CN
C5670
应用筛选条件
关键词:'C5670'
显示 1-30 共 2296 条结果 关于 "C5670" 范围 论文
Philippe Bourassa et al.
Molecular pharmacology, 86(2), 138-149 (2014-05-31)
In this study, we used a combination of traditional signaling investigation approaches, bioluminescence resonance energy transfer (BRET) biosensors, and the label-free approach surface plasmon resonance (SPR) spectroscopy to monitor the signaling cascades of the μ-opioid receptor (MOP). In human embryonic
Chellakkan S Blesson et al.
Endocrinology, 155(8), 3036-3046 (2014-05-07)
Type II diabetes originates from various genetic and environmental factors. Recent studies showed that an adverse uterine environment such as that caused by a gestational low-protein (LP) diet can cause insulin resistance in adult offspring. The mechanism of insulin resistance
Lorraine Frew et al.
PloS one, 9(8), e103434-e103434 (2014-08-05)
hCAP18/LL-37 is the sole human cathelicidin; a family of host defence peptides with key roles in innate host defence. hCAP18/LL-37 is expressed primarily by neutrophils and epithelial cells, but its production and function in the lower genital tract is largely
Neil T Pfister et al.
Genes & development, 29(12), 1298-1315 (2015-06-18)
Mutant p53 impacts the expression of numerous genes at the level of transcription to mediate oncogenesis. We identified vascular endothelial growth factor receptor 2 (VEGFR2), the primary functional VEGF receptor that mediates endothelial cell vascularization, as a mutant p53 transcriptional
Harry J Gould et al.
Oncotarget, 9(21), 15606-15615 (2018-04-13)
Sodium influx through voltage-gated sodium channels (VGSCs) coupled with balanced removal of sodium ions via Na+, K+-ATPase is a major determinant of cellular homeostasis and intracellular ionic concentration. Interestingly, many metastatic carcinomas express high levels of these channels. We hypothesized
Elizabeth Henry et al.
PLoS genetics, 11(4), e1005199-e1005199 (2015-04-29)
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an important enzyme in energy metabolism with diverse cellular regulatory roles in vertebrates, but few reports have investigated the importance of plant GAPDH isoforms outside of their role in glycolysis. While animals possess one GAPDH isoform
Lili Wu et al.
Acta biomaterialia, 27, 294-304 (2015-09-01)
Coculture of osteoblasts and osteoclasts is a subject of interest in the understanding of how magnesium (Mg)-based implants influence the bone metabolism and remodeling upon degradation. Human telomerase reverse transcriptase (hTERT) transduced mesenchymal stem cells (SCP-1) were first differentiated into
Stacey E Wahl et al.
Developmental biology, 405(1), 108-122 (2015-07-07)
Folate deficiency has been associated with numerous diseases and birth defects including orofacial defects. However, whether folate has a role in the face during early orofacial development has been unclear. The present study reveals that pharmacological and antisense oligonucleotide mediated
Linjie Huang et al.
International journal of molecular sciences, 15(7), 11817-11831 (2014-07-06)
mast cells play an important role in airway inflammation in asthma. The transient receptor potential melastatin-like 7 (TRPM7) channel is expressed in primary human lung mast cells and plays a critical role for cell survival. This study aimed to investigate
Rahul Misra et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 69, 326-336 (2015-02-11)
Liquid-crystalline folate nanoparticles are ordered in structure which offers several advantages like high encapsulation of drugs, controlled release rates, biocompatible in nature. Moreover, it facilitates the cellular uptake of nanodrugs without any extra step of folate ligand based targeting. The
Seiichi Ohta et al.
Journal of bioscience and bioengineering, 119(6), 718-723 (2014-12-10)
Carboxymethyl cellulose (CMC) is a plant-derived material that has high biocompatibility and water solubility. We developed a CMC nonwoven sheet as a hemostatic agent by carboxymethylating a continuous filament cellulose nonwoven sheet. The CMC nonwoven sheet was able to absorb
Barbara Lies et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(1), G98-106 (2014-05-17)
Nitric oxide (NO) is a major inhibitory neurotransmitter in the gastrointestinal (GI) tract. Its main effector, NO-sensitive guanylyl cyclase (NO-GC), is expressed in several GI cell types, including smooth muscle cells (SMC), interstitial cells of Cajal (ICC), and fibroblast-like cells.
David Charier et al.
ACS chemical neuroscience, 6(3), 393-397 (2015-01-15)
Intracranial hemorrhage, whether due to traumatic brain injury or ruptured cerebral aneurysm, is characterized by major neurological damage and a high mortality rate. Apart from cerebral vasospasm and mass effect, brain injury results from the release of unclotted blood that
Dhananjay M Nawandar et al.
PLoS pathogens, 11(10), e1005195-e1005195 (2015-10-03)
Epstein-Barr virus (EBV) is a human herpesvirus associated with B-cell and epithelial cell malignancies. EBV lytically infects normal differentiated oral epithelial cells, where it causes a tongue lesion known as oral hairy leukoplakia (OHL) in immunosuppressed patients. However, the cellular
M H Christensen et al.
Journal of developmental origins of health and disease, 6(3), 182-200 (2014-10-24)
Prenatal nicotine exposure (PNE) is a risk factor for developing an addiction to nicotine at a later stage in life. Understanding the neurobiological changes in reward related circuitry induced by exposure to nicotine prenatally is vital if we are to
Pascal Fossat et al.
The Journal of experimental biology, 218(Pt 17), 2745-2752 (2015-07-04)
In the animal kingdom, biogenic amines are widespread modulators of the nervous system that frequently interact to control mood. Our previous investigations in crayfish (Procambarus clarkii) have established that stress induces changes in brain serotonin (5-HT) concentrations that are responsible
Xia Lian et al.
Journal of neuroscience research, 93(6), 873-881 (2015-01-24)
Focal adhesion kinase (FAK) is one of the nonreceptor protein tyrosine kinases critical for the dynamic regulation of cell adhesion structures. Recent studies have demonstrated that FAK is also localized at excitatory glutamatergic synapses and is involved in long-term modification
Jessica R Ivy et al.
PloS one, 10(8), e0134620-e0134620 (2015-08-25)
Insect nephrocytes are highly endocytic scavenger cells that represent the only invertebrate model for the study of human kidney podocytes. Despite their importance, nephrocyte development is largely uncharacterised. This work tested whether the insect ortholog of mammalian Kidney Krüppel-Like Factor
Wiebke Kallenborn-Gerhardt et al.
Pain, 155(10), 2161-2170 (2014-08-21)
Emerging lines of evidence indicate that production of reactive oxygen species (ROS) at distinct sites of the nociceptive system contributes to the processing of neuropathic pain. However, the mechanisms underlying ROS production during neuropathic pain processing are not fully understood.
E Buraka et al.
Chemico-biological interactions, 220, 200-207 (2014-07-13)
The ability to intercalate between DNA strands determines the cytotoxic activity of numerous anticancer drugs. Strikingly, intercalating activity was also reported for some compounds considered to be antimutagenic. The aim of this study was to determine the mode of interaction
Eun Young Kim et al.
PloS one, 9(5), e97747-e97747 (2014-05-23)
Adipose tissue, mainly composed of adipocytes, plays an important role in metabolism by regulating energy homeostasis. Obesity is primarily caused by an abundance of adipose tissue. Therefore, specific targeting of adipose tissue is critical during the treatment of obesity, and
G S Newkirk et al.
PloS one, 10(9), e0137702-e0137702 (2015-09-10)
Amacrine cells were targeted for whole cell recording using two-photon fluorescence microscopy in a transgenic mouse line in which the promoter for dopamine receptor 2 drove expression of green fluorescent protein in a narrow field tristratified amacrine cell (TNAC) that
Meerim K Nurbaeva et al.
Scientific reports, 5, 15803-15803 (2015-10-31)
Dental enamel formation requires large quantities of Ca(2+) yet the mechanisms mediating Ca(2+) dynamics in enamel cells are unclear. Store-operated Ca(2+) entry (SOCE) channels are important Ca(2+) influx mechanisms in many cells. SOCE involves release of Ca(2+) from intracellular pools
Finosh Gnanaprakasam Thankam et al.
Journal of materials science. Materials in medicine, 25(8), 1953-1965 (2014-05-23)
Amphiphilic biosynthetic hydrogels comprising natural polysaccharide alginate (I) and synthetic polyester polypropylene fumarate (II) units were prepared by crosslinking the copolymer of I and II with calcium ion and vinyl monomers viz, 2-hydroxyethyl methacrylate (HEMA), methyl methacrylate (MMA), butyl methacrylate
Mei Huang et al.
Pharmacology, biochemistry, and behavior, 138, 49-57 (2015-09-19)
Blonanserin is a novel atypical antipsychotic drug (APD), which, unlike most atypical APDs, has a slightly higher affinity for dopamine (DA) D2 than serotonin (5-HT)2A receptors, and is an antagonist at both, as well as at D3 receptors. The effects
Anna Crisford et al.
PLoS neglected tropical diseases, 9(10), e0004062-e0004062 (2015-10-06)
The anthelmintic emodepside paralyses adult filarial worms, via a mode of action distinct from previous anthelmintics and has recently garnered interest as a new treatment for onchocerciasis. Whole organism data suggest its anthelmintic action is underpinned by a selective activation
Fang-Tian Xu et al.
American journal of translational research, 7(2), 257-270 (2015-04-23)
To investigate whether activated autologous platelet-rich plasma (PRP) can promote proliferation and osteogenic differentiation of human adipose-derived stem cells (hASCs) in vitro. hASCs were isolated from lipo-aspirates, and characterized by specific cell markers and multilineage differentiation capacity after culturing to
Sonya A MacParland et al.
Virology journal, 12, 93-93 (2015-06-19)
Hepatitis C virus (HCV) can replicate in cells of the immune system and productively propagate in primary T lymphocytes in vitro. We aimed to determine whether exposure to authentic, patient-derived HCV can modify the proliferation capacity, susceptibility to apoptosis and
Akhilesh Dubey et al.
PloS one, 10(5), e0127493-e0127493 (2015-05-27)
Metallic nanoparticles are widely used in cosmetics, food products and textile industry. These particles are known to cause respiratory toxicity and epithelial inflammation. They are eventually released to aquatic environment necessitating toxicity studies in cells from respiratory organs of aquatic
Youtian Hu et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(2), G149-G157 (2014-05-31)
Eosinophilic esophagitis (EoE) is characterized with eosinophils and mast cells predominated allergic inflammation in the esophagus and present with esophageal dysfunctions such as dysphagia, food impaction, and heartburn. However, the underlying mechanism of esophageal dysfunctions is unclear. This study aims
1/77