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K Kharsany et al.
Journal of ethnopharmacology, 238, 111867-111867 (2019-04-13)
Propolis, a resinous substance produced by the Apis mellifera bee, contains a number of flavonoids sourced from plants found in the surrounding region. Whilst bees use this substance to seal off and protect the beehive, humans have used propolis therapeutically
Saikh Mohammad Wabaidur et al.
Journal of separation science, 38(15), 2597-2606 (2015-05-20)
An ultra high performance liquid chromatography with mass spectrometry method has been developed for the simultaneous separation, identification and determination of 22 phenolic constituents in honey from various floral sources from Yemen. Solid-phase extraction was used for extraction of the
Young-Hyun Go et al.
Biomedicines, 8(11) (2020-10-31)
Despite recent advances in clinical stem cell therapy applications based on human pluripotent stem cells (hPSCs), potential teratoma formation due to the presence of residual undifferentiated hPSCs remains a serious risk factor that challenges widespread clinical application. To overcome this
P Prabhakar Reddy et al.
Bioorganic & medicinal chemistry letters, 19(21), 6078-6081 (2009-09-29)
A comprehensive reinvestigation of chemical constituents from the rhizomes of Hedychium spicatum led to the isolation of two new labdane-type diterpene (1, 2), together with six known compounds (3-8). Their structures were established on the basis of extensive spectroscopic (IR
Yan-Mei Sun et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 962, 59-67 (2014-06-08)
A fast analytical strategy of second-order calibration method based on the alternating trilinear decomposition algorithm (ATLD)-assisted high performance liquid chromatography coupled with a diode array detector (HPLC-DAD) was established for the simultaneous determination of eight flavonoids (rutin, quercetin, luteolin, kaempferol
Atsuyoshi Nishina et al.
Biological & pharmaceutical bulletin, 38(11), 1794-1800 (2015-11-03)
We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among the compounds, luteolin, diosmetin, and chrysoeriol partly inhibited adipogenesis by blocking the accumulation of triacylglycerol in the cells. Conversely, tricetin facilitated triacylglycerol accumulation in the cells.
Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.
Yosuke Nishizaki et al.
Bioorganic & medicinal chemistry letters, 19(16), 4706-4710 (2009-07-14)
The effect of 32 flavonoids on androgen (AR) and glucocorticoid receptors (GR) was investigated using an MDA-kb2 human breast cancer cell line to predict potential AR and GR activities. Among them, 5-hydroxyflavone (7) had the highest AR antagonistic activity with
A M Marin et al.
Microbiology (Reading, England), 159(Pt 1), 167-175 (2012-11-06)
Several bacteria are able to degrade flavonoids either to use them as carbon sources or as a detoxification mechanism. Degradation pathways have been proposed for several bacteria, but the genes responsible are not known. We identified in the genome of
Ai-Mei Gao et al.
Chemico-biological interactions, 206(1), 100-108 (2013-09-03)
Nuclear factor-E2-related factor 2 (Nrf2) is an important cytoprotective transcription factor which plays a key role in antioxidant and detoxification processes. Recent studies have reported that development of chemoresistance is associated with the constitutive activation of the Nrf2-mediated signaling pathway
Leena Pohjala et al.
PloS one, 6(12), e28923-e28923 (2011-12-30)
Chikungunya virus (CHIKV), an alphavirus, has recently caused epidemic outbreaks and is therefore considered a re-emerging pathogen for which no effective treatment is available. In this study, a CHIKV replicon containing the virus replicase proteins together with puromycin acetyltransferase, EGFP
Qiang Du et al.
Molecular medicine reports, 6(1), 100-104 (2012-05-04)
Chrysin, a flavonoid obtained from various natural sources, has been reported to possess anti-inflammatory, antitumor, antioxidant and anti-allergic activities. However, its anti-inflammatory and immunoregulatory activities in asthma animal models are poorly understood. In the present study, we examined the effects
Xiao-Min Yu et al.
Cancer, 119(4), 774-781 (2012-09-20)
Anaplastic thyroid cancer (ATC) is a very aggressive thyroid gland malignancy with very poor prognosis. It is suspected that the Notch signaling pathway, which is not active in ATC, may have a tumor suppressor function in this neoplasm. However, it
Chi Zhang et al.
Molecular medicine reports, 19(2), 1222-1229 (2018-12-12)
High‑mobility group box chromosomal protein (HMGB‑1) contributes to osteoarthritis (OA) by modulating various oxidative, inflammatory and apoptotic signaling pathways. The effect of chrysin (CH), a natural plant flavonoid, and its functional interaction with HMGB‑1, was investigated in a chondrocyte model
Na Sha et al.
Journal of natural products, 72(4), 799-801 (2009-03-13)
A pair of new flavanol racemates (1a and 1b) and a new flavanol racemic mixture (2) were isolated from crude propolis from Henan Province, People's Republic of China. Also obtained were nine known compounds, including two flavones, four flavonols, two
Yunbao Liu et al.
Journal of natural products, 73(7), 1193-1195 (2010-06-23)
Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple formazan by mitochondrial enzymes. NADPH is the basis of established in vitro cell viability assays. An antioxidant assay
Ai-Lin Liu et al.
Bioorganic & medicinal chemistry, 16(15), 7141-7147 (2008-07-22)
Flavonoids are polyphenolic compounds that widely exist in plant kingdom, and the structure-activity relationship (SAR) of 25 flavonoids was studied on neuraminidase (NA) activity of influenza virus. Three typical influenza virus strains A/PR/8/34 (H1N1), A/Jinan/15/90 (H3N2), and B/Jiangshu/10/2003 were used
Mariana Torres-Piedra et al.
Bioorganic & medicinal chemistry, 19(1), 542-546 (2010-12-07)
In our search for potential antihypertensive agents, a series of structurally-related flavonoids was screened. Ex vivo and in vitro biological evaluations indicated that compounds 1-7 displayed an important vasorelaxant effect on the endothelium-intact (E(+)) and -denuded (E(-)) aortic rings test.
Guohua An et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1357-1366 (2014-07-09)
Organic anion transporter 1 (OAT1) has been reported to be involved in the nephrotoxicity of many anionic xenobiotics. As current clinically used OAT1 inhibitors are often associated with safety issues, identifying potent OAT1 inhibitors with little toxicity is of great
E Torres et al.
Prikladnaia biokhimiia i mikrobiologiia, 48(2), 175-182 (2012-05-17)
Quercetin, rutin, naringin, hesperidin and chrysin were tested as substrates for chloroperoxidase to produce reactive quinones to graft onto chitosan. Quercetin and rutin quinones were successfully chemically attached to low molecular weight chitosan. The quercetin-modified chitosan showed an enhancement of
Uroš Gašić et al.
Journal of AOAC International, 97(5), 1259-1267 (2015-04-24)
Composition of phenolic compounds and the sugar content were determined as the basis for characterization of lime honey from Serbia. Particular attention was given to differences in phytochemical profiles of ripe and unripe lime honey and lime tree nectar. Melissopalynological
Zhao-Hui Xie et al.
BMC cancer, 11, 322-322 (2011-08-02)
5-allyl-7-gen-difluoromethoxychrysin (AFMC) is a novel synthetic analogue of chrysin that has been reported to inhibit proliferation in various cancer cell lines. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anti-cancer agent. The cytotoxicity of A549 and WI-38 cells were
Peng-Cheng Lv et al.
European journal of medicinal chemistry, 46(1), 393-398 (2010-12-07)
A series of novel chrysin derivatives was firstly synthesized and evaluated on their immunosuppressive activity in the search for potential immunosuppressive agents. Among them, compounds 5c displayed the most potent immunosuppressive inhibitory activity with IC(50) of 0.78 μM, which was comparable
Pei-Shan Wu et al.
PloS one, 10(6), e0130599-e0130599 (2015-06-19)
Luteolin and apigenin are dietary flavones and exhibit a broad spectrum of biological activities including antioxidant, anti-inflammatory, anti-cancer and neuroprotective effects. The lipid peroxidation product 4-hydroxy-2-nonenal (4-HNE) has been implicated as a causative agent in the development of neurodegenerative disorders.
Min-Kyung Kang et al.
Journal of molecular medicine (Berlin, Germany), 93(7), 759-772 (2015-06-13)
Renal fibrosis is a crucial event in the pathogenesis of diabetic nephropathy (DN). The process known as epithelial to mesenchymal transition (EMT) contributes to the accumulation of matrix proteins in kidneys, in which renal tubular epithelial cells play an important
Aline Lamien-Meda et al.
Phytochemistry, 119, 51-61 (2015-10-03)
The present study focuses on development of phytochemical methods for quality assessment of two West-African Cochlospermum species (Cochlospermum planchonii and Cochlospermum tinctorium) traditionally used for malaria treatment in Burkina Faso. Antimalarial activity of preparations from dried rhizomes (decoction) was tested
Ling Tong et al.
Journal of pharmaceutical and biomedical analysis, 70, 6-12 (2012-06-19)
A liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin in rat plasma, using naringin as an internal standard. After acidifying with HCl, plasma samples were pretreated
Xin Li et al.
Chemico-biological interactions, 232, 12-20 (2015-03-17)
Cisplatin is a chemotherapy drug commonly used for the treatment of human cancers, however, drug resistance poses a major challenge to clinical application of cisplatin in cancer therapy. Recent studies have shown that chrysin, a natural flavonoid widely found in
Chie Amano et al.
PloS one, 10(9), e0137207-e0137207 (2015-09-12)
To explore a novel method using liposomes to suppress macrophages, we screened food constituents through cell culture assays. Curcumin was one of the strongest compounds exhibiting suppressive effects on macrophages. We subsequently tried various methods to prepare liposomal curcumin, and
Jing Yao et al.
Molecular medicine reports, 12(5), 7693-7698 (2015-10-28)
Asthma is a chronic airway inflammatory disease characterized by an increased mass of airway smooth muscle (ASM). Chrysin (5,7-dihydroxyflavone), a natural flavonoid, has been shown to exert multiple biological activities, including anti-inflammatory, anti-proliferative and anti-oxidant effects, as well as the
Hamit Çelik et al.
Neurotoxicology, 81, 197-208 (2020-10-31)
Isoniazid (INH) is among the most important anti-tuberculosis agents widely prescribed. However, its clinical use is restricted due to its severe side effects associated with neurotoxicity. The aim of the present study was to investigate the neuroprotective effects of chrysin
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