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Michael H Hayes et al.
Biology open, 5(6), 801-806 (2016-05-25)
A hallmark of Alzheimer's, Huntington's and similar diseases is the assembly of proteins into amyloids rather than folding into their native state. There is an increasing appreciation that amyloids, under specific conditions, may be non-pathogenic. Here we show that amyloids
Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator.
Vasilopoulou, et al.
Redox Biology, 56, 102462-102462 (2022)
Kyung Mi Lee et al.
Frontiers in aging neuroscience, 16, 1388654-1388654 (2024-08-07)
Blood inflammatory biomarkers have emerged as important tools for diagnosing, assessing treatment responses, and predicting neurodegenerative diseases. This study evaluated the associations between blood inflammatory biomarkers and brain tissue volume loss in elderly people. This study included 111 participants (age
Yujuan Su et al.
Journal of biomedical research, 36(4), 255-268 (2022-08-16)
Amyloids have traditionally been considered pathologic protein aggregates which contribute to neurodegeneration. New evidence however increasingly suggests that non-pathological amyloids are formed in animals during normal development. Amyloid-like aggregate formation was originally thought to be a conserved feature of animal
Guilherme A P de Oliveira et al.
Scientific reports, 6, 37990-37990 (2016-12-03)
Parkinson's disease is a neurological disease in which aggregated forms of the α-synuclein (α-syn) protein are found. We used high hydrostatic pressure (HHP) coupled with NMR spectroscopy to study the dissociation of α-syn fibril into monomers and evaluate their structural
Andreia C Oliveira et al.
Disease models & mechanisms, 16(1) (2023-01-06)
Tau pathology is defined by the intracellular accumulation of abnormally phosphorylated Tau (MAPT) and is prevalent in several neurodegenerative disorders. The identification of modulators of Tau abnormal phosphorylation and aggregation is key to understanding disease progression and developing targeted therapeutic
Shobini Jayaraman et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(32), E6507-E6515 (2017-07-27)
Serum amyloid A (SAA) is an acute-phase plasma protein that functions in innate immunity and lipid homeostasis. SAA is a protein precursor of reactive AA amyloidosis, the major complication of chronic inflammation and one of the most common human systemic
Sivaraman Purushothuman et al.
PloS one, 8(3), e59740-e59740 (2013-04-05)
Understanding the response of the brain to haemorrhagic damage is important in haemorrhagic stroke and increasingly in the understanding the cerebral degeneration and dementia that follow head trauma and head-impact sports. In addition, there is growing evidence that haemorrhage from
Cristiane Latge et al.
The Journal of biological chemistry, 290(33), 20527-20540 (2015-07-08)
Cerebral dopamine neurotrophic factor (CDNF) is a promising therapeutic agent for Parkinson disease. As such, there has been great interest in studying its mode of action, which remains unknown. The three-dimensional crystal structure of the N terminus (residues 9-107) of
Eleni Panagiotidou et al.
Redox biology, 65, 102817-102817 (2023-07-21)
Proteostasis reinforcement is a promising approach in the design of therapeutic interventions against proteinopathies, including Alzheimer's disease. Understanding how and which parts of the proteostasis network should be enhanced is crucial in developing efficient therapeutic strategies. The ability of specific
Functional amyloids in the mouse sperm acrosome.
Guyonnet, B; Egge, N; Cornwall, GA
Molecular and cellular biology null
Feng Liang et al.
Scientific reports, 7(1), 5722-5722 (2017-07-20)
Considerable evidence shows critical roles of intracellular pathogenic events of Alzheimer's disease (AD). In particular, intracellular amyloid-β accumulation and oligomerization are early AD pathologic processes, which may lead to changes in inflammatory molecules and other AD-related pathological components. Curcumin and
Raquel Pérez-Tavarez et al.
Scientific reports, 9(1), 16298-16298 (2019-11-11)
Most fish-allergic patients have anti-β-parvalbumin (β-PV) immunoglobulin E (IgE), which cross-reacts among fish species with variable clinical effects. Although the β-PV load is considered a determinant for allergenicity, fish species express distinct β-PV isoforms with unknown pathogenic contributions. To identify
Jérôme Robert et al.
Molecular neurodegeneration, 12(1), 60-60 (2017-08-24)
Alzheimer's Disease (AD), characterized by accumulation of beta-amyloid (Aβ) plaques in the brain, can be caused by age-related failures to clear Aβ from the brain through pathways that involve the cerebrovasculature. Vascular risk factors are known to increase AD risk
Ricardo Sant'Anna et al.
Molecular medicine (Cambridge, Mass.), 29(1), 111-111 (2023-08-19)
Soluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of the main toxic species in Parkinson's disease (PD) leading to degeneration. aSyn-O can induce Ca2+ influx, over activating downstream pathways leading to PD phenotype. Calcineurin (CN), a phosphatase
Nicole Heinzl et al.
Frontiers in oncology, 12, 976725-976725 (2022-09-27)
The tumor suppressor protein p53 is mutated in half of all cancers and has been described to form amyloid-like structures, commonly known from key proteins in neurodegenerative diseases. Still, the clinical relevance of p53 aggregates remains largely unknown, which may
Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP.
Silverberg, GD; Miller, MC; Pascale, CL; Caralopoulos, IN; Agca, Y; Agca, C; Stopa, EG
Fluids and Barriers of the Cns null
Milagros Castellanos et al.
Biomolecules, 8(1) (2018-03-21)
Acid proteins capable of nucleating Ca2+ and displaying aggregation capacity play key roles in the formation of calcium carbonate biominerals. The helix-loop helix EF-hands are the most common Ca2+-binding motifs in proteins. Calcium is bound by the loop region. These
Edsel M Abud et al.
Neuron, 94(2), 278-293 (2017-04-21)
Microglia play critical roles in brain development, homeostasis, and neurological disorders. Here, we report that human microglial-like cells (iMGLs) can be differentiated from iPSCs to study their function in neurological diseases, like Alzheimer's disease (AD). We find that iMGLs develop
Clustering and internalization of toxic amylin oligomers in pancreatic cells require plasma membrane cholesterol.
Trikha, S; Jeremic, AM
The Journal of Biological Chemistry null
Sabine Hellwig et al.
Scientific reports, 5, 14624-14624 (2015-09-30)
The role of microglia in amyloid-β (Aβ) deposition is controversial. In the present study, an organotypic hippocampal slice culture (OHSC) system with an in vivo-like microglial-neuronal environment was used to investigate the potential contribution of microglia to Aβ plaque formation.
Martina Zandl-Lang et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1863(1), 40-60 (2017-09-25)
Amyloid-β peptides (Aβ) accumulate in cerebral capillaries indicating a central role of the blood-brain barrier (BBB) in the pathogenesis of Alzheimer's disease (AD). Although a relationship between apolipoprotein-, cholesterol- and Aβ metabolism is evident, the interconnecting mechanisms operating in brain
Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer's disease mouse model.
Washington, PM; Morffy, N; Parsadanian, M; Zapple, DN; Burns, MP
Journal of Neurotrauma null
Hugo M Botelho et al.
The Journal of biological chemistry, 287(50), 42233-42242 (2012-10-19)
S100A6 is a small EF-hand calcium- and zinc-binding protein involved in the regulation of cell proliferation and cytoskeletal dynamics. It is overexpressed in neurodegenerative disorders and a proposed marker for Amyotrophic Lateral Sclerosis (ALS). Following recent reports of amyloid formation
Yong-Gang Fan et al.
British journal of pharmacology, 181(6), 896-913 (2023-06-13)
Overexpression of astrocytic lactoferrin (Lf) was observed in the brain of Alzheimer's disease (AD) patients, whereas the role of astrocytic Lf in AD progression remains unexplored. In this study, we aimed to evaluate the effects of astrocytic Lf on AD
Sarah L Griner et al.
eLife, 8 (2019-10-16)
Alzheimer's disease (AD) pathology is characterized by plaques of amyloid beta (Aβ) and neurofibrillary tangles of tau. Aβ aggregation is thought to occur at early stages of the disease, and ultimately gives way to the formation of tau tangles which
Gabriel Fung et al.
Oncotarget, 8(43), 74767-74780 (2017-11-02)
Protein quality control (PQC) plays a key role in maintaining cardiomyocyte function and homeostasis, and malfunction in PQC is implicated in various forms of heart diseases. Molecular chaperones serve as the primary checkpoint for PQC; however, their roles in the
Peng Liu et al.
iScience, 27(3), 109239-109239 (2024-03-04)
Amyloid-β (Aβ) oligomers consist of fibrillar and non-fibrillar soluble assemblies of the Aβ peptide. Aβ∗56 is a non-fibrillar Aβ assembly that is linked to memory deficits. Previous studies did not decipher specific forms of Aβ present in Aβ∗56. Here, we
Nancy Bartolotti et al.
Journal of Alzheimer's disease : JAD, 66(4), 1425-1435 (2018-11-08)
Plant derivatives offer a novel and natural source of therapeutics. The desert plant Achillea fragrantissima (Forssk) Sch. Bip (Af) is characterized by protective antioxidative and anti-inflammatory properties. Here, we examined the effect of two Af-derived phytochemicals on learning and memory
Deepthi Yedlapudi et al.
Scientific reports, 9(1), 19648-19648 (2019-12-25)
A significant number of people with Parkinson's disease (PD) develop dementia in addition to cognitive dysfunction and are diagnosed as PD with dementia (PDD). This is characterized by cortical and limbic alpha synuclein (α-syn) accumulation, and high levels of diffuse
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