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B19800
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关键词:'B19800'
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Perla D Maldonado et al.
The journal of physical chemistry. B, 115(45), 13408-13417 (2011-10-15)
S-Allylcysteine (SAC) is the most abundant compound in aged garlic extracts, and its antioxidant properties have been demonstrated. It is known that SAC is able to scavenge different reactive species including hydroxyl radical (•OH), although its potential ability to scavenge
Naohisa Ogo et al.
Bioorganic & medicinal chemistry letters, 17(14), 3921-3924 (2007-05-26)
Inhibition of Eg5 represents a novel approach for the treatment of cancer. Here, we report the synthesis and structure-activity relationship of S-trityl-L-cysteine (STLC) derivatives as Eg5 inhibitors. Some of these derivatives such as 4f demonstrated enhanced inhibitory activity against Eg5
N Golenhofen et al.
Renal physiology and biochemistry, 18(4), 191-197 (1995-07-01)
We investigated the last step of mercapturic acid formation, the N-acetylation of cysteine S-conjugates, in the established opossum kidney (OK) cell line which exhibits characteristics of the proximal tubule. S-Benzyl-L-cysteine was used as a model substance for such a cysteine
M Inoue et al.
Biochemical pharmacology, 36(13), 2145-2150 (1987-07-01)
Biosynthesis of N-acetylcysteine S-conjugates of toxic electrophiles, mercapturic acids, occurs via inter-organ metabolism and transport in which liver, small intestine and kidney play an important role. Since a mercapturic acid is a hydrophobic organic anion and strongly binds to plasma
B E Hall et al.
Xenobiotica; the fate of foreign compounds in biological systems, 16(7), 609-614 (1986-07-01)
Benzylmercapturic acid is a major metabolite of [methylene-14C]benzyl chloride in the marmoset, as in the rat. The excretion of the minor metabolites benzylmercapturic acid sulphoxide and benzylcysteine accounted for a greater proportion of the dose than in the rat. Excretion
Mercapturic acid formation in cultured opossum kidney cells.
N Golenhofen et al.
Toxicology letters, 53(1-2), 261-261 (1990-09-01)
Atefeh Rafiei et al.
Rapid communications in mass spectrometry : RCM, 29(1), 119-127 (2014-12-03)
Data analysis is a key step in mass spectrometry based untargeted metabolomics, starting with the generation of generic peak lists from raw liquid chromatography/mass spectrometry (LC/MS) data. Due to the use of various algorithms by different workflows, the results of
A E Pegg et al.
Biochemistry, 32(45), 11998-12006 (1993-11-16)
Human O6-alkylguanine-DNA alkyltransferase was rapidly inactivated by low concentrations of O6-benzylguanine, but the alkyltransferase from the Escherichia coli ogt gene was much less sensitive and alkyltransferases from the E. coli ada gene or from yeast were not affected. O6-Benzyl-2'-deoxyguanosine was
M Rooseboom et al.
Chemical research in toxicology, 14(1), 127-134 (2001-02-15)
Previously, it was shown that beta-elimination of selenocysteine Se-conjugates by rat renal cytosol leading to pyruvate formation was not solely catalyzed by pyridoxal phosphate-dependent enzymes. It was hypothesized that selenoxidation of the selenocysteine Se-conjugates, followed by syn-elimination, may be an
P J Sausen et al.
The Journal of biological chemistry, 265(11), 6139-6145 (1990-04-15)
Cysteine conjugate S-oxidase activity, with S-benzyl-L-cysteine as substrate, was found mostly in the microsomal fractions of rat liver and kidney. In the presence of oxygen and NADPH, S-benzyl-L-cysteine is converted to S-benzyl-L-cysteine sulfoxide; no S-benzyl-L-cysteine sulfone was detected. The Vmax
S Mukherjee et al.
Nuclear medicine and biology, 20(4), 413-426 (1993-05-01)
To explore the possibility of utilizing cysteine derivatives for technetium-99m radiopharmaceutical preparation with clinical potential, we synthesized two benzyl substituted cysteine compounds, namely, S-benzyl cysteine 1 and cysteine benzyl ester 3. It was expected, from our previous studies on benzoyl
Michelle Rudden et al.
Scientific reports, 10(1), 12500-12500 (2020-07-29)
Body odour is a characteristic trait of Homo sapiens, however its role in human behaviour and evolution is poorly understood. Remarkably, body odour is linked to the presence of a few species of commensal microbes. Herein we discover a bacterial
M Inoue et al.
Journal of biochemistry, 95(1), 247-254 (1984-01-01)
Biosynthesis of N-acetylcysteine S-conjugates of xenobiotics, mercapturic acids, occurs via inter-organ metabolism of the corresponding glutathione derivatives (Inoue, M., Okajima, K., & Morino, Y. (1982) Hepatology 2, 311-316). To elucidate the mechanism of mercapturate biosynthesis and its urinary elimination, hepato-renal
Formation of a dehydroalanyl residue from S-benzylcysteine upon HF cleavage of a [Sar1, Cys8]-angiotensin II peptide resin.
E A Hallinan
International journal of peptide and protein research, 38(6), 601-602 (1991-12-01)
A A Elfarra
Chemico-biological interactions, 96(1), 47-55 (1995-04-28)
Several xenobiotics and their corresponding cysteine S-conjugates are metabolized in vivo to cysteine S-conjugate sulfoxides and/or N-acetylcysteine S-conjugate sulfoxides. Homocysteine S-conjugates, such as methionine and ethionine, are also metabolized in vivo to sulfoxides. The enzymatic basis for these metabolic reactions
K Okajima et al.
European journal of biochemistry, 142(2), 281-286 (1984-07-16)
Acetylation of cysteine S-conjugates of xenobiotics by microsomal N-acetyltransferase is the final step of detoxicative metabolism leading to mercapturic acid biosynthesis. To elucidate the subcellular site of N-acetylation and the effective mechanism by which the final metabolites are eliminated from
[Synthesis and antifibrinolytic activity of dipeptides of E-aminocaproic acid and sulfur-containing amino acids].
K Midura-Nowaczek et al.
Acta poloniae pharmaceutica, 45(1), 35-41 (1988-01-01)
A potent pyridoxal model capable of promoting transamination and beta-elimination of amino acids.
H Kondo et al.
Progress in clinical and biological research, 144A, 101-108 (1984-01-01)
Reema Deol et al.
Xenobiotica; the fate of foreign compounds in biological systems, 47(3), 202-207 (2016-05-18)
1. The mercapturic acid (MA) pathway is a metabolic route for the processing of glutathione conjugates to MA (N-acetylcysteine conjugates). An N-acetyltransferase enzyme, NAT8, catalyzes the transfer of an acetyl group from acetyl-CoA to the cysteine amino group, producing a MA
A Heuner et al.
Pflugers Archiv : European journal of physiology, 417(5), 523-527 (1991-01-01)
We investigated the capacity and the localization of N-acetylation of the mercapturic acid precursor S-benzyl-L-cysteine (BC), as well as the tubular reabsorption of this compound in the rat kidney in vivo et situ by renal clearance and continuous microinfusion and
R S Phillips et al.
The Journal of biological chemistry, 266(28), 18642-18648 (1991-10-05)
Lysine 269 in Escherichia coli tryptophan indole-lyase (tryptophanase) has been changed to arginine by site-directed mutagenesis. The resultant K269R mutant enzyme exhibits kcat values about 10% those of the wild-type enzyme with S-(o-nitrophenyl)-L-cysteine, L-tryptophan, and S-benzyl-L-cysteine, while kcat/Km values are
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