搜索范围
C6305
应用筛选条件
关键词:'C6305'
显示 1-30 #N/A 158 条结果 关于 "C6305" 范围 论文
Eleftherios Michailidis et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(3), 1678-1688 (2020-01-10)
Primary human hepatocytes (PHHs) are an essential tool for modeling drug metabolism and liver disease. However, variable plating efficiencies, short lifespan in culture, and resistance to genetic manipulation have limited their use. Here, we show that the pyrrolizidine alkaloid retrorsine
M Kuoppamäki et al.
European journal of pharmacology, 245(2), 179-182 (1993-04-15)
The effects of the atypical antipsychotic drug, clozapine, and its two major metabolites in man, N-desmethylclozapine and clozapine N-oxide, on 5-HT1C receptor mediated phosphoinositide hydrolysis were studied in rat choroid plexus. Clozapine and N-desmethylclozapine antagonized 5-HT-stimulated phosphoinositide hydrolysis with IC50
K Brami-Cherrier et al.
Molecular psychiatry, 19(11), 1193-1200 (2014-07-16)
Alterations of the dopaminergic system are associated with the cognitive and functional dysfunctions that characterize complex neuropsychiatric disorders. We modeled a dysfunctional dopaminergic system using mice with targeted ablation of dopamine (DA) D2 autoreceptors in mesencephalic dopaminergic neurons. Loss of
Niraj S Trasi et al.
The journal of physical chemistry. B, 118(33), 9974-9982 (2014-07-31)
Amorphous forms of drugs are increasingly being used to deliver poorly water-soluble compounds. Therefore, understanding the magnitude and origin of differences in crystallization kinetics is highly important. The goal of this study was to better understand the factors that influence
Diego Soares Domingues et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 993-994, 26-35 (2015-05-20)
This study reports on the development of a rapid, selective, and sensitive column-switching liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to analyze sixteen drugs (antidepressants, anticonvulsants, anxiolytics, and antipsychotics) in plasma samples from schizophrenic patients. The developed organic-inorganic hybrid monolithic column
Mao-Liang Chen et al.
International immunopharmacology, 23(2), 550-557 (2014-12-03)
Antipsychotic drugs (APDs) have been used to ease the symptoms of schizophrenia. APDs have recently been reported to regulate the immune response. Our previous studies revealed that the atypical APDs risperidone and clozapine and the typical APD haloperidol can inhibit
Paul C Baier et al.
PloS one, 9(10), e110310-e110310 (2014-10-24)
Increasing evidence suggests that clock genes may be implicated in a spectrum of psychiatric diseases, including sleep and mood related disorders as well as schizophrenia. The bHLH transcription factors SHARP1/DEC2/BHLHE41 and SHARP2/DEC1/BHLHE40 are modulators of the circadian system and SHARP1/DEC2/BHLHE40
S S Olmez et al.
Die Pharmazie, 68(2), 110-116 (2013-03-09)
In this study, clozapine orally disintegrating tablets (ODTs) were prepared by direct compression method. Disintegration time, resistance to crushing of tablets, porosity, friability, dissolution tests were performed and dissolution profiles of ODTs were investigated. Morphological and interaction studies were also
Hao Li et al.
eLife, 13 (2024-05-03)
Cholecystokinin (CCK) is an essential modulator for neuroplasticity in sensory and emotional domains. Here, we investigated the role of CCK in motor learning using a single pellet reaching task in mice. Mice with a knockout of Cck gene (Cck-/-) or
Chunyang Dong et al.
Cell, 184(10), 2779-2792 (2021-04-30)
Ligands can induce G protein-coupled receptors (GPCRs) to adopt a myriad of conformations, many of which play critical roles in determining the activation of specific signaling cascades associated with distinct functional and behavioral consequences. For example, the 5-hydroxytryptamine 2A receptor
Vera Alves et al.
Journal of chromatography. A, 1408, 30-40 (2015-07-21)
A powerful and sensitive method, by microextraction packed sorbent (MEPS), and ultra-high performance liquid chromatography (UHPLC) with a photodiode array (PDA) detection, is described for the determination of fluoxetine, clomipramine and their active metabolites in human urine samples. The MEPS
Israel D de Souza et al.
Talanta, 140, 166-175 (2015-06-07)
The present study (1) reports on the synthesis of two hybrid silica monoliths functionalized with aminopropyl or cyanopropyl groups by the sol-gel process; (2) evaluates these monoliths as selective stationary phase for microextraction by packed sorbent (MEPS) to determine drugs
Jimmi Nielsen et al.
The Journal of clinical psychiatry, 74(6), 603-613 (2013-07-12)
To identify the outcome of potentially serious adverse effects of clozapine, particularly those frequently cited as reasons for clozapine discontinuation, and to characterize management strategies for adverse effects that do not warrant discontinuation. A structured search was performed of PubMed
Alberto Canfrán-Duque et al.
PloS one, 10(10), e0141829-e0141829 (2015-10-31)
First- and second-generation antipsychotics (FGAs and SGAs, respectively), both inhibit cholesterol biosynthesis and impair the intracellular cholesterol trafficking, leading to lipid accumulation in the late endosome/lysosome compartment. In this study we examined if curcumin, a plant polyphenol that stimulates exosome
Shalini Jain et al.
The Journal of clinical investigation, 123(4), 1750-1762 (2013-03-13)
Type 2 diabetes (T2D) has emerged as a major threat to human health in most parts of the world. Therapeutic strategies aimed at improving pancreatic β cell function are predicted to prove beneficial for the treatment of T2D. In the
Julia Rossmann et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1000, 84-94 (2015-07-27)
Matrix effects that occur during quantitative measurement by liquid chromatography mass spectrometry specifically when using electrospray ionization are a widely recognized phenomenon. Sample matrix compounds affect the ionization process of the target analytes, lead to a low signal response, and
Taro Kishi et al.
Comprehensive psychiatry, 59, 91-97 (2015-03-01)
We conducted a cross-sectional survey to assess the prevalence of physical pain in Japanese major depressive disorder (MDD) and schizophrenia (SZ) patients as well as in healthy controls (HCs). We also examined the association between their psychopathology and characteristics of
Rania A H Ishak et al.
Carbohydrate polymers, 94(1), 669-676 (2013-04-03)
Engineering polymer surfaces reduces nanoparticles (NPs) aggregation and phagocytosis due to effective shielding, hindering recognition by the reticuloendothelial system (RES). The shielding of NPs is complex and affected by the type of groups used in terms of charge and hydrophilicity.
Rita Citraro et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 12(1), 250-262 (2014-11-19)
Antipsychotic drugs (APs) are of great benefit in several psychiatric disorders, but they can be associated with various adverse effects, including seizures. To investigate the effects of chronic antipsychotic treatment on seizure susceptibility in genetically epilepsy-prone rats, some APs were
Javier Sanz-Fuentenebro et al.
Schizophrenia research, 149(1-3), 156-161 (2013-07-23)
In first-episode patients with psychosis, clozapine may be potentially valuable as an initial treatment seeking to limit early on clinical and cognitive deterioration. Nevertheless, until recently its restricted use has limited the study of this possibility. Our research group is
Shu-Yu Yang et al.
The Journal of clinical psychiatry, 74(1), e79-e86 (2013-02-20)
Like mood stabilizers, most second-generation antipsychotics are widely used to treat patients with bipolar disorder, yet their safety is still a concern. This study explored the association between antipsychotics and mood stabilizers and the risk of pneumonia, and it provides
Sarah Ann R Anderson et al.
The Journal of clinical investigation, 123(12), 5334-5341 (2013-11-16)
Negative affect is critical for conferring vulnerability to opiate addiction as reflected by the high comorbidity of opiate abuse with major depressive disorder (MDD). Rodent models implicate amygdala prodynorphin (Pdyn) as a mediator of negative affect; however, evidence of PDYN
Chronic benign neutropenia/agranulocytosis associated with non-clozapine antipsychotics.
Fidel Vila-Rodriguez et al.
The American journal of psychiatry, 170(10), 1213-1214 (2013-10-03)
Fabiana Barzotti Kohlrausch
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 35(3), 305-317 (2013-10-22)
Clozapine is quite effective to treat schizophrenia, but its use is complicated by several factors. Although many patients respond to antipsychotic therapy, about 50% of them exhibit inadequate response, and ineffective medication trials may entail weeks of unremitted illness, potential
Maurizio S Riga et al.
The international journal of neuropsychopharmacology, 17(8), 1269-1282 (2014-03-22)
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a natural hallucinogen component of Ayahuasca, an Amazonian beverage traditionally used for ritual, religious and healing purposes that is being increasingly used for recreational purposes in US and Europe. 5MeO-DMT is of potential interest for schizophrenia research
Adam P Hill et al.
Molecular pharmacology, 85(5), 769-776 (2014-03-04)
The Kv11.1 potassium channel is the molecular target for the majority of drugs implicated in acquired long QT syndrome, the most common cause of drug-induced sudden cardiac death, and a common reason for drug restriction or withdrawal from the market.
Jerome Ma et al.
Physical chemistry chemical physics : PCCP, 17(30), 19766-19776 (2015-07-15)
Permeation of drugs across lipid bilayers is a key factor in dictating how effective they will be. In vivo, the issue is compounded by the presence of drug-exporter proteins such as P-glycoprotein. However, despite intense effort, exactly what controls permeation
Piotr Popik et al.
Psychopharmacology, 232(6), 1025-1038 (2014-09-28)
In addition to the negative and positive symptoms of schizophrenia, cognitive deficits, including prefrontal cortical dysfunction, are now recognized as core features of this disorder. Compounds increasing the NMDA receptor function via the strychnine-insensitive glycine receptors have been proposed as
Chun-Hsin Chen et al.
The Journal of clinical psychiatry, 74(5), e424-e430 (2013-06-14)
Many studies have shown that metformin can decrease body weight and improve metabolic abnormalities in patients with schizophrenia. Whether or not the beneficial effects can be sustained after discontinuation of metformin needs to be evaluated. We conducted a 24-week randomized
M von Wilmsdorff et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 46(11), 782-788 (2014-08-12)
Antipsychotic drugs are known to have sex-dependent effects on metabolic homeostasis. Liver plays a crucial role in drug degradation as well as in glucose and lipid metabolism. The present study examines the influence of clozapine and haloperidol on metabolic liver
1/6