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Yasuyuki Arai et al.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 21(8), 564-569 (2015-06-01)
Presepsin, a soluble CD14 subtype, is increasingly recognized as a useful biomarker for sepsis. However, little is known about the biological characteristics of presepsin in humans. Furthermore, there are no studies evaluating clinical validity of measuring the presepsin levels in
Su-Jin Heo et al.
eLife, 5 (2016-12-03)
Mesenchymal stem cell (MSC) differentiation is mediated by soluble and physical cues. In this study, we investigated differentiation-induced transformations in MSC cellular and nuclear biophysical properties and queried their role in mechanosensation. Our data show that nuclei in differentiated bovine
Angelika Kunze et al.
PloS one, 10(5), e0125540-e0125540 (2015-05-12)
There is an urgent need for improved models for cardiotoxicity testing. Here we propose acoustic sensing applied to beating human cardiomyocyte clusters for non-invasive, surrogate measuring of the QT interval and other characteristics of the contractile machinery. In experiments with
Sriram Sundaravel et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(46), E6359-E6368 (2015-11-19)
Anemia is the predominant clinical manifestation of myelodysplastic syndromes (MDS). Loss or deletion of chromosome 7 is commonly seen in MDS and leads to a poor prognosis. However, the identity of functionally relevant, dysplasia-causing, genes on 7q remains unclear. Dedicator
Seishiro Hirano et al.
PloS one, 10(11), e0142062-e0142062 (2015-11-07)
The Macrophage Receptor with COllagenous structure (MARCO) protein is a plasma membrane receptor for un-opsonized or environmental particles on phagocytic cells. Here, we show that MARCO was internalized either by ruffling of plasma membrane followed by macropinocytosis or by endocytosis
Boguslaw S Wojczyk et al.
Transfusion, 54(12), 3186-3197 (2014-07-22)
In mice, refrigerator-stored red blood cells (RBCs) are cleared by extravascular hemolysis and induce cytokine production. To enhance understanding of this phenomenon, we sought to model it in vitro. Ingestion of refrigerator-stored murine RBCs and subsequent cytokine production were studied
Laure Béven et al.
PloS one, 7(10), e48606-e48606 (2012-11-03)
Spiroplasma citri is a plant pathogenic mollicute transmitted by the leafhopper vector Circulifer haematoceps. Successful transmission requires the spiroplasmas to cross the intestinal epithelium and salivary gland barriers through endocytosis mediated by receptor-ligand interactions. To characterize these interactions we studied
Jiajia Bi et al.
Oncology letters, 16(5), 6540-6546 (2018-11-09)
Lipid rafts, distinct liquid-ordered plasma membrane microdomains, have been shown to regulate tumor cell migration by internalizing and recycling cell-surface proteins. The present study reports that lipid rafts are a prerequisite for lamellipodia formation, which is the first step in
Ankita B Jaykumar et al.
Molecular cancer therapeutics, 20(10), 1800-1808 (2021-07-14)
Metastasis is the major cause of mortality in patients with breast cancer. Many signaling pathways have been linked to cancer invasiveness, but blockade of few protein components has succeeded in reducing metastasis. Thus, identification of proteins contributing to invasion that
Valentina Magliocca et al.
Oncotarget, 8(67), 111096-111109 (2018-01-18)
The development of the nervous system requires cytoskeleton-mediated processes coordinating self-renewal, migration, and differentiation of neurons. It is not surprising that many neurodevelopmental problems and neurodegenerative disorders are caused by deficiencies in cytoskeleton-related genes. For this reason, we focus on
Marco Antonio Escárcega-Tame et al.
PloS one, 10(12), e0144078-e0144078 (2015-12-03)
Dystroglycan has recently been characterised in blood tissue cells, as part of the dystrophin glycoprotein complex involved in the differentiation process of neutrophils. In the present study we have investigated the role of dystroglycan in the human promyelocytic leukemic cell
Youn-Kyoung Goo et al.
Experimental parasitology, 135(1), 42-49 (2013-06-26)
Host cell invasion by apicomplexan parasites driven by gliding motility and empowered by actin-based movement is essential for parasite survival and pathogenicity. The parasites share a conserved invasion process: actin-based motility led by the coordination of adhesin-cytoskeleton via aldolase. A
Jena Fediuk et al.
American journal of physiology. Lung cellular and molecular physiology, 307(11), L877-L887 (2014-10-05)
In hypoxic pulmonary arterial (PA) myocytes, challenge with thromboxane mimetic U46619 induces marked actin polymerization and contraction, phenotypic features of persistent pulmonary hypertension of the newborn (PPHN). Rho GTPases regulate the actin cytoskeleton. We previously reported that U46619-induced actin polymerization
Fushan Shi et al.
Journal of neuroimmunology, 260(1-2), 121-125 (2013-05-18)
Prion diseases are neurodegenerative disorders characterized by the accumulation of misfolded prion protein. In a previous study, we showed that neurotoxic prion peptide (PrP106-126) induced NALP3 inflammasome activation in mouse primary and immortalized microglia. In the present work, we examined
Comparative mechanisms of protein transduction mediated by cell-penetrating peptides in prokaryotes.
Betty Revon Liu et al.
The Journal of membrane biology, 248(2), 355-368 (2015-02-07)
Bacterial and archaeal cell envelopes are complex multilayered barriers that serve to protect these microorganisms from their extremely harsh and often hostile environments. Import of exogenous proteins and nanoparticles into cells is important for biotechnological applications in prokaryotes. In this
Pavla Plačková et al.
Journal of enzyme inhibition and medicinal chemistry, 30(1), 57-62 (2014-04-01)
6-Chloropurines substituted at the position 9 with variously modified bicyclic skeletons represent promising antiviral and anticancer agents. This work aimed to investigate the transport mechanisms of 9-[(1R*,2R*,4S*)-bicyclo[2.2.1]hept-2-yl]-6-chloro-9H-purine (9-norbornyl-6-chloropurine, NCP) and their relationship to the metabolism and biological activity of the
Nils Schallner et al.
The Journal of clinical investigation, 125(7), 2609-2625 (2015-05-27)
Subarachnoid hemorrhage (SAH) carries a 50% mortality rate. The extravasated erythrocytes that surround the brain contain heme, which, when released from damaged red blood cells, functions as a potent danger molecule that induces sterile tissue injury and organ dysfunction. Free
Esra Roan et al.
Biophysical journal, 109(10), 2051-2057 (2015-11-21)
Epithelial cell migration during wound repair involves a complex interplay of intracellular processes that enable motility while preserving contact among the cells. Recent evidence suggests that fluctuations of the intracellular biophysical state of cells generate traction forces at the basal
Christina B Wölwer et al.
PloS one, 10(11), e0142655-e0142655 (2015-11-17)
Erythroid enucleation is critical for terminal differentiation of red blood cells, and involves extrusion of the nucleus by orthochromatic erythroblasts to produce reticulocytes. Due to the difficulty of synchronizing erythroblasts, the molecular mechanisms underlying the enucleation process remain poorly understood.
Subhash B Arya et al.
The Journal of biological chemistry, 293(25), 9892-9909 (2018-04-06)
ADP-ribosylation factor-like GTPase 11 (ARL11) is a cancer-predisposing gene that has remained functionally uncharacterized to date. In this study, we report that ARL11 is endogenously expressed in mouse and human macrophages and regulates their activation in response to lipopolysaccharide (LPS)
Nathaniel J Hogrebe et al.
Nature biotechnology, 38(4), 460-470 (2020-02-26)
Generation of pancreatic β cells from human pluripotent stem cells (hPSCs) holds promise as a cell replacement therapy for diabetes. In this study, we establish a link between the state of the actin cytoskeleton and the expression of pancreatic transcription
N R Popova et al.
Molecules (Basel, Switzerland), 25(13) (2020-07-02)
Cerium oxide nanoparticles (nanoceria) are believed to be the most versatile nanozyme, showing great promise for biomedical applications. At the same time, the controlled intracellular delivery of nanoceria remains an unresolved problem. Here, we have demonstrated the radioprotective effect of
Simon Döhrmann et al.
Infection and immunity, 82(10), 4011-4020 (2014-07-16)
Streptococcal collagen-like protein 1 (Scl-1) is one of the most highly expressed proteins in the invasive M1T1 serotype group A Streptococcus (GAS), a globally disseminated clone associated with higher risk of severe invasive infections. Previous studies using recombinant Scl-1 protein
Qiaoya Lin et al.
Pharmaceutical research, 31(6), 1438-1449 (2013-04-30)
Molecular therapeutics often require an effective nanoparticle-based delivery strategy to transport them to cytosolic organelles to be functional. Recently, a cytosolic delivery strategy based on the scavenger receptor class B type I (SR-BI) mediated pathway has shown great potential for
W-J Sohn et al.
Journal of dental research, 93(1), 78-83 (2013-10-25)
In mouse tooth development, the roots of the first lower molar develop after crown formation to form 2 cylindrical roots by post-natal day 5. This study compared the morphogenesis and cellular events of the mesial-root-forming (MRF) and bifurcation-forming (BF) regions
ACE2-enriched extracellular vesicles enhance infectivity of live SARS-CoV-2 virus.
Sze Keong Tey et al.
Journal of extracellular vesicles, 11(5), e12231-e12231 (2022-05-19)
Yanzuo Chen et al.
International journal of nanomedicine, 10, 4043-4057 (2015-07-08)
The therapeutic effect of methotrexate (MTX)-conjugated Pluronic-based polymeric mixed micelles (F127/P105-MTX) on the folate receptor-overexpressing tumors treatment was investigated in this study. Due to its high structural similarity to folic acid and the high expression of folate receptor in most
Aaron R Navratil et al.
Infection and immunity, 82(8), 3299-3311 (2014-05-29)
Francisella tularensis induces the synthesis of prostaglandin E(2) (PGE(2)) by infected macrophages to alter host immune responses, thus providing a survival advantage to the bacterium. We previously demonstrated that PGE(2) synthesis by F. tularensis-infected macrophages requires cytosolic phospholipase A2 (cPLA(2))
Elena Fdez et al.
iScience, 25(6), 104476-104476 (2022-06-21)
Mutations in LRRK2 increase its kinase activity and cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab proteins which allows for their binding to RILPL1. The phospho-Rab/RILPL1 interaction causes deficits in ciliogenesis and interferes with the cohesion of duplicated centrosomes.
María José Olivares et al.
PloS one, 9(6), e99001-e99001 (2014-06-06)
The cortical actin network is dynamically rearranged during secretory processes. Nevertheless, it is unclear how de novo actin polymerization and the disruption of the preexisting actin network control transmitter release. Here we show that in bovine adrenal chromaffin cells, both
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