B103500

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Butyric acid production from red algae by a newly isolated Clostridium sp. S1.

Kyung Min Lee et al.

Biotechnology letters, 37(9), 1837-1844 (2015-06-01)

To produce butyric acid from red algae such as Gelidium amansii in which galactose is a main carbohydrate, microorganisms utilizing galactose and tolerating inhibitors in hydrolysis including levulinic acid and 5-hydroxymethylfurfural (HMF) are required. A newly isolated bacterium, Clostridium sp.

Faecalibacterium prausnitzii and Crohn's disease - is there any connection?

Mirosława Gałecka et al.

Polish journal of microbiology, 62(1), 91-95 (2013-07-09)

The aim of the study was evaluation of the correlation between the level of clinical activity of Crohn's disease (CD) and the number of Faecalibacterium prausnitzii, total number of bacteria and the concentration of selected short chain fatty acids (SCFA)

Thomas D Horvath et al.

iScience, 25(5), 104158-104158 (2022-05-03)

Gut microbes can synthesize multiple neuro-active metabolites. We profiled neuro-active compounds produced by the gut commensal Bacteroides ovatus in vitro and in vivo by LC-MS/MS. We found that B. ovatus generates acetic acid, propionic acid, isobutyric acid, and isovaleric acid. In vitro, B. ovatus consumed

In vivo and in vitro antitumor activity of butyroyloxymethyl-diethyl phosphate (AN-7), a histone deacetylase inhibitor, in human prostate cancer.

Ada Rephaeli et al.

International journal of cancer, 116(2), 226-235 (2005-04-01)

AN-7, a prodrug of butyric acid, induced histone hyperacetylation and differentiation and inhibited proliferation of human prostate 22Rv1 cancer cells in vitro and in vivo. In nude mice implanted with these cells, 50 mg/kg AN-7 given orally thrice a week

Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site.

Pradeep Sharma et al.

Archives of biochemistry and biophysics, 529(1), 1-10 (2012-11-15)

Short peptidoglycan recognition protein (PGRP-S) is a member of the mammalian innate immune system. PGRP-S from Camelus dromedarius (CPGRP-S) has been shown to bind to lipopolysaccharide (LPS), lipoteichoic acid (LTA) and peptidoglycan (PGN). Its structure consists of four molecules A

Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation.

Gili Berkovitch et al.

Journal of medicinal chemistry, 51(23), 7356-7369 (2008-11-15)

Multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid in cancer cell lines inhibited the proteasome and induced apoptosis and heme synthesis. The most potent prodrug was butyryloxymethyl 5-amino-4-oxopentanoate (1a). The metabolically released formaldehyde from the prodrugs was the dominant factor affecting

Elizabeth B Brown et al.

eLife, 10 (2021-05-06)

Chemosensory systems are critical for evaluating the caloric value and potential toxicity of food. While animals can discriminate between thousands of odors, much less is known about the discriminative capabilities of taste systems. Fats and sugars represent calorically potent and

Development of High-purity Certified Reference Materials for 17 Proteinogenic Amino Acids by Traceable Titration Methods.

Megumi Kato et al.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(8), 805-814 (2015-08-11)

To ensure the reliability of amino acid analyses, the National Metrology Institute of Japan of the National Institute of Advanced Industrial Science and Technology (NMIJ/AIST) has developed high-purity certified reference materials (CRMs) for 17 proteinogenic amino acids. These CRMs are

Tumor-associated tissue eosinophilia promotes angiogenesis and metastasis in head and neck squamous cell carcinoma.

Tsung-Lun Lee et al.

Neoplasia (New York, N.Y.), 35, 100855-100855 (2022-11-22)

Eosinophils are terminally differentiated leukocytes that participate in the process of chronic inflammation and allergy and are able to release multiple cytokines into the surrounding tissue environment. Tumor-associated tissue eosinophilia (TATE) is the presence of eosinophils in the tumor or

The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke.

Preeti Dohare et al.

Free radical biology & medicine, 77, 168-182 (2014-09-17)

The contribution of oxidative stress to ischemic brain damage is well established. Nevertheless, for unknown reasons, several clinically tested antioxidant therapies have failed to show benefits in human stroke. Based on our previous in vitro work, we hypothesized that the

Sodium butyrate, a histone deacetylase inhibitor, regulates Lymphangiogenic factors in oral cancer cell line HSC-3.

Takashi Yamamura et al.

Anticancer research, 34(4), 1701-1708 (2014-04-03)

Tumor angiogenesis is a focus of molecularly-targeted therapies. This study investigated the effect of sodium butyrate (SB), a histone deacetylase inhibitor, on the synthesis of antiangiogenic and lymphangiogenic factors in oral squamous cell carcinoma. Gene alterations in HSC-3 cells were

Optimization and microbial community analysis of anaerobic co-digestion of food waste and sewage sludge based on microwave pretreatment.

Junya Zhang et al.

Bioresource technology, 200, 253-261 (2015-10-27)

The effects of microwave pretreatment (MW) on co-digestion of food waste (FW) and sewage sludge (SS) have never been investigated. In this study, a series of mesophilic biochemical methane potential (BMP) tests were conducted to determine the optimized ratio of

Improving the serum D-xylose test for the identification of patients with small intestinal malabsorption.

E D Ehrenpreis et al.

Journal of clinical gastroenterology, 33(1), 36-40 (2001-06-22)

D-Xylose absorption testing is a simple, low-cost method of screening for small intestinal malabsorption. The optimum method to measure D-xylose absorption (serum vs. urine testing) is uncertain. We present a method of improving the accuracy of D-xylose testing. Fifty-one consecutive

Sodium butyrate inhibits platelet-derived growth factor-induced proliferation and migration in pulmonary artery smooth muscle cells through Akt inhibition.

Silvia Cantoni et al.

The FEBS journal, 280(9), 2042-2055 (2013-03-08)

Sodium butyrate (BU) is a molecule that acts as a histone deacetylase inhibitor. As compared with its well-known antineoplastic/antiproliferative effects, little is known about BU action on vascular cell dynamics. An imbalance of proliferation and migration in pulmonary arterial smooth

Intestinal dysbiosis and depletion of butyrogenic bacteria in Clostridium difficile infection and nosocomial diarrhea.

Vijay C Antharam et al.

Journal of clinical microbiology, 51(9), 2884-2892 (2013-06-28)

Clostridium difficile infection (CDI) causes nearly half a million cases of diarrhea and colitis in the United States each year. Although the importance of the gut microbiota in C. difficile pathogenesis is well recognized, components of the human gut flora

Dietary fatty acids promote sleep through a taste-independent mechanism.

Estelle L S Pamboro et al.

Genes, brain, and behavior, 19(4), e12629-e12629 (2019-12-18)

Consumption of foods that are high in fat contribute to obesity and metabolism-related disorders. Dietary lipids are comprised of triglycerides and fatty acids, and the highly palatable taste of dietary fatty acids promotes food consumption, activates reward centers in mammals

Characterization of cucumber fermentation spoilage bacteria by enrichment culture and 16S rDNA cloning.

Fred Breidt et al.

Journal of food science, 78(3), M470-M476 (2013-03-06)

Commercial cucumber fermentations are typically carried out in 40000 L fermentation tanks. A secondary fermentation can occur after sugars are consumed that results in the formation of acetic, propionic, and butyric acids, concomitantly with the loss of lactic acid and

A rosemary extract rich in carnosic acid selectively modulates caecum microbiota and inhibits β-glucosidase activity, altering fiber and short chain fatty acids fecal excretion in lean and obese female rats.

María Romo-Vaquero et al.

PloS one, 9(4), e94687-e94687 (2014-04-16)

Carnosic acid (CA) and rosemary extracts (RE) show body-weight, energy metabolism and inflammation regulatory properties in animal models but the mechanisms are not yet understood. Gut microbiota plays an important role in the host metabolism and inflammatory status and is

4-Heptanone

Davis R, et al.

Organic Syntheses, 47, 75-75 (1967)

CD8+ TA cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4.

Liao, et al.

Cancer Cell, 40, 365-378 (2023)

Ketogenic Diet Exacerbates L-Arginine-Induced Acute Pancreatitis and Reveals the Therapeutic Potential of Butyrate.

He Xia et al.

Nutrients, 15(20) (2023-10-28)

The ketogenic diet (KD) has emerged as a popular weight-loss regimen in recent years. However, it has been confirmed to elicit a mild inflammatory response in the intestinal epithelium and exacerbate various digestive disorders. The severity of acute pancreatitis (AP)

Analysis of the syntrophic anaerobic digestion of volatile fatty acids using enriched cultures in a fixed-bed reactor.

T Amani et al.

Water environment research : a research publication of the Water Environment Federation, 84(5), 460-472 (2012-08-03)

Volatile fatty acids (VFAs) are key intermediates in anaerobic digestion. Enriched acetogenic and methanogenic cultures were used for the syntrophic anaerobic digestion of VFAs in a continuous fixed-bed reactor at mesophilic conditions. The interactive effects of propionic (HPr), butyric (HBu)

Inactivating mutations of acetyltransferase genes in B-cell lymphoma.

Laura Pasqualucci et al.

Nature, 471(7337), 189-195 (2011-03-11)

B-cell non-Hodgkin's lymphoma comprises biologically and clinically distinct diseases the pathogenesis of which is associated with genetic lesions affecting oncogenes and tumour-suppressor genes. We report here that the two most common types--follicular lymphoma and diffuse large B-cell lymphoma--harbour frequent structural

Polymer enzyme conjugates as chiral ligands for sharpless dihydroxylation of alkenes in organic solvents.

Stefan Konieczny et al.

Chembiochem : a European journal of chemical biology, 16(1), 83-90 (2014-11-26)

Conjugates of enzymes and poly(2-methyloxazoline) were used as organosoluble amphiphilic polymer nanocontainers for dissolving osmate, thereby converting the enzymes into organosoluble artificial metalloenzymes. These were shown to catalyze the dihydroxylation of different alkenes with high enantioselectivity. The highest selectivities, found

Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening.

Arindam Chatterjee et al.

Bioorganic & medicinal chemistry, 22(22), 6409-6421 (2014-12-03)

Calpain mediated cleavage of CDK5 natural precursor p35 causes a stable complex formation of CDK5/p25, which leads to hyperphosphorylation of tau. Thus inhibition of this complex is a viable target for numerous acute and chronic neurodegenerative diseases involving tau protein

Effect of urea addition on giant reed ensilage and subsequent methane production by anaerobic digestion.

Shan Liu et al.

Bioresource technology, 192, 682-688 (2015-06-22)

The effect of urea addition on giant reed ensilage and sequential anaerobic digestion (AD) of the ensiled giant reed was evaluated. The dry matter loss during ensilage (up to 90 days) with or without urea addition was about 1%. Addition

Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications.

Biswajit Das et al.

Virology, 474, 65-81 (2014-12-03)

HIV patients with severe periodontitis have high levels of residual virus in their saliva and plasma despite effective therapy (HAART). Multiple short chain fatty acids (SCFAs) from periodontal pathogens reactivate HIV-1 in both Jurkat and primary T-cell models of latency.

Effect of 1,3-propanediol, organic acids, and ethanol on growth and metabolism of Clostridium butyricum DSP1.

Daria Szymanowska-Powałowska et al.

Applied microbiology and biotechnology, 99(7), 3179-3189 (2014-12-20)

Knowledge of tolerance of bacteria to toxic stress is important, especially for processes targeted at high final titers of product. Information on environmental limits and stress responses may help during selection of strains or design and control of processes. The

Microbial butyrate and its role for barrier function in the gastrointestinal tract.

Svenja Plöger et al.

Annals of the New York Academy of Sciences, 1258, 52-59 (2012-06-27)

Butyrate production in the large intestine and ruminant forestomach depends on bacterial butyryl-CoA/acetate-CoA transferase activity and is highest when fermentable fiber and nonstructural carbohydrates are balanced. Gastrointestinal epithelia seem to use butyrate and butyrate-induced endocrine signals to adapt proliferation, apoptosis

[Alternative effects of a metabolic by-product, butyric acid, produced by oral anaerobes].

Kuniyasu Ochiai et al.

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 144(2), 81-87 (2014-08-12)

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