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Riki Okita et al.
Oncology reports, 34(6), 2864-2870 (2015-10-28)
EGFR/HER2 are frequently expressed in MPM tissues, however, no studies have shown the clinical benefit of using EGFR/HER2-targeting drugs in patients with malignant pleural mesothelioma (MPM). It was reported that the tyrosine kinase inhibitor (TKI) lapatinib enhanced trastuzumab-mediated antibody-dependent cellular
Tim Luetkens et al.
Cancer immunology, immunotherapy : CII, 63(11), 1151-1162 (2014-08-01)
Multiple myeloma (MM) is the malignancy with the most frequent expression of the highly immunogenic cancer-testis antigens (CTA), and we have performed the first analysis of longitudinal expression, immunological properties, and fine specificity of CTA-specific antibody responses in MM. Frequency
Anna Benrick et al.
Acta diabetologica, 51(6), 963-972 (2014-09-15)
To compare the effect of a single session of acupuncture with either low-frequency electrical or manual stimulation on insulin sensitivity and molecular pathways in the insulin-resistant dihydrotestosterone-induced rat polycystic ovary syndrome (PCOS) model. Both stimulations cause activation of afferent nerve
Aparna Gudlur et al.
Nature communications, 5, 5164-5164 (2014-10-10)
The ER-resident regulatory protein STIM1 triggers store-operated Ca(2+) entry by direct interaction with the plasma membrane Ca(2+) channel ORAI1. The mechanism of channel gating remains undefined. Here we establish that STIM1 gates the purified recombinant ORAI1 channel in vitro, and
Poonam Sonawane et al.
British journal of pharmacology, 171(23), 5330-5344 (2014-07-22)
Isotretinoin (13-cis-retinoic acid; 13-cRA) is a differentiation inducer used to treat minimal residual disease after myeloablative therapy for high-risk neuroblastoma. However, more than 40% of children develop recurrent disease during or after 13-cRA treatment. The plasma concentrations of 13-cRA in
Rafijul Bari et al.
Scientific reports, 5, 11098-11098 (2015-06-13)
Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). To identify recipient risk factors, a genome-wide study was performed including 481,820 single-nucleotide polymorphisms (SNPs). Two GVHD susceptibility loci (rs17114803 and rs17114808)
Youseung Kim et al.
Bioorganic & medicinal chemistry, 23(15), 4980-4988 (2015-06-06)
PABA/NO [O(2)-{2,4-dinitro-5-[4-(N-methylamino)benzoyloxy]phenyl} 1-(N,N-dimethylamino) diazen-1-ium-1,2-diolate] is a nitric oxide (NO)-releasing arylating agent designed to be selectively activated by reaction with glutathione (GSH) on catalysis by glutathione S-transferase P1 (GSTP1), an enzyme frequently overexpressed in cancer cells. PABA/NO has proven active in
Reina N Fuji et al.
Science translational medicine, 7(273), 273ra15-273ra15 (2015-02-06)
Inhibition of the kinase activity of leucine-rich repeat kinase 2 (LRRK2) is under investigation as a possible treatment for Parkinson's disease. However, there is no clinical validation as yet, and the safety implications of targeting LRRK2 kinase activity are not
Yetrib Hathout et al.
Human molecular genetics, 23(24), 6458-6469 (2014-07-17)
It is expected that serum protein biomarkers in Duchenne muscular dystrophy (DMD) will reflect disease pathogenesis, progression and aid future therapy developments. Here, we describe use of quantitative in vivo stable isotope labeling in mammals to accurately compare serum proteomes
W M Chatila et al.
Clinical and experimental immunology, 177(1), 341-352 (2014-03-19)
Chronic obstructive pulmonary disease (COPD) is characterized by an abnormal regulatory T cell (T(reg)) response and increases in T helper type 1 (Th1) and Th17 cell responses. It is unclear if dysregulation of microRNAs (miRNA) within T(reg) cells contributes to
Frithjof Lohmann et al.
Biochimica et biophysica acta, 1842(7), 945-958 (2014-03-04)
Podocytes are terminally differentiated cells of the glomerular filtration barrier that react with hypertrophy in the course of injury such as in membranous nephropathy (MGN). The neuronal deubiquitinase ubiquitin C-terminal hydrolase L1 (UCH-L1) is expressed and activated in podocytes of
David R Colquhoun et al.
Proteomics, 15(12), 2066-2077 (2015-04-29)
Protein acylation plays a critical role in protein localization and function. Acylation is essential for human immunodeficiency virus 1 (HIV-1) assembly and budding of HIV-1 from the plasma membrane in lipid raft microdomains and is mediated by myristoylation of the
Ellen De Langhe et al.
Respiratory research, 16, 38-38 (2015-04-08)
Effective treatments for fibrotic diseases such as idiopathic pulmonary fibrosis are largely lacking. Transforming growth factor beta (TGFβ) plays a central role in the pathophysiology of fibrosis. We hypothesized that bone morphogenetic proteins (BMP), another family within the TGFβ superfamily
Fangjia Lu et al.
Journal of controlled release : official journal of the Controlled Release Society, 204, 51-59 (2015-03-10)
The use of nanoparticles for delivery of vaccine antigens and as vaccine adjuvants is appealing because their size allows efficient uptake by dendritic cells and their biological properties can be tailored to the desired function. Here, we report the effect
Todd J Cohen et al.
Nature communications, 6, 5845-5845 (2015-01-06)
TDP-43 pathology is a disease hallmark that characterizes amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). Although a critical role for TDP-43 as an RNA-binding protein has emerged, the regulation of TDP-43 function is poorly understood. Here, we identify
Michael Thiele et al.
Journal of immunology (Baltimore, Md. : 1950), 195(5), 2343-2352 (2015-07-26)
Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and counterregulator of glucocorticoids, is a potential therapeutic target. MIF is markedly different from other cytokines because it is constitutively expressed, stored in the cytoplasm, and present in the circulation of healthy
Peng Guo et al.
Theranostics, 6(1), 1-13 (2016-01-02)
Lipocalin 2 (Lcn2) is a promising therapeutic target as well as a potential diagnostic biomarker for breast cancer. It has been previously shown to promote breast cancer progression by inducing the epithelial to mesenchymal transition in breast cancer cells as
Vasilios Panagopoulos et al.
The international journal of biochemistry & cell biology, 68, 128-138 (2015-09-20)
Peroxidases are heme-containing enzymes released by activated immune cells at sites of inflammation. To-date their functional role in human health has mainly been limited to providing a mechanism for oxidative defence against invading bacteria and other pathogenic microorganisms. Our laboratory
Genee Y Lee et al.
Cancer research, 74(11), 3114-3126 (2014-04-24)
Cancer genomes maintain a complex array of somatic alterations required for maintenance and progression of the disease, posing a challenge to identify driver genes among this genetic disorder. Toward this end, we mapped regions of recurrent amplification in a large
John Martin et al.
Human gene therapy methods, 24(4), 253-269 (2013-07-16)
Adeno-associated virus (AAV) producer cell lines represent an effective method for large-scale production of AAV vectors. We set out to evaluate and characterize the use of an abbreviated protocol to generate "masterwells" (MWs; a nonclonal cell population) as a platform
Yansheng Hao et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(10), 2674-2683 (2014-03-13)
Classical Hodgkin lymphoma (cHL) and primary mediastinal large B-cell lymphoma (MLBCL) share similar histologic, clinical, and genetic features. In recent studies, we found that disease-specific chromosome 9p24.1/JAK2 amplification increased JAK2 expression and activity in both cHL and MLBCL. This prompted
Lianjin Jin et al.
Breast cancer research and treatment, 146(1), 41-50 (2014-05-28)
Caloric restriction (CR) has been shown to cause tumor regression in models of triple-negative breast cancer (TNBC), and the regression is augmented when coupled with ionizing radiation (IR). In this study, we sought to determine if the molecular interaction between
Lisa M McFadden et al.
Neuropharmacology, 93, 146-154 (2015-02-04)
Others and we have reported that prior methamphetamine (METH) exposure attenuates the persistent striatal dopaminergic deficits caused by a subsequent high-dose "binge" METH exposure. The current study investigated intermediate neurochemical changes that may contribute to, or serve to predict, this
Graham K Farrington et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(11), 4764-4778 (2014-07-30)
The blood-brain barrier (BBB) prevents the access of therapeutic antibodies to central nervous system (CNS) targets. The engineering of bispecific antibodies in which a therapeutic "arm" is combined with a BBB-transcytosing arm can significantly enhance their brain delivery. The BBB-permeable
V Smit
Electrophoresis, 15(2), 251-254 (1994-02-01)
Native electrophoresis on the Pharmacia PhastSystem using a new buffer system is used to monitor chemical modifications of human interleukin-3. The method is faster, more gentle and more convenient than amino acid analysis. Micrograms of protein suffice in contrast with
M Banadakoppa et al.
Clinical and experimental immunology, 177(3), 743-749 (2014-05-08)
Spontaneous abortion in early pregnancy due to unknown reasons is a common problem. The excess complement activation and consequent placental inflammation and anti-angiogenic milieu is emerging as an important associated factor in many pregnancy-related complications. In the present study we
Michael D Weber et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 316-324 (2015-01-09)
Exposure to acute and chronic stressors sensitizes the proinflammatory response of microglia to a subsequent immune challenge. However, the proximal signal by which stressors prime microglia remains unclear. Here, high mobility group box-1 (HMGB-1) protein was explored as a potential
Sunandan Saha et al.
Nucleic acids research, 43(3), 1770-1782 (2015-01-22)
Non-viral transposons have been used successfully for genetic modification of clinically relevant cells including embryonic stem, induced pluripotent stem, hematopoietic stem and primary human T cell types. However, there has been limited evaluation of undesired genomic effects when using transposons
Sookhee Bang et al.
Gastroenterology research and practice, 2015, 568981-568981 (2015-05-20)
Implantation of self-expanding metal stents (SEMS) is palliation for patients suffering from inoperable malignant obstructions associated with biliary and pancreatic cancers. Chemotherapeutic agent-eluting stents have been developed because SEMS are susceptible to occlusion by tumor in-growth. We reported recently that
Yajing Peng et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(20), 6772-6789 (2014-05-16)
The import of acetyl-CoA into the ER lumen by AT-1/SLC33A1 is essential for the N(ε)-lysine acetylation of ER-resident and ER-transiting proteins. A point-mutation (S113R) in AT-1 has been associated with a familial form of spastic paraplegia. Here, we report that
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