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Yoon Kyung Kwon et al.
Chemical & pharmaceutical bulletin, 63(12), 1076-1080 (2015-12-04)
The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis Koehne showed the highest ChAT-activating effect in vitro in an assay that used
Q H Zhai et al.
Poultry science, 92(7), 1824-1829 (2013-06-19)
A total of five hundred forty 19-wk-old HyLine Brown hens were used to study the long-term effects of increasing choline with 0 (control), 425, 850, 1,700, 3,400, and 6,800 mg/kg of corn-soybean meal-based diets on productive performance and egg quality.
Zahra Helalat-Nezhad et al.
Journal of chromatography. A, 1394, 46-53 (2015-04-11)
A novel sample preparation method based on the complete dissolution of marine biological samples in choline chloride-oxalic acid (ChCl-Ox) deep eutectic solvent was developed for fast and efficient extraction of eight polycyclic aromatic hydrocarbons (PAHs) using minimum volumes of cyclohexane.
Basil T Thommen et al.
eLife, 12 (2023-11-07)
Plasmodium falciparum accounts for the majority of over 600,000 malaria-associated deaths annually. Parasites resistant to nearly all antimalarials have emerged and the need for drugs with alternative modes of action is thus undoubted. The FK506-binding protein PfFKBP35 has gained attention
Jingliang Zhang et al.
Cell reports, 36(5), 109495-109495 (2021-08-05)
Scn2a encodes the voltage-gated sodium channel NaV1.2, a main mediator of neuronal action potential firing. The current paradigm suggests that NaV1.2 gain-of-function variants enhance neuronal excitability, resulting in epilepsy, whereas NaV1.2 deficiency impairs neuronal excitability, contributing to autism. However, this
Jason J Liu et al.
The American journal of clinical nutrition, 97(4), 794-799 (2013-03-01)
Dietary and genetic factors involved in the one-carbon metabolism pathway may affect telomere length through DNA methylation and synthesis, but this has not been comprehensively investigated in epidemiologic studies. We cross-sectionally examined associations between dietary and genetic factors in the
Ajit G Thomas et al.
PloS one, 10(8), e0127785-e0127785 (2015-08-08)
The cystine-glutamate antiporter (system xc-) is a Na+-independent amino acid transporter that exchanges extracellular cystine for intracellular glutamate. It is thought to play a critical role in cellular redox processes through regulation of intracellular glutathione synthesis via cystine uptake. In
Inês Carneiro et al.
British journal of pharmacology, 171(14), 3404-3419 (2014-04-05)
Despite the abundant expression of the UDP-sensitive P2Y6 receptor in urothelial cells and sub-urothelial myofibroblasts its role in the control of bladder function is not well understood. We compared the effects of UDP and of the selective P2Y6 receptor agonist
Irena Roci et al.
Metabolomics : Official journal of the Metabolomic Society, 16(12), 125-125 (2020-11-30)
Choline is an essential human nutrient that is particular important for proliferating cells, and altered choline metabolism has been associated with cancer transformation. Yet, the various metabolic fates of choline in proliferating cells have not been investigated systematically. This study
Thanyaporn Wongnate et al.
The FEBS journal, 280(13), 3009-3027 (2013-04-13)
Enzymes in the glucose-methanol-choline (GMC) oxidoreductase superfamily catalyze the oxidation of an alcohol moiety to the corresponding aldehyde. In this review, the current understanding of the sugar oxidation mechanism in the reaction of pyranose 2-oxidase (P2O) is highlighted and compared
Ashley R Barrett et al.
Applied and environmental microbiology, 74(14), 4498-4508 (2008-05-27)
Allelic replacement in the Burkholderia genus has been problematic due to the lack of appropriate counter-selectable and selectable markers. The counter-selectable marker sacB, commonly used in gram-negative bacteria, is nonselective on sucrose in many Burkholderia species. In addition, the use
Lorena Pochini et al.
International immunopharmacology, 29(1), 21-26 (2015-05-06)
OCTN1 was immuno-detected in the cervical cancer cell HeLa, in which the complete pattern of acetylcholine metabolizing enzymes is expressed. Comparison of immuno-staining intensity of HeLa OCTN1 with the purified recombinant human OCTN1 allowed measuring the specific OCTN1 concentration in
Determination of high-affinity choline uptake (HACU) and choline acetyltransferase (ChAT) activity in the same population of cultured cells
Ray B, et al.
Brain Research, 1297(11), 160-168 (2009)
Faith M Strickland et al.
Arthritis and rheumatism, 65(7), 1872-1881 (2013-04-12)
Lupus flares occur when genetically predisposed individuals encounter appropriate environmental agents. Current evidence indicates that the environment contributes by inhibiting T cell DNA methylation, causing overexpression of normally silenced genes. DNA methylation depends on both dietary transmethylation micronutrients and ERK-regulated
Marianela Garcia-Munoz et al.
Neuropharmacology, 89, 54-63 (2014-09-23)
N-methyl-D-aspartate receptors (NMDAR) are crucial for the function of excitatory neurotransmission and are present at the synapse and on the extrasynaptic membrane. The major nucleus of the basal ganglia, striatum, receives a large glutamatergic excitatory input carrying information about movements
N A Ibrahim et al.
Carbohydrate polymers, 94(1), 612-618 (2013-04-03)
This study was devoted to enhancing the antibacterial functionality of pigment printed cotton, linen and viscose fabrics. Ag-NP's/PVP colloid, triclosan derivatives, chitosan or choline chloride was successfully incorporated into the pigment paste followed by printing and microwave curing to impart
Laila C Schenkel et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 1663-1675 (2014-12-04)
Fibroblasts from a patient with postural orthostatic tachycardia syndrome (POTS), who presented with low plasma choline and betaine, were studied to determine the metabolic characteristics of the choline deficiency. Choline is required for the synthesis of the phospholipid phosphatidylcholine (PC)
Vanessa L Mygind et al.
Asia Pacific journal of clinical nutrition, 22(2), 319-324 (2013-05-03)
Recently, choline has been associated with neurodevelopment, cognitive function and neural tube defect incidence. However, data on usual intakes are limited, and estimates of dietary intakes of choline and its metabolite betaine, are not available for New Zealanders. The objective
Osamu Kimura et al.
Biological & pharmaceutical bulletin, 37(9), 1475-1479 (2014-09-02)
The uptake mechanism of aristolochic acid I (AAI) was investigated using Caco-2 cells cultured on dishes and permeable membranes. The uptake of AAI from the apical membrane of Caco-2 cells cultured on a dish was rapid, and a decrease in
Stefano Musardo et al.
eLife, 11 (2022-04-23)
Social interaction during adolescence strongly influences brain function and behavior, and the recent pandemic has emphasized the devastating effect of social distancing on mental health. While accumulating evidence has shown the importance of the reward system in encoding specific aspects
Sonia Tabasum Ahmed et al.
Food chemistry, 188, 481-488 (2015-06-05)
The effects of diets supplemented with four levels (0%, 0.5%, 1.0% and 2.0%) of pomegranate by-product (PB) on meat composition, fatty acid profile and oxidative stability of broiler meat were evaluated. The crude protein and moisture contents increased, whereas ether
Maram Hilwi et al.
The Journal of biological chemistry, 289(49), 34258-34266 (2014-10-24)
The sodium- and chloride-coupled GABA transporter GAT-1 is a member of the neurotransmitter:sodium:symporters, which are crucial for synaptic transmission. Structural work on the bacterial homologue LeuT suggests that extracellular loop 4 closes the extracellular solvent pathway when the transporter becomes
Behzad Mortazavi et al.
Environmental pollution (Barking, Essex : 1987), 182, 53-62 (2013-07-31)
We investigated how additions of choline, a naturally occurring methylated nitrogen-containing compound, accelerated hydrocarbon degradation in sandy sediments contaminated with moderately weathered crude oil (4000 mg kg(-1) sediment). Addition of lauroylcholine chloride (LCC) and tricholine citrate (TCC) to oil contaminated
E Gisbert et al.
Journal of animal science, 93(1), 278-286 (2015-01-09)
Terrestrial animal byproduct meals, including nonruminant blood meal and blood products, represent the largest and largely untapped safe source of animal protein available within the international market for the aquafeed industry. Spray-dried blood and spray-dried plasma (SDP) proteins have long
V M Rychikhin et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(3), 10-12 (2013-06-19)
The anticonvulsant effect of dicholine succinate (DCS), a neuronal insulin sensitizer, has been studied on two models of primary generalized epilepsy induced by corazole and maximal electroshock (ME) in mice. It has been found that DCS administered intraperitoneally for 7
Aleksandra Topczewska et al.
Cell reports, 42(7), 112699-112699 (2023-06-27)
Dorsal and ventral medial entorhinal cortex (mEC) regions have distinct neural network firing patterns to differentially support functions such as spatial memory. Accordingly, mEC layer II dorsal stellate neurons are less excitable than ventral neurons. This is partly because the
Wolfgang Bernhard et al.
European journal of nutrition, 54(5), 733-741 (2014-08-26)
Choline is essential to human development, particularly of the brain in the form of phosphatidylcholine, sphingomyelin and acetylcholine, for bile and lipoprotein formation, and as a methyl group donator. Choline is actively transported into the fetus, and maternal supply correlates
Functional calcium imaging in developing cortical networks
Dawitz J, et al.
Journal of Visualized Experiments, 119(56), e3550-e3550 (2011)
Marina Yazigi Solis et al.
The British journal of nutrition, 111(7), 1272-1274 (2013-12-03)
The present cross-sectional study aimed to examine the influence of diet on brain creatine (Cr) content by comparing vegetarians with omnivores. Brain Cr content in the posterior cingulate cortex was assessed by proton magnetic resonance spectroscopy (¹H-MRS). Dietary Cr intake
Bieke Onghena et al.
Dalton transactions (Cambridge, England : 2003), 43(30), 11566-11578 (2014-06-19)
The ionic liquid choline bis(trifluoromethylsulfonyl)imide, [Chol][Tf2N], was used for the extraction of neodymium(III), in combination with choline hexafluoroacetylacetonate, [Chol][hfac], as the extractant. The binary mixture of [Chol][Tf2N] and water shows temperature-dependent phase behavior, with an upper critical solution temperature of
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