c0625

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Biological activities and phytochemical profiles of extracts from different parts of bamboo (Phyllostachys pubescens).

Akinobu Tanaka et al.

Molecules (Basel, Switzerland), 19(6), 8238-8260 (2014-06-20)

Besides being a useful building material, bamboo also is a potential source of bioactive substances. Although some studies have been performed to examine its use in terms of the biological activity, only certain parts of bamboo, especially the leaves or

Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

Gang Yu et al.

Bioorganic & medicinal chemistry letters, 20(3), 896-902 (2010-01-05)

A novel class of phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore attached to its C-2, C-3 or C-4 position was designed for evaluation as anti-inflammatory (AI) agents. A number of compounds exhibited a combination of potent in vitro cyclooxygenase-2 (COX-2)

Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster.

Elizabeth L Cordonier et al.

The Journal of nutritional biochemistry, 26(11), 1379-1384 (2015-08-26)

Holocarboxylase synthetase (HLCS) is the sole protein-biotin ligase in the human proteome. HLCS has key regulatory functions in intermediary metabolism, including fatty acid metabolism, and in gene repression through epigenetic mechanisms. The objective of this study was to identify food-borne

Chemical profiling and in vitro biological effects of Cardiospermum halicacabum L. (Sapindaceae) aerial parts and seeds for applications in neurodegenerative disorders.

Francesco Menichini et al.

Journal of enzyme inhibition and medicinal chemistry, 29(5), 677-685 (2013-10-10)

Cardiospermum halicacabum is widely used in traditional medicine. Previous studies have focused on the aerial parts, while the seeds have been poorly investigated. This work aimed to analyse the chemical composition of extracts from aerial parts and seeds obtained using

Protective effects of polyphenols-enriched extract from Huangshan Maofeng green tea against CCl4-induced liver injury in mice.

Yanmang Cui et al.

Chemico-biological interactions, 220, 75-83 (2014-06-29)

The study was to characterize the polyphenolic composition, antioxidant properties, and hepatoprotective effects of a polyphenols-enriched extract (HMTP) from Huangshan Maofeng green tea. HPLC analysis showed that three predominantly polyphenolic compounds present in HMTP were epigallocatechin (271.2 μg/mg extract), rutin

Caffeic Acid Inhibits UVB-induced Inflammation and Photocarcinogenesis Through Activation of Peroxisome Proliferator-activated Receptor-γ in Mouse Skin.

Agilan Balupillai et al.

Photochemistry and photobiology, 91(6), 1458-1468 (2015-08-26)

In this study, the effect of caffeic acid (CA) on both acute and chronic UVB-irradiation-induced inflammation and photocarcinogenesis was investigated in Swiss albino mice. Animals were exposed to 180 mJ cm(-2) of UVB once daily for 10 consecutive days and

RNA-Seq Based De Novo Transcriptome Assembly and Gene Discovery of Cistanche deserticola Fleshy Stem.

Yuli Li et al.

PloS one, 10(5), e0125722-e0125722 (2015-05-06)

Cistanche deserticola is a completely non-photosynthetic parasitic plant with great medicinal value and mainly distributed in desert of Northwest China. Its dried fleshy stem is a crucial tonic in traditional Chinese medicine with roles of mainly improving male sexual function

Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

Morshed Alam Chowdhury et al.

Bioorganic & medicinal chemistry letters, 18(23), 6138-6141 (2008-10-24)

A hitherto unknown class of celecoxib analogs was designed for evaluation as dual inhibitors of the 5-lipoxygenase/cyclooxygenase-2 (5-LOX/COX-2) enzymes. These compounds possess a SO(2)Me (11a), or SO(2)NH(2) (11b) COX-2 pharmacophore at the para-position of the N(1)-phenyl ring in conjunction with

Centella asiatica and Its Fractions Reduces Lipid Peroxidation Induced by Quinolinic Acid and Sodium Nitroprusside in Rat Brain Regions.

Naiani Ferreira Marques et al.

Neurochemical research, 40(6), 1197-1210 (2015-04-24)

Oxidative stress has been implicated in several pathologies including neurological disorders. Centella asiatica is a popular medicinal plant which has long been used to treat neurological disturbances in Ayurvedic medicine. In the present study, we quantified of compounds by high

Determination of organic acids in Salicornia herbacea by solid-phase extraction combined with liquid chromatography.

Dandan Han et al.

Natural product communications, 8(2), 203-206 (2013-03-22)

A solid-phase extraction (SPE) method for the determination of procatechuic acid, ferulic acid and caffeic acid in Salicornia herbacea L. (Hamcho) has been developed. The optimal conditions were obtained by using a C18 SPE cartridge. By using ethanol and acetonitrile

Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.

Alessio Innocenti et al.

Bioorganic & medicinal chemistry, 18(6), 2159-2164 (2010-02-27)

A series of phenolic acids and phenol natural products, such as p-hydroxybenzoic acid, p-coumaric acid, caffeic acid, ferulic acid, gallic acid, syringic acid, quercetin, and ellagic acid, were investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA, EC

The impact of drying techniques on phenolic compound, total phenolic content and antioxidant capacity of oat flour tarhana.

Nurcan Değirmencioğlu et al.

Food chemistry, 194, 587-594 (2015-10-17)

In this study, the changes in phenolic composition, total phenolic content, and antioxidant capacity of tarhanas supplemented with oat flour (OF) at the levels of 20-100% (w/w) after three drying treatments (sun-, oven-, and microwave drying) were investigated. A total

Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts.

Ayokunle O Ademosun et al.

Journal of basic and clinical physiology and pharmacology, 26(5), 471-477 (2015-06-02)

Citrus peels are consumed in the form of infusions, candy or wine, based on their well-documented nutritional and medicinal properties. This study sought to investigate the effect of some citrus peels' [grapefruit (Citrus paradisii), orange (Citrus sinensis) and shaddock (Citrus

Differences in Vvufgt and VvmybA1 Gene Expression Levels and Phenolic Composition in Table Grape (Vitis vinifera L.) 'Red Globe' and Its Somaclonal Variant 'Pink Globe'.

Luis Bustamante et al.

Journal of agricultural and food chemistry, 65(13), 2793-2804 (2017-03-10)

A novel 'Red Globe' (RG)-derived grape variety, 'Pink Globe' (PG), was described and registered as a new genotype, with earlier ripening and sweeter taste than those of RG. Microsatellite analysis revealed that PG and RG are undifferentiable; however, the PG

Use of the Combination Index to determine interactions between plant-derived phenolic acids on hepatotoxicity endpoints in human and rat hepatoma cells.

Yitong Liu et al.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(5), 461-468 (2013-02-06)

The beneficial or adverse effects of isolated phytochemicals are not always concordant with effects of the botanical dietary supplements from which they were derived. This disparity could be due to interactions between the various phytochemicals present in the whole plant.

Oxidative Stress Differentially Influences the Survival and Metabolism of Cells in the Melanoma Microenvironment.

Emily R Trzeciak et al.

Cells, 11(6) (2022-03-26)

The cellular composition of the tumor microenvironment, including tumor, immune, stromal, and endothelial cells, significantly influences responses to cancer therapies. In this study, we analyzed the impact of oxidative stress, induced by cold atmospheric plasma (CAP), on tumor cells, T

Analysis of Phenolic Compounds in Some Medicinal Herbs by LC-MS.

Alina O Matei et al.

Journal of chromatographic science, 53(7), 1147-1154 (2015-01-15)

In this paper, a liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry in negative mode method was developed for the identification and quantitative determination of 13 individual phenolics (chlorogenic acid, caffeic acid, coumaric acid, ferulic acid, (+)-catechin, (-)-epicatechin, rutin, quercitrin, isoquercitrin, fisetin

Synthesis, structure and structure-activity relationship analysis of caffeic acid amides as potential antimicrobials.

Jie Fu et al.

European journal of medicinal chemistry, 45(6), 2638-2643 (2010-02-26)

A series of caffeic acid amides 1-23 were synthesized and nine of which (13-17, 19-21 and 23) were reported for the first time. The chemical structures of these compounds were confirmed by means of 1H NMR, ESI MS and elemental

Interactions between α-tocopherol and rosmarinic acid and its alkyl esters in emulsions: synergistic, additive, or antagonistic effect?

Atikorn Panya et al.

Journal of agricultural and food chemistry, 60(41), 10320-10330 (2012-09-20)

Many antioxidants can interact to produce synergistic interactions that can more effectively inhibit lipid oxidation in foods. Esterification of rosmarinic acid produces a variety of compounds with different antioxidant activity due to differences in polarity and thus differences in partitioning

Phenolic Acids in Jerusalem Artichoke (Helianthus tuberosus L.): Plant Organ Dependent Antioxidant Activity and Optimized Extraction from Leaves.

Muhammad Mir Showkat et al.

Molecules (Basel, Switzerland), 24(18) (2019-09-13)

Phenolic acids including chlorogenic acids are major polyphenolic compounds found in Jerusalem artichoke (Helianthus tuberosus L.). The plant itself is an emerging biorefinery crop due to the inulin-rich tubers, a bioethanol feedstock, but the aerial parts represent a rich source

Engineering E. coli for caffeic acid biosynthesis from renewable sugars.

Haoran Zhang et al.

Applied microbiology and biotechnology, 97(8), 3333-3341 (2012-11-28)

Caffeic acid is a valuable aromatic compound that possesses many important pharmacological activities. In structure, caffeic acid belongs to the hydroxycinnamic acid family and can be biosynthesized from the aromatic amino acid tyrosine. In the present paper, the caffeic acid

Polymethacrylate monolithic columns for hydrophilic interaction liquid chromatography prepared using a secondary surface polymerization.

Sinéad Currivan et al.

Journal of chromatography. A, 1402, 82-93 (2015-05-30)

Zwitterionic methacrylate based polymeric monolithic columns were prepared in two-step polymerizations, with reduced polymerization times. Characteristic properties such as hydrodynamic permeability, porosity, retention factors, and pore size distribution charts were used for column evaluation. A scaffold column was fabricated by

Hepatoprotective constituents from the roots and stems of Erycibe hainanesis.

Shuang Song et al.

Journal of natural products, 73(2), 177-184 (2010-01-23)

Eleven new diglycosides, erycibosides A-K (1-11), four new chlorogenic acid derivatives (14-17), and a new bis-coumarin (18), together with 21 known compounds, have been isolated from an EtOH extract of the roots and stems of Erycibe hainanesis. Their structures were

In vitro and in vivo antimutagenic effects of DIG, a herbal preparation of Berberis vulgaris, Taraxacum officinale and Arctium lappa, against mitomycin C.

C Di Giorgio et al.

Journal of natural medicines, 69(3), 267-277 (2015-02-11)

DIG, a liquid herbal preparation made from a mixture of diluted mother tinctures of Berberis vulgaris, Taraxacum officinale and Arctium lappa, was assessed for its antimutagenic properties against mitomycin C. The micronucleus assay on Chinese hamster ovary (CHO)-K1 cells was

Inhibition of Shiga toxin 2 (Stx2) in apple juices and its resistance to pasteurization.

Reuven Rasooly et al.

Journal of food science, 75(5), M296-M301 (2010-07-16)

In the present study, we evaluated Shiga toxin (Stx2) activity in apple juices by measuring a decrease in dehydrogenase activity of Vero cells with the microculture tetrazolium (MTT) assay. Freshly prepared juice from Red Delicious apples and Golden Delicious apples

Antioxidant stilbenoid and flavanonol from stem of Erythrophleum suaveolens (Guill. & Perr.).

Joseph Ngoupayo et al.

Magnetic resonance in chemistry : MRC, 53(8), 612-615 (2015-05-29)

Urea and carbamate derivatives of primaquine: synthesis, cytostatic and antioxidant activities.

M Simunović et al.

Bioorganic & medicinal chemistry, 17(15), 5605-5613 (2009-07-08)

The novel urea primaquine derivatives 3 were prepared by aminolysis of primaquine benzotriazolide 2 with several hydroxyamines and ethylendiamine, while carbamates 4 were synthesized from the same precursor 2 and alcohols. All compounds are fully chemically characterized and evaluated for

DJ-1 plays an important role in caffeic acid-mediated protection of the gastrointestinal mucosa against ketoprofen-induced oxidative damage.

Yu-Ting Cheng et al.

The Journal of nutritional biochemistry, 25(10), 1045-1057 (2014-07-20)

Ketoprofen is widely used to alleviate pain and inflammation in clinical medicine; however, this drug may cause oxidative stress and lead to gastrointestinal (GI) ulcers. We previously reported that nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role

Kinetic study of Sasa veitchii extract as a radical scavenger and an antioxidant.

Youji Okada et al.

Journal of food science, 77(11), C1211-C1217 (2012-10-13)

We examined the free radical scavenging activity of Sasa veitchii extract (Hoshi's Striped Bamboo Extract(®), HSBE), well known in folk medicine as an efficient drug and antioxidant in detail. To evaluate the free radical scavenging activity of HSBE, its reactivity

First characterisation of flavonoid- and diarylheptanoid-type antioxidant phenolics in Corylus maxima by HPLC-DAD-ESI-MS.

Eszter Riethmüller et al.

Journal of pharmaceutical and biomedical analysis, 107, 159-167 (2015-01-17)

Corylus maxima Mill. (Betulaceae) leaves have been used in traditional medicine both internally and externally, nevertheless phytochemical exploration of the plant remains incomplete. In this study, the in vitro antioxidant activity and polyphenolic composition of the ethyl acetate and methanolic

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