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Gianluca Zambanini et al.
Development (Cambridge, England), 149(23) (2022-11-11)
Upon WNT/β-catenin pathway activation, stabilized β-catenin travels to the nucleus where it associates with the TCF/LEF transcription factors, constitutively bound to genomic Wnt-responsive elements (WREs), to activate target gene transcription. Discovering the binding profile of β-catenin is therefore required to
Sayanur Rahaman et al.
Science advances, 9(39), eadh9545-eadh9545 (2023-09-27)
The half-life of mRNAs, as well as their translation, increases in proportion to the optimal codons, indicating a tight coupling of codon-dependent differential translation and degradation. Little is known about the regulation of this coupling. We found that the mRNA
Porter M Hall et al.
Nature structural & molecular biology, 29(12), 1217-1227 (2022-12-06)
CRISPR (clustered regularly interspaced short palindromic repeats) utility relies on a stable Cas effector complex binding to its target site. However, a Cas complex bound to DNA may be removed by motor proteins carrying out host processes and the mechanism
Hugo Bernard et al.
Cell reports. Medicine, 1(7), 100125-100125 (2020-11-19)
Enteroviruses are suspected to contribute to insulin-producing β cell loss and hyperglycemia-induced diabetes. However, mechanisms are not fully defined. Here, we show that coxsackievirus B type 4 (CVB4) infection in human islet-engrafted mice and in rat insulinoma cells displays loss
Nucleocytoplasmic shuttling of FTO does not affect starvation-induced autophagy
Aas A, et al.
Testing, 12(3), e0168182-e0168182 (2017)
Xin Wang et al.
Molecular pharmacology, 85(6), 932-945 (2014-04-10)
b-AP15 [(3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-1-(prop-2-enoyl)piperidin-4-one] is a small molecule inhibitor of the ubiquitin specific peptidase (USP) 14/ubiquitin carboxyl-terminal hydrolase (UCH) L5 deubiquitinases of the 19S proteasome that shows antitumor activity in a number of tumor models, including multiple myeloma. b-AP15 contains an α,β-unsaturated
Juan S Ramirez-Prado et al.
Bio-protocol, 11(21), e4211-e4211 (2021-12-04)
Characterizing the molecular mechanisms regulating gene expression is crucial for understanding the regulatory processes underlying physiological responses to environmental and developmental signals in eukaryotes. The covalent modification of histones contributes to the compaction levels of chromatin, as well as the
Maxime Pinard et al.
Molecular brain, 15(1), 98-98 (2022-12-01)
The mechanism of assembly of RNA polymerase III (Pol III), the 17-subunit enzyme that synthesizes tRNAs, 5 S rRNA, and other small-nuclear (sn) RNAs in eukaryotes, is not clearly understood. The recent discovery of the HSP90 co-chaperone PAQosome (Particle for Arrangement
Alex Martínez-Sabadell et al.
Cell reports, 41(3), 111430-111430 (2022-10-20)
Despite the revolution of immunotherapy in cancer treatment, patients eventually progress due to the emergence of resistance. In this scenario, the selection of the tumor antigen can be decisive in the success of the clinical response. T cell bispecific antibodies (TCBs)
Laura C Lehmann et al.
Cell reports, 33(12), 108529-108529 (2020-12-29)
Upon DNA damage, the ALC1/CHD1L nucleosome remodeling enzyme (remodeler) is activated by binding to poly(ADP-ribose). How activated ALC1 recognizes the nucleosome, as well as how this recognition is coupled to remodeling, is unknown. Here, we show that remodeling by ALC1
Kankan Wang et al.
Current protocols, 2(3), e401-e401 (2022-03-23)
As the largest family of ubiquitin (Ub) E3 ligases, cullin-RING ligases (CRLs) play crucial roles in various cellular processes, and their activities are tightly regulated by orchestrated mechanisms. Neddylation, the conjugation of a Ub-like protein NEDD8 to a target protein
Ahmed-Noor A Agip et al.
eLife, 12 (2023-01-10)
Respiratory complex I powers ATP synthesis by oxidative phosphorylation, exploiting the energy from NADH oxidation by ubiquinone to drive protons across an energy-transducing membrane. Drosophila melanogaster is a candidate model organism for complex I due to its high evolutionary conservation
JiaWen Lim et al.
Scientific reports, 12(1), 3000-3000 (2022-02-24)
Human papillomaviruses are DNA tumor viruses. A persistent infection with high-risk HPV types is the necessary risk factor for the development of anogenital carcinoma. The E6 protein is a viral oncoprotein that directly interacts with different cellular regulatory proteins mainly
Lubos Cipak et al.
STAR protocols, 3(1), 101137-101137 (2022-02-08)
Many cellular processes require the activities of complex molecular machines composed of several protein subunits. Insights into these systems can be gained by isolation of protein complexes followed by in vitro analyses determining the identity, posttranslational modifications, and interactions among
André Felipe Rodrigues et al.
Clinical science (London, England : 1979), 135(11), 1353-1367 (2021-05-21)
In spite of the fact that the modulatory effects of angiotensin II (Ang II) on the sympathetic nerve activity to targeted organs involved in blood pressure (BP) regulation is well acknowledged, the local production of this peptide in the brain
Alexander L Nielsen et al.
RSC chemical biology, 2(2), 612-626 (2021-08-31)
Sirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer chain acyl groups from post-translationally modified lysine residues. It affects diverse biological functions in the cell and has been considered a drug target in relation to
Stefano Rosa et al.
Frontiers in molecular biosciences, 10, 1017757-1017757 (2023-03-21)
Genetically-encoded combinatorial peptide libraries are convenient tools to identify peptides to be used as therapeutics, antimicrobials and functional synthetic biology modules. Here, we report the identification and characterization of a cyclic peptide, G4CP2, that interferes with the GAL4 protein, a
Unphosphorylated Form of the PAQosome Core Subunit RPAP3 Binds Ribosomal Preassembly Complexes to Modulate Ribosome Biogenesis.
Pinard, et al.
Journal of Proteome Research, 21, 1073-1082 (2022)
Nicholas M Kanaan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(27), 9858-9868 (2011-07-08)
Aggregated filamentous forms of hyperphosphorylated tau (a microtubule-associated protein) represent pathological hallmarks of Alzheimer's disease (AD) and other tauopathies. While axonal transport dysfunction is thought to represent a primary pathogenic factor in AD and other neurodegenerative diseases, the direct molecular
Mitchell G Kluesner et al.
Nature communications, 12(1), 2437-2437 (2021-04-25)
CRISPR-Cas9 cytidine and adenosine base editors (CBEs and ABEs) can disrupt genes without introducing double-stranded breaks by inactivating splice sites (BE-splice) or by introducing premature stop (pmSTOP) codons. However, no in-depth comparison of these methods or a modular tool for
Chiara Santulli et al.
Cell death & disease, 13(12), 1048-1048 (2022-12-17)
Parkinson's disease (PD) presents the selective loss of A9 dopaminergic (DA) neurons of Substantia Nigra pars compacta (SNpc) and the presence of intracellular aggregates called Lewy bodies. α-synuclein (α-syn) species truncated at the carboxy-terminal (C-terminal) accumulate in pathological inclusions and
Ines Schoberleitner et al.
Cell reports, 37(1), 109769-109769 (2021-10-06)
The ATP-dependent chromatin remodeling factor CHD1 is essential for the assembly of variant histone H3.3 into paternal chromatin during sperm chromatin remodeling in fertilized eggs. It remains unclear, however, if CHD1 has a similar role in normal diploid cells. Using
Young Joo Sun et al.
The Journal of clinical investigation, 131(10) (2021-04-13)
Drugs targeting host proteins can act prophylactically to reduce viral burden early in disease and limit morbidity, even with antivirals and vaccination. Transmembrane serine protease 2 (TMPRSS2) is a human protease required for SARS coronavirus 2 (SARS-CoV-2) viral entry and
Luca Tadini et al.
The Plant journal : for cell and molecular biology, 101(5), 1198-1220 (2019-10-28)
Correct chloroplast development and function require co-ordinated expression of chloroplast and nuclear genes. This is achieved through chloroplast signals that modulate nuclear gene expression in accordance with the chloroplast's needs. Genetic evidence indicates that GUN1, a chloroplast-localized pentatricopeptide repeat (PPR)
The O-GlcNAc transferase OGT interacts with and post-translationally modifies the transcription factor HOXA 1
Draime A, et al.
Febs Letters, 592(7), 1185-1201 (2018)
Scott A Sinclair et al.
Current biology : CB, 27(22), 3403-3418 (2017-11-07)
Etiolated growth in darkness or the irreversible transition to photomorphogenesis in the light engages alternative developmental programs operating across all organs of a plant seedling. Dark-grown Arabidopsis de-etiolated by zinc (dez) mutants exhibit morphological, cellular, metabolic, and transcriptional characteristics of
Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction.
Fontana, et al.
Biological Research, 56, 19-19 (2023)
Sarah A Loddick et al.
Molecular cancer therapeutics, 12(9), 1715-1727 (2013-07-19)
Continued androgen receptor (AR) expression and signaling is a key driver in castration-resistant prostate cancer (CRPC) after classical androgen ablation therapies have failed, and therefore remains a target for the treatment of progressive disease. Here, we describe the biological characterization
Xin Ee Yong et al.
RNA biology, 18(5), 718-731 (2021-01-08)
The capsid protein of dengue virus strain 2 (DENV2C) promotes nucleic acid structural rearrangements using chaperone activity. However, the role of DENV2C during the interaction of RNA elements in the conserved 5' untranslated region (5'UTR) to the 3' untranslated region
Prostate cancer disease recurrence after radical prostatectomy is associated with HLA type and local cytomegalovirus immunity.
Classon, et al.
Molecular Oncology, 16, 3452-3464 (2022)
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