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JiaWen Lim et al.
Scientific reports, 12(1), 3000-3000 (2022-02-24)
Human papillomaviruses are DNA tumor viruses. A persistent infection with high-risk HPV types is the necessary risk factor for the development of anogenital carcinoma. The E6 protein is a viral oncoprotein that directly interacts with different cellular regulatory proteins mainly
Alexander L Nielsen et al.
RSC chemical biology, 2(2), 612-626 (2021-08-31)
Sirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer chain acyl groups from post-translationally modified lysine residues. It affects diverse biological functions in the cell and has been considered a drug target in relation to
André Felipe Rodrigues et al.
Clinical science (London, England : 1979), 135(11), 1353-1367 (2021-05-21)
In spite of the fact that the modulatory effects of angiotensin II (Ang II) on the sympathetic nerve activity to targeted organs involved in blood pressure (BP) regulation is well acknowledged, the local production of this peptide in the brain
Yichen Zhong et al.
Nucleic acids research, 52(9), 5285-5300 (2024-02-17)
The signal recognition particle (SRP) is a critical component in protein sorting pathways in all domains of life. Human SRP contains six proteins bound to the 7S RNA and their structures and functions have been mostly elucidated. The SRP68/72 dimer
Porter M Hall et al.
Nature structural & molecular biology, 29(12), 1217-1227 (2022-12-06)
CRISPR (clustered regularly interspaced short palindromic repeats) utility relies on a stable Cas effector complex binding to its target site. However, a Cas complex bound to DNA may be removed by motor proteins carrying out host processes and the mechanism
Gianluca Zambanini et al.
Development (Cambridge, England), 149(23) (2022-11-11)
Upon WNT/β-catenin pathway activation, stabilized β-catenin travels to the nucleus where it associates with the TCF/LEF transcription factors, constitutively bound to genomic Wnt-responsive elements (WREs), to activate target gene transcription. Discovering the binding profile of β-catenin is therefore required to
Sayanur Rahaman et al.
Science advances, 9(39), eadh9545-eadh9545 (2023-09-27)
The half-life of mRNAs, as well as their translation, increases in proportion to the optimal codons, indicating a tight coupling of codon-dependent differential translation and degradation. Little is known about the regulation of this coupling. We found that the mRNA
Devashish Sen et al.
iScience, 26(7), 107128-107128 (2023-07-07)
Coordinated temporal control of gene expression is essential for physiological homeostasis, especially during metabolic transitions. However, the interplay between chromatin architectural proteins and metabolism in regulating transcription is less understood. Here, we demonstrate a conserved bidirectional interplay between CTCF (CCCTC-binding
Kankan Wang et al.
Current protocols, 2(3), e401-e401 (2022-03-23)
As the largest family of ubiquitin (Ub) E3 ligases, cullin-RING ligases (CRLs) play crucial roles in various cellular processes, and their activities are tightly regulated by orchestrated mechanisms. Neddylation, the conjugation of a Ub-like protein NEDD8 to a target protein
Lubos Cipak et al.
STAR protocols, 3(1), 101137-101137 (2022-02-08)
Many cellular processes require the activities of complex molecular machines composed of several protein subunits. Insights into these systems can be gained by isolation of protein complexes followed by in vitro analyses determining the identity, posttranslational modifications, and interactions among
Maxime Pinard et al.
Molecular brain, 15(1), 98-98 (2022-12-01)
The mechanism of assembly of RNA polymerase III (Pol III), the 17-subunit enzyme that synthesizes tRNAs, 5 S rRNA, and other small-nuclear (sn) RNAs in eukaryotes, is not clearly understood. The recent discovery of the HSP90 co-chaperone PAQosome (Particle for Arrangement
Kavita J Rangan et al.
Cell, 186(12), 2531-2543 (2023-06-10)
RNA editing is a widespread epigenetic process that can alter the amino acid sequence of proteins, termed "recoding." In cephalopods, most transcripts are recoded, and recoding is hypothesized to be an adaptive strategy to generate phenotypic plasticity. However, how animals
Alex Martínez-Sabadell et al.
Cell reports, 41(3), 111430-111430 (2022-10-20)
Despite the revolution of immunotherapy in cancer treatment, patients eventually progress due to the emergence of resistance. In this scenario, the selection of the tumor antigen can be decisive in the success of the clinical response. T cell bispecific antibodies (TCBs)
Laura C Lehmann et al.
Cell reports, 33(12), 108529-108529 (2020-12-29)
Upon DNA damage, the ALC1/CHD1L nucleosome remodeling enzyme (remodeler) is activated by binding to poly(ADP-ribose). How activated ALC1 recognizes the nucleosome, as well as how this recognition is coupled to remodeling, is unknown. Here, we show that remodeling by ALC1
Ahmed-Noor A Agip et al.
eLife, 12 (2023-01-10)
Respiratory complex I powers ATP synthesis by oxidative phosphorylation, exploiting the energy from NADH oxidation by ubiquinone to drive protons across an energy-transducing membrane. Drosophila melanogaster is a candidate model organism for complex I due to its high evolutionary conservation
Xin Wang et al.
Molecular pharmacology, 85(6), 932-945 (2014-04-10)
b-AP15 [(3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-1-(prop-2-enoyl)piperidin-4-one] is a small molecule inhibitor of the ubiquitin specific peptidase (USP) 14/ubiquitin carboxyl-terminal hydrolase (UCH) L5 deubiquitinases of the 19S proteasome that shows antitumor activity in a number of tumor models, including multiple myeloma. b-AP15 contains an α,β-unsaturated
Jigar V Desai et al.
Cell, 186(13), 2802-2822 (2023-05-24)
Systemic candidiasis is a common, high-mortality, nosocomial fungal infection. Unexpectedly, it has emerged as a complication of anti-complement C5-targeted monoclonal antibody treatment, indicating a critical niche for C5 in antifungal immunity. We identified transcription of complement system genes as the
Nucleocytoplasmic shuttling of FTO does not affect starvation-induced autophagy
Aas A, et al.
Testing, 12(3), e0168182-e0168182 (2017)
Nicholas M Kanaan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(27), 9858-9868 (2011-07-08)
Aggregated filamentous forms of hyperphosphorylated tau (a microtubule-associated protein) represent pathological hallmarks of Alzheimer's disease (AD) and other tauopathies. While axonal transport dysfunction is thought to represent a primary pathogenic factor in AD and other neurodegenerative diseases, the direct molecular
Mitchell G Kluesner et al.
Nature communications, 12(1), 2437-2437 (2021-04-25)
CRISPR-Cas9 cytidine and adenosine base editors (CBEs and ABEs) can disrupt genes without introducing double-stranded breaks by inactivating splice sites (BE-splice) or by introducing premature stop (pmSTOP) codons. However, no in-depth comparison of these methods or a modular tool for
Juan S Ramirez-Prado et al.
Bio-protocol, 11(21), e4211-e4211 (2021-12-04)
Characterizing the molecular mechanisms regulating gene expression is crucial for understanding the regulatory processes underlying physiological responses to environmental and developmental signals in eukaryotes. The covalent modification of histones contributes to the compaction levels of chromatin, as well as the
Hugo Bernard et al.
Cell reports. Medicine, 1(7), 100125-100125 (2020-11-19)
Enteroviruses are suspected to contribute to insulin-producing β cell loss and hyperglycemia-induced diabetes. However, mechanisms are not fully defined. Here, we show that coxsackievirus B type 4 (CVB4) infection in human islet-engrafted mice and in rat insulinoma cells displays loss
Unphosphorylated Form of the PAQosome Core Subunit RPAP3 Binds Ribosomal Preassembly Complexes to Modulate Ribosome Biogenesis.
Pinard, et al.
Journal of Proteome Research, 21, 1073-1082 (2022)
Stefano Rosa et al.
Frontiers in molecular biosciences, 10, 1017757-1017757 (2023-03-21)
Genetically-encoded combinatorial peptide libraries are convenient tools to identify peptides to be used as therapeutics, antimicrobials and functional synthetic biology modules. Here, we report the identification and characterization of a cyclic peptide, G4CP2, that interferes with the GAL4 protein, a
Eleni Dimou et al.
Cell reports, 42(7), 112725-112725 (2023-07-02)
Tau is a soluble protein interacting with tubulin to stabilize microtubules. However, under pathological conditions, it becomes hyperphosphorylated and aggregates, a process that can be induced by treating cells with exogenously added tau fibrils. Here, we employ single-molecule localization microscopy
Adam Giess et al.
Cell reports, 31(3), 107534-107534 (2020-04-23)
Translation initiation is often attributed as the rate-determining step of eukaryotic protein synthesis and key to gene expression control. Despite this centrality, the series of steps involved in this process is poorly understood. Here, we capture the transcriptome-wide occupancy of
Enrique J Arenas et al.
Nature communications, 12(1), 1237-1237 (2021-02-25)
Immunotherapy has raised high expectations in the treatment of virtually every cancer. Many current efforts are focused on ensuring the efficient delivery of active cytotoxic cells to tumors. It is assumed that, once these active cytotoxic cells are correctly engaged
Carla Umansky et al.
Nature communications, 13(1), 745-745 (2022-02-10)
Formaldehyde (FA) is a ubiquitous endogenous and environmental metabolite that is thought to exert cytotoxicity through DNA and DNA-protein crosslinking, likely contributing to the onset of the human DNA repair condition Fanconi Anaemia. Mutations in the genes coding for FA
Loni Klaus et al.
The EMBO journal, 42(3), e112100-e112100 (2022-12-23)
All multicellular life relies on differential gene expression, determined by regulatory DNA elements and DNA-binding transcription factors that mediate activation and repression via cofactor recruitment. While activators have been extensively characterized, repressors are less well studied: the identities and properties
Graeme Hewitt et al.
Molecular cell, 81(4), 767-783 (2020-12-18)
Chromatin is a barrier to efficient DNA repair, as it hinders access and processing of certain DNA lesions. ALC1/CHD1L is a nucleosome-remodeling enzyme that responds to DNA damage, but its precise function in DNA repair remains unknown. Here we report
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