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Christopher M Jenkins et al.
Biochemistry, 52(24), 4250-4263 (2013-05-25)
The multifaceted roles of calcium-independent phospholipase A2β (iPLA2β) in numerous cellular processes have been extensively examined through utilization of the iPLA2-selective inhibitor (E)-6-(bromomethylene)-3-(1-naphthalenyl)-2H-tetrahydropyran-2-one (BEL). Herein, we employed accurate mass/high resolution mass spectrometry to demonstrate that the active site serine (S465)
A F Vanin et al.
Biofizika, 58(1), 126-136 (2013-05-09)
Current notions and new experimental data of the authors on physico-chemical features of dinitrosyl iron complexes with natural thiol-containing ligands (glutathione or cysteine), underlying the ability of the complexes to act as NO molecule and nitrosonium ion donors, are considered.
Jiahua Li et al.
American journal of physiology. Cell physiology, 305(2), C190-C196 (2013-05-17)
Claudins constitute a family of tight junction transmembrane proteins whose first extracellular loop (ECL1) determines the paracellular permeability and ion selectivity in epithelia. There are two cysteines in the ECL1 that are conserved among all claudins. We hypothesized that these
Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation.
Harlaar, et al.
Nature Biomedical Engineering, 6, 389-402 (2022)
Anna B Meier et al.
Nature biotechnology, 41(12), 1787-1800 (2023-04-04)
The epicardium, the mesothelial envelope of the vertebrate heart, is the source of multiple cardiac cell lineages during embryonic development and provides signals that are essential to myocardial growth and repair. Here we generate self-organizing human pluripotent stem cell-derived epicardioids
T L Stepuro et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 99(1), 111-119 (2013-05-11)
The aim of the present study was to investigate the role of nitric oxide (NO) in the regulation of hemoglobin oxygen affinity (HOA) in the presence of different oxygen partial pressure. In this research the effect of NO donors on
Mingdeng Liu et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(11), 2444-2450 (2013-06-12)
In the present work, cysteine-modified orange peel (COP) for the removal of Cu(II) from aqueous solutions has been developed and comparatively studied with diethylenetriamine-modified orange peel (DOP). Both COP and DOP were systematically evaluated via their capabilities for adsorbing Cu(II)
Pramod Kumar Yadav et al.
The Journal of biological chemistry, 288(27), 20002-20013 (2013-05-24)
Mercaptopyruvate sulfurtransferase (MST) is a source of endogenous H2S, a gaseous signaling molecule implicated in a wide range of physiological processes. The contribution of MST versus the other two H2S generators, cystathionine β-synthase and γ-cystathionase, has been difficult to evaluate
D J Powell et al.
Poultry science, 92(8), 2163-2173 (2013-07-23)
Early posthatch satellite cell (SC) mitotic activity is a critical component of muscle development and growth. Satellite cells are stem cells that can be induced by nutrition to follow other cellular developmental pathways. The objective of the current study was
N A Strutyns'ka et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 3-10 (2013-05-30)
In experiments in vivo and in vitro on the mitochondria isolated from the control and spontaneously hypertensive rats (SHR) hearts, we studied the effects of a donor of hydrogen sulfide (H2S), NaHS, and H2S biosynthesis substrate, L-cysteine, on the sensitivity
[Targeted effect profile - proven effectiveness].
MMW Fortschritte der Medizin, 155(5), 70-71 (2013-05-10)
Nitric oxide quenches the fire in heart mitochondria.
Paul T Schumacker
Nature medicine, 19(6), 666-667 (2013-06-08)
Michael Hellwig et al.
Journal of agricultural and food chemistry, 63(30), 6723-6730 (2015-07-18)
Maillard reaction products (MRPs) are taken up in substantial amounts with the daily diet, but the majority are not transported across the intestinal epithelium. The aim of this study was to obtain first insights into the stability of dietary MRPs
Wei Seong Toh et al.
Methods in molecular biology (Clifton, N.J.), 407, 333-349 (2008-05-06)
Human embryonic stem cells (hESCs) have the ability to self-replicate and differentiate into cells from all three embryonic germ layers, thereby holding great promise for tissue regeneration applications. However, controlling the differentiation of hESCs and obtaining homogenous differentiated cell populations
Gustavo H C Varca et al.
Drug development and industrial pharmacy, 41(3), 430-435 (2014-01-15)
The performance of the standardized extrusion-spheronization technique, operational conditions, formulation parameters and storage of the final product over the bioactivity of papain containing pellets has been evaluated to obtain an insight into the potential of the technique for the manufacture
Wei Seong Toh et al.
Methods in molecular biology (Clifton, N.J.) (2014-07-13)
Human embryonic stem cells (hESCs) have the ability to self-renew and differentiate into any cell lineage of the three germ layers, therefore holding great promise for regenerative applications in dentistry and medicine. We previously described a micromass culture system as
Borna Ghosh et al.
The Journal of biological chemistry, 288(24), 17420-17431 (2013-05-04)
General anesthetics exert many of their CNS actions by binding to and modulating membrane-embedded pentameric ligand-gated ion channels (pLGICs). The structural mechanisms underlying how anesthetics modulate pLGIC function remain largely unknown. GLIC, a prokaryotic pLGIC homologue, is inhibited by general
Biochemistry: Oxidation controls the DUB step.
Michael J Clague
Nature, 497(7447), 49-50 (2013-05-03)
Vandana Kumari et al.
Bio-protocol, 12(22) (2023-01-10)
Babesiosis is a tick-borne disease caused by pathogens belonging to the genus Babesia. In humans, the disease presents as a malaria-like illness and can be fatal in immunocompromised and elderly people. In the past few years, human babesiosis has been
Durga P Neupane et al.
PLoS pathogens, 18(8), e1010731-e1010731 (2022-08-13)
Children are particularly susceptible to typhoid fever caused by the bacterial pathogen Salmonella Typhi. Typhoid fever is prevalent in developing countries where diets can be less well-balanced. Here, using a murine model, we investigated the role of the macronutrient composition
The CIAMIB: a Large and Metabolically Diverse Collection of Inflammation-Associated Bacteria from the Murine Gut.
Wong, et al.
mBio, 13, e0294921-e0294921 (2023)
Colin T Stomberski et al.
Cell reports, 41(4), 111538-111538 (2022-10-27)
Accumulating evidence suggests that protein S-nitrosylation is enzymatically regulated and that specificity in S-nitrosylation derives from dedicated S-nitrosylases and denitrosylases that conjugate and remove S-nitrosothiols, respectively. Here, we report that mice deficient in the protein denitrosylase SCoR2 (S-nitroso-Coenzyme A Reductase
Theresa Mau et al.
mSphere, 4(2) (2019-03-22)
Between October 2016 and June 2017, a C57BL/6J mouse colony that was undergoing a pre- and perinatal methyl donor supplementation diet intervention to study the impact of parental nutrition on offspring susceptibility to disease was found to suffer from an
Fangfang Zhang et al.
Frontiers in cell and developmental biology, 10, 1038867-1038867 (2022-10-25)
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) represent an excellent in vitro model in cardiovascular research. Changes in their action potential (AP) dynamics convey information that is essential for disease modeling, drug screening and toxicity evaluation. High-throughput
Richard S. Lord, J. Alexander Bralley
Laboratory Evaluations for Integrative and Functional Medicine (2008)
Laurine Legroux et al.
Journal of neuroscience methods, 247, 23-31 (2015-03-31)
Flow cytometry is an efficient and powerful technique to characterize and quantify numerous cells. However, the strengths of this technique have not been widely harnessed in neurosciences due to the critical step of CNS tissue preparation into a single cell
Zrinka Karačić et al.
Biological chemistry, 393(12), 1523-1532 (2013-05-15)
Human dipeptidyl peptidase III (DPP III) is a member of the metallopeptidase family M49, involved in protein metabolism and oxidative stress response. DPPIII crystal structure shows the two lobe-like domains separated by a wide cleft. The human enzyme has a
Charles Ansong et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(25), 10153-10158 (2013-05-31)
Characterization of the mature protein complement in cells is crucial for a better understanding of cellular processes on a systems-wide scale. Toward this end, we used single-dimension ultra-high-pressure liquid chromatography mass spectrometry to investigate the comprehensive "intact" proteome of the
Austin G Rottinghaus et al.
Cell systems, 13(3), 204-214 (2021-11-13)
Microbial biosensors have diverse applications in metabolic engineering and medicine. Specific and accurate quantification of chemical concentrations allows for adaptive regulation of enzymatic pathways and temporally precise expression of diagnostic reporters. Although biosensors should differentiate structurally similar ligands with distinct
Hui Zhang et al.
eLife, 10 (2021-12-14)
Multidimensional landscapes of regulatory genes in neuronal phenotypes at whole-brain levels in the vertebrate remain elusive. We generated single-cell transcriptomes of ~67,000 region- and neurotransmitter/neuromodulator-identifiable cells from larval zebrafish brains. Hierarchical clustering based on effector gene profiles ('terminal features') distinguished
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