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关键词:'C5670'
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Simona Buracco et al.
Journal of cell science, 128(17), 3304-3316 (2015-07-26)
The Nramp (Slc11) protein family is widespread in bacteria and eukaryotes, and mediates transport of divalent metals across cellular membranes. The social amoeba Dictyostelium discoideum has two Nramp proteins. Nramp1, like its mammalian ortholog (SLC11A1), is recruited to phagosomal and
Yihao Zang et al.
iScience, 24(8), 102930-102930 (2021-08-20)
Cotton fiber is an excellent model for studying plant cell elongation and cell wall biogenesis as well because they are highly polarized and use conserved polarized diffuse growth mechanism. Fiber strength is an important trait among cotton fiber qualities due
Margaret R Taylor et al.
Plant & cell physiology, 56(7), 1355-1363 (2015-04-25)
The transport function of four rice (Oryza sativa) amino acid permeases (AAPs), OsAAP1 (Os07g04180), OsAAP3 (Os06g36180), OsAAP7 (Os05g34980) and OsAAP16 (Os12g08090), was analyzed by expression in Xenopus laevis oocytes and electrophysiology. OsAAP1, OsAAP7 and OsAAP16 functioned, similarly to Arabidopsis AAPs
P R V Satyaki et al.
PLoS genetics, 10(3), e1004240-e1004240 (2014-03-22)
Hybrid incompatibilities (HIs) cause reproductive isolation between species and thus contribute to speciation. Several HI genes encode adaptively evolving proteins that localize to or interact with heterochromatin, suggesting that HIs may result from co-evolution with rapidly evolving heterochromatic DNA. Little
Alejandro Peinado et al.
PloS one, 10(6), e0131259-e0131259 (2015-06-23)
Detecting neurodevelopμental disorders of cognition at the earliest possible stages could assist in understanding them mechanistically and ultimately in treating them. Finding early physiological predictors that could be visualized with functional neuroimaging would represent an important advance in this regard.
Takahiro Akamine et al.
The Journal of pharmacology and experimental therapeutics, 354(1), 65-72 (2015-05-13)
Patients with diabetes often develop peripheral nerve complications, including numbness and pain in the extremities. Diabetes-induced peripheral neuropathic pain is characterized by hypersensitivity to innocuous stimuli, known as tactile allodynia. Pregabalin (PGN) is currently used to treat diabetes-induced peripheral neuropathy
Marta Maycas et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(7), 1231-1244 (2014-12-23)
Osteocytes have a major role in the control of bone remodeling. Mechanical stimulation decreases osteocyte apoptosis and promotes bone accrual, whereas skeletal unloading is deleterious in both respects. PTH1R ablation or overexpression in osteocytes in mice produces trabecular bone loss
Mette D Mosgaard et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 493-500 (2015-07-15)
To develop a high-throughput in vitro intestinal lipolysis (HTP) model, without any means of pH-stat-titration, to enable a fast evaluation of lipid-based drug delivery systems (LbDDS). The HTP model was compared to the traditionally used dynamic in vitro lipolysis (DIVL)
S K Sahoo et al.
Acta poloniae pharmaceutica, 70(1), 123-127 (2013-04-25)
5-Fluorouracil loaded calcium-zinc-gellan and calcium-zinc-gellan-ethyl cellulose microbeads were successfully prepared by simple ionotropic gelation and oil in water ionotropic gelation technique, respectively. Prepared microbeads were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and evaluated for particle size, drug
Maria Favia et al.
American journal of physiology. Lung cellular and molecular physiology, 307(1), L48-L61 (2014-05-13)
Cystic fibrosis transmembrane conductance regulator (CFTR) carrying the F508del mutation is retained in endoplasmic reticulum and fails to traffic to the cell surface where it functions as a protein kinase A (PKA)-activated chloride channel. Pharmacological correctors that rescue the trafficking
Arjun Kumar et al.
The journal of pain : official journal of the American Pain Society, 16(11), 1200-1210 (2015-09-08)
Interactions between exogenous and endogenous opioids are not commonly investigated as a basis for sexually dimorphic opioid analgesia. We investigated the influence of spinal endomorphin 2 (EM2), an endogenous mu-opioid receptor (MOR) ligand, on the spinal antinociception produced by intrathecally
Holly Wilkinson et al.
PeerJ, 3, e987-e987 (2015-06-10)
Altering speed and moving on a gradient can affect an animal's posture and gait, which in turn can change the energetic requirements of terrestrial locomotion. Here, the energetic and kinematic effects of locomoting on an incline were investigated in the
Yusuke Kitazawa et al.
Histochemistry and cell biology, 144(3), 195-208 (2015-05-16)
Immune responses are generally accompanied by antigen presentation and proliferation and differentiation of antigen-specific lymphocytes (immunoproliferation), but analysis of these events in situ on tissue sections is very difficult. We have developed a new method of simultaneous multicolor immunofluorescence staining
Christoph B Messner et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(28), 7403-7407 (2017-06-28)
The evolutionary origins of metabolism, in particular the emergence of the sugar phosphates that constitute glycolysis, the pentose phosphate pathway, and the RNA and DNA backbone, are largely unknown. In cells, a major source of glucose and the large sugar
Alexandrea Macpherson et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(7), 557-568 (2014-03-13)
The alpha 7 nicotinic receptor (α7nAChR) is expressed by oral keratinocytes. α7nAChR activation mediates anti-inflammatory responses. The objective of this study was to determine if α7nAChR activation inhibited pathogen-induced interleukin-8 (IL-8) expression by oral keratinocytes. Periodontal tissue expression of α7nAChR
Arnaud Day et al.
Proteomics, 13(5), 812-825 (2013-01-03)
Sequential salt (CaCl2 , LiCl) extractions were used to obtain fractions enriched in cell wall proteins (CWPs) from the stem of 60-day-old flax (Linum usitatissimum) plants. High-resolution FT-ICR MS analysis and the use of recently published genomic data allowed the
S Y Oh et al.
Cell death & disease, 6, e1750-e1750 (2015-05-08)
Arachidonic acid (AA) is largely released during injury, but it has not been fully studied yet how AA modulates wound repair with stem cells. Therefore, we investigated skin wound-healing effect of AA-stimulated human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs)
Y Marin-Felix et al.
Mycoses, 58(8), 451-460 (2015-06-23)
Two interesting fungi were isolated from fluvial sediments collected in the North of Spain. They were morphologically related to the thermally dimorphic fungi of the family Ajellomycetaceae, but the analysis of the internal transcribed spacer region of the rDNA, and
Marc C Ford et al.
Nature communications, 6, 8073-8073 (2015-08-26)
Action potential timing is fundamental to information processing; however, its determinants are not fully understood. Here we report unexpected structural specializations in the Ranvier nodes and internodes of auditory brainstem axons involved in sound localization. Myelination properties deviated significantly from
Marta Kandziora-Ciupa et al.
Environmental science and pollution research international, 20(7), 4920-4932 (2013-01-16)
The purpose of this study was to explore a possible relationship between the availability of metals in soil (Cd, Fe, Mn, Pb and Zn) and their concentrations in leaves of Vaccinium myrtillus L. as a species which has been reported
Arbace Officioso et al.
Toxins, 7(8), 3359-3371 (2015-08-26)
The cholesterol synthesis inhibitor Triparanol has been shown to trigger apoptosis in several malignancies. Similar to the apoptosis of nucleated cells, erythrocytes may enter eryptosis, the suicidal death characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to
Shefeeq M Theparambil et al.
Glia, 63(9), 1581-1594 (2015-03-31)
Cytosolic H(+) buffering plays a major role for shaping intracellular H(+) shifts and hence for the availability of H(+) for biochemical reactions and acid/base-coupled transport processes. H(+) buffering is one of the prime means to protect the cell from large
Michaela Stolz et al.
Pflugers Archiv : European journal of physiology, 467(10), 2121-2140 (2015-01-17)
The P2X7 receptor (P2X7R) is a ligand-gated ion channel that conducts Na(+), K(+), and Ca(2+) when activated by extracellular ATP. In various cell types, such as secretory epithelia, the P2X7R is co-expressed with Ca(2+)-dependent Cl(-) channels of the TMEM16/anoctamin family.
Yamhilette Licon et al.
Pflugers Archiv : European journal of physiology, 467(8), 1699-1709 (2014-09-11)
Voltage-gated, CaV2.3 calcium channels and neurokinin-1 (NK1) receptors are both present in nuclei of the central nervous system. When transiently coexpressed in human embryonic kidney (HEK) 293 cells, CaV2.3 is primarily inhibited during strong, agonist-dependent activation of NK1 receptors. NK1
Hideharu Hoshino et al.
Developmental biology, 402(2), 175-191 (2015-04-26)
The initial landmark of anterior-posterior (A-P) axis formation in mouse embryos is the distal visceral endoderm, DVE, which expresses a series of anterior genes at embryonic day 5.5 (E5.5). Subsequently, DVE cells move to the future anterior region, generating anterior
Stephanie A Rey et al.
Nature communications, 6, 8043-8043 (2015-08-22)
Efficient recycling of synaptic vesicles is thought to be critical for sustained information transfer at central terminals. However, the specific contribution that retrieved vesicles make to future transmission events remains unclear. Here we exploit fluorescence and time-stamped electron microscopy to
Ann Ran-Ran Qin et al.
Bioanalysis, 7(9), 1069-1079 (2015-06-04)
In early drug-discovery research, traditional techniques to analyze drug concentrations in tissues for bioanalytical needs include bead beaters and probe homogenization devices, but are not as effective for tough fibrous tissues. To prepare these tissues, the enzyme collagenase was used
Sebastian Mana-Capelli et al.
Molecular biology of the cell, 25(10), 1676-1685 (2014-03-22)
The Hippo pathway regulates the transcriptional coactivator YAP to control cell proliferation, organ size, and stem cell maintenance. Multiple factors, such as substrate stiffness, cell density, and G protein-coupled receptor signaling, regulate YAP through their effects on the F-actin cytoskeleton
Sergiy V Korol et al.
PloS one, 10(4), e0124765-e0124765 (2015-05-01)
Glucagon-like peptide-1 (GLP-1) is a metabolic hormone that is secreted in a glucose-dependent manner and enhances insulin secretion. GLP-1 receptors are also found in the brain where their signalling affects neuronal activity. We have previously shown that the GLP-1 receptor
Bikash Sahay et al.
The Journal of infectious diseases, 210(9), 1499-1507 (2014-05-16)
Ingestion of Bacillus anthracis spores causes gastrointestinal (GI) anthrax. Humoral immune responses, particularly immunoglobulin A (IgA)-secreting B-1 cells, play a critical role in the clearance of GI pathogens. Here, we investigated whether B. anthracis impacts the function of colonic B-1
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