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关键词:'C2040'
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L Allegra et al.
Arzneimittel-Forschung, 38(8), 1163-1166 (1988-08-01)
The results of 6 clinical trials involving a total of 174 patients are reported. Levodropropizine (S(-)-3-(4-phenyl-piperazin-1-yl)-propane-1,2-diol, DF 526) was compared in double-blind manner with placebo, morclofone and cloperastine. The antitussive activity and therapeutic efficacy of the drug were shown to
P Aliprandi et al.
Drugs under experimental and clinical research, 30(4), 133-141 (2004-11-24)
The medical and social impact of cough is substantial. Current antitussive agents at effective doses have adverse events such as drowsiness, nausea and constipation that limit their use. There is also recent evidence that standard antitussive agents, such as codeine
Antonia García et al.
Journal of pharmaceutical and biomedical analysis, 61, 230-236 (2012-01-10)
The classification of an impurity of a drug substance as genotoxic means that the "threshold of toxicological concern" (TTC) value of 1.5 μg/day intake, considered to be associated with an acceptable risk, should be the admissible limit in the raw
Gen Yamamoto et al.
Canadian journal of physiology and pharmacology, 87(11), 893-899 (2009-11-26)
We investigated the effects of the centrally acting antitussives dextromethorphan and cloperastine on urinary bladder dysfunction 24 h after cerebral infarction in rats using the cystometry technique. First, cystometrography was performed in conscious male Sprague-Dawley rats. Cerebral infarction was then
[Clinical study of a new antitussive: cloperastine].
D Olivieri et al.
Archivio Monaldi per la tisiologia e le malattie dell'apparato respiratorio, 38(5-6), 209-218 (1983-09-01)
Gen Yamamoto et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 131(4), 523-532 (2011-04-07)
Clinically, both overactive bladder (OAB) and dysuria are known to occur in patients with cerebral infarction (CI). A few anticholinergic drugs are used to treat OAB in such patients, although the effect is not satisfactory. On the other hand, little
Hao Li et al.
Journal of pharmaceutical and biomedical analysis, 51(3), 716-722 (2009-11-03)
A rapid and sensitive method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma has been developed and validated. After sample preparation by liquid-liquid extraction, the analytes and
Akira Takahara et al.
Journal of pharmacological sciences, 120(3), 165-175 (2012-10-11)
Cloperastine is an antitussive drug, which can be received as an over-the-counter cold medicine. The chemical structure of cloperastine is quite similar to that of the antihistamine drug diphenhydramine, which is reported to inhibit hERG K⁺ channels and clinically induce
Kazuaki Kawaura et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 130(5), 699-705 (2010-05-13)
We have previously found that antitussive drugs inhibit G protein-coupled inwardly rectifying potassium (GIRK) channel currents in brain neurons. Potassium efflux through GIRK channels causes membrane hyperpolarization, and thus plays an important role in the inhibitory regulation of neuronal excitability.
Nobuki Matsumoto et al.
Scientific reports, 11(1), 1492-1492 (2021-01-17)
Cancer therapy is often hampered by the disease's development of resistance to anticancer drugs. We previously showed that the autonomously upregulated product of fibroblast growth factor 13 gene (FGF13; also known as FGF homologous factor 2 (FHF2)) is responsible for
Cloperastine-based cough syrup and acute dystonic reactions.
Mercedes Serrano et al.
Developmental medicine and child neurology, 54(3), 287-287 (2012-02-14)
[Cloperastine fendizoate in the treatment of cough-producing diseases in pediatrics].
L Scotti et al.
Minerva pediatrica, 40(5), 283-286 (1988-05-01)
[The pharmacologic activity of 1(2-(p-chloro-alpha-phenylbenzyloxy)ethyl)piperidine (cloperastine)].
G Canti et al.
Bollettino chimico farmaceutico, 122(8), 384-392 (1983-08-01)
[Effect of cloperastine on muco-ciliary clearance].
D Olivieri et al.
Archivio Monaldi per la tisiologia e le malattie dell'apparato respiratorio, 38(5-6), 219-223 (1983-09-01)
Yukoh Sakata et al.
International journal of pharmaceutics, 335(1-2), 12-19 (2006-11-23)
Tablets containing both paracetamol (PM) and cloperastine hydrochloride (CLH) in a combination formulation prepared by standard vertical granulation technology were found to have altered pharmaceutical properties. The hardness and disintegration time of tablets containing both PM and CLH gradually increased
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