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关键词:'C1926'
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Parid Sava et al.
Microcirculation (New York, N.Y. : 1994), 22(1), 54-67 (2014-09-13)
Neutrophil extravasation at post-capillary venules, consisting of EC, PC, and the shared ECM, increases following fibrotic remodeling in the lung, liver, and skin. The role of fibrotic pericyte-derived ECM in regulating EC activation and neutrophil recruitment remains unexplored. To elucidate
Dongju Zhu et al.
Diabetology & metabolic syndrome, 13(1), 89-89 (2021-08-28)
Diabetic nephropathy (DN) is a common complication of diabetes. Long non-coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2) is reported to exert a protective role in DN by a previous study. The working mechanism underlying the protective role of CASC2
Modulation of designer biomimetic matrices for optimized differentiated intestinal epithelial cultures.
Xi, et al.
Biomaterials, 282, 121380-121380 (2022)
Niki Prakoura et al.
The American journal of pathology, 183(5), 1474-1487 (2013-09-17)
Renal fibrosis is the common anatomical feature underlying the progression of chronic kidney disease, a leading cause of morbidity and mortality worldwide. In a previous study, we demonstrated that during development of renal fibrosis in a rat model of unilateral
Katarina Berankova et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 25(2), 136-142 (2013-09-14)
Bronchial asthma often starts in early childhood. Clinical manifestation of the disease is likely due to inflammatory processes in the airways initiated by various stimuli. Developed remodelling is regularly observed in the bronchial mucosa of adult asthmatics but we still
Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons
Bhatt RS, et al.
Genes & Development, 14(17), 2216-2228 (2000)
A crucial sequence for transglutaminase type 2 extracellular trafficking in renal tubular epithelial cells lies in its N-terminal beta-sandwich domain
Chou CY, et al.
Test, 286(31), 27825-27835 (2011)
Mojgan Houshmandi et al.
Caries research, 48(6), 534-548 (2014-07-06)
This study investigated the distribution patterns of glial networks disclosed by reactivity for glial fibrillary acidic protein (GFAP) and S100B in healthy and carious human teeth. The objective was to determine the assembly and collapse of glial networks in response
Ricardo Braganca de Vasconcellos Fontes et al.
PloS one, 10(10), e0139283-e0139283 (2015-10-02)
Several studies describing the ultrastructure and extracellular matrix (ECM) of intervertebral discs (IVDs) involve animal models and specimens obtained from symptomatic individuals during surgery for degenerative disease or scoliosis, which may not necessarily correlate to changes secondary to normal aging
Yumi Yamamoto et al.
Journal of neuropathology and experimental neurology, 72(5), 416-431 (2013-04-16)
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common form of familial brain arteriopathy, is associated with deposition of granular osmiophilic material (GOM). We used immunohistochemistry and immunogold electron microscopy (EM) to examine the distribution of
Outi Huttala et al.
International journal of molecular sciences, 21(5) (2020-03-12)
Drug treatments have been designed to inhibit tumor angiogenesis in hope of stopping tumor growth. However, not all tumor types respond to this type of treatment. A screening method which identifies angiogenesis inducing cancer types would help predict the efficacy
Xiang Zhou et al.
Nature neuroscience, 23(3), 337-350 (2020-03-01)
Tissue repair after spinal cord injury requires the mobilization of immune and glial cells to form a protective barrier that seals the wound and facilitates debris clearing, inflammatory containment and matrix compaction. This process involves corralling, wherein phagocytic immune cells
Aleksandra Kuzan et al.
Glycoconjugate journal, 35(1), 95-103 (2018-01-07)
The most abundant proteins in the arteries are those of extracellular matrix, ie. collagen and elastin. Due to their long half-lifes these proteins have an increased chance to undergo glycation. The aim of this study was to determine relationship between
The aromatase inhibitor anastrozole is associated with favorable embryo development and implantation markers in mice ovarian stimulation cycles
Karaer O, et al.
Fertility and Sterility, 83(6), 1797-1806 (2005)
Yoshiki Hase et al.
Brain pathology (Zurich, Switzerland), 28(6), 832-843 (2018-05-15)
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized by strategic white matter (WM) hyperintensities on MRI. Pathological features include WM degeneration, arteriolosclerosis, lacunar infarcts, and the deposition of granular osmiophilic material. Based on the hypothesis that
Siao-Syun Guan et al.
Scientific reports, 5, 14561-14561 (2015-10-10)
In this study, we investigated the role of ATP synthase subunit-β (ATP5b) in diabetic nephropathy. Histopathological changes, fibrosis, and protein expressions of α-smooth muscle actin (α-SMA), advanced glycation end-products (AGEs), and ATP5b were obviously observed in the kidneys of db/db
Outi Huttala et al.
Biomedicines, 10(2) (2022-02-26)
Vascularization plays an important role in the microenvironment of the tumor. Therefore, it should be a key element to be considered in the development of in vitro cancer assays. In this study, we decellularized in vitro capillaries to remove genetic
Kenichiro Kobayashi et al.
Hepatology communications, 2(3), 230-236 (2018-03-07)
Liver fibrosis is a common complication associated with transient myeloproliferative disorder (TMD) in Down syndrome (DS). The exact molecular pathogenesis that regulates disease progression is largely unknown. We recently found serum and/or urinary monocyte chemoattractant protein-1 (MCP-1) as a novel
Outi Huttala et al.
Basic & clinical pharmacology & toxicology, 123 Suppl 5, 62-71 (2018-02-15)
Many adipose tissue-related diseases, such as obesity and type 2 diabetes, are worldwide epidemics. For studying these diseases, relevant human cell models are needed. In this study, we developed a vascularized adipose tissue model where human adipose stromal cells and
Eeva-Mari Jouhilahti et al.
The American journal of pathology, 178(2), 500-505 (2011-02-02)
Cutaneous neurofibromas are the hallmarks of neurofibromatosis type 1 (NF1). They are composed of multiple cell types, and traditionally they are believed to arise from small nerve tributaries of the skin. A key finding in the context of this view
M M Neis et al.
Skin pharmacology and physiology, 23(1), 29-39 (2010-01-22)
Organotypic skin models are frequently used for a wide range of applications and latterly also for dermatotoxicological studies. To evaluate their practicability for the investigation of xenobiotic metabolism in human skin we compared three types of organotypic skin models, acquired
Ramin M Farahani et al.
The Journal of comparative neurology, 527(4), 780-796 (2018-11-25)
Consistent adult neurogenic activity in humans is observed in specific niches within the central nervous system. However, the notion of an adult neurogenic niche is challenged by accumulating evidence for ectopic neurogenic activity in other cerebral locations. Herein we interface
Ren Ding et al.
Brain pathology (Zurich, Switzerland), 30(6), 1087-1101 (2020-07-25)
White matter (WM) disease is associated with disruption of the gliovascular unit, which involves breach of the blood-brain barrier (BBB). We quantified pericytes as components of the gliovascular unit and assessed their status in vascular and other common dementias. Immunohistochemical
Structure and Function of Basement Membranes
LeBleu VS et al
Exp. Biol. Med, 232, 1121-1129 (2007)
Maurice Y Nahabedian et al.
Plastic and reconstructive surgery, 152(6), 1262-1272 (2023-03-30)
Microbial pathogens local to prosthetic breast devices may promote infection, inflammation, and capsular contracture. Although antimicrobial solutions have been used, their effects on human acellular dermal matrix (HADM) incorporation when used with prosthetic devices are unknown. The authors' objective was
Aleksandra Kuzan et al.
Folia histochemica et cytobiologica, 59(1), 8-21 (2021-02-10)
Extracellular matrix (ECM) proteins have been associated with atherosclerotic complications, such as plaque rupture, calcification and aneurysm. It is not clear what role different types of collagen play in the pathomechanism of atherosclerosis. The aim of the study was to
Both Specific Endothelial and Proximal Tubular Adam17 Deletion Protect against Diabetic Nephropathy.
Vanesa Palau et al.
International journal of molecular sciences, 22(11) (2021-06-03)
ADAM17 is a disintegrin and metalloproteinase capable of cleaving the ectodomains of a diverse variety of molecules including TNF-α, TGF-α, L-selectin, and ACE2. We have previously demonstrated that renal ADAM17 is upregulated in diabetic mice. The role of endothelial (eAdam17)
Ramin M Farahani et al.
The Journal of comparative neurology, 527(4), 780-796 (2018-11-25)
Consistent adult neurogenic activity in humans is observed in specific niches within the central nervous system. However, the notion of an adult neurogenic niche is challenged by accumulating evidence for ectopic neurogenic activity in other cerebral locations. Herein we interface
Katelyn V Batterman et al.
Frontiers in immunology, 12, 607691-607691 (2021-03-06)
Normal aging is characterized by declines in processing speed, learning, memory, and executive function even in the absence of neurodegenerative diseases such as Alzheimer's Disease (AD). In normal aging monkeys and humans, neuronal loss does not account for cognitive impairment.
Ren Ding et al.
Acta neuropathologica communications, 9(1), 130-130 (2021-08-04)
Cerebral pericytes are an integral component of the neurovascular unit, which governs the blood-brain barrier. There is paucity of knowledge on cortical pericytes across different dementias. We quantified cortical pericytes in capillaries in 124 post-mortem brains from subjects with post-stroke
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