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Pingliang Li et al.
Journal of agricultural and food chemistry, 60(12), 3013-3019 (2012-03-08)
Diacetyl is a natural byproduct of fermentation and known to be an important flavor compound in many food products. Because of the potential undesirable effects of diacetyl on health safety and beer flavor, determination of its concentration in beer samples
Arthur Forer et al.
Protoplasma, 225(1-2), 1-4 (2005-05-04)
BDM (2,3-butanedione monoxime) has been used extensively to inhibit nonmuscle myosin. However, recent articles raise the question of what BDM actually does, because of experiments in which BDM did not affect the actin-activated ATPase of nonmuscle myosins. We describe results
T R Leonard et al.
American journal of physiology. Cell physiology, 299(6), C1398-C1401 (2010-09-17)
It has been accepted for half a century that, for a given level of activation, the steady-state isometric force of a muscle sarcomere depends exclusively on the amount of overlap between the contractile filaments actin and myosin, or equivalently sarcomere
Pascal Fuchsmann et al.
Journal of chromatography. A, 1601, 60-70 (2019-06-11)
Headspace in-tube extraction (HS-ITEX) and solid phase microextraction (HS-SPME) sampling, followed by gas chromatography-mass spectrometry (GC-MS), are widely used to analyze volatile compounds in various food matrices. While the extraction efficiency of volatile compounds from foodstuffs is crucial for obtaining
Gisele C da Silva et al.
Food chemistry, 167, 71-77 (2014-08-26)
Two methods for the extraction, identification and quantification of the highest occurrence and lowest perception threshold off-flavours in fifteen different samples of Brazilian Pilsner beers were developed. For this purpose, headspace solid phase microextraction in combination with a gas chromatography
Smaro Kokkinidou et al.
Journal of agricultural and food chemistry, 62(32), 8023-8033 (2014-07-30)
The application of phenolic compounds to suppress Maillard chemistry and off-flavor development in ultrahigh-termperature (UHT)-processed milk during processing and storage was investigated. Five phenolic compounds were examined for structure-reactivity relationships (catechin, genistein, daidzein, 1,2,3-trihydroxybenzene, and 1,3,5-trihydroxybenzene). The levels of key
Quality changes during storage of cooked and sliced meat products measured with PTR-MS and HS-GC-MS.
E S Holm et al.
Meat science, 95(2), 302-310 (2013-06-12)
The changes in the VOC composition of industrially produced saveloy were measured with Proton-Transfer-Reaction Mass-Spectrometry (PTR-MS) and HeadSpace Gas chromatography-mass spectrometry (HS-GC-MS) during a six weeks storage period. A decrease in the volatile organic compounds contributing to the fresh aroma
Shaiban Jubair et al.
American journal of physiology. Heart and circulatory physiology, 309(4), H676-H684 (2015-06-14)
Accumulating evidence indicates that substance P is cardioprotective following ischemia-reperfusion primarily due to its potent coronary vasodilator actions. However, an anti-apoptotic effect of substance P has been observed in tenocytes following ischemia, which involved activation of the AKT pathway. This
A Espinosa-Mansilla et al.
Analytical biochemistry, 255(2), 263-273 (1998-02-06)
A sensitive and simple liquid chromatographic method to determine glyoxal, methylglyoxal, and diacetyl is reported. The method is based on the conversion to the corresponding pteridin derivatives (pterin, 6-methylpterin, and 6,7-dimethylpterin). The proposed method using fluorometric detection has been applied
Francine L Kelly et al.
American journal of respiratory cell and molecular biology, 51(4), 568-574 (2014-05-13)
Diacetyl (DA), a component of artificial butter flavoring, has been linked to the development of bronchiolitis obliterans (BO), a disease of airway epithelial injury and airway fibrosis. The epidermal growth factor receptor ligand, amphiregulin (AREG), has been implicated in other
Kristin J Cummings et al.
Occupational and environmental medicine, 71(8), 549-554 (2014-06-04)
To better understand respiratory symptoms and lung function in flavouring manufacturing workers. We offered a questionnaire and lung function testing to the current workforce of a flavouring manufacturing facility that had transitioned away from diacetyl and towards substitutes in recent
Eveline J Bartowsky et al.
International journal of food microbiology, 96(3), 235-252 (2004-09-30)
The diketone, diacetyl, is a major flavour metabolite produced by lactic acid bacteria (LAB). Of the LAB associated with wine, Oenococcus oeni is encouraged during the malolactic (ML) fermentation, a biodeacidification of wine during which the metabolism of diacetyl occurs.
R C Mehta et al.
Journal of chromatography, 430(2), 341-349 (1988-09-09)
Serum albumins and polylactic acid (PLA) have been used as bioerodable polymers in the preparation of drug-containing microspheres for parenteral drug delivery. The albumin microsphere may be prepared via either chemical cross-linking or heat denaturation of the protein. Heat-denatured albumin
Zélia Alves et al.
PloS one, 10(11), e0143641-e0143641 (2015-11-26)
Winemaking is a highly industrialized process and a number of commercial Saccharomyces cerevisiae strains are used around the world, neglecting the diversity of native yeast strains that are responsible for the production of wines peculiar flavours. The aim of this
E Peretti et al.
The Journal of pharmacology and experimental therapeutics, 243(2), 686-689 (1987-11-01)
The effect of isoniazid and its metabolites on the disposition of acetylhydrazine, a toxic metabolite formed from isoniazid, was studied in humans. Acetylhydrazine was administered i.v. with and without prior ingestion of 300 mg of isoniazid. In the studies with
Nathalie Moreira et al.
Food chemistry, 270, 518-526 (2018-09-04)
A method based on headspace solid-phase microextraction (HS-SPME) coupled to gas chromatography-triple quadrupole/mass spectrometry detection (GC-TQ/MS) with a prior derivatization step with O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA) was developed to quantify carbonyl compounds in different categories of Port wines. Optimal extraction conditions
S Ghimenti et al.
Journal of breath research, 7(1), 017115-017115 (2013-03-01)
The evolution of breath composition during oral glucose tolerance tests (OGTTs) was analysed by thermal desorption/gas chromatography/mass spectrometry in 16 subjects and correlated to blood glucose levels. The glucose tolerance tests classified five of the subjects as diabetics, eight as
Margarita Andreevskaya et al.
Applied and environmental microbiology, 81(11), 3800-3811 (2015-03-31)
Lactococcus piscium is a psychrotrophic lactic acid bacterium and is known to be one of the predominant species within spoilage microbial communities in cold-stored packaged foods, particularly in meat products. Its presence in such products has been associated with the
Alessandra Amoroso et al.
Food chemistry, 140(4), 654-659 (2013-05-23)
α-Dicarbonyl compounds (α-DCs), such as glyoxal, methylglyoxal and 2,3-butanedione, are highly reactive substances occurring in thermally treated and fermented foods, that may react with amino and sulphydryl groups of side chains of proteins to form Maillard reaction end products, inducing
Xia-Jing Tong et al.
eLife, 4, e09648-e09648 (2015-11-18)
Changing receptor abundance at synapses is an important mechanism for regulating synaptic strength. Synapses contain two pools of receptors, immobilized and diffusing receptors, both of which are confined to post-synaptic elements. Here we show that immobile and diffusing GABA(A) receptors
Zhong-wei Liu et al.
Acta pharmacologica Sinica, 36(3), 323-333 (2015-01-27)
Matrine is an alkaloid from Sophora alopecuroides L, which has shown a variety of pharmacological activities and potential therapeutic value in cardiovascular diseases. In this study we examined the protective effects of matrine against diabetic cardiomyopathy (DCM) in rats. Male
The sweet, sweet smell of diacetyl.
D P Smith
Neuron, 16(3), 469-471 (1996-03-01)
Chih-Wei Chou et al.
PloS one, 9(9), e107997-e107997 (2014-09-24)
While the endothelium-organ interaction is critical for regulating cellular behaviors during development and disease, the role of blood flow in these processes is only partially understood. The dorsal aorta performs paracrine functions for the timely migration and differentiation of the
L Brines et al.
Acta physiologica (Oxford, England), 206(1), 29-41 (2012-04-14)
Myocardial stretching is an arrhythmogenic factor. Optical techniques and mechanical uncouplers are used to study the mechanoelectric feedback. The aim of this study is to determine whether the mechanical uncouplers 2,3-butanedione monoxime and Blebbistatin hinder or modify the electrophysiological effects
M I Rincon-Delgadillo et al.
Journal of dairy science, 95(3), 1128-1139 (2012-03-01)
Starter distillates (SDL) are used as ingredients in the formulation of many food products such as cottage cheese, margarine, vegetable oil spreads, processed cheese, and sour cream to increase the levels of naturally occurring buttery aroma associated with fermentation. This
Thomas J Wheeler et al.
PloS one, 7(4), e35023-e35023 (2012-05-05)
Earlier studies by our group showed that fructose-1,6-bisphosphate (FBP) enhances the hypothermic preservation of rat cardiac myocytes and the functional recovery of animal hearts after hypothermic storage. However, the mechanisms involved were not clear. We extended the cardiomyocyte studies by
David S Egilman et al.
International journal of occupational and environmental health, 18(1), 29-42 (2012-05-04)
Respiratory exposure to diacetyl and diacetyl-containing flavorings used in butter-flavored microwave popcorn (BFMP) causes lung disease, including bronchiolitis obliterans (BO), in flavorings and popcorn manufacturing workers. However, there are no published reports of lung disease among BFMP consumers. We present
Takeshi Hara et al.
Chemistry & biodiversity, 12(2), 248-258 (2015-02-14)
Human body odor, which contains several volatile organic compounds, possesses various odor qualities. To identify key volatile compounds responsible for the common unpleasant odors derived from human axillae and feet, the odor quality and intensity of 118 human axillae and
Xiaohu Tang et al.
Breast cancer research : BCR, 16(4), 415-415 (2014-08-06)
Remodeling of cellular metabolism appears to be a consequence and possibly a cause of oncogenic transformation in human cancers. Specific aspects of altered tumor metabolism may be amenable to therapeutic intervention and could be coordinated with other targeted therapies. In
Swati S More et al.
Journal of agricultural and food chemistry, 60(12), 3311-3317 (2012-03-06)
Diacetyl (DA), a natural butter flavorant, is a causative agent for the lung disease obliterative bronchiolitis. Mutagenic properties of 1,2-dicarbonyls have previously been empirically linked to their possible interaction with DNA nucleobases. This study for the first time identifies chemically
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