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Xianyun Ren et al.
Ecotoxicology and environmental safety, 104, 79-86 (2014-03-19)
The purpose of this study was to investigate the impact of benzo[a]pyrene (BaP) on metabolic detoxification system and bioaccumulation of white shrimp Litopenaeus vannamei. In this study, juvenile white shrimp L. vannamei were exposed for 21 days at four different
Daniel J Kim et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(27), 15837-15845 (2020-06-24)
Despite broad appreciation of their clinical utility, it has been unclear how vitamin B12 and folic acid (FA) function at the molecular level to directly prevent their hallmark symptoms of deficiency like anemia or birth defects. To this point, B12
N Caballero-Casero et al.
Analytica chimica acta, 890, 124-133 (2015-09-09)
Alkyl carboxylic acid-based nanostructured solvents, synthesized in mixtures of tetrahydrofuran (THF) and water through self-assembly and coacervation, were proved to behave as restricted access liquids. Both physical and chemical mechanisms were found responsible for exclusion of macromolecules such as proteins
Rie Yanagisawa et al.
Journal of immunotoxicology, 15(1), 31-40 (2016-12-01)
Benzo[a]pyrene (BaP) can induce developmental and reproductive toxicity; however, the full scope of its immunotoxic effects remains unknown. This study aimed to assess effects of lactational exposure to low-dose BaP (comparable to human exposure) on potential allergic\non-allergic immune responses in
Yadong Wang et al.
Archives of toxicology, 89(3), 451-458 (2014-05-23)
Benzo(a)pyrene (BaP) is one of the strongest carcinogens in cigarette smoke, which is an established human carcinogen. Twist, a transcription factor of the basic helix-loop-helix class, is reported to regulate lung cancer metastasis. Evidence has shown that BaP could induce
Woo-Keun Kim et al.
Bulletin of environmental contamination and toxicology, 92(5), 540-545 (2014-01-31)
In this study, antioxidant responses including lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST), were evaluated in the liver, gill and muscle tissues of pale chub (Zacco platypus) exposed to copper (Cu) and benzo[a]pyrene (BaP). Cu
Ana Isabel Haza et al.
Journal of the science of food and agriculture, 93(12), 2995-3000 (2013-03-19)
Honey contains a variety of polyphenols and represents a good source of antioxidants, while the human diet often contains compounds that can cause DNA damage. The present study investigated the protective effect of three commercial honey samples of different floral
Soma Banerjee et al.
Journal of molecular recognition : JMR, 27(8), 510-520 (2014-07-06)
Electron transfer (ET) reactions are important for their implications in both oxidative and reductive DNA damages. The current contribution investigates the efficacy of caffeine, a xanthine alkaloid in preventing UVA radiation induced ET from a carcinogen, benzo[a]pyrene (BP) to DNA
Kusum Rathore et al.
Cancer letters, 333(1), 113-123 (2013-01-29)
Stem-like cells and the epithelial-to-mesenchymal transition (EMT) program are postulated to play important roles in various stages of cancer development, but their roles in breast cell carcinogenesis and intervention remain to be clarified. We investigated stem-like cell- and EMT-associated properties
Emilien L Jamin et al.
PloS one, 8(3), e58591-e58591 (2013-03-14)
Colorectal neoplasia is the third most common cancer worldwide. Environmental factors such as diet are known to be involved in the etiology of this cancer. Several epidemiological studies have suggested that specific neo-formed mutagenic compounds related to meat consumption are
M Melusova et al.
Neoplasma, 61(6), 690-699 (2014-10-25)
For several thousand years natural products were successfully used to treat a variety of diseases and to maintain health in humans, but until now it is not fully known what causes these medicinal effects. In our study we assessed the cytotoxic
Relevance of quantitation of benzo(a)pyrene metabolites in animal excretes to evaluate individual human cancer risk.
A J Likhachev et al.
Progress in clinical and biological research, 374, 435-452 (1992-01-01)
Vanessa Brinkmann et al.
Aging, 13(1), 104-133 (2020-12-23)
Genetic, dietary, and environmental factors concurrently shape the aging process. The aryl hydrocarbon receptor (AhR) was discovered as a dioxin-binding transcription factor involved in the metabolism of different environmental toxicants in vertebrates. Since then, the variety of pathophysiological processes regulated
Bernhard Rainer et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 36(9), 1419-1432 (2019-07-10)
A major challenge in the safety assessment of food contact materials (FCM) is the evaluation of unknown non-intentionally added substances (NIAS). Even though consumer exposure levels may be quantitatively low, these substances are considered to be of high toxicological concern
Markus Christmann et al.
Nucleic acids research, 44(22), 10727-10743 (2016-10-04)
A coordinated and faithful DNA damage response is of central importance for maintaining genomic integrity and survival. Here, we show that exposure of human cells to benzo(a)pyrene 9,10-diol-7,8-epoxide (BPDE), the active metabolite of benzo(a)pyrene (B(a)P), which represents a most important
Luchun Duan et al.
Environment international, 70, 192-202 (2014-06-18)
Oral bioavailability of benzo[a]pyrene (B[a]P) was studied in a swine model using eight spiked soil samples after incubation for 50 and/or 90 days. Silica sand was used as a reference material and the relative bioavailability (RB) of B[a]P in soils
Xiaoli Peng et al.
Cancer prevention research (Philadelphia, Pa.), 8(6), 509-517 (2015-03-19)
Our previous study selected a promising chemopreventive agent 3,6-dihydroxyflavone (3,6-DHF) and found that 3,6-DHF significantly upregulates miR-34a and downregulates miR-21 in breast carcinogenesis, yet the upstream and downstream events of the anticancer mechanism remain unclear. The present study showed that
R Kozack et al.
Mutation research, 450(1-2), 41-59 (2000-06-06)
The process of carcinogenesis is initiated by mutagenesis, which often involves replication past damaged DNA. One question - what exactly is a DNA polymerase seeing when it incorrectly copies a damaged DNA base (e.g., inserting dATP opposite a dG adduct)?
Qi Zhang et al.
Molecular carcinogenesis, 52(9), 686-691 (2012-03-30)
Betanin, also called beetroot red, has been extensively used as a food colorant. In this study, the chemopreventive activity of betanin by oral consumption was investigated in two mouse lung tumor models. Vinyl carbamate (VC) and benzo(a)pyrene (B(a)P) were used
Nisha Verma et al.
Proteomics, 12(11), 1731-1755 (2012-05-25)
Benzo[a]pyrene (BaP), a five-ring polycyclic aromatic hydrocarbon, is a well-recognized environmental pollutant. Coal-processing waste products, petroleum sludge, asphalt, creosote, and tobacco smoke, all contain high levels of BaP. Exposure to BaP elicits many adverse biological effects, including tumor formation, immunosuppression
Louisa A Hooven et al.
Bioorganic & medicinal chemistry letters, 15(5), 1283-1287 (2005-02-17)
In this study, we investigated the effects of histone deacetylase (HDAC) inhibitors suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA) on the metabolism of polycyclic aromatic hydrocarbons (PAH) in human mammary carcinoma derived MCF-7 cells in culture. Benzo[a]pyrene (B[a]P) induces
Sahel Pakzad Toochaei et al.
Environmental science and pollution research international, 26(25), 26090-26101 (2019-07-08)
Global DNA methylation, as an epigenetic modifications, can be a promising genomic marker for monitoring the contaminants and predicting their adverse health effects. The study aims to assess the effects of 16 PAH concentration on the altered DNA methylation levels
Studies on the metabolism of benzo[a]pyrene and dose-dependent differences in the mutagenic profile of its ultimate carcinogenic metabolite.
A H Conney et al.
Drug metabolism reviews, 26(1-2), 125-163 (1994-01-01)
Yuji Fujita et al.
Bioorganic & medicinal chemistry, 18(3), 1194-1203 (2010-01-12)
The physiological role of aryl hydrocarbon receptor (AhR) is not yet fully understood, and investigation is hampered by the limited solubility of reported AhR ligands in aqueous media. To achieve improved solubility, we focused on our previous finding that planarity-disruption
Isaac A Adedara et al.
Renal failure, 37(3), 497-504 (2015-01-24)
Benzo(a)pyrene (B[a]P), a polycyclic aromatic hydrocarbon generally formed from incomplete combustion of organic matter, reportedly causes renal injury and elicits a nephropathic response. The present study investigated the modulatory effect of Kolaviron, an isolated bioflavonoid from the seed of Garcinia
Ana-Maria Rosu et al.
Carbohydrate polymers, 93(1), 184-190 (2013-03-08)
For the development of renewable bioproducts able to solubilize organic persistent pollutant such as benzo[a]pyrene (BaP), modified potato starch was synthesized by alkylation. The addition of alkyl chains was performed with three different alkylation agents: epoxyalkane, alkenyl succinic anhydride and
Nesta Bortey-Sam et al.
The Japanese journal of veterinary research, 61 Suppl, S72-S74 (2013-05-02)
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants produced from incomplete combustion of fuel or vegetation fires. Their presence in air deserves attention because they can produce carcinogenic and mutagenic effects. As an industrialized and economically significant city in Ghana, Kumasi
Jose Thaiparambil et al.
Cancer prevention research (Philadelphia, Pa.), 13(11), 923-934 (2020-07-14)
Chronic obstructive pulmonary disease (COPD) is a long-term lung disease characterized by irreversible lung damage resulting in airflow limitation, abnormal permanent air-space enlargement, and emphysema. Cigarette smoking is the major cause of COPD with 15% to 30% of smokers developing
Francesca Vinchi et al.
Gastroenterology, 146(5), 1325-1338 (2014-02-04)
The liver has one of the highest rates of heme synthesis of any organ. More than 50% of the heme synthesized in the liver is used for synthesis of P450 enzymes, which metabolize exogenous and endogenous compounds that include natural
Sébastien Corre et al.
Nature communications, 9(1), 4775-4775 (2018-11-16)
BRAF inhibitors target the BRAF-V600E/K mutated kinase, the driver mutation found in 50% of cutaneous melanoma. They give unprecedented anti-tumor responses but acquisition of resistance ultimately limits their clinical benefit. The master regulators driving the expression of resistance-genes remain poorly
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