D103705

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Multivalent linkers for improved covalent binding of oligonucleotides to dye-doped silica nanoparticles.

S M Kelleher et al.

Nanotechnology, 26(36), 365703-365703 (2015-08-22)

This paper describes the fabrication of oligonucleotide-coated Cy5-doped silica nanoparticles using a combination of multivalent linkers and their use in surface-based DNA sandwich hybridization assays. Dipodal silane is introduced as a means to fabricate amine-coated silica nanoparticles and its advantages

Heterotelechelic polymer prodrug nanoparticles: Adaptability to different drug combinations and influence of the dual functionalization on the cytotoxicity.

Daniele Vinciguerra et al.

Journal of controlled release : official journal of the Controlled Release Society, 295, 223-236 (2019-01-07)

Well-defined, heterotelechelic polymer prodrugs for combination therapy were synthesized by using a combination of the "drug-initiated" nitroxide-mediated polymerization from a gemcitabine-alkoxyamine initiator and the nitroxide exchange reaction using TEMPO-bearing drugs to end-cap the drug-polymer chain-end by a second drug. This

Electrochemiluminescence sensor based on upconversion nanoparticles and oligoaniline-crosslinked gold nanoparticles imprinting recognition sites for the determination of dopamine.

Ying Gu et al.

Biosensors & bioelectronics, 128, 129-136 (2019-01-19)

For the determination of dopamine (DA) in serum samples, a quenching-type electrochemiluminescence sensor (MIECLS) was constructed in this study. Upconversion nanoparticles (UCNPs) enhanced by covalent organic frameworks (COFs)-based hybrid and oligoaniline-crosslinked gold nanoparticles (AuNPs) imprinting recognition sites were introduced in

A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine.

Jiao Feng et al.

Science advances, 5(2), eaau5148-eaau5148 (2019-02-23)

The clinical use of endogenous neuropeptides has historically been limited due to pharmacokinetic issues, including plasma stability and blood-brain barrier permeability. In this study, we show that the rapidly metabolized Leu-enkephalin (LENK) neuropeptide may become pharmacologically efficient owing to a

Modulation effect of acidulated human serum albumin on Cu

Baolong Xie et al.

Journal of inorganic biochemistry, 171, 67-75 (2017-04-04)

Aggregation of amyloid β-proteins (Aβ) induced by Cu

Fabrication of porous covalent organic frameworks as selective and advanced adsorbents for the on-line preconcentration of trace elements against the complex sample matrix.

Jing-Min Liu et al.

Journal of hazardous materials, 344, 220-229 (2017-10-19)

Herein, for the first time, the typical porous Covalent Organic Frameworks (COFs) CTpBD with superior chemical stability and large surface area were applied as sorbents for solid phase extraction of trace ions via flow injection followed by inductively coupled plasma

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