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Amanda Drilling et al.
International forum of allergy & rhinology, 4(12), 953-960 (2014-10-02)
Staphylococcus aureus infection is known to play a role in recalcitrant chronic rhinosinusitis (CRS). However, it is unknown if recurrent S. aureus infections are caused by the same strain or are due to independent acquisitions of different strains. Samples were
Bugwesa Z Katale et al.
BMC infectious diseases, 14, 616-616 (2014-11-19)
Non-tuberculous mycobacteria (NTM), which are ubiquitous micro-organisms occurring in humans, animals and the environment, sometimes receive public health and veterinary attention as opportunistic disease-causing agents. In Tanzania, there is limited information regarding the diversity of NTM species, particularly at the
Crystal Passmore et al.
Human vaccines & immunotherapeutics, 10(3), 615-622 (2013-12-12)
Respiratory Syncytial Virus (RSV) is a ubiquitous virus that infects almost all people by age two and is a major source of respiratory illness in infants, the elderly and others with compromised immune systems. Currently there is no available vaccine.
Jianbo Sun et al.
Journal of ethnopharmacology, 159, 296-300 (2014-07-06)
Dictamnus angustifolius (Rutaceae) has been used as an alternative for folk medicine, Dictamnus dasycarpus in the treatment of rheumatism, bleeding, itching, jaundice, chronic hepatitis, and skin diseases in Xinjiang Province of China. The aim of this study was to evaluate
Yuan Deng et al.
Tissue engineering. Part A, 20(13-14), 2019-2029 (2014-02-07)
Osteogenic induction with either growth factors or genetic modification has limitations due to the short half-life and cost of the former, or safety concerns regarding the latter. The objective of this study was to employ a microcapsulation technique to separate
Chengming Fei et al.
European journal of haematology, 93(6), 476-486 (2014-06-04)
The contribution of bone marrow mesenchymal stromal cells (BMMSCs) to the pathogenesis of myelodysplastic syndrome (MDS) has created controversies. In this study, we confirmed that BMMSCs from MDS patients showed prominent features of senescence, which were characterized by increased cell
Jiawen Si et al.
Stem cells international, 2015, 565732-565732 (2015-04-04)
Emerging evidence suggests amniotic epithelial cells (AECs) as a promising source of progenitor cells in regenerative medicine and bone tissue engineering. However, investigations comparing the regenerative properties of AECs with other sources of stem cells are particularly needed before the
Hsiu-Hsia Lin et al.
PloS one, 9(4), e94395-e94395 (2014-04-12)
Multiple myeloma (MM) is characterized by advanced osteolytic lesions resulting from the activation of osteoclasts (OCs) and inhibition of osteoblasts (OBs). OBs are derived from mesenchymal stem cells (MSCs) from the bone marrow (BM), however the pool and function of
Young-Sool Hah et al.
International journal of medical sciences, 11(11), 1116-1128 (2014-08-30)
We investigated the adipogenic activity of cultured human periosteal-derived cells and studied perioxisome proliferator-activated receptor (PPAR) ligand-mediated differentiation of cultured human periosteal-derived cells into osteoblasts. Periosteal-derived cells expressed adipogenic markers, including CCAAT/enhancer binding protein α (C/EBP- α), C/EBP-δ, aP2, leptin
Fei Zhou et al.
Molecular medicine reports, 11(3), 1639-1646 (2014-11-19)
Aromatase inhibitors (AIs) are widely used in the treatment of hormone‑dependent breast cancer and as a result, aromatase inhibitor‑associated bone loss (AIBL) has become a major concern amongst patients receiving AI treatment. Modified Shu‑Gan‑Liang‑Xue decoction (mSGLXD), a clinical prescription, has
Lígia Marquez Andrade et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(1), 40-47 (2014-05-13)
The aim of this study was to develop lipid nanoparticles to deliver genistein (GEN) to deeper skin layers. To do so, the impact of lipid dynamic behavior (nanoparticle flexibility) on stability, release and skin permeation studies was verified. GEN-loaded solid
E Torreggiani et al.
European cells & materials, 28, 137-151 (2014-09-23)
Despite the popularity of platelet-rich plasma (PRP) and platelet lysate (PL) in orthopaedic practice, the mechanism of action and the effectiveness of these therapeutic tools are still controversial. So far, the activity of PRP and PL has been associated with
Evgenia Karousou et al.
Molecules (Basel, Switzerland), 19(6), 7959-7980 (2014-06-14)
Glycosaminoglycans (GAGs) due to their hydrophilic character and high anionic charge densities play important roles in various (patho)physiological processes. The identification and quantification of GAGs in biological samples and tissues could be useful prognostic and diagnostic tools in pathological conditions.
Mijeong Jeon et al.
Archives of oral biology, 59(10), 1013-1023 (2014-06-25)
Stem cells from human exfoliated deciduous teeth (SHED) are a good source of dental tissue for regeneration therapy, and can be obtained using different primary culture methods. The aim of this study was to determine the differences in the in
Naoyuki Kawao et al.
American journal of physiology. Endocrinology and metabolism, 307(3), E278-E288 (2014-06-12)
Further development in research of bone regeneration is necessary to meet the clinical demand for bone reconstruction. Recently, we reported that plasminogen is crucial for bone repair through enhancement of vessel formation. However, the details of the role of tissue-type
José Gerardo Carneiro et al.
Basic & clinical pharmacology & toxicology, 115(4), 335-342 (2014-03-29)
Sulphated polysaccharides from marine algae are widely used in biotechnological and pharmaceutical areas. In this study, we evaluated the effects of sulphated polysaccharides from the green marine alga Caulerpa mexicana (Cm-SPs) in nociceptive and inflammatory models in rodents. Cm-SPs (10
Guo-Jyun Lai et al.
Carbohydrate polymers, 111, 288-297 (2014-07-20)
Nanofibrous membrane scaffolds of chitosan (CS), silk fibroin (SF) and CS/SF blend were prepared by electrospinning and studied for growth and osteogenic differentiation of human bone marrow mesenchymal stem cells (hMSCs). The morphology and physico-chemical properties of all membrane scaffolds
Ashley A Amini et al.
Advanced healthcare materials, 3(6), 897-905 (2013-12-20)
Lactoferrin is a bioactive globular protein with unique properties towards musculo-skeletal cells and anabolic to bone in vivo. Even though the potent anti-apoptotic and osteogenic activity of lactoferrin has been reported, the mechanism of action has not been fully elucidated.
Michel Kayomo Kaswa et al.
PloS one, 9(4), e94618-e94618 (2014-04-16)
Multidrug Resistant Tuberculosis (MDR-TB) is a serious threat which jeopardizes the worldwide efforts to control TB. The Democratic Republic of Congo (DRC) is one of 27 countries with a high burden of MDR-TB. Data on the magnitude, trends, and the
Layaly Obeid et al.
Journal of colloid and interface science, 432, 182-189 (2014-08-03)
Adsorption of cetylpyridinium chloride (CPC), a cationic surfactant, by magnetic alginate beads (MagAlgbeads) was investigated. The magnetic adsorbent (called magsorbent) was prepared by encapsulation of magnetic functionalized nanoparticles in an alginate gel. The influence on CPC adsorption of several parameters
Mengke Wang et al.
ACS applied materials & interfaces, 7(8), 4560-4572 (2015-02-12)
Human pluripotent stem cells (hPSCs) are a promising cell source with pluripotency and capacity to differentiate into all human somatic cell types. Designing simple and safe biomaterials with an innate ability to induce osteoblastic lineage from hPSCs is desirable to
Bing-jiao Zhao et al.
Fundamental & clinical pharmacology, 28(5), 583-592 (2013-10-12)
Periodontal ligament stem cells (PDLSCs) are considered as potential mesenchymal stem cell sources for future clinical applications in periodontal regeneration therapy. Simvastation, widely used for lowering serum cholesterol, is known to have a bone stimulatory effect. However, it is not
S Patntirapong et al.
Journal of clinical pharmacy and therapeutics, 39(4), 349-353 (2014-03-26)
Alendronate (ALN) is used for the treatment of post-menopausal osteoporosis. By reducing bone turnover, it increases bone mineral density. However, recent reports suggest an increased risk of atypical bone fractures after long-term ALN administration. Despite its well-known anti-osteoclastic activity, it
Natássia Albuquerque Ribeiro et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(7), 569-580 (2014-03-19)
Marine algae are abundant sources of sulfated polysaccharides with various biological activities. Consequently, their biomolecules are of great of commercial interest. In this study, we investigated the potential antinociceptive activity of a sulfated polysaccharide obtained from the green seaweed Caulerpa
Jangho Kim et al.
Biomaterials, 35(33), 9058-9067 (2014-08-16)
Stem cell-based therapy has been proposed as an enabling alternative not only for the treatment of diseases but also for the regeneration of tissues beyond complex surgical treatments or tissue transplantation. In this study, we approached a conceptual platform that
José M Prieto et al.
Clinical and vaccine immunology : CVI, 21(8), 1077-1085 (2014-05-30)
The enzyme-linked immunosorbent assay (ELISA) is the diagnostic test most commonly used in efforts to control paratuberculosis in domestic ruminants. However, commercial ELISAs have not been validated for detecting antibodies against Mycobacterium avium subsp. paratuberculosis in wild animals. In this
Takako Naganuma et al.
PloS one, 9(11), e112326-e112326 (2014-11-07)
Nacreous layers of pearl oyster are one of the major functional biominerals. By participating in organic compound-crystal interactions, they assemble into consecutive mineral lamellae-like photonic crystals. Their biomineralization mechanisms are controlled by macromolecules; however, they are largely unknown. Here, we
Sai Zhang et al.
Journal of biomaterials applications, 29(10), 1394-1406 (2015-01-17)
Nano/micro engineered polymeric materials offer expansive scope of biomimetic scaffolds for bone tissue engineering especially those involving electrospun biodegradable nanofibers incorporated with inorganic nanoparticles, thus mimicking the extracellular matrix of bone both structurally and chemically. For the first time, poly-3-hydroxybutyrate-co-3-hydroxyvalerate
Matthew Prideaux et al.
Calcified tissue international, 95(2), 183-193 (2014-06-12)
The central importance of osteocytes in regulating bone homeostasis is becoming increasingly apparent. However, the study of these cells has been restricted by the relative paucity of cell line models, especially those of human origin. Therefore, we investigated the extent
Minnah Thomas et al.
Materials science & engineering. C, Materials for biological applications, 45, 320-332 (2014-12-11)
Interfacial properties of biomaterials play an important role in governing their interaction with biological microenvironments. This work investigates the role of surface hydrophilicity of electrospun poly(lactide-co-glycolide) (PLGA) fibers in determining their biological response. For this, PLGA is blended with varying
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