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Kei Kato et al.
Electrophoresis, 34(8), 1212-1218 (2013-02-13)
The zeta potential of nanoliposomes with a diameter below 100 nm has been studied by the combined use of on-chip microcapillary electrophoresis (μCE) and sensitive fluorescence imaging. Tracking the electrophoretic migration of individual nanoliposomes has enabled the accurate evaluation of
Kyall Pocock et al.
Biomaterials science, 7(6), 2410-2420 (2019-03-29)
Micro and nano-particulate carriers have potential to increase bioavailability of oral drugs, but must first overcome the mucus barrier of the intestinal epithelium to facilitate absorption and entry to systemic circulation. We report on mucus-silica nanoparticulate carrier interactions in an
P Busse et al.
Bone & joint research, 8(2), 41-48 (2019-03-28)
Intra-articular injections of local anaesthetics (LA), glucocorticoids (GC), or hyaluronic acid (HA) are used to treat osteoarthritis (OA). Contrast agents (CA) are needed to prove successful intra-articular injection or aspiration, or to visualize articular structures dynamically during fluoroscopy. Tranexamic acid
Loek D Loozen et al.
Tissue engineering. Part A, 24(19-20), 1423-1431 (2018-05-17)
Ex vivo nonviral gene delivery of bone inductive factors has the potential to heal bone defects. Due to their inherent role in new bone formation, multipotent stromal cells (MSCs) have been studied as the primary target cell for gene delivery
Miriam Wiesner et al.
Journal of cellular physiology, 233(4), 3315-3329 (2017-09-10)
Adipose-derived stromal/stem cells (ASCs) represent a widely used cell source with multi-lineage differentiation capacity in approaches for tissue engineering and regenerative medicine. Despite the multitude of literature on their differentiation capacity, little is reported about the physiological properties contributing to
Marissa K Srour et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(2), 297-308 (2014-08-22)
The clinical need for methods to repair and regenerate large cartilage and bone lesions persists. One way to make new headway is to study skeletal regeneration when it occurs naturally. Cartilage repair is typically slow and incomplete. However, an exception
Salvatore Antonucci et al.
Antioxidants & redox signaling, 34(7), 531-550 (2020-06-12)
Aims: Doxorubicin cardiomyopathy is a lethal pathology characterized by oxidative stress, mitochondrial dysfunction, and contractile impairment, leading to cell death. Although extensive research has been done to understand the pathophysiology of doxorubicin cardiomyopathy, no effective treatments are available. We investigated
Astrid Liedert et al.
International journal of molecular sciences, 21(21) (2020-11-11)
In the adult skeleton, bone remodeling is required to replace damaged bone and functionally adapt bone mass and structure according to the mechanical requirements. It is regulated by multiple endocrine and paracrine factors, including hormones and growth factors, which interact
Weiwei Dai et al.
Clinical orthopaedics and related research, 473(8), 2495-2504 (2015-03-31)
One of the strongest predictors for osteoporosis is peak bone mass. Interventions to augment peak bone mass have yet to be developed. β-Ecdysone (βEcd), a natural steroid-like compound produced by arthropods to initiate metamorphosis, is believed to have androgenic effects
Kai Zhou et al.
ACS nano, 13(8), 9595-9606 (2019-08-06)
Hydroxyapatite (HA), the traditional bone tissue replacement material was widely used in the clinical treatment of bone defects because of its excellent biocompatibility. However, the processing difficulty and poor osteoinductive ability greatly limit the application of HA. Although many strategies
Stanislav R Kurpe et al.
International journal of molecular sciences, 21(17) (2020-09-06)
Controlling the aggregation of vital bacterial proteins could be one of the new research directions and form the basis for the search and development of antibacterial drugs with targeted action. Such approach may be considered as an alternative one to
Xi Zhao et al.
Analytical chemistry, 87(6), 3208-3215 (2015-02-12)
The toxicity of artificial nanoparticles is a major concern in industrial applications. Cellular uptake of hard nanoparticles could follow either endocytic or nonendocytic pathways, leading to different stimuli to the cells. Yet the cellular responses to nanoparticles following different pathways
Mitsuhiro Yomoda et al.
Journal of biomaterials applications, 29(10), 1385-1393 (2015-01-01)
Previous studies have reported the excellent biocompatibility of calcium phosphate cement. However, calcium phosphate cement needs further improvement in order for it to promote bone replacement and eventual bone substitution, as it exhibits slow biodegradability and thus remains in the
Loryn Holokai et al.
PLoS pathogens, 15(1), e1007468-e1007468 (2019-02-01)
Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response to infection that is fundamental to the initiation of H.
Morten Nørgaard Andersen et al.
Cancer immunology, immunotherapy : CII, 68(3), 489-502 (2019-01-15)
Tumor-associated macrophages (TAMs) are of major importance in cancer-related immune suppression, and tumor infiltration by CD163pos TAMs is associated with poor outcome in most human cancers. Therefore, therapeutic strategies for reprogramming TAMs from a tumor-supporting (M2-like) phenotype towards a tumoricidal
Min Gon Kim et al.
Scientific reports, 7(1), 14092-14092 (2017-10-28)
Single-cell analysis is essential to understand the physical and functional characteristics of cells. The basic knowledge of these characteristics is important to elucidate the unique features of various cells and causative factors of diseases and determine the most effective treatments
Alexis J Torres et al.
Analytical chemistry, 86(23), 11562-11569 (2014-10-28)
Arrays of subnanoliter wells (nanowells) provide a useful system to isolate single cells and analyze their secreted proteins. Two general approaches have emerged: one that uses open arrays and local capture of secreted proteins, and a second (called microengraving) that
Abhishek Chandra et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 32(2), 360-372 (2016-10-21)
Focal radiotherapy is frequently associated with skeletal damage within the radiation field. Our previous in vitro study showed that activation of Wnt/β-catenin pathway can overcome radiation-induced DNA damage and apoptosis of osteoblastic cells. Neutralization of circulating sclerostin with a monoclonal
Jianquan Chen et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(2), 369-378 (2014-09-10)
Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase controlling many physiological processes in mammals. mTOR functions in two distinct protein complexes, namely mTORC1 and mTORC2. Compared to mTORC1, the specific roles of mTORC2 are less well understood.
Shuai Shi et al.
Physical chemistry chemical physics : PCCP, 23(2), 1475-1488 (2021-01-06)
A promising alternative to classical antibiotics are antimicrobial peptides and their synthetic mimics (smAMPs) that supposedly act directly on membranes. For a more successful design of smAMPs, we need to know how the type of interaction with the membrane determines
Rianne Bartelds et al.
PloS one, 13(4), e0194179-e0194179 (2018-04-13)
Niosomes are used in studies for drug delivery or gene transfer. However, their physical properties and features relative to liposomes are not well documented. To characterize and more rationally optimize niosome formulations, the properties of these vesicle systems are compared
Geoffroy Noël et al.
The Journal of comparative neurology, 528(3), 407-418 (2019-08-28)
The basement membrane that seperates the endothelial cells and astrocytic endfeet that comprise the blood-brain barrier is rich in collagen, laminin, agrin, and perlecan. Previous studies have demonstrated that the proper recruitment of the water-permeable channel aquaporin-4 (AQP4) to astrocytic
Alzbeta Tuerkova et al.
eLife, 9 (2020-03-14)
Every cell is protected by a semipermeable membrane. Peptides with the right properties, for example Antimicrobial peptides (AMPs), can disrupt this protective barrier by formation of leaky pores. Unfortunately, matching peptide properties with their ability to selectively form pores in
Parvin Zamani et al.
Journal of controlled release : official journal of the Controlled Release Society, 303, 223-236 (2019-04-19)
Liposomal peptide-based vaccines can potentially suppress cancer cells proliferation in the host. To enhance the effectiveness of vaccination against cancer, additional strategies should also be employed. One strategy to promote peptide-based vaccine efficacy and induce powerful immune responses, is simultaneous
Byungji Kim et al.
Nature communications, 9(1), 1969-1969 (2018-05-19)
The incidence of adverse effects and pathogen resistance encountered with small molecule antibiotics is increasing. As such, there is mounting focus on immunogene therapy to augment the immune system's response to infection and accelerate healing. A major obstacle to in
Bin Jia et al.
PloS one, 12(9), e0183738-e0183738 (2017-09-15)
The efficacy of protein-conjugated pneumococcal polysaccharide vaccines has been well characterized for children. The level of protection conferred by unconjugated polysaccharide vaccines remains less clear, particularly for elderly individuals who have had prior antigenic experience through immunization with unconjugated polysaccharide
Woochul Chang et al.
Molecules and cells, 38(7), 643-650 (2015-06-13)
The use of conditioned medium from mesenchymal stem cells may be a feasible approach for regeneration of bone defects through secretion of various components of mesenchymal stem cells such as cytokines, chemokines, and growth factors. Mesenchymal stem cells secrete and
Accelerated bone formation by biphasic calcium phosphate with a novel sub-micron surface topography.
R Duan et al.
European cells & materials, 37, 60-73 (2019-01-29)
Osteoinductive calcium phosphate (CaP) bone grafts have equivalent performance to autografts in repairing critical-size bone defects. The osteoinductive potential of CaP is linked to the size of the surface topographical features. In the present study, two novel biphasic calcium phosphate
Susan C Fitzer et al.
Ecology and evolution, 5(21), 4875-4884 (2015-12-08)
Ocean acidification threatens organisms that produce calcium carbonate shells by potentially generating an under-saturated carbonate environment. Resultant reduced calcification and growth, and subsequent dissolution of exoskeletons, would raise concerns over the ability of the shell to provide protection for the
S P Singh et al.
Scientific reports, 5, 17814-17814 (2015-12-08)
Here, we demonstrate the flexibility of peptide-functionalized poly(ethylene glycol) (PEG) hydrogels for modeling tumor progression. The PEG hydrogels were formed using thiol-ene chemistry to incorporate a matrix metalloproteinase-degradable peptide crosslinker (KKCGGPQG↓IWGQGCKK) permissive to proteolytic remodeling and the adhesive CRGDS peptide
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