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Mark R Thomas et al.
Platelets, 25(8), 612-618 (2014-01-18)
There is wide variation in response to antiplatelet therapy and high on-treatment platelet reactivity is associated with adverse cardiovascular events. The objective here was to determine whether the results of a novel strategy for assessing platelet reactivity (based on P-selectin
P A Mosier-Boss et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 153, 591-598 (2015-10-07)
SERS substrates were fabricated by filtering either Ag or Au colloidal particles onto rigid, ceramic filters - onto which suspensions of bacteria were then filtered. SERS spectra of the bacteria were obtained using a Raman spectrometer that has an 'orbital
Robrecht Thoonen et al.
Nature communications, 6, 8482-8482 (2015-10-08)
Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC mice expressing haem-free sGC. Apo-sGC mice are viable
Ningning He et al.
Molecular cancer therapeutics, 13(10), 2463-2473 (2014-08-15)
The recent proliferation of data on large collections of well-characterized cancer cell lines linked to therapeutic drug responses has made it possible to identify lineage- and mutation-specific transcriptional markers that can help optimize implementation of anticancer agents. Here, we leverage
Mariano D Susman et al.
Small (Weinheim an der Bergstrasse, Germany), 11(32), 3942-3953 (2015-05-06)
Galvanic replacement reactions (GRRs) on nanoparticles (NPs) are typically performed between two metals, i.e., a solid metal NP and a replacing salt solution of a more noble metal. The solution pH in GRRs is commonly considered an irrelevant parameter. Yet
K Saagar Vijayaragavan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 118-126 (2014-08-03)
Vaccine production faces a challenge in adopting conventional downstream processing steps that can efficiently purify large viral particles. Some major issues that plague vaccine purification are purity, potency, and quality. The industry currently considers 30% as an acceptable virus recovery
Jeffrey A Kline et al.
Thrombosis research, 136(4), 769-774 (2015-09-05)
Pulmonary embolism (PE) can cause intracardiac hemolysis and increased plasma hemoglobin and arginase-1, which can worsen pulmonary vasoconstriction. We test the hypothesis that patients with PE that causes tricuspid regurgitation (TR), indicative of higher pulmonary arterial pressures, have decreased leukocyte
Didem Rodoplu et al.
Current pharmaceutical design, 21(37), 5389-5400 (2015-09-18)
Magnetic nanoparticles are considered as the ideal substrate to selectively isolate target molecules or organisms from sample solutions in a wide variety of applications including bioassays, bioimaging and environmental chemistry. The broad array of these applications in fields requires the
Eric Dugat-Bony et al.
PloS one, 10(4), e0124360-e0124360 (2015-04-14)
Cheese ripening is a complex biochemical process driven by microbial communities composed of both eukaryotes and prokaryotes. Surface-ripened cheeses are widely consumed all over the world and are appreciated for their characteristic flavor. Microbial community composition has been studied for
Partha Pratim Bose et al.
Acta tropica, 152, 208-214 (2015-09-24)
Visceral form of leishmaniasis (also known as Kala-azar) is a fatal neglected tropical disease affecting 95 countries worldwide. Recently, substantial proportion of resistance related treatment failure cases have been reported against its first line drug, sodium-antimony gluconate (SAG). We report
Arutselvan Natarajan et al.
Molecular imaging, 14 (2015-03-13)
Manufacturing of 64Cu-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-rituximab injection under good manufacturing practices (GMP) was validated for imaging of patients with CD20+ B-cell non-Hodgkin lymphoma. Rituximab was purified by size exclusion high performance liquid chromatography (HPLC) and conjugated to DOTA-mono-(N-hydroxysuccinimidyl) ester. 64CuCl2, buffers
Caterina Fede et al.
Microvascular research, 97, 147-155 (2014-12-03)
A new in vitro model system, adding advection and shear stress associated with a flowing medium, is proposed for the investigation of nanoparticles uptake and toxicity towards endothelial cells, since these processes are normally present when nanoparticles formulations are intravenously
Shengtao Yu et al.
Scientific reports, 5, 13600-13600 (2015-09-05)
This report investigates the influence of surface chemistry (or wettability) on the evaporation performance of free-standing double-layered thin film on the surface of water. Such newly developed evaporation system is composed of top plasmonic light-to-heat conversion layer and bottom porous
João Conde et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(11), E1278-E1287 (2015-03-04)
Multidrug resistance (MDR) in cancer cells is a substantial limitation to the success of chemotherapy. Here, we describe facile means to overcome resistance by silencing the multidrug resistance protein 1 (MRP1), before chemotherapeutic drug delivery in vivo with a single
Mudasir Bhat et al.
Environmental monitoring and assessment, 187(7), 398-398 (2015-06-04)
Dissipation patterns were studied following two applications of difenoconazole (score 25% EC) at 300 and 600 g ai ha(-1) as single and double dose respectively on Golden Delicious and Starkrimson cultivars of apple. Samples were collected at 0, 3, 6
Anderson G M da Silva et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(35), 12314-12320 (2015-08-01)
New AgAu tadpole nanocrystals were synthesized in a one-step reaction involving simultaneous galvanic replacement between Ag nanospheres and AuCl4(-)(aq.) and AuCl4(-)(aq.) reduction to Au in the presence of citrate. The AgAu tadpoles display nodular polycrystalline hollow heads, while their undulating
Héctor Rodríguez-Rodríguez et al.
Small (Weinheim an der Bergstrasse, Germany), 11(13), 1555-1561 (2014-12-03)
3D remote control of multifunctional fluorescent up-converting nanoparticles (UCNPs) using optical forces is being required for a great variety of applications including single-particle spectroscopy, single-particle intracellular sensing, controlled and selective light-activated drug delivery and light control at the nanoscale. Most
Rasmus I Jølck et al.
Advanced healthcare materials, 3(10), 1680-1687 (2014-04-16)
External beam radiation therapy relies on the ability to deliver high radiation doses to tumor cells with minimal exposure to surrounding healthy tissue. Advanced irradiation techniques, including image-guided radiation therapy (IGRT), rely on the ability to locate tumors to optimize
Guoqiang Liu et al.
Small (Weinheim an der Bergstrasse, Germany), 11(23), 2807-2816 (2015-02-05)
A facile route to fabricate a nanocomposite of Fe3O4@poly[N-isopropylacrylamide (NIPAM)-co-2-(dimethylamino)ethyl methacrylate (DMAEMA)]@Au (Fe3O4@PND@Au) is developed for magnetically recyclable and thermally tunable catalysis. The negatively charged Au nanoparticles with an average diameter of 10 nm are homogeneously loaded onto positively charged
Chenchen Bao et al.
Scientific reports, 5, 12297-12297 (2015-07-21)
Gold nanobeacons can be used as a powerful tool for cancer theranostics. Here, we proposed a nanomaterial platform based on gold nanobeacons to detect, target and inhibit the expression of a mutant Kras gene in an in vivo murine gastric
Alternative QuEChERS-based modular approach for pesticide residue analysis in food of animal origin.
Karolina Lichtmannegger et al.
Analytical and bioanalytical chemistry, 407(13), 3727-3742 (2015-03-17)
The approach for pesticide residue analysis in food of animal origin differs strongly from the one established for food of plant origin, as laboratories mainly focus on conventional methods for the analysis of non-polar pesticides known to accumulate in fatty
Seyda Korkut et al.
Environmental technology, 37(2), 163-171 (2015-06-24)
The present work reported a compartment-less enzymatic fuel cell (EFC) based on newly synthesized Poly(pyrrole-2-carboxylic acid-co-3-thiophene acetic acid) film containing glucose oxidase and laccase effectively wired by p-benzoquinone incorporated into the copolymer structure. The resulting system generated a power density
Anh H Nguyen et al.
Biosensors & bioelectronics, 67, 443-449 (2014-09-16)
Circulating tumor DNA (ctDNA) bearing tumor-specific mutation and methylation are promising biomarkers for noninvasive cancer assessment. However, existing methods for ctDNA detection are restricted to genetic mutations. Recently, nanoplasmonics has emerged as a platform for one-step dual detection with high
Fang Gao et al.
Talanta, 143, 344-352 (2015-06-17)
Sudan I is a carcinogenic and mutagenic azo-compound that has been utilized as a common adulterant in spice and spice blends to impart a desirable red color to foods. A novel biosensor combining molecularly imprinted polymers (MIPs), thin layer chromatography
Yifeng Wang et al.
Materials science & engineering. C, Materials for biological applications, 53, 222-228 (2015-06-05)
Electrodeposition of chitosan provides a controllable means to simultaneously assemble biological materials and nanoparticles for various applications. Here, we present a new method to construct biopolymer/nanoparticle composite films with conductivity and antibacterial activity by electrodeposition of chitosan/gelatin/nanosilver. Besides, this method
Yang-Chi Fan et al.
Journal of AOAC International, 98(3), 575-579 (2015-05-31)
Danofloxacin is an antibacterial drug of the fluoroquinolone group developed for therapeutic purposes in veterinary medicine. The studies described here include investigations of the residues following a single dose or multiple doses of danofloxacin. Residue depletion studies were performed to
Hiroyuki Yanagisawa et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(7), 635-641 (2015-07-15)
The effect of the sp(2)/sp(3) ratio in an unbalanced magnetron sputtered nanocarbon film electrode was studied for determining Cd(2+) and Pb(2+) by anodic stripping voltammetry (ASV). The signal-to-noise ratio in the ASV measurement improved as the sp(3) concentration in the
Kurian A Kuttiyiel et al.
Nature communications, 5, 5185-5185 (2014-11-07)
Considerable efforts to make palladium and palladium alloys active catalysts and a possible replacement for platinum have had a marginal success. Here we report on a structurally ordered Au10Pd₄₀Co₅₀ catalyst that exhibits comparable activity to conventional platinum catalysts in both
Yan-Ming Liu et al.
Colloids and surfaces. B, Biointerfaces, 122, 287-293 (2014-07-30)
A label-free and ultrasensitive electrochemiluminescence (ECL) aptasensor was constructed for the detection of thrombin. Molybdenum sulfide-graphene nanocomposites with good conductivity and large surface area were immobilized on glassy carbon electrode (GCE), and then Nafion was fixed to chemosorb the Ru(bpy)3(2+)
Kamil Przyborowski et al.
PloS one, 10(6), e0130908-e0130908 (2015-06-27)
1-Methylnicotinamide (MNA), which was initially considered to be a biologically inactive endogenous metabolite of nicotinamide, has emerged as an anti-thrombotic and anti-inflammatory agent with the capacity to release prostacyclin (PGI2). In the present study, we characterized the effects of MNA
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