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Inderbir Singh et al.
Expert opinion on drug delivery, 10(9), 1179-1191 (2013-04-18)
The objective of the study was to investigate the effect of iron oxide in the development of mucoadhesive tablets of cinnarizine using Eudragit RLPO polymer. A simplex lattice design was employed for optimizing the drug delivery system. Different concentrations of
Maha M Abdelrahman
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 113, 291-296 (2013-06-06)
Accurate, selective and sensitive spectrophotometric methods have been developed and validated for simultaneous determination of Cinnarizine and Domperidone, a binary mixture with overlapping spectra, without preliminary separation. These methods include area under the curve (AUC) and dual wavelength spectrophotometry. For
Cinnarizine in the treatment of peripheral vascular disease: mechanisms related to its clinical action
Emanuel MB and Will JA
Proceedings of the Royal Society of Medicine, 70(8), 7-12 (1977)
Jonathan W Astin et al.
Molecular cancer therapeutics, 13(10), 2450-2462 (2014-07-24)
The growth of new lymphatic vessels (lymphangiogenesis) in tumors is an integral step in the metastatic spread of tumor cells, first to the sentinel lymph nodes that surround the tumor and then elsewhere in the body. Currently, no selective agents
F Morad et al.
Pharmacological research, 35(3), 177-180 (1997-03-01)
The calcium channel blockers Diltiazem HCl (2 mg kg-1 day-1, IP) or Cinnarizine (8 mg kg-1 day-1, IP) were given for a period of 30 days to adult male and female albino rats. The effect of each calcium channel blocker
I Sundararajan et al.
The Journal of laryngology and otology, 125(6), 572-575 (2011-01-29)
We report a prospective, randomised study of 51 patients with benign paroxysmal positional vertigo treated with Epley's manoeuvre alone or Epley's manoeuvre plus labyrinthine sedative, at Sundaram Medical Foundation, Chennai, India. To compare the efficacy of Epley's manoeuvre versus Epley's
P Y Cezarino et al.
Climacteric : the journal of the International Menopause Society, 14(4), 492-496 (2011-03-24)
To evaluate the effectiveness and safety of cinnarizine in the treatment of menopausal symptoms. A total of 100 climacteric and symptomatic women participated in a double-blind, placebo-controlled study. They were divided into two groups of the same size: Gcin, intake
A Elimadi et al.
European journal of pharmacology, 348(1), 115-121 (1998-07-03)
We investigated the effects of cinnarizine and flunarizine on mitochondrial permeability transition, ATP synthesis, membrane potential and NAD(P)H oxidation. Both drugs were effective in inhibiting the mitochondrial permeability transition induced either by Ca2+ alone or in the presence of tert-butylhydroperoxide.
Hélio A G Teive et al.
Parkinsonism & related disorders, 10(4), 243-245 (2004-05-04)
Drug-Induced Parkinsonism (DIP) represents the second leading cause of Parkinsonism (PK) in several countries. Flunarizine and cinnarizine are some of the most common drugs that cause DIP. This paper reviews the first description of Flunarizine and Cinnarizine-Induced Parkinsonism (FCIP), as
Influence of drug load and physical form of cinnarizine in new SNEDDS dosing regimens: in vivo and in vitro evaluations
Siqueira SDVS, et al.
The AAPS Journal, 19(2), 587-594 (2017)
[Vertigo in elderly patients. Early therapy chronification].
MMW Fortschritte der Medizin, 153(46), 52-53 (2011-12-08)
Ales Hahn et al.
Clinical drug investigation, 31(6), 371-383 (2011-03-16)
Vertigo may arise from dysfunction in the peripheral and/or the central vestibular system. Simultaneous activity of a medication at both sites will serve to improve the efficacy of antivertigo treatment. The aim of this study was to compare the efficacy
Anne T Larsen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 339-350 (2012-11-28)
The in vivo performance of self-nanoemulsifying drug delivery systems (SNEDDSs) with different in vitro physicochemical properties were determined with the purpose of elucidating the parameters determining the in vivo performance of SNEDDSs. The in vitro characterisation included the use of
Amnon Gil et al.
Clinical neuropharmacology, 35(1), 37-39 (2011-12-06)
The objective of the study was to compare the efficacy of transdermal scopolamine and cinnarizine in the prevention of seasickness and their adverse reactions. Seventy-six naval crew members participated in a double-blind, randomized, crossover study. On 2 voyages, they were
Mohamed A Alhnan et al.
International journal of pharmaceutics, 416(1), 55-60 (2011-06-18)
Poorly water soluble basic drugs are very sensitive to pH changes and following dissolution in the acidic stomach environment tend to precipitate upon gastric emptying, which leads to compromised or erratic oral bioavailability. In this work, we show that the
Nathalie M Pinkerton et al.
Molecular pharmaceutics, 10(1), 319-328 (2012-12-25)
We present an in situ hydrophobic salt forming technique for the encapsulation of weakly hydrophobic, ionizable active pharmaceutical ingredients (API) into stable nanocarriers (NCs) formed via a rapid precipitation process. Traditionally, NC formation via rapid precipitation has been difficult with
Aggravation of Parkinson's disease by cinnarizine.
Masso JFM, et al.
Journal of Neurology, Neurosurgery, and Psychiatry, 50(6), 804-805 (1987)
Flunarizine-and cinnarizine-induced extrapyramidal reactions
Micheli F, et al.
Neurology, 37(5), 881-881 (1987)
Cinnarizine--a labyrinthine sedative.
G Towse
The Journal of laryngology and otology, 94(9), 1009-1015 (1980-09-01)
Shyam Vithlani et al.
Drug development and industrial pharmacy, 38(10), 1188-1194 (2011-12-27)
The main objectives of this study were to improve the aqueous solubility and to modify in vitro dissolution profile of hydrophobic drug using self-emulsifying drug delivery systems (SEDDS). SEDDS were formulated using Capmul PG-12, Cremophor RH 40 and Tween 20
Niraj S Trasi et al.
The journal of physical chemistry. B, 118(33), 9974-9982 (2014-07-31)
Amorphous forms of drugs are increasingly being used to deliver poorly water-soluble compounds. Therefore, understanding the magnitude and origin of differences in crystallization kinetics is highly important. The goal of this study was to better understand the factors that influence
[Drug-induced parkinsonism].
O S Levin et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(8), 76-81 (2012-10-26)
J R Daniel et al.
The Annals of pharmacotherapy, 29(1), 73-75 (1995-01-01)
Flunarizine and cinnarizine have been well documented to cause EPS. Other CCBs, on rare occasions, also have been reported to cause EPS. Theoretical explanations for these events include the inhibition of calcium influx into striatal cells and direct dopaminergic antagonistic
Tri-Hung Nguyen et al.
Journal of controlled release : official journal of the Controlled Release Society, 153(2), 180-186 (2011-04-19)
This study is the first to demonstrate the ability of nanostructured liquid crystal particles to sustain the absorption of a poorly water soluble drug after oral administration. Cubic (V(2)) liquid crystalline nanostructured particles (cubosomes) formed from phytantriol (PHY) were shown
M V Grigor'eva et al.
Bulletin of experimental biology and medicine, 153(5), 634-637 (2012-11-01)
In narcotized rats, verapamil and cinnarizine modified some heart rate variability (HRV) indices and heart rate (HR) indicating up-regulation of parasympathetic tone in contrast to nifedipine that elevated activity of sympathetic subdivision of ANS producing no influence on HR. In
[Evidence grade 1 a for the fixed combination of cinnarizine and dimenhydrinate].
MMW Fortschritte der Medizin, 155(1), 74-75 (2013-04-12)
Ahmad Abdul-Wahhab Shahba et al.
AAPS PharmSciTech, 13(3), 967-977 (2012-07-05)
Due to its extreme lipophilicity, the oral delivery of cinnarizine (CN) encounters several problems such as poor aqueous solubility and pH-dependent dissolution, which result in low and erratic bioavailability. The current study aims to design self-nanoemulsifying drug delivery systems (SNEDDS)
Yinjun Xie et al.
Journal of the American Chemical Society, 134(51), 20613-20616 (2012-12-14)
A novel, highly selective palladium-catalyzed vinylation reaction for the direct synthesis of allylic amines from styrenes and aminals has been established. The utility of this method was also demonstrated by the rapid synthesis of cinnarizine from aldehydes, amines, and simple
David Cadagan et al.
Anticancer research, 33(10), 4381-4387 (2013-10-15)
Modulating agents are used to circumvent drug resistance in the clinical setting. However achievable serum concentrations are often lower than those which are optimal in vitro. Combination of modulating agents with non-overlapping toxicities may overcome this obstacle. We have investigated
Arne-Wulf Scholtz et al.
Clinical drug investigation, 32(6), 387-399 (2012-04-18)
Vestibular neuritis (VN) is a strongly disabling disease of the peripheral vestibular system. Rapid and effective relief of symptoms is important to allow patients to promptly return to normal physical activity. The aim of this prospective, randomized, double-blind study was
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