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Nawal Bahia El Idrissi et al.
Acta neuropathologica, 129(5), 653-667 (2015-03-17)
Peripheral nerve damage is the hallmark of leprosy pathology but its etiology is unclear. We previously identified the membrane attack complex (MAC) of the complement system as a key determinant of post-traumatic nerve damage and demonstrated that its inhibition is
Gabriela Piccolo Maitan-Alfenas et al.
Bioresource technology, 192, 670-676 (2015-06-22)
Biomass enzymatic hydrolysis depends on the pretreatment methods employed, the composition of initial feedstock and the enzyme cocktail used to release sugars for subsequent fermentation into ethanol. In this study, sugarcane bagasse was pretreated with 1% H2SO4 and 1% NaOH
Modesto T Lopez-Lopez et al.
PloS one, 10(7), e0133878-e0133878 (2015-07-25)
We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin-agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was
Yuan Yan Sin et al.
Cell biochemistry and function, 33(7), 421-426 (2015-10-09)
Heat shock protein 20 (HSP20) has cardioprotective qualities, which are triggered by PKA phosphorylation. PKD1 is also a binding partner for HSP20, and this prompted us to investigate whether the chaperone was a substrate for PKD1. We delineate the PKD1
Lili Wu et al.
Acta biomaterialia, 27, 294-304 (2015-09-01)
Coculture of osteoblasts and osteoclasts is a subject of interest in the understanding of how magnesium (Mg)-based implants influence the bone metabolism and remodeling upon degradation. Human telomerase reverse transcriptase (hTERT) transduced mesenchymal stem cells (SCP-1) were first differentiated into
Stacey E Wahl et al.
Developmental biology, 405(1), 108-122 (2015-07-07)
Folate deficiency has been associated with numerous diseases and birth defects including orofacial defects. However, whether folate has a role in the face during early orofacial development has been unclear. The present study reveals that pharmacological and antisense oligonucleotide mediated
Yaron Vagima et al.
PLoS pathogens, 11(5), e1004893-e1004893 (2015-05-15)
Pneumonic plague is a fatal disease caused by Yersinia pestis that is associated with a delayed immune response in the lungs. Because neutrophils are the first immune cells recruited to sites of infection, we investigated the mechanisms responsible for their
Li Zhong et al.
The Journal of biological chemistry, 290(25), 15866-15877 (2015-05-10)
Triggering receptor expressed on myeloid cells 2 (TREM2) is a DAP12-associated receptor expressed in microglia, macrophages, and other myeloid-derived cells. Previous studies have suggested that TREM2/DAP12 signaling pathway reduces inflammatory responses and promotes phagocytosis of apoptotic neurons. Recently, TREM2 has
Benjamin Tillmann Käsdorf et al.
Biophysical journal, 109(10), 2171-2181 (2015-11-21)
The efficient treatment of many ocular diseases depends on the rapid diffusive distribution of solutes such as drugs or drug delivery vehicles through the vitreous humor. However, this multicomponent hydrogel possesses selective permeability properties, which allow for the diffusion of
Xia Lian et al.
Journal of neuroscience research, 93(6), 873-881 (2015-01-24)
Focal adhesion kinase (FAK) is one of the nonreceptor protein tyrosine kinases critical for the dynamic regulation of cell adhesion structures. Recent studies have demonstrated that FAK is also localized at excitatory glutamatergic synapses and is involved in long-term modification
Jessica R Ivy et al.
PloS one, 10(8), e0134620-e0134620 (2015-08-25)
Insect nephrocytes are highly endocytic scavenger cells that represent the only invertebrate model for the study of human kidney podocytes. Despite their importance, nephrocyte development is largely uncharacterised. This work tested whether the insect ortholog of mammalian Kidney Krüppel-Like Factor
Daniel J Whitcomb et al.
Scientific reports, 5, 10934-10934 (2015-06-10)
The acute neurotoxicity of oligomeric forms of amyloid-β 1-42 (Aβ) is implicated in the pathogenesis of Alzheimer's disease (AD). However, how these oligomers might first impair neuronal function at the onset of pathology is poorly understood. Here we have examined
Marijn Schouten et al.
Scientific reports, 5, 12448-12448 (2015-07-25)
Adult neurogenesis continuously contributes new neurons to hippocampal circuits and the programmed death of a subset of immature cells provides a primary mechanism controlling this contribution. Epileptic seizures induce strong structural changes in the hippocampus, including the induction of adult
Philipp Arnold et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3549-3557 (2015-05-10)
The meprin β metalloproteinase is an important enzyme in extracellular matrix turnover, inflammation, and neurodegeneration in humans and mice. Previous studies showed a diminished cleavage of certain meprin β substrates in the presence of calcium, although the mechanism was not
Zhidan Liang et al.
The Analyst, 140(11), 3803-3813 (2014-12-30)
Neuropeptides (NPs), a unique and highly important class of signaling molecules across the animal kingdom, have been extensively characterized in the neuronal tissues of various crustaceans. Because many NPs are released into circulating fluid (hemolymph) and travel to distant sites
I Z A Pawluczyk et al.
Experimental cell research, 326(2), 251-258 (2014-05-13)
Evidence is emerging that podocytes are able to endocytose proteins such as albumin using kinetics consistent with a receptor-mediated process. To date the role of the fatty acid moiety on albumin uptake kinetics has not been delineated and the receptor
Chee Man Cheong et al.
Experimental cell research, 332(1), 24-38 (2015-02-01)
Increased expression of the tetraspanin TSPAN7 has been observed in a number of cancers; however, it is unclear how TSPAN7 plays a role in cancer progression. We investigated the expression of TSPAN7 in the haematological malignancy multiple myleoma (MM) and
Kristin M Whitworth et al.
Biology of reproduction, 91(3), 78-78 (2014-08-08)
Targeted modification of the pig genome can be challenging. Recent applications of the CRISPR/Cas9 system hold promise for improving the efficacy of genome editing. When a designed CRISPR/Cas9 system targeting CD163 or CD1D was introduced into somatic cells, it was
Chanmi Park et al.
Plant & cell physiology, 56(9), 1808-1819 (2015-07-15)
Several E3 ubiquitin ligases have been associated with the response to abiotic and biotic stresses in higher plants. Here, we report that the hot pepper (Capsicum annuum) ABA-Insensitive RING protein 1 gene (CaAIR1) is essential for a hypersensitive response to
Mieke H van Marion et al.
Journal of molecular and cellular cardiology, 87, 79-91 (2015-08-19)
Cardiomyocyte progenitor cells (CMPCs) are a candidate cell source for cardiac regenerative therapy. However, like other stem cells, after transplantation in the heart, cell retention and differentiation capacity of the CMPCs are low. Combining cells with biomaterials might overcome this
Mais Al-Natsheh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 103-109 (2015-02-11)
A gas chromatography/mass spectrometric method was developed for the simultaneous determination of eight phthalic acid esters (PAEs) in toys and child care articles that are made of plasticized plastic. The novel method was used to determine the total concentration of
Varoon Singh et al.
Journal of chromatography. A, 1395, 48-56 (2015-04-13)
A sample preparation method involving extraction, enrichment and derivatization of acidic degradation products of nerve agents was developed using magnetic strong anion exchange resins (MSAX). The method was performed in a single vial involving magnetic dispersive solid phase extraction (MDSPE).
Taulant Bacaj et al.
PLoS biology, 13(10), e1002267-e1002267 (2015-10-06)
In forebrain neurons, Ca(2+) triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7, thereby inducing fast and slow vesicle exocytosis, respectively. Loss-of-function of synaptotagmin-1 or -7 selectively impairs the fast and slow phase of release, respectively, but
Pei-Yu Shih et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(29), 9789-9802 (2014-07-18)
Neuronal nAChRs in the medial habenula (MHb) to the interpeduncular nucleus (IPN) pathway are key mediators of nicotine's aversive properties. In this paper, we report new details regarding nAChR anatomical localization and function in MHb and IPN. A new group
Josué L Castro-Mejía et al.
Microbiome, 3, 64-64 (2015-11-19)
The human gut is densely populated with archaea, eukaryotes, bacteria, and their viruses, such as bacteriophages. Advances in high-throughput sequencing (HTS) as well as bioinformatics have opened new opportunities for characterizing the viral communities harbored in our gut. However, limited
Hong-Jin Wu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(2), 741-752 (2015-05-30)
Licorice has been used to treat many diseases, including palpitations, in both Eastern and Western societies for thousands of years. It has been reported that glycyrrhetinic acid (GA), an aglycone saponin extracted from licorice root, exerts protective effects on the
Woo Jae Kim et al.
The Journal of biological chemistry, 290(23), 14381-14390 (2015-04-18)
WTX encodes a tumor suppressor implicated in the pediatric kidney cancer Wilms tumor and in mesenchymal differentiation with potentially distinct functions in the cytoplasm, at the plasma membrane, and in the nucleus. Although modulating components of the WNT signaling pathway
Mark D Kaji et al.
British journal of pharmacology, 172(15), 3737-3747 (2015-04-09)
Cys-loop GABA receptors represent important targets for human chemotherapeutics and insecticides and are potential targets for novel anthelmintics (nematicides). However, compared with insect and mammalian receptors, little is known regarding the pharmacological characteristics of nematode Cys-loop GABA receptors. Here we
Matthias R Meyer et al.
Scientific reports, 4, 7564-7564 (2014-12-24)
Coronary atherosclerosis and myocardial infarction in postmenopausal women have been linked to inflammation and reduced nitric oxide (NO) formation. Natural estrogen exerts protective effects on both processes, yet also displays uterotrophic activity. Here, we used genetic and pharmacologic approaches to
Kaitlin C Murphy et al.
Cell and tissue research, 357(1), 91-99 (2014-05-02)
Mesenchymal stem cells (MSCs) have great therapeutic potential for the repair of nonhealing bone defects, because of their proliferative capacity, multilineage potential, trophic factor secretion and lack of immunogenicity. However, a major challenge to the translation of cell-based therapies into
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