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Anniina Färkkilä et al.
The Journal of clinical endocrinology and metabolism, 96(12), E1973-E1981 (2011-10-14)
Ovarian granulosa cell tumors (GCT) are highly vascularized and express vascular endothelial growth factor A (VEGF) and its functional receptor VEGF receptor 2 (VEGFR-2). Angiogenesis inhibitors have been used in the treatment of ovarian carcinomas, whereas their roles in GCT
Yashini Govender et al.
PloS one, 9(5), e96497-e96497 (2014-05-21)
Clinical studies suggest that the injectable contraceptive medroxyprogesterone acetate (MPA) increases susceptibility to infections such as HIV-1, unlike the injectable contraceptive norethisterone enanthate (NET-EN). We investigated the differential effects, molecular mechanism of action and steroid receptor involvement in gene expression
Shang-Long Liu et al.
Oncology letters, 17(2), 2057-2062 (2019-01-25)
The biological features of pancreatic cancer and the associated hypoxic environment around the cancer cells often lead to resistance to radiotherapy and chemotherapy. The present study was performed in order to explore the effect pancreatic stellate cells (PSCs) have on
Xuefeng Gu et al.
Neuro-oncology, 16(2), 217-227 (2013-12-07)
Background The translationally controlled tumor protein (TCTP) is a multifunctional protein that plays important roles in immune responses, cell proliferation, tumorigenicity and cell apoptosis. Here, we examined the clinical value of TCTP in glioma patient survival and investigated the functional
Deepika Ahuja et al.
RNA biology, 13(11), 1152-1165 (2016-10-30)
Tumor suppressor protein p53 plays a crucial role in maintaining genomic integrity in response to DNA damage. Regulation of translation of p53 mRNA is a major mode of regulation of p53 expression under genotoxic stress. The AU/U-rich element-binding protein HuR
Timothy P S Perera et al.
Molecular cancer therapeutics, 16(6), 1010-1020 (2017-03-28)
Fibroblast growth factor (FGF) signaling plays critical roles in key biological processes ranging from embryogenesis to wound healing and has strong links to several hallmarks of cancer. Genetic alterations in FGF receptor (FGFR) family members are associated with increased tumor
Yu Qin et al.
Molecular medicine reports, 9(3), 877-881 (2014-01-09)
The development of multidrug resistance (MDR) in hepatocellular carcinoma (HCC) may markedly reduce the efficacy of its chemotherapeutic treatment. However, the mechanism regulating the development of MDR in these tumors remains unknown. Given the emerging role of small ubiquitin‑like modifier
Susan Hua et al.
International journal of nanomedicine, 14, 2191-2206 (2019-04-17)
Targeted intervention to the uterus has great potential for the treatment of obstetric complications (eg, preterm birth, dysfunctional labor, and postpartum hemorrhage) by improving the effectiveness and safety of therapeutic compounds. In particular, targeting the oxytocin receptor (OTR) is a
Nan Li et al.
Nature communications, 10(1), 4363-4363 (2019-09-27)
The LKB1/AMPK pathway plays a major role in cellular homeostasis and tumor suppression. Down-regulation of LKB1/AMPK occurs in several human cancers and has been implicated in metabolic diseases. However, the precise upstream regulation of LKB1-AMPK pathway is largely unknown. Here, we
George B Kyei et al.
mBio, 9(6) (2018-11-08)
The main obstacle to an HIV cure is the transcriptionally inert proviruses that persist in resting CD4 T cells and other reservoirs. None of the current approaches has significantly reduced the size of the viral reservoir. Hence, alternative approaches, such
Mariarita Perri et al.
Biochimica et biophysica acta, 1800(9), 993-1001 (2010-07-06)
Vitamin A is suggested to be protective against oxidative stress. However, different authors observed pro-oxidant effects of retinoids both in experimental works and clinical trials. These discordances are the bases for the investigation of the proliferative and anti-proliferative properties of
Alberto Barbiroli et al.
Biomolecules, 9(10) (2019-10-17)
The search for bioactivities influencing the human wellbeing of food proteins and peptides is a topic of broad and current interest. γ-Conglutin (γC) is a lupin seed protein drawing remarkable pharmacological and/or nutraceutical interest, as it is able to reduce
Judit Espana-Agusti et al.
Nature communications, 8(1), 2026-2026 (2017-12-13)
Inactivation of the VHL (Von Hippel Lindau) tumour suppressor has long been recognised as necessary for the pathogenesis of clear cell renal cancer (ccRCC); however, the molecular mechanisms underlying transformation and the requirement for additional genetic hits remain unclear. Here
Cassandra D Kelly-Cirino et al.
Infection and immunity, 77(11), 4859-4867 (2009-08-26)
The anthrax protective antigen (PA) is the receptor-binding subunit common to lethal toxin (LT) and edema toxin (ET), which are responsible for the high mortality rates associated with inhalational Bacillus anthracis infection. Although recombinant PA (rPA) is likely to be
Mikko Anttonen et al.
Laboratory investigation; a journal of technical methods and pathology, 91(11), 1605-1614 (2011-08-03)
Ovarian granulosa cell tumors (GCTs) are sex cord stromal tumors that constitute 3-5% of all ovarian cancers. GCTs usually present with an indolent course but there is a high risk of recurrence, which associates with increased mortality, and targeted treatments
Khalid M AlGhamdi et al.
Lasers in medical science, 30(5), 1541-1551 (2015-05-09)
The aim of this study was to investigate the effects of different low-level laser therapies (LLLTs) of various wavelengths and energies on normal cultured human melanocytes. Various studies have shown the effects of LLLs on various types of cultured cells.
Abdullah Maha et al.
Hematology (Amsterdam, Netherlands), 13(1), 13-20 (2008-06-07)
Despite the advances in understanding the pathophysiology of acute myeloid leukaemia (AML), the cure rate for acute myeloid leukaemia patients remains low. Cytogenetic abnormalities and age are the prognostic factors that guide treatment decisions. However, many AML patients still die.
Chao Wang et al.
Experimental cell research, 345(2), 125-133 (2015-04-08)
Benign prostatic hyperplasia (BPH) is one of the major disorders of the urinary system in elderly men. Docosahexaenoic acid (DHA) is the main component of n-3 polyunsaturated fatty acids (n-3 PUFAs) and has nerve protective, anti-inflammatory and tumour-growth inhibitory effects.
Antonietta Liotti et al.
The Prostate, 81(7), 407-417 (2021-03-19)
Growing evidence supports the pivotal role played by periprostatic adipose tissue (PPAT) in prostate cancer (PCa) microenvironment. We investigated whether PPAT can affect response to Docetaxel (DCTX) and the mechanisms associated. Conditioned medium was collected from the in vitro differentiated
Evidence for a systemic regulation of neurotrophin synthesis in response to peripheral nerve injury.
Antos Shakhbazau et al.
Journal of neurochemistry, 122(3), 501-511 (2012-05-23)
Up-regulation of neurotrophin synthesis is an important mechanism of peripheral nerve regeneration after injury. Neurotrophin expression is regulated by a complex series of events including cell interactions and multiple molecular stimuli. We have studied neurotrophin synthesis at 2 weeks time-point in
Yong He et al.
Acta pharmacologica Sinica, 30(7), 1053-1059 (2009-07-04)
Somatostatin receptor subtype 2 (SSTR2) is the principal mediator of somatostatin's (SST) antiproliferative effects on normal and cancer cells. Therefore, we investigated whether the enhanced expression of SSTR2 could inhibit the proliferation of tumor cells, and, if so, the mechanisms
Khalid M AlGhamdi et al.
Dermatologic therapy, 33(3), e13312-e13312 (2020-03-17)
Normal human cultured melanocytes were exposed to various glutathione concentrations (0.1, 0.5, 1.0, 5.0, and 10.0 mg/mL) for 72 hours. At the end of the experiment, proliferation, viability, migration, and ultrastructural changes were monitored. Glutathione at the doses of 0.5 to
Renan B Ferreira et al.
Oncotarget, 8(17), 28971-28989 (2017-04-21)
Many breast cancer deaths result from tumors acquiring resistance to available therapies. Thus, new therapeutic agents are needed for targeting drug-resistant breast cancers. Drug-refractory breast cancers include HER2+ tumors that have acquired resistance to HER2-targeted antibodies and kinase inhibitors, and
Sara Borrego-González et al.
Materials science & engineering. C, Materials for biological applications, 120, 111679-111679 (2021-02-07)
Fibrous biopolymeric collagen extracted from animal tissues has been widely used for fabricating matrices for bone tissue engineering (BTE). However, animal extracted collagens can trigger immune reactions when implanted in vivo and the presence of native crosslinks leads to batch-to-batch
Carla M R Lacerda et al.
American journal of physiology. Heart and circulatory physiology, 302(10), H1983-H1990 (2012-02-22)
This study addressed the following questions: 1) Does cyclic tensile strain induce protein expression patterns consistent with myxomatous degeneration in mitral valves? 2) Does cyclic strain induce local serotonin synthesis in mitral valves? 3) Are cyclic strain-induced myxomatous protein expression
Zhenduo Shi et al.
Cellular and molecular biology (Noisy-le-Grand, France), 66(1), 42-48 (2020-05-04)
To investigate the antitumor mechanism of MAP30 in human bladder cell line (T24) and its potential toxic effects in mice. In this study, the biological behavior of MAP30's influence on bladder cell was investigated to reveal the antitumor mechanism and
Madhuchhanda Kundu et al.
Cells, 11(2) (2022-01-22)
Although some therapies are available for regular breast cancers, there are very few options for triple-negative breast cancer (TNBC). Here, we demonstrated that serum level of IL-12p40 monomer (p40) was much higher in breast cancer patients than healthy controls. On
Hyunwon Yang et al.
Journal of immunology (Baltimore, Md. : 1950), 183(5), 3040-3052 (2009-08-04)
Aging of thymus is characterized by reduction in naive T cell output together with progressive replacement of lymphostromal thymic zones with adipocytes. Determining how calorie restriction (CR), a prolongevity metabolic intervention, regulates thymic aging may allow identification of relevant mechanisms
Qianqian Liang et al.
Arthritis research & therapy, 23(1), 58-58 (2021-02-20)
Our previous studies reveal that impaired draining function of the synovial lymphatic vessel (LV) contributes to the pathogenesis of inflammatory arthritis, but the cellular and molecular mechanisms involved are not fully understood. To investigate the involvement of lymphatic muscle cells
Qiuyu Lin et al.
Journal of cellular and molecular medicine, 22(10), 4640-4652 (2018-07-25)
This study is aimed to investigate the methylation level of candidate genes and its impact on thyroid carcinoma (THCA) development. Infinium Human Methylation 450 BeadChip Arrays by Illumina (Illumina HM450K) was the most popular CpG microarray platform widely used in
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