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François Versace et al.
Bioanalysis, 6(15), 2043-2055 (2014-10-18)
Direct-infusion ESI-MS/MS is a powerful approach for the identification of substances in complex mixtures. The aim of this work was to investigate its applicability to the toxicological screening of blood samples. A simple protein precipitation was used, followed by a
M E H Wigard et al.
Tijdschrift voor psychiatrie, 55(2), 113-121 (2013-02-15)
The addition of fluvoxamine to clozapine induces a rise of plasma concentrations of clozapine. This enables the prescription of a lower number of clozapine tablets, yet it attains sufficient clozapine plasma concentrations, and facilitates treatment adherence. Providing practical advice for
Peng Zhong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(18), 6352-6366 (2014-05-03)
Dopamine neurons in the ventral tegmental area (VTA) govern reward and motivation and dysregulated dopaminergic transmission may account for anhedonia and other symptoms of depression. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that regulates a broad range of
Belen Batanero et al.
The Journal of organic chemistry, 78(18), 9477-9481 (2013-08-21)
The one-pot concomitant electrochemical reduction of phenanthrenequinones (1, 2) and arenediazonium salts (3a-f) led to the formation of 1,3,4-oxadiazol-2(3H)-ones (4a-f, 5a) and dibenzo[c,e]azepines (6a-f) when N-methylformamide was used as the solvent. A new pathway, different from those previously described with
Systematic assessment of the replicability and generalizability of preclinical findings: Impact of protocol harmonization across laboratory sites.
Arroyo-Araujo, et al.
PLoS Biology, 20, e3001886-e3001886 (2022)
Daigo Imoto et al.
Molecular metabolism, 54, 101366-101366 (2021-11-04)
The regulation of food intake is a major research area in the study of obesity, which plays a key role in the development of metabolic syndrome. Gene targeting studies have clarified the roles of hypothalamic neurons in feeding behavior, but
Valerio Zerbi et al.
Neuron, 103(4), 702-718 (2019-06-23)
The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates many fundamental brain functions. Studies in humans have suggested that strong LC activation might shift network connectivity to favor salience processing. To causally test this hypothesis, we
Benjamin W J Spencer et al.
Pharmacogenomics, 14(15), 1907-1914 (2013-11-19)
Clozapine is a uniquely efficacious antipsychotic drug in treatment-resistant schizophrenia. Its use is restricted due to adverse effects including a rare but dangerous reduction in neutrophils (agranulocytosis) and the mandatory hematological monitoring this entails in many countries. We review the
Jocelyne Moisan et al.
Canadian journal of psychiatry. Revue canadienne de psychiatrie, 58(4), 218-224 (2013-04-04)
The association between the use of antipsychotics and diabetes mellitus (DM) is still unclear, as depicted by several conflicting reports. Our study aims to assess the risk of DM in new users of antipsychotics. Our nested case-control study used the
Karen E Stevens et al.
Schizophrenia research, 149(1-3), 121-126 (2013-07-19)
Deficient sensory inhibition, the failure to inhibit responses to repeated stimuli, is a hallmark of schizophrenia, and is thought to be related to difficulties with attention and working memory. Sensory inhibition is assessed by comparing the auditory-evoked EEG responses to
Aboubakr Rahmani et al.
Analytical and bioanalytical chemistry, 406(29), 7729-7739 (2014-09-27)
Several molecularly imprinted polymers (MIPs) were prepared in the present work, and their binding properties were evaluated in comparison with a nonimprinted polymer (NIP). An optimized MIP was selected and applied for selective extraction and analysis of haloperidol in rabbit
Yu Liu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(33), 6409-6427 (2020-07-17)
The mesolimbic dopamine system comprises distinct compartments supporting different functions in learning and motivation. Less well understood is how complex addiction-related behaviors emerge from activity patterns across these compartments. Here we show how different forms of relapse to alcohol-seeking in
Stephanie W Watts et al.
Journal of cardiovascular pharmacology, 80(2), 314-322 (2022-08-09)
The 5-hydroxytryptamine 7 (5-HT 7 ) receptor is reported to have considerable constitutive activity when transfected into cells. Constitutive activity-receptor activity in the absence of known agonist-is important for understanding the contributions of a receptor to (patho)physiology. We test the
Saeko Ikai et al.
The Annals of pharmacotherapy, 47(7-8), e31-e31 (2013-06-13)
To report on a patient who was successfully rechallenged with clozapine after perforation of the large intestine and pulmonary embolism post operatively, and provide a literature review on clozapine rechallenge. A 46-year-old Japanese man with treatment-resistant schizophrenia developed constipation and
Sailaja A Goda et al.
Progress in neuro-psychopharmacology & biological psychiatry, 61, 44-51 (2015-04-12)
Altered activity of the nucleus accumbens (NAc) is thought to be a core feature of schizophrenia and animal models of the disease. Abnormal high frequency oscillations (HFO) in the rat NAc have been associated with pharmacological models of schizophrenia, in
Karin Hellman et al.
ACS chemical neuroscience, 11(2), 173-183 (2019-12-19)
Current antipsychotic drugs are notably ineffective at addressing the cognitive deficits associated with schizophrenia. N-Desmethylclozapine (NDMC), the major metabolite of clozapine, displays muscarinic M1 receptor (M1) agonism, an activity associated with improvement in cognitive functioning. Preclinical and clinical data support
A Kiss et al.
Journal of neuroscience research, 88(3), 677-685 (2009-09-24)
Acute administration of antipsychotics elicits regionally distinct patterns of Fos expression in the rat brain. Stimulation of oxytocin (OXY) and vasopressin (AVP) release in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei indicates that antipsychotics may play a role in
Alexandre Picard et al.
Diabetes, 70(7), 1443-1457 (2021-04-23)
The counterregulatory response to hypoglycemia is an essential survival function. It is controlled by an integrated network of glucose-responsive neurons, which trigger endogenous glucose production to restore normoglycemia. The complexity of this glucoregulatory network is, however, only partly characterized. In
Evangelia Eirini Tsermpini et al.
Pharmacogenomics, 15(1), 95-110 (2013-12-18)
Schizophrenia is a severe disorder that significantly affects the quality of life and total functioning of patients and their caregivers. Clozapine is the first atypical antipsychotic with fewer adverse effects and established efficacy. As a rule of thumb, risperidone is
Wei Zhang et al.
Scientific reports, 8(1), 15753-15753 (2018-10-27)
Epidemiological observations have shown that schizophrenia patients after long-term drug treatment exhibited reduced tumor incidences. The potential anticancer effects of antipsychotic drugs are subsequently demonstrated. These drugs are of great interest as agents against untreatable brain metastases because of their
Alberto Danese et al.
Cell reports, 40(3), 111124-111124 (2022-07-21)
Leber's hereditary optic neuropathy (LHON), a disease associated with a mitochondrial DNA mutation, is characterized by blindness due to degeneration of retinal ganglion cells (RGCs) and their axons, which form the optic nerve. We show that a sustained pathological autophagy
Kenneth M McCullough et al.
Biological psychiatry, 89(12), 1138-1149 (2021-03-16)
Stress is implicated in the pathophysiology of major depression and posttraumatic stress disorder. These conditions share core features, including motivational deficits, heighted anxiety, and sleep dysregulation. Chronic stress produces these same features in rodents, with some individuals being susceptible or
Winnie Ng et al.
Chemical research in toxicology, 27(7), 1104-1108 (2014-06-27)
Clozapine is effective in the treatment of schizophrenia; however, its use is limited by a relatively high incidence of idiosyncratic agranulocytosis. The mechanism of clozapine-induced idiosyncratic agranulocytosis is unknown. Although most patients treated with clozapine do not develop agranulocytosis, most
Sustained weight loss after treatment with a glucagon-like peptide-1 receptor agonist in an obese patient with schizophrenia and type 2 diabetes.
Pelle L Ishøy et al.
The American journal of psychiatry, 170(6), 681-682 (2013-06-05)
A Archie et al.
Tijdschrift voor psychiatrie, 55(4), 287-291 (2013-04-19)
Visual hallucinations (VH) are sometimes difficult to treat in patients with Lewy body dementia (LBD). We describe the concurrent use of clozapine and levodopa for the treatment of persistent VH and parkinsonism in a patient with LBD and severely increased
Vanessa Bobb et al.
The Psychiatric quarterly, 84(3), 343-349 (2012-12-12)
We assessed the predictors of clozapine initiation among youth 18 years and younger within a state psychiatric hospital. Administrative data (n = 358) were evaluated of inpatients from a long-term state child and adolescent psychiatric hospital. We investigated 25 background
Taixiang Saur et al.
PLoS genetics, 9(2), e1003313-e1003313 (2013-03-08)
We report a genome-wide RNA interference (RNAi) screen for Suppressors of Clozapine-induced Larval Arrest (scla genes) in Caenorhabditis elegans, the first genetic suppressor screen for antipsychotic drug (APD) targets in an animal. The screen identifies 40 suppressors, including the α-like
Haiping Wang et al.
Journal of pharmaceutical sciences, 103(10), 3302-3309 (2014-08-15)
The experimental measurement of plasma protein binding is a useful in vitro Absorption Distribution Metabolism and Excretion(ADME) assay currently conducted in both screening and definitive early development candidate modes. The fraction unbound is utilized to calculate important pharmacokinetic (PK) parameters
Robert Gurke et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 990, 23-30 (2015-04-05)
Based on regional prescription data several pharmaceuticals with variable amounts of prescription and corresponding metabolites were selected and analyzed in influent and effluent samples of the sewage treatment plant (STP) in Dresden, Germany. Pharmaceuticals of the following most prescribed therapeutic
Effectiveness of a clozapine-aripiprazole combination in Tourette syndrome and bipolar spectrum disorder.
Armando Piccinni et al.
The Journal of neuropsychiatry and clinical neurosciences, 25(1), E45-E45 (2013-03-15)
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