C277

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关键词:'C277'

显示 1-13 共 13 条结果关于 "C277" 范围论文

The combination of Cl-IB-MECA with paclitaxel: a new anti-metastatic therapeutic strategy for melanoma.

Ana S Soares et al.

Cancer chemotherapy and pharmacology, 74(4), 847-860 (2014-08-15)

Metastatic melanoma is considered one of the most aggressive malignant tumours, representing the deadliest form of skin cancer. Melanoma progression is associated with the abrogation of normal controls that limit cell proliferation, migration, and invasion, eventually leading to metastasis. Based

Cl-IB-MECA [2-Chloro-N6-(3-iodobenzyl) adenosine-5?-N-methylcarboxamide] Reduces Ischemia/Reperfusion Injury in Mice by Activating the A Adenosine Receptor

Ge ZD, et al.

Journal of Pharmacology and Experimental Therapeutics, 319(3), 1200-1210 (2006)

Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus.

T V Dunwiddie et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(2), 607-614 (1997-01-15)

The adenosine A3 receptor is expressed in brain, but the consequences of activation of this receptor on electrophysiological activity are unknown. We have characterized the actions of a selective adenosine A3 receptor agonist, 2-chloro-N6-(3-lodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA), and a selective A3 receptor

Adenosine A3 receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A3 antagonists.

Y Yao et al.

Biochemical and biophysical research communications, 232(2), 317-322 (1997-03-17)

The effects of novel, selective adenosine (ADO) A3 receptor antagonists of diverse structure on cells of the human HL-60 leukemia and U-937 lymphoma cell lines were examined. Both 3-ethyl 5-benzyl 2-methyl-6-phenyl-4-phenylethynyl-1,4-(+/-)-dihydropyridine-3, 5-dicarboxylate (MRS 1191, 0.5 microM) and 6-carboxy-methyl-5, 9-dihydro-9-methyl-2-phenyl-[1,2,4]-triazolo [5,1-a][2,7]naphthyridine

Activation of A1 and A2a adenosine receptors promotes neural progenitor cell proliferation.

Jie Lv et al.

Brain research, 1686, 65-71 (2018-02-25)

Neural progenitor cells (NPCs) play a key role not only in the maintenance of the adult central nervous system (CNS) but also in the ability to recover from injury and disease. In this study, we established a 96-well-based screening system

A Novel Antagonistic CD73 Antibody for Inhibition of the Immunosuppressive Adenosine Pathway.

Melanie Wurm et al.

Molecular cancer therapeutics, 20(11), 2250-2261 (2021-09-06)

Despite some impressive clinical results with immune checkpoint inhibitors, the majority of patients with cancer do not respond to these agents, in part due to immunosuppressive mechanisms in the tumor microenvironment. High levels of adenosine in tumors can suppress immune

A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia.

K Stambaugh et al.

The American journal of physiology, 273(1 Pt 2), H501-H505 (1997-07-01)

The possible cardioprotective roles of adenosine A1 and A3 receptors were investigated in a cardiac myocyte model of injury. The adenosine A3 receptor is a novel cardiac receptor capable of mediating potentially important cardioprotective functions. Prolonged hypoxia with glucose deprivation

Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy.

S Daniele et al.

Cell death & disease, 5, e1539-e1539 (2014-11-28)

Therapies that target the signal transduction and biological characteristics of cancer stem cells (CSCs) are innovative strategies that are used in combination with conventional chemotherapy and radiotherapy to effectively reduce the recurrence and significantly improve the treatment of glioblastoma multiforme

The A3 adenosine receptor agonist 2-Cl-IB-MECA facilitates epileptiform discharges in the CA3 area of immature rat hippocampal slices

Laudadio MA, et al.

Epilepsy Research, 59(2), 83-94 (2004)

Potentiation by metal ions of the efficacy of the ionophores, monensin and tetronasin, towards four species of ruminal bacteria.

C James Newbold et al.

FEMS microbiology letters, 338(2), 161-167 (2012-12-06)

Concentrations of Na(+), K(+) and Ca(2+) in the growth medium were varied within limits normally found in vivo to determine how cation concentrations affect the sensitivity of ruminal bacteria to the ionophores, monensin (a Na(+)/H(+) and K(+)/H(+) exchanger) and tetronasin

Structural analysis of human CCR2b and primate CCR2b by molecular modeling and molecular dynamics simulation.

Xiu-Fan Shi et al.

Journal of molecular modeling, 8(7), 217-222 (2002-08-23)

CCR2b, a chemokine receptor for MCP-1, -2, -3, -4, plays an important role in a variety of diseases involving infection, inflammation, and/or injury, as well as being a coreceptor for HIV-1 infection. Two models of human CCR2b (hCCR2b) were generated

Disease-causing mutations C277R and C277Y modify gating of human ClC-1 chloride channels in myotonia congenita.

Sebastian Weinberger et al.

The Journal of physiology, 590(15), 3449-3464 (2012-05-30)

Myotonia congenita is a genetic condition that is caused by mutations in the muscle chloride channel gene CLCN1 and characterized by delayed muscle relaxation and muscle stiffness. We here investigate the functional consequences of two novel disease-causing missense mutations, C277R

Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin reductase null yeast.

Christopher S Stoner et al.

Biochemistry, 48(38), 9156-9169 (2009-08-18)

Reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. To investigate the role of thioredoxin in controlling p53 activity, the level of reporter gene transactivation by p53 was determined in yeast

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