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Digoxin: time to reconsider its role in atrial fibrillation?
Mohit K Turagam
Southern medical journal, 106(6), 381-381 (2013-06-06)
Honokiol inhibits pathological retinal neovascularization in oxygen-induced retinopathy mouse model.
Divya Teja Vavilala et al.
Biochemical and biophysical research communications, 438(4), 697-702 (2013-08-08)
Aberrant activation of the hypoxia inducible factor (HIF) pathway is the underlying cause of retinal neovascularization, one of the most common causes of blindness worldwide. The HIF pathway also plays critical roles during tumor angiogenesis and cancer stem cell transformation.
Seema Saksena et al.
American journal of physiology. Gastrointestinal and liver physiology, 304(6), G615-G622 (2013-01-19)
Intestinal P-glycoprotein (Pgp/multidrug resistance 1), encoded by the ATP-binding cassette B1 gene, is primarily involved in the transepithelial efflux of toxic metabolites and xenobiotics from the mucosa into the gut lumen. Reduced Pgp function and expression has been shown to
Judy W M Cheng et al.
The American journal of geriatric pharmacotherapy, 8(5), 419-427 (2011-02-22)
Digoxin has been reported to improve symptoms and reduce hospitalization in patients with heart failure as well as to control rapid ventricular rate in patients with atrial fibrillation. Both of these are high-prevalence diseases in the elderly, and yet studies
Julie Master et al.
Cardiology journal, 16(5), 483-486 (2009-09-16)
Digoxin remains one of the most frequently prescribed drugs in the management of atrial fibrillation. The main indications for digoxin in atrial fibrillation are restoration of sinus rhythm, prevention of recurrence and slowing of the ventricular rate. However, none of
Digoxin for patients with atrial fibrillation and heart failure: paradise lost or not?
Dirk J van Veldhuisen et al.
European heart journal, 34(20), 1468-1470 (2013-01-18)
[Clinical pharmacist intercepts iatrogenic event through medication reconciliation: a case report].
C Michel et al.
Journal de pharmacie de Belgique, (4)(4), 28-30 (2014-01-24)
Kenji Tsuji et al.
Biochemical and biophysical research communications, 447(1), 108-114 (2014-04-03)
The kidneys are exposed to hypoxic conditions during development. Hypoxia-inducible factor (HIF), an important mediator of the response to hypoxia, is believed to have an important role in development. However, the relationship between HIF and branching morphogenesis has not been
Ali Ahmed et al.
The American journal of medicine, 127(1), 61-70 (2013-11-22)
Heart failure is the leading cause for hospital readmission, the reduction of which is a priority under the Affordable Care Act. Digoxin reduces 30-day all-cause hospital admission in chronic systolic heart failure. Whether digoxin is effective in reducing readmission after
Wesley Palatnick et al.
Emergency medicine practice, 16(2), 1-19 (2014-06-03)
While it is relatively uncommon, an overdose of calcium-channel blockers, beta blockers, or digoxin has a significant morbidity and mortality rate, and its management can be complex. Digoxin toxicity can present with an acute overdose or as chronic toxicity while
A patient with systolic dysfunction and an alternating axis.
P Elliott Miller et al.
JAMA internal medicine, 174(12), 2027-2028 (2014-10-28)
Chunbo Zhang et al.
Epilepsia, 54(7), 1154-1160 (2013-04-05)
Antiepileptic drugs (AEDs) do not effectively treat 30-40% of patients with epilepsy. Export of AEDs by P-glycoprotein (Pgp, ABCB1, or MDR1), which is overexpressed in the blood-brain barrier in drug-resistant patients, may be a mechanism for resistance to AEDs. For
Georg Petschenka et al.
Proceedings. Biological sciences, 280(1759), 20123089-20123089 (2013-03-22)
Because cardenolides specifically inhibit the Na(+)K(+)-ATPase, insects feeding on cardenolide-containing plants need to circumvent this toxic effect. Some insects such as the monarch butterfly rely on target site insensitivity, yet other cardenolide-adapted lepidopterans such as the oleander hawk-moth, Daphnis nerii
Robert C Bourge et al.
The American journal of medicine, 126(8), 701-708 (2013-03-16)
Heart failure is a leading cause of hospital admission and readmission in older adults. The new United States healthcare reform law has created provisions for financial penalties for hospitals with higher than expected 30-day all-cause readmission rates for hospitalized Medicare
Vanita Suri et al.
Indian journal of medical sciences, 63(9), 411-414 (2009-10-07)
Sustained fetal supraventricular tachycardia (SVT) with a heart rate of approximately 210 bpm may lead to increased atrial and venous pressures and congestive heart failure. There is no clear consensus regarding the best drug-treatment regimens for fetal SVT. However, considerable
Natalia Lampon et al.
Clinical laboratory, 58(11-12), 1301-1304 (2013-01-08)
Although the possible interference of digoxin-like immunoreactive substances (DLIS) on the Architect iDigoxin chemiluminiscent microparticle immunoassay (CMIA) has been emphasized by the manufacturer, a specific study about this subject has still not been carried out. Apparent serum digoxin concentrations were
Prescrire international, 22(137), 98-98 (2013-05-11)
Several epidemiological studies, some of which included several thousand women, have shown a link between digoxin exposure and the risk of breast cancer. A cohort study of women with angina, identified in the Danish Prescription Registry, showed a statistically significant
Maor Sauler et al.
Clinics in chest medicine, 34(4), 799-810 (2013-11-26)
Recent advances in pulmonary arterial hypertension (PAH) research have created a new era of PAH-specific therapies. Although these therapeutics have revolutionized PAH therapy, their innovation was predated by supportive but nonspecific medical therapies adapted from their use in more common
Mihai Gheorghiade et al.
Acute cardiac care, 11(2), 83-87 (2009-04-23)
Digitalis preparations have been used for centuries. Digoxin is an agent that is readily available, can be administered acutely and long-term, intravenously or orally, is safe and may be beneficial in both acute and chronic heart failure (HF). It may
Acute rate control in atrial fibrillation with left ventricular dysfunction.
Shin-ichi Momomura
Circulation journal : official journal of the Japanese Circulation Society, 77(4), 893-894 (2013-03-19)
Nuggehally R Srinivas et al.
Bioanalysis, 1(1), 97-113 (2009-04-01)
Digoxin is an important therapeutic agent for the treatment of congestive cardiac failure. In spite of its narrow therapeutic index, digoxin has been used extensively by the medical community and, lately, the use of digoxin as a mechanistic probe for
Sibylle Neuhoff et al.
Journal of pharmaceutical sciences, 102(9), 3161-3173 (2013-05-21)
Digoxin is the recommended substrate for assessment of P-glycoprotein (P-gp)-mediated drug-drug interactions (DDIs) in vivo. The overall aim of our study was to investigate the inhibitory potential of both verapamil and norverapamil on the P-gp-mediated efflux of digoxin in both
Andrew P Ambrosy et al.
Journal of the American College of Cardiology, 63(18), 1823-1832 (2014-03-13)
Digoxin is the oldest cardiac drug still in contemporary use, yet its role in the management of patients with heart failure (HF) remains controversial. A purified cardiac glycoside derived from the foxglove plant, digoxin increases ejection fraction, augments cardiac output
When 'digoxin use' is not the same as 'digoxin use': lessons from the AFFIRM trial.
Sabina A Murphy
European heart journal, 34(20), 1465-1467 (2013-04-18)
Mark Bush et al.
Postgraduate medicine, 124(6), 55-72 (2013-01-17)
Albiglutide is a glucagon-like peptide-1 analog that is currently under investigation for the treatment of type 2 diabetes mellitus as a once-weekly injection. Three open-label phase 1 studies were conducted in healthy human participants to investigate potential pharmacokinetic (PK) and/or
Chuenjid Kongkaew et al.
Archives of cardiovascular diseases, 105(10), 507-516 (2012-10-16)
Digoxin is highly potent and efficacious for treatment of heart failure (HF) and/or atrial fibrillation (AF) yet compliance is often poor. To examine prevalence rates of non-compliance with digoxin; variations between clinical settings, types of non-compliance and methods of detection;
Reference laboratory values for digoxin following publication of Digitalis Investigation Group (DIG) trial data.
Paul J Hauptman et al.
JAMA internal medicine, 173(16), 1552-1554 (2013-06-26)
The reply.
Ali Ahmed et al.
The American journal of medicine, 128(1), e19-e19 (2015-01-03)
Weibin Zha et al.
PloS one, 8(1), e54349-e54349 (2013-02-02)
HIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases. We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammatory response through inhibiting endoplasmic reticulum (ER) stress in macrophages.
Robert J Biggar
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(8), 2133-2137 (2012-03-01)
Digoxin, a phyto-estrogen, binds with estrogen receptors (ER) and can cause gynecomastia. Among women currently using digoxin, breast and uterus cancer incidences are significantly increased (approximate risk ratios, 1.3-1.5). Both cancers are often estrogen sensitive. In contrast, ovary and cervix
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