C0496

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Mechanism of radioprotection by dihydroxy-1-selenolane (DHS): Effect of fatty acid conjugation and role of glutathione peroxidase (GPx).

Prachi Verma et al.

Biochimie, 144, 122-133 (2017-11-04)

Dihydroxy-1-selenolane (DHS) previously reported to exhibit radioprotective activity was investigated to understand its mechanism of action in CHO cells of epithelial origin. DHS pre-treatment at 25 μM for 16 h significantly protected CHO cells from radiation (4-11 Gy)-induced delayed mitotic cell death. Further

Base excision repair-inspired DNA motor powered by intracellular apurinic/apyrimidinic endonuclease.

Lidan Li et al.

Nanoscale, 11(3), 1343-1350 (2019-01-04)

The transition of DNA nanomachines from test tubes to living cells would realize the ultimate goal of smart therapeutic dynamic DNA nanotechnology. The operation of DNA nanomachines in living cells remains challenging because it is difficult to utilize an endogenous

The redox function of apurinic/apyrimidinic endonuclease 1 as key modulator in photodynamic therapy.

Leonardo Pereira Franchi et al.

Journal of photochemistry and photobiology. B, Biology, 211, 111992-111992 (2020-08-18)

Photodynamic therapy (PDT) is an anticancer modality depicting an induced oxidative stress as the mechanism of action that ultimately culminates in cell death. The apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a key protein promoting bad prognostic in several cancer types.

A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta.

De-Sheng Pei et al.

Nucleic acids research, 39(8), 3156-3165 (2010-12-22)

DNA repair is required to maintain genome stability in stem cells and early embryos. At critical junctures, oxidative damage to DNA requires the base excision repair (BER) pathway. Since early zebrafish embryos lack the major polymerase in BER, DNA polymerase

A specific DNA-nanoprobe for tracking the activities of human apurinic/apyrimidinic endonuclease 1 in living cells.

Junqiu Zhai et al.

Nucleic acids research, 45(6), e45-e45 (2016-12-08)

Human apurinic/apyrimidinic endonuclease/redox effector factor 1 (APE1) is an essential DNA repair protein. Herein, we demonstrate that avidin-oriented abasic site-containing DNA strands (AP-DNA) on the surface of silica coated magnetic nanoparticles (SiMNP) can selectively respond to APE1 while resist the

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy.

Meryem Alagoz et al.

Nucleic acids research, 42(5), 3089-3103 (2013-12-18)

Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents. Despite their frequency, the overlapping mechanisms that repair these forms

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.

Jeroen E J Guikema et al.

The Journal of experimental medicine, 204(12), 3017-3026 (2007-11-21)

Antibody class switch recombination (CSR) occurs by an intrachromosomal deletion requiring generation of double-stranded breaks (DSBs) in switch-region DNA. The initial steps in DSB formation have been elucidated, involving cytosine deamination by activation-induced cytidine deaminase and generation of abasic sites

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