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Axelle Chiffre et al.
Environmental science and pollution research international, 22(22), 17486-17498 (2015-07-04)
This study investigates the variations of polycyclic aromatic hydrocarbon (PAH) levels in surface water, suspended particulate matter (SPM) and sediment upstream and downstream of the discharges of two wastewater treatment plant (WWTP) effluents. Relationships between the levels of PAHs in
Susanna Sforzini et al.
Chemosphere, 107, 282-289 (2014-01-15)
An immunohistochemical method using antibodies against polycyclic aromatic hydrocarbons (PAHs) and dioxins was developed on frozen tissue sections of the earthworm Eisenia andrei exposed to environmentally relevant concentrations of benzo[a]pyrene (B[a]P) (0.1, 10, 50 ppm) and 2,3,7,8-tetrachloro-dibenzo-para-dioxin (TCDD) (0.01, 0.1
Ramya Mohandass et al.
Journal of environmental biology, 33(6), 985-989 (2013-06-08)
Polycyclic aromatic hydrocarbons are a group of compounds that pose threat to humans and animal life. Methods to reduce the amount of PAHs in the environment are continuously being sought. The bacterial consortium capable of utilizing benzo(a)pyrene as the sole
Yuyun Chen et al.
International journal of environmental research and public health, 12(11), 14148-14163 (2015-11-13)
Weihe River is a typical river located in the arid and semi-arid regions of Northwest China. In this study, the distribution and sources of 16 polycyclic aromatic hydrocarbons (PAHs) in Weihe River were investigated. The concentrations of ∑PAHs ranged from
Xiaochen Duan et al.
Environmental toxicology and chemistry, 34(2), 283-290 (2014-10-22)
The aims of the present study were to compare the toxic effects of benzo[a]pyrene (BaP) and to screen for rapid and sensitive biomarkers that can be used to assess the environmental risks of BaP in earthworms in different natural soil
Ming Kei Chung et al.
Analytical biochemistry, 435(2), 140-149 (2013-01-22)
Exposure to polycyclic aromatic hydrocarbons has often been quantified via DNA or human serum albumin (HSA) adducts of the carcinogenic metabolite benzo[a]pyrene diol epoxide (BPDE). We previously reported a sandwich ELISA, using 8E11 as capture antibody and anti-HSA as detection
J F Collins et al.
Regulatory toxicology and pharmacology : RTP, 13(2), 170-184 (1991-04-01)
Benzo[a]pyrene is the most studied carcinogenic polycyclic aromatic hydrocarbon and one of the most potent, and it is often used as a toxicological prototype or surrogate for all carcinogenic polycyclic aromatic hydrocarbons. Quantitative risk assessment of benzo[a]pyrene has been hampered
Vasilis P Androutsopoulos et al.
Toxicology letters, 230(2), 304-313 (2013-09-03)
Eupatorin-5-methyl ether (E5M) is a flavone containing 4 methoxy groups that is present in plants with medicinal activity, whereas luteolin (L) is a polyhydroxylated flavone commonly encountered in dietary products. In the present study we investigated the interaction of the
Sonja Kaisarevic et al.
Environmental toxicology and pharmacology, 39(1), 358-368 (2015-01-03)
Rat hepatoma cells H4IIE were treated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons (PAHs) (dibenz(a,h)anthracene, benzo(a)pyrene, benz(a)anthracene, chrysene), low-concentration mixtures of PAHs and TCDD, and environmental mixtures contaminated by PAHs and their derivatives. Expression of the gene battery comprising cytochrome
Anne Graupner et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 772, 34-41 (2014-10-14)
The OECD has developed test guidelines (TG) to identify agents with genotoxic effects. The in vivo alkaline single cell gel electrophoresis (SCGE) assay is currently being prepared to become such a TG. The performance of a combined SCGE/Pig-a gene mutation
I W H Jarvis et al.
Toxicology letters, 229(1), 25-32 (2014-06-10)
Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants that occur naturally in complex mixtures. Many of the adverse health effects of PAHs including cancer are linked to the activation of intracellular stress response signaling. This study has investigated intracellular MAPK
Wei Zhao et al.
Toxicology, 309, 73-80 (2013-05-09)
To explore the relationship between DNA polymerase β (pol β) overexpression and benzo[a]pyrene (BaP) carcinogenesis. Firstly, mouse embryonic fibroblasts that express wild-type level of DNA polymerase β (pol β cell) and high level of pol β (pol β oe cell)
Larisa Ilijin et al.
Environmental toxicology and chemistry, 34(11), 2618-2624 (2015-06-17)
Increased presence of benzo[a]pyrene in the environment underlines the need for development of sensitive biomarkers for monitoring. Antioxidative enzymes could be used as early-warning signals because of their sensitivity and applicability. The activity of 2 antioxidative enzymes, superoxide dismutase (SOD)
Yoshinori Ikenaka et al.
The Journal of toxicological sciences, 38(1), 131-136 (2013-01-30)
We estimated acute toxicity of benzo[a]pyrene (B[a]P) using two cladoceran species, Ceriodaphnia reticulata and Daphnia magna, and also analyzed its impact on zooplankton community throughout an exposure experiment using small-scale mesocosms. LC(50) of B[a]P for C. reticulata and D. magna
Seema Bansal et al.
The Journal of biological chemistry, 289(14), 9936-9951 (2014-02-06)
We report that polycyclic aromatic hydrocarbon (PAH)-inducible CYP1B1 is targeted to mitochondria by sequence-specific cleavage at the N terminus by a cytosolic Ser protease (polyserase 1) to activate the cryptic internal signal. Site-directed mutagenesis, COS-7 cell transfection, and in vitro
Juan Du et al.
Archives of environmental contamination and toxicology, 66(3), 370-378 (2014-02-21)
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in aquatic ecosystems and have been shown to be one of the causes of sediment toxicity to benthic invertebrates. Benzo[a]pyrene (BaP) was selected as a representative for the PAH family of compounds for developing
S R Crowell et al.
Toxicology letters, 228(1), 48-55 (2014-04-29)
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous and often carcinogenic contaminants released into the environment during natural and anthropogenic combustion processes. Benzo[a]pyrene (B[a]P) is the prototypical carcinogenic PAH, and dibenzo[def,p]chrysene (DBC) is a less prevalent, but highly potent transplacental carcinogenic PAH.
Hui Chang et al.
Carcinogenesis, 35(8), 1847-1854 (2014-05-28)
The mammalian target of rapamycin (mTOR), which is a master regulator of cellular catabolism and anabolism, plays an important role in tumourigenesis and progression. In this study, we report the chemopreventive effect of the dietary compound ampelopsin (AMP) on breast
Haixia Lin et al.
Toxicological sciences : an official journal of the Society of Toxicology, 139(2), 338-349 (2014-03-07)
Ginkgo biloba has been used for many thousand years as a traditional herbal remedy and its extract has been consumed for many decades as a dietary supplement. Ginkgo biloba leaf extract is a complex mixture with many constituents, including flavonol
Rajesh Mandarapu et al.
Journal of immunotoxicology, 12(1), 48-55 (2014-02-07)
In the past two decades, hematologic and immunologic disorders in humans have been increasingly reported as a result of pesticide exposures. Therefore, safety assessment is required to assess the effects on hematopoiesis and thus on the immune system in addition
Tong Liu et al.
Gene, 555(2), 108-118 (2014-12-03)
HSP70 and HSP90 are the most important heat shock proteins (HSPs), which play the key roles in the cell as molecular chaperones and may involve in metabolic detoxification. The present research has obtained full-length cDNAs of genes HSP70 and HSP90
Claudia Luckert et al.
Toxicology letters, 222(2), 180-188 (2013-07-13)
Metabolic activation of polycyclic aromatic hydrocarbons (PAH) is mediated mainly by cytochrome P₄₅₀ monooxygenases (CYP) CYP1A1, 1A2 and 1B1. Several PAH are known to induce these CYP via aryl hydrocarbon receptor (AhR) signaling. Recently, it was shown that the PAH
Chibuike Chigbo et al.
Environmental science and pollution research international, 20(12), 8955-8963 (2013-06-12)
Polycyclic aromatic hydrocarbons and heavy metals in the environment are a concern, and their removal to acceptable level is required. Phytoremediation, the use of plants to treat contaminated soils, could be an interesting alternative to conventional remediation processes. This work
Marten A Schults et al.
Mutagenesis, 28(2), 181-185 (2013-01-18)
Genetic polymorphisms can partially explain the large inter-individual variation in DNA adduct levels following exposure to polycyclic aromatic hydrocarbons. Effects of genetic polymorphisms on DNA adduct formation are difficult to assess in human studies because exposure misclassification attenuates underlying relationships.
Marlon J A Jetten et al.
Toxicology, 323, 61-69 (2014-06-21)
Large differences in toxicity responses occur within the human population. In this study we evaluate whether interindividual variation in baseline enzyme activity (EA)/gene expression (GE) levels in liver predispose for the variation in toxicity responses by assessing dose-response relationships for
Diane Benford et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48 Suppl 1, S42-S48 (2009-10-13)
Benzo[a]pyrene (BaP) and a number of other polycyclic aromatic hydrocarbons (PAH) are mutagenic and are also carcinogenic in rodent bioassays. Oral carcinogenicity data are not available for individual PAH other than BaP, and so BaP has been used as a
Samuel Obiri et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 48(4), 408-416 (2013-02-06)
This study is part of a broader initiative to characterize, quantify and assess the human health risk associated with exposure to polycyclic aromatic hydrocarbons (PAHs) in street dust along the Trans-ECOWAS highway in West Africa. In the first part, PAHs
H A Hattemer-Frey et al.
Toxicology and industrial health, 7(3), 141-157 (1991-05-01)
A multimedia transport model was used to evaluate the environmental partitioning of benzo-a-pyrene (BaP). Measured and predicted environmental concentrations were used to estimate the accumulation of BaP in the food chain and the subsequent extent of human exposure from inhalation
María I Cuartero et al.
Circulation, 130(23), 2040-2051 (2014-11-02)
Aryl hydrocarbon receptor (AhR) is a transcription factor that belongs to the basic helix-loop-helix PAS (Per-Arnt-Sim homology domain) family known to mediate the toxic and carcinogenic effects of xenobiotics. Interestingly, AhR is widely expressed in the central nervous system, but
F Mermillod-Blondin et al.
The Science of the total environment, 450-451, 230-241 (2013-03-19)
The interactions between invertebrates and micro-organisms living in streambed sediments often play key roles in the regulation of nutrient and organic matter fluxes in aquatic ecosystems. However, benthic sediments also constitute a privileged compartment for the accumulation of persistent organic
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