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[Current aspects of physiology and physiopathology of cyanocobalamin metabolism].
V Fica et al.
Fiziologia normala si patologica, 17(4), 301-312 (1971-07-01)
Sharmistha Sinha et al.
Journal of molecular biology, 426(12), 2328-2345 (2014-04-22)
Bacterial microcompartments (MCPs) are the simplest organelles known. They function to enhance metabolic pathways by confining several related enzymes inside an all-protein envelope called the shell. In this study, we investigated the factors that govern MCP assembly by performing scanning
L Masucci et al.
Ontario health technology assessment series, 13(24), 1-24 (2014-01-01)
Vitamin B12 deficiency can lead to adverse health effects such as anemia and, in some cases, permanent neurologic damage. In Canada, patients with vitamin B12 deficiency are typically given intramuscular injections, which incur considerable cost and inconvenience. The clinical evidence-based
Giuseppe Scalabrino et al.
Clinical chemistry and laboratory medicine, 51(3), 601-606 (2012-11-28)
The pathogenesis of cobalamin (Cbl)-deficient (Cbl-D) neuropathy and the role of normal prions (PrPcs) in myelin maintenance are both subjects of debate. We have demonstrated that Cbl deficiency damages myelin by increasing tumor necrosis factor (TNF)-α, and decreasing epidermal growth
Martin Bommer et al.
Science (New York, N.Y.), 346(6208), 455-458 (2014-10-04)
Organohalide-respiring microorganisms can use a variety of persistent pollutants, including trichloroethene (TCE), as terminal electron acceptors. The final two-electron transfer step in organohalide respiration is catalyzed by reductive dehalogenases. Here we report the x-ray crystal structure of PceA, an archetypal
Amrita Khaire et al.
Reproduction, fertility, and development, 27(2), 341-350 (2013-12-21)
Maternal vitamin B12 deficiency leads to an adverse pregnancy outcome and increases the risk for developing diabetes and metabolic syndrome in mothers in later life. Our earlier studies have demonstrated that vitamin B12 and n-3 polyunsaturated fatty acids (PUFA) are
Cyanocobalamin
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 16(1), 2178-2179 (2014)
Angelo Macri et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 253(3), 425-430 (2014-11-16)
Increased levels of oxidative stress have been seen in animal models of dry eye and in the conjunctival epithelial cells of patients with Sjögren's syndrome. The aims of this study were to compare the levels of oxidative stress in patients
Tomohiro Bito et al.
FEBS open bio, 4, 722-729 (2014-08-28)
In this study, we showed that cyanocobalamin dodecylamine, a ribose 5'-carbamate derivative of cyanocobalamin, was absorbed and accumulated to significant levels by Caenorhabditis elegans and was not further metabolized. The levels of methylmalonic acid and homocysteine, which serve as indicators
Jae Hoon Moon et al.
Stroke, 46(4), 1024-1030 (2015-03-05)
We investigated the association between cardiovascular risk factors, including carotid intima-media thickness (CIMT), and future risk of mild cognitive impairment (MCI) and dementia in elderly subjects. We conducted a population-based prospective study as a part of the Korean Longitudinal Study
Katsumi Shibata et al.
Bioscience, biotechnology, and biochemistry, 78(12), 2102-2109 (2014-08-15)
We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season. In this study, we investigated the levels of B-group vitamins in the
Nisha G Kemse et al.
PloS one, 9(11), e111902-e111902 (2014-11-19)
Our earlier studies have highlighted that an altered one carbon metabolism (vitamin B12, folic acid, and docosahexaenoic acid) is associated with preeclampsia. Preeclampsia is also known to be associated with oxidative stress and inflammation. The current study examines whether maternal
Brad Hine et al.
Journal of cellular biochemistry, 115(11), 1948-1954 (2014-06-11)
Intestinal uptake of vitamin B12 (hereafter B12) is impaired in a significant proportion of the human population. This impairment is due to inherited or acquired defects in the expression or function of proteins involved in the binding of diet-derived B12
Ontario health technology assessment series, 13(23), 1-45 (2014-01-01)
More than 2.9 million serum vitamin B12 tests were performed in 2010 in Ontario at a cost of $40 million. Vitamin B12 deficiency has been associated with a few neurocognitive disorders. To determine the clinical utility of B12 testing in
Ultra-high performance liquid chromatographic and mass spectrometric analysis of active vitamin B12 in cells of Propionibacterium and fermented cereal matrices.
Chamlagain B, Edelmann M, Kariluoto S, et al.
Inflammation and regeneration, 166, 630-638 (2014)
Jean-Louis Guéant et al.
Biochimie, 95(5), 1033-1040 (2013-02-19)
Vitamin B12 (cobalamin, cbl) is a cofactor of methionine synthase (MTR) in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAM), which is involved in epigenomic regulatory mechanisms. We have established a neuronal cell model with
Rony Dev et al.
Cancer, 120(10), 1586-1593 (2014-03-01)
A high frequency of hypogonadism has been reported in male patients with advanced cancer. The current study was performed to evaluate the association between low testosterone levels, symptom burden, and survival in male patients with cancer. Of 131 consecutive male
Shen-Chih Chang et al.
Nutrition and cancer, 67(2), 212-223 (2015-01-22)
Evidence is accumulating regarding a role of micronutrients in folate metabolism in cancer risk. We investigated the associations of plasma folate, vitamin B12, and homocysteine with upper gastrointestinal (GI) cancers in a population-based case-control study in Taixing City, China. With
Determination of cyanocobalamin, betamethasone, and diclofenac sodium in pharmaceutical formulations, by high performance liquid chromatography
Gonzalez L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 20(3), 487-492 (1999)
High-performance liquid chromatography method for the simultaneous determination of thiamine hydrochloride, pyridoxine hydrochloride and cyanocobalamin in pharmaceutical formulations using coulometric electrochemical and ultraviolet detection
Marszall LM, et al.
Journal of Chromatography A, 1094(1-2), 91-98 (2005)
Sereyvath Yoeun et al.
Journal of plant research, 128(1), 201-209 (2014-10-20)
Allene oxide synthase-1 from Oryza sativa (OsAOS1) localizes to the chloroplast, but lacks a putative chloroplast targeting sequence typically found in dicot AOS. Here, kinetic parameters and the oligomerization state/subunit composition of OsAOS1 were characterized in vitro in the absence
Ann-Chee Yap et al.
Sensors (Basel, Switzerland), 14(11), 21140-21150 (2014-11-13)
Homocysteine and methylmalonic acid are important biomarkers for diseases associated with an impaired central nervous system (CNS). A new chemoassay utilizing coumarin-based fluorescent probe 1 to detect the levels of homocysteine is successfully implemented using Parkinson's disease (PD) patients' blood
Ling-Wei Chen et al.
The Journal of nutrition, 145(1), 113-120 (2014-12-21)
Maternal folate, vitamin B-12, and vitamin B-6 concentrations during pregnancy have been shown to influence birth outcomes, but the evidence is inconclusive. We aimed to examine the associations of maternal B-vitamin status with gestational age, birth weight, and length in
Binuraj R K Menon et al.
The Journal of biological chemistry, 289(49), 34161-34174 (2014-09-13)
Cobalamin-dependent enzymes enhance the rate of C-Co bond cleavage by up to ∼10(12)-fold to generate cob(II)alamin and a transient adenosyl radical. In the case of the pyridoxal 5'-phosphate (PLP) and cobalamin-dependent enzymes lysine 5,6-aminomutase and ornithine 4,5 aminomutase (OAM), it
Little Flower Augustine et al.
Journal of the American College of Nutrition, 33(5), 354-362 (2014-10-11)
The link between stress-related increases in inflammatory markers, hepcidin, and iron status are poorly understood, especially in developing countries like India. The aim of the study was to examine the relationship between adolescent life-event stress (ALES), inflammatory markers, and its
Sarah Dobrozsi et al.
Pediatric blood & cancer, 61(4), 753-755 (2013-10-12)
Vitamin B12 deficiency is rare in children, with nonspecific symptoms including failure to thrive, vomiting, anorexia, and neurologic changes with or without hematologic disturbances. The neuropathy can be severe and irreversible. We report four cases of children with B12 deficiency
Emmanuel Andrès et al.
Drugs & aging, 25(11), 927-932 (2008-10-25)
The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment in elderly patients. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Prospective randomized studies (n=3), a
Penelope A E Main et al.
Autism research : official journal of the International Society for Autism Research, 8(1), 94-104 (2014-11-06)
Autism spectrum disorders are a set of neurodevelopmental disorders that are highly hereditable. Increased genomic instability has been observed in other heritable paediatric neurobiological disorders; therefore, the aim of our study was to test the hypothesis that DNA damage is
Ava Grace Tan et al.
Investigative ophthalmology & visual science, 56(1), 216-220 (2014-11-20)
We assessed associations between serum levels of homocysteine, vitamin B12, and folate, and the prevalence and 5-year incidence of posterior subcapsular cataract (PSC) in Blue Mountains Eye Study participants. We examined 3508 participants aged 49+ years during 1997 to 2000
Clinical analysis of late-onset methylmalonic acidaemia and homocystinuria, cblC type with a neuropsychiatric presentation.
Yan-ru Liu et al.
Journal of neurology, neurosurgery, and psychiatry, 86(4), 472-475 (2014-08-06)
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