvillous cells in the mouse main olfactory epithelium and effect of acetylcholine on olfactory sensory neurons and supporting cells.

Tatsuya Ogura et al.

Journal of neurophysiology, 106(3), 1274-1287 (2011-06-17)

The mammalian olfactory epithelium is made up of ciliated olfactory sensory neurons (OSNs), supporting cells, basal cells, and microvillous cells. Previously, we reported that a population of nonneuronal microvillous cells expresses transient receptor potential channel M5 (TRPM5). Using transgenic mice

Sulforaphane Improves Ischemia-Induced Detrusor Overactivity by Downregulating the Enhancement of Associated Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Rat Bladder.

Huai-Ching Tai et al.

Scientific reports, 6, 36110-36110 (2016-11-09)

Atherosclerosis-associated pelvic ischemia has been reported to be a risk factor for bladder dysfunction and subsequent lower urinary tract symptoms (LUTS) in the elderly population. However, the molecular mechanisms of this association remain unclear. We hypothesized that stress-induced cellular responses

Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.

Sinead M Clancy et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(24), 6388-6399 (2007-06-15)

Many inhibitory neurotransmitters in the brain activate Kir3 channels by stimulating pertussis toxin (PTX)-sensitive G-protein-coupled receptors. Here, we investigated the regulation of native muscarinic receptors and Kir3 channels expressed in NGF-differentiated PC12 cells, which are similar to sympathetic neurons. Quantitative

Control of insulin secretion by cholinergic signaling in the human pancreatic islet.

Judith Molina et al.

Diabetes, 63(8), 2714-2726 (2014-03-25)

Acetylcholine regulates hormone secretion from the pancreatic islet and is thus crucial for glucose homeostasis. Little is known, however, about acetylcholine (cholinergic) signaling in the human islet. We recently reported that in the human islet, acetylcholine is primarily a paracrine

An acetylcholine-activated microcircuit drives temporal dynamics of cortical activity.

Naiyan Chen et al.

Nature neuroscience, 18(6), 892-902 (2015-04-29)

Cholinergic modulation of cortex powerfully influences information processing and brain states, causing robust desynchronization of local field potentials and strong decorrelation of responses between neurons. We found that intracortical cholinergic inputs to mouse visual cortex specifically and differentially drive a

Number and type of synapses on the distal dendrite of a rat striatal cholinergic interneuron: a quantitative, ultrastructural study.

Rachel J Sizemore et al.

Journal of anatomy, 217(3), 223-235 (2010-07-16)

Knowledge of the innervation of interneurons within the striatum is critical to determining their role in the functioning of the striatal network. To this end, the synaptic innervation of a distal dendrite of a rat striatal cholinergic interneuron was quantified

Human tenocytes are stimulated to proliferate by acetylcholine through an EGFR signalling pathway.

Gloria Fong et al.

Cell and tissue research, 351(3), 465-475 (2012-12-06)

Studies of human patellar and Achilles tendons have shown that primary tendon fibroblasts (tenocytes) not only have the capacity to produce acetylcholine (ACh) but also express muscarinic ACh receptors (mAChRs) through which ACh can exert its effects. In patients with

Cardiac resynchronization therapy restores sympathovagal balance in the failing heart by differential remodeling of cholinergic signaling.

Deeptankar DeMazumder et al.

Circulation research, 116(10), 1691-1699 (2015-03-04)

Cardiac resynchronization therapy (CRT) is the only heart failure (HF) therapy documented to improve left ventricular function and reduce mortality. The underlying mechanisms are incompletely understood. Although β-adrenergic signaling has been studied extensively, the effect of CRT on cholinergic signaling

Genetic Single Neuron Anatomy Reveals Fine Granularity of Cortical Axo-Axonic Cells.

Xiaojun Wang et al.

Cell reports, 26(11), 3145-3159 (2019-03-14)

Parsing diverse nerve cells into biological types is necessary for understanding neural circuit organization. Morphology is an intuitive criterion for neuronal classification and a proxy of connectivity, but morphological diversity and variability often preclude resolving the granularity of neuron types. Combining

Atrial arrhythmias and autonomic dysfunction in rats exposed to chronic intermittent hypoxia.

Sara L Bober et al.

American journal of physiology. Heart and circulatory physiology, 314(6), H1160-H1168 (2018-02-10)

Obstructive sleep apnea, which involves chronic intermittent hypoxia (CIH), is a major risk factor for developing atrial fibrillation (AF). Whether or not CIH alone alters cardiac mechanisms to support AF is unknown. This study investigated the effects of CIH on

1/1