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关键词:'C4129'
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Osvaldo E Sponton et al.
Food chemistry, 146, 577-582 (2013-11-02)
β-Lactoglobulin (BLG) is a member of lipocalin family, proteins with ability to bind small hydrophobic ligands, such as retinol, vitamins and fatty acids. Moreover, BLG is susceptible to protease action producing a wide range of polypeptides depending on the hydrolysis
Peng-Chao Guo et al.
Scientific reports, 5, 11863-11863 (2015-07-08)
Serpins generally serve as inhibitors that utilize a mobile reactive center loop (RCL) as bait to trap protease targets. Here, we present the crystal structure of serpin18 from Bombyx mori at 1.65 Å resolution, which has a very short and
Jyotica Batra et al.
The Journal of biological chemistry, 288(14), 9848-9859 (2013-02-23)
Human chymotrypsin C (CTRC) is a pancreatic serine protease that regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. In cleaving these regulatory sites, which are characterized by multiple flanking acidic residues
Saad Khan et al.
PloS one, 7(11), e50547-e50547 (2012-12-12)
In the present study, withaferin A (WA), a steroidal lactone with anti-inflammatory and anti-tumor properties, inhibited proteasome activity and induced endoplasmic reticulum (ER) and cytoplasmic HSP accumulation in Xenopus laevis A6 kidney epithelial cells. Proteasomal inhibition by WA was indicated
Llinos G Harris et al.
Applied and environmental microbiology, 79(4), 1393-1395 (2012-12-12)
Staphylococcus aureus and Staphylococcus epidermidis biofilms cause chronic infections due to their ability to form biofilms. The excretions/secretions of Lucilia sericata larvae (maggots) have effective activity for debridement and disruption of bacterial biofilms. In this paper, we demonstrate how chymotrypsin
Antonio Jesús Vizcaíno et al.
Marine drugs, 18(6) (2020-06-24)
This piece of research evaluates the presence of protease inhibitors in the macroalga Ulva ohnoi and provides an initial overview of their mode of action. The ability of Ulva protease inhibitors to inhibit digestive proteases of three marine fish species
Jae-Wan Jung et al.
Journal of biotechnology, 249, 42-50 (2017-04-02)
Lysosomal storage diseases are a group of inherited metabolic disorders. Patients are treated with enzyme replacement therapy (ERT), in which the replacement enzymes are required to carry terminal mannose or mannose 6-phosphate residues to allow efficient uptake into target cells
M V Kolodzeĭskaia et al.
Ukrainskii biokhimicheskii zhurnal (1978), 60(4), 103-117 (1988-07-01)
Recent data on the nature of trypsin-, chymotrypsin-like proteinases of fish are generalized. Localization and secretion of these enzymes in pyloric appendages of fish are considered in detail. Trypsin and chymotrypsin are in the state of proenzymes and transform into
Gang Huang et al.
Nature communications, 8(1), 935-935 (2017-10-19)
Biological nanopores are nanoscale sensors employed for high-throughput, low-cost, and long read-length DNA sequencing applications. The analysis and sequencing of proteins, however, is complicated by their folded structure and non-uniform charge. Here we show that an electro-osmotic flow through Fragaceatoxin
T J Caperna et al.
Domestic animal endocrinology, 45(3), 154-162 (2013-09-10)
Hepatic responses to proinflammatory signals are controlled by the activation of several transcription factors, including, nuclear factor-κ B (NF-κB). In this study, hepatocytes prepared from suckling pigs and maintained in serum-free monolayer culture were used to define a novel proinflammatory
Farrukh Mansoor et al.
Journal of Asian natural products research, 16(2), 210-215 (2013-11-26)
The bioassay-guided fractionation of Daphne retusa Hemsl. has led to the isolation of a new aryl tetrahydronaphthalene lignan derivative named as daphnretusic acid (1), along with six new source compounds such as 5,7-dihydroxyflavone (2), 7-hydroxyflavone (3), 6-methoxyflavone (4), (+) pinoresinol
Jennifer Ehren et al.
PloS one, 4(7), e6313-e6313 (2009-07-22)
Celiac sprue is a life-long disease characterized by an intestinal inflammatory response to dietary gluten. A gluten-free diet is an effective treatment for most patients, but accidental ingestion of gluten is common, leading to incomplete recovery or relapse. Food-grade proteases
Marcella Denaro et al.
Antioxidants (Basel, Switzerland), 10(2) (2021-01-28)
Recently, several studies have highlighted the role of Citrus flavanones in counteracting oxidative stress and inflammatory response in bowel diseases. The aim of study was to identify the most promising Citrus flavanones by a preliminary antioxidant and anti-inflammatory screening by
Blocking serine protease activity prevents semenogelin degradation leading to hyperviscous semen in humans.
Anamthathmakula, et al.
Biology of reproduction, 106, 879-887 (2023)
Adriana Patricia Corredor et al.
PloS one, 13(6), e0199397-e0199397 (2018-06-22)
The envelope glycoprotein 51 (gp51) is essential for bovine leukaemia virus (BLV) entry to bovine B-lymphocytes. Although the bovine adaptor protein 3 complex subunit delta-1 (boAP3D1) has been proposed as the potential receptor, the specific ligand-receptor interaction has not yet
Estela Maria Gonçalves et al.
Cytokine, 64(1), 343-350 (2013-06-12)
Cancer-cachexia causes severe weight loss, particularly from the wasting of skeletal muscle, which occurs due to increased protein catabolism and/or decreased protein synthesis. The muscle protein degradation observed in cancer patients is mediated by a specific cytokine, proteolysis-inducing factor (PIF)
S Yamashita et al.
The British journal of surgery, 100(9), 1220-1228 (2013-06-15)
Pancreatic fistula (PF) remains the most serious complication after digestive surgery. It is difficult to prevent because of the inability to visualize the leakage of pancreatic juice during surgery or to evaluate the protease activity of leaked fluid, which is
Amit Singh et al.
Pharmaceutics, 15(1) (2023-01-22)
Till date, different types of conventional drugs have been used to fight tumors. However, they have significant flaws, including their usage being constrained because of their low bioavailability, poor supply, and serious side effects. The modern combination therapy has been
Marine Tournois et al.
Journal of chromatography. A, 1614, 460720-460720 (2019-12-02)
The interest for a better understanding of ion-exchange mechanisms at the atomic level has strongly increased over the past decades. Indeed, molecular-level information about physico-chemical mechanisms could help optimizing chromatographic processes for protein purification, which are sub-optimized due to the
N Tomita et al.
Biochemical and biophysical research communications, 158(2), 569-575 (1989-01-31)
The cDNA clone encoding human prechymotrypsinogen was isolated from a human pancreas cDNA library and its nucleotide sequence was determined. The sequence consists of a 16 bp 5' non-coding region, a 789 bp amino acid coding region and a 60
Chen Zhang et al.
Biotechnology progress, 29(2), 493-504 (2013-01-16)
Delayed wound healing in many chronic wounds has been linked to the degradation of fibronectin (FN) by abnormally high protease levels. We sought to develop a proteolytically stable and functionally active form of FN. For this purpose, we conjugated 3.35
Qiang Jin et al.
Biosensors & bioelectronics, 83, 193-199 (2016-04-30)
A near-infrared fluorescent probe (DDAB) for highly selective and sensitive detection of carboxylesterase 2 (CE2) has been designed, synthesized, and systematically studied both in vitro and in vivo. Upon addition of CE2, the ester bond of DDAB could be rapidly
Li Li et al.
Molecular and cellular endocrinology, 500, 110627-110627 (2019-10-23)
Diabetes affects oocyte nuclear and cytoplasmic quality. In this study, we generated a type 1 diabetes (T1D) mouse model by STZ injection to study the effects of T1D on zona pellucida and genomic DNA methylation of oocytes and granulosa cells.
Pharmacogenetic perturbations in humans as a tool to generate mechanistic insight.
Jose C Florez
Diabetes, 62(9), 3019-3021 (2013-08-24)
The impact of food-grade carrageenans and consumer age on the in vitro proteolysis of whey proteins.
Shlomit David et al.
Food research international (Ottawa, Ont.), 130, 108964-108964 (2020-03-12)
The food additive carrageenan (E407) (CGN) is a family of sulphated galactans widely used in numerous processed foods, including dairy. There are various indications that CGN may hinder digestive proteolysis. This study sought to link CGN macromolecular characteristics to its
J Abrudan et al.
Insect molecular biology, 22(2), 211-232 (2013-02-13)
As important vectors of human disease, phlebotomine sand flies are of global significance to human health, transmitting several emerging and re-emerging infectious diseases. The most devastating of the sand fly transmitted infections are the leishmaniases, causing significant mortality and morbidity
J Robyn et al.
Beneficial microbes, 3(4), 299-308 (2012-12-14)
Thermotolerant Campylobacter spp., specifically Campylobacter jejuni and Campylobacter coli, are the most common bacterial causes of human gastroenteritis in developed countries. Consumption of improperly prepared poultry products and cross contamination are among the main causes of human campylobacteriosis. The aim
Fatma H Al-Awadhi et al.
Chembiochem : a European journal of chemical biology, 19(8), 815-825 (2018-02-07)
Three new 3-amino-6-hydroxy-2-piperidone (Ahp)-containing cyclic depsipeptides, named loggerpeptins A-C (1-3), along with molassamide (4), were discovered from a marine cyanobacterium, extending the structural diversity of this prevalent scaffold of cyanobacterial serine protease inhibitors. Molassamide, which contains a 2-amino-butenoic (Abu) unit
Kamaldeen A Muili et al.
The Journal of biological chemistry, 288(1), 570-580 (2012-11-14)
Biliary pancreatitis is the leading cause of acute pancreatitis in both children and adults. A proposed mechanism is the reflux of bile into the pancreatic duct. Bile acid exposure causes pancreatic acinar cell injury through a sustained rise in cytosolic
Zongyun Chen et al.
PloS one, 8(3), e57529-e57529 (2013-03-28)
Serine protease inhibitors act as modulators of serine proteases, playing important roles in protecting animal toxin peptides from degradation. However, all known serine protease inhibitors discovered thus far from animal venom belong to the Kunitz-type subfamily, and whether there are
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